Review
Biochemistry & Molecular Biology
Giulia D. S. Ferretti, Julia Quarti, Gileno dos Santos, Luciana P. Rangel, Jerson L. Silva
Summary: p53 is a mutated tumor suppressor protein that often aggregates and promotes cancer growth. Studying new molecules and therapeutic targets that disrupt p53 aggregates is a promising strategy against cancer. This review classifies anticancer molecules into four categories and highlights the role of autophagy in degrading aggregated p53.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Shengliang Zhang, Lindsey Carlsen, Liz Hernandez Borrero, Attila A. Seyhan, Xiaobing Tian, Wafik S. El-Deiry
Summary: This article summarizes the current progress in targeting wild-type and mutant p53 for cancer therapy using biotherapeutic and biopharmaceutical methods. Strategies include boosting p53 activity, restoring p53 pathway function, targeting p53 in immunotherapy, and combination therapies.
Review
Oncology
Murali Munisamy, Nayonika Mukherjee, Levin Thomas, Amy Trinh Pham, Arash Shakeri, Yusheng Zhao, Jill Kolesar, Praveen P. N. Rao, Vivek M. Rangnekar, Mahadev Rao
Summary: Ubiquitination is crucial in regulating p53 stability and function in cancer, particularly through the p53-MDM2-MDMX pathway. Targeting the ubiquitination pathway shows promise as a strategy for precision therapy in cancer treatment.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Veronika Obsilova, Karolina Honzejkova, Tomas Obsil
Summary: ASK1, a crucial cellular stress sensor, activates JNKs and p38 MAPKs which when excessively activated can lead to cell death, inflammation and fibrosis. Targeted inhibition of ASK1, the upstream activator of these kinases, is a promising therapeutic strategy for treating various severe conditions including neurological disorders, cardiovascular diseases, diabetes and cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Neurosciences
Juan Gao, Jifei Liu, Yonghong Li, Junxi Liu, He Wang, Miao Chai, Ying Dong, Zhenchang Zhang, Gang Su, Manxia Wang
Summary: There is a lack of specific therapies for neuroinflammation, making p53 a potential crucial target for regulation. This article provides a comprehensive review on the potential of targeting p53 in the treatment of neuroinflammation after ischemic stroke (IS). It describes the function of p53, the major immune cells involved in neuroinflammation, and the role of p53 in inflammatory responses mediated by these cells. Finally, it summarizes the therapeutic strategies of targeting p53 in regulating the neuroinflammatory response after IS, providing new directions and ideas for the treatment of ischemic brain injury.
JOURNAL OF NEUROSCIENCE RESEARCH
(2023)
Article
Multidisciplinary Sciences
Amit Jangid, Md Zubbair Malik, Ram Ramaswamy, R. K. Brojen Singh
Summary: In the study, it was found that the p53 regulatory network exhibits four distinct dynamical states, including active, apoptotic, pre-malignant, and cancer states, depending on the nature and level of the external stress signal. Transitions between these states are unidirectional and irreversible, with the system moving to an irreversible cancerous state under significantly large stress.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Chrisanta Harakandi, Lauraine Nininahazwe, Haiwei Xu, Bingrui Liu, Chenghua He, Yi-Chao Zheng, Hang Zhang
Summary: The USP7-MDM2-p53 network plays a crucial role in regulating p53 and cancer development, with inhibiting USP7 and MDM2 proteins reactivating the p53 signaling pathway leading to cell cycle arrest and apoptosis.
BIOORGANIC CHEMISTRY
(2021)
Review
Chemistry, Multidisciplinary
Jerson L. Silva, Debora Foguel, Vitor F. Ferreira, Tuane C. R. G. Vieira, Mayra A. Marques, Giulia D. S. Ferretti, Tiago F. Outeiro, Yraima Cordeiro, Guilherme A. P. de Oliveira
Summary: Biomolecular condensates, arising from liquid-liquid phase separation, have dual roles in health and disease. This review focuses on their role in cancer, particularly in relation to the p53 tumor suppressor. Mutations in the TP53 gene, present in over half of malignant tumors, have significant implications for future cancer treatment strategies. Targeting the phase transitions of mutant p53 offers a promising direction for innovative cancer diagnostics and therapeutics.
