Article
Nutrition & Dietetics
Ryo Katsuki, Tsukasa Shiraishi, Shinji Sakata, Tatsuhiko Hirota, Yasunori Nakamura, Shin-ichi Yokota
Summary: Components of LAB, specifically LTA, have been shown to suppress DEX-induced Atrogin-1 expression in skeletal muscle, with the GroP moiety playing a key role in this inhibitory activity. Heat-killed cells cultured under low-Mn2+ conditions showed lower inhibitory activity due to reduced poly-GroP polymers in LTA.
JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY
(2021)
Article
Cell Biology
Mengyuan Niu, Li Li, Zhonglan Su, Lulu Wei, Wenyuan Pu, Chen Zhao, Yibing Ding, Junaid Wazir, Wangsen Cao, Shiyu Song, Qian Gao, Hongwei Wang
Summary: Cancer cachexia is a multifactorial metabolic syndrome that causes up to 20% of cancer-related deaths. Investigating the key genes and protein-protein interactions revealed that Ddit4 plays a crucial role in cancer cachexia by inhibiting the mTOR pathway. This study sheds light on the underlying pathological mechanisms of cancer cachexia and potential therapeutic targets.
CELL DEATH & DISEASE
(2021)
Article
Nutrition & Dietetics
Francielly Morena da Silva, Megan E. Rosa-Caldwell, Eleanor R. Schrems, Lauren Martinez, Madeline G. Amos, Seongkyun Lim, Ana Regina Cabrera, Jacob L. Brown, Tyrone A. Washington, Nicholas P. Greene
Summary: This study investigated the potential protective effect of peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1α) overexpression on cancer cachexia. The results showed that the mitochondrial antioxidant MitoTEMPO (MitoT) could attenuate myotube atrophy induced by cancer cells in vitro. However, in vivo, PGC-1α overexpression was insufficient to protect muscle mass and mitochondrial health despite mitigation of cachexia-associated signaling pathways.
APPLIED PHYSIOLOGY NUTRITION AND METABOLISM
(2022)
Review
Biochemistry & Molecular Biology
Dulce Peris-Moreno, Laura Cussonneau, Lydie Combaret, Cecile Polge, Daniel Taillandier
Summary: Skeletal muscle loss is a harmful side effect of chronic diseases, increasing mortality and morbidity. The ubiquitin proteasome system plays a key role in regulating muscle contraction and metabolism through targeting key proteins for degradation or activity modulation via E3 ubiquitin ligases.
Article
Endocrinology & Metabolism
Qifang Li, Kiyo-aki Ishii, Kyoko Kamoshita, Kenta Takahashi, Halimulati Abuduwaili, Hiroaki Takayama, Cynthia M. Galicia-Medina, Ryota Tanida, Hein Ko Oo, Guzel Gafiyatullina, Xingyu Yao, Tuerdiguli Abuduyimiti, Jun Hamazaki, Hisanori Goto, Yujiro Nakano, Yumie Takeshita, Kenichi Harada, Shigeo Murata, Toshinari Takamura
Summary: Muscle atrophy is both a cause and consequence of obesity. Disruption of proteasome function in the skeletal muscles mediates obesity-induced ER stress and insulin resistance. The specific role of proteasome function in skeletal muscles and its regulation by obesity is not well understood.
Article
Biochemistry & Molecular Biology
Yohei Ikeno, Maya Inomata, Yuka Tsukimura, Yuta Suzuki, Hiroto Takeuchi, Yui Harada, Risako Kon, Nobutomo Ikarashi, Yoshihiko Chiba, Takeshi Yamada, Junzo Kamei, Hiroyasu Sakai
Summary: Cisplatin-induced muscle atrophy can be attenuated by EPA through down-regulation of up-regulated Ub gene expression.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Article
Engineering, Environmental
Apoorva H. Nagendra, Mohd Altaf Najar, Bipasha Bose, Shenoy P. Sudhee
Summary: Fluoride at high doses is known to be toxic to the musculoskeletal system, primarily affecting bone and cartilage cells. However, there is limited research on the toxicity of fluoride to skeletal muscle. This study found that during skeletal fluorosis, muscle is also affected. Short-term exposure to sodium fluoride (NaF) led to muscle hypertrophy through activation of the IGF1/PI3/Akt/mTOR signaling pathway, while long-term exposure resulted in muscle atrophy due to activation of the ubiquitin-proteasome pathway. Differentially expressed proteins were identified and characterized using proteomic analysis.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Cardiac & Cardiovascular Systems
Liuqing Yang, Nirmal Parajuli, Penglong Wu, Jinbao Liu, Xuejun Wang
Summary: The study establishes that PKA activates 26S proteasomes through pS14-Rpn6 and identifies pS14-Rpn6 as a key factor in cardiac proteinopathy.
CIRCULATION RESEARCH
(2023)
Review
Pharmacology & Pharmacy
Lin Yin, Na Li, Weihua Jia, Nuoqi Wang, Meidai Liang, Xiuying Yang, Guanhua Du
Summary: Skeletal muscle is crucial for various bodily functions, but pathological issues can lead to muscle wasting and atrophy, characterized by weakness and reduced mass. While exercise is effective, it is not universally applicable, highlighting the need for further research into treatment options.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Environmental Sciences
Rodrigo Zuloaga, Oscar Varas, Camila Ahrendt, Victor M. Pulgar, Juan A. Valdes, Alfredo Molina, Cristian Duarte, Angel Urzua, Fabian Guzman-Rivas, Marcela Aldana, Jose Pulgar
Summary: Upwelling oceanographic phenomenon affects food availability, seawater temperature and pH, which in turn significantly influence fish muscle growth. This study evaluated the muscle fibers size, protein content, and gene expression of growth and atrophy-related genes in fish from upwelling and downwelling zones. The results showed that fish from upwelling zones had larger muscle fibers and higher protein content, associated with lower protein ubiquitination and gene expression of F-box only protein 32. This study highlights how oceanographic conditions can modulate food quality and fish muscle physiology in an integrated way, with important implications for marine conservation and sustainable fisheries management.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Endocrinology & Metabolism
Svenia Schmid, Barbara Heim-Kupr, Joaquin Perez-Schindler, Shivani Mansingh, Markus Beer, Nitish Mittal, Nikolaus Ehrenfeuchter, Christoph Handschin
Summary: This study reveals the role of PGC-1β in the regulation of catabolic pathways in muscle-specific loss-of-function mouse models. PGC-1β plays a crucial role