Review
Pharmacology & Pharmacy
Xuerong Zhang, Shehan Li, Zibo Li, Liangkai Cheng, Zhongqiu Liu, Caiyan Wang
Summary: Heat shock protein (Hsp) 90 plays a crucial role in protein folding, maturation, and stability. Inhibition of Hsp90 production and activity can lead to the degradation of client proteins, but it has toxic side effects. Cell division cycle 37 (Cdc37) is an important co-chaperone of Hsp90 that regulates the activity of client proteins and cell survival. Blocking Hsp90-Cdc37 protein-protein interaction (PPI) has higher selectivity and better application prospects compared to ATP competitive Hsp90 inhibitors.
CURRENT DRUG TARGETS
(2022)
Article
Chemistry, Multidisciplinary
Long Li, Zhen Li, Ziying Wang, Shuyu Chen, Rongying Liu, Xuyang Xu, Zhi Zhang, Linfei Ye, Yu Ding, Quan Luo, Sheng Cao, Lei Zhang, Anne Imberty, Guosong Chen
Summary: By controlling the symmetry and number of supramolecular interactions on protein surfaces, nonspecific interactions between proteins can be induced to form various nanoscale assemblies, including coiling nanowires, nanotubes, and nanosheets, without manipulating the protein's native surfaces. These nanoscale assemblies can spontaneously evolve into more ordered architectures, crystals. These findings reveal a transformation mechanism of protein self-assembly that has not been exploited before and may provide an approach to generate complex and transformable biomacromolecular self-assemblies.
Article
Oncology
Joana B. Loureiro, Liliana Raimundo, Juliana Calheiros, Carla Carvalho, Valentina Barcherini, Nuno R. Lima, Celia Gomes, Maria Ines Almeida, Marco G. Alves, Jose Luis Costa, Maria M. M. Santos, Lucilia Saraiva
Summary: Melanoma, a deadly form of skin cancer, is highly metastatic and therapy-resistant. The p53-activating agent SLMP53-2 shows promising antitumor activity by inducing cell cycle arrest and apoptosis, inhibiting invasion and migration, and increasing sensitivity to chemotherapy. It also has the potential to improve outcomes in advanced melanoma, either alone or in combination therapy.
Review
Oncology
Francesca Mancini, Ludovica Giorgini, Emanuela Teveroni, Alfredo Pontecorvi, Fabiola Moretti
Summary: Sex profoundly influences cancer incidence and therapy susceptibility, with sex hormones playing a significant role. The association of the p53 circuitry with genetic variation underlies sex-related altered cancer risk and sensitivity to therapy. Estrogenic hormones can affect the levels and function of the p53 network in both hormone-dependent and independent cancers.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Tao Shi, Paulien E. Polderman, Marc Pages-Gallego, Robert M. Van Es, Harmjan R. Vos, Boudewijn M. T. Burgering, Tobias B. Dansen
Summary: Reversible cysteine oxidation is crucial in redox signaling and plays a role in altering protein structure and function. The tumor suppressor p53 is known to be redox-sensitive and can form disulfide-dependent interactions with other proteins under oxidizing conditions, potentially playing a role in regulating p53 activity.
Review
Medicine, General & Internal
Victor Llombart, Marc R. Mansour
Summary: c-MYC plays a crucial role in regulating gene expression and is involved in tumor initiation and maintenance. Inhibition of MYC shows promising anti-proliferative effects and tumor regression, making it a potential therapeutic target for cancer treatment.
Article
Biochemistry & Molecular Biology
Yi-Cheng Chen, Yu-Chi Chou, Yu-Tung Hsieh, Pin-Yu Kuo, Mei-Lin Yang, Hao-Earn Chong, Chao-Liang Wu, Ai-Li Shiau, Chrong-Reen Wang
Summary: The study revealed increased p53-dependent lncRNA expression and accelerated cell apoptosis in the lungs of SLE-associated DAH patients, suggesting the therapeutic potential of targeting intra-pulmonary lncRNA expression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Maria Kapanidou, Semin Lee, Victor M. Bolanos-Garcia
TRENDS IN MOLECULAR MEDICINE
(2015)
Review
Biochemistry & Molecular Biology
Maria Kapanidou, Natalie L. Curtis, Victor M. Bolanos-Garcia
TRENDS IN BIOCHEMICAL SCIENCES
(2017)
Article
Biochemistry & Molecular Biology
Guillaume Combes, Helena Barysz, Chantal Garand, Luciano Gama Braga, Ibrahim Alharbi, Philippe Thebault, Luc Murakami, Dominic P. Bryne, Stasa Stankovic, Patrick A. Eyers, Victor M. Bolanos-Garcia, William C. Earnshaw, John Maciejowski, Prasad V. Jallepalli, Sabine Elowe
Article
Biochemistry & Molecular Biology
Patricia M. A. Silva, Rita M. Reis, Victor M. Bolanos-Garcia, Claudia Florindo, Alvaro A. Tavares, Hassan Bousbaa
Article
Cell Biology
Priyanka Ghongane, Maria Kapanidou, Adeel Asghar, Sabine Elowe, Victor M. Bolanos-Garcia
JOURNAL OF CELL SCIENCE
(2014)
Article
Biochemistry & Molecular Biology
Sofia Pina Olmos, Roberto Diaz Torres, Eman Elbakrawy, Louise Hughes, Joseph Mckenna, Mark A. Hill, Munira Kadhim, Patricia Ramirez Noguera, Victor M. Bolanos-Garcia
Review
Chemistry, Physical
Andrada Tomoni, Jonathan Lees, Andres G. Santana, Victor M. Bolanos-Garcia, Agatha Bastida
Article
Chemistry, Physical
Paula Morales, Natalie L. Curtis, Sandra G. Zarate, Agatha Bastida, Victor M. Bolanos-Garcia
Review
Biochemistry & Molecular Biology
Sabine Elowe, Victor M. Bolanos-Garcia
Summary: In this article, the roles of BUB1 and BUBR1 in mitosis are discussed, as well as their highly specific interactions through SLiMs, which drive SAC signaling and ensure genome stability.
TRENDS IN BIOCHEMICAL SCIENCES
(2022)
Editorial Material
Biochemistry & Molecular Biology
Francesc Rabanal, Mark S. Johnson, Alessandro Alaimo, Victor M. Bolanos-Garcia, Travis Beddoe
Article
Chemistry, Physical
Alfredo Rus, Victor M. Bolanos-Garcia, Agatha Bastida, Paula Morales
Summary: This study utilizes virtual screening and molecular docking to identify potential HPSE inhibitors that may have therapeutic potential in treating chronic and infectious diseases.
Article
Physiology
Maria-Alexa Cosma, Natalie L. Curtis, Charlotte Pain, Verena Kriechbaumer, Victor M. Bolanos-Garcia
Summary: This study investigates the structure and function of plant CDC20, a key regulator of APC/C in mitosis. The research reveals the presence of conserved protein degradation sites in AtCDC20, similar to other eukaryotes, but also identifies unique features and evolutionary processes in plant species.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Lauren Pugh, Alisha Pancholi, Priscila Celeste Purat, Sandra Agudo-Alvarez, Raul Benito-Arenas, Agatha Bastida, Victor M. Bolanos-Garcia
Summary: This study investigated the interaction dynamics between human Mps1 kinase and isoflavones using computational biology approach and compared it with the crystal structure of Mps1 in complex with reversine. The findings suggest that isoflavones can serve as a chemical scaffold for developing new Mps1 inhibitors for cancer treatment associated with Mps1 amplification and aberrant chromosome segregation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Infectious Diseases
Sandra G. Zarate, Paula Morales, Katarzyna Swiderek, Victor M. Bolanos-Garcia, Agatha Bastida
Article
Pediatrics
Fernando Rodriguez, Carla Vallejos, Victor M. Bolanos-Garcia, Diana Ponce, Nancy Unanue, Francisco Garay, Fernando Cassorla, Mariana Aracena
JOURNAL OF PEDIATRIC GENETICS
(2018)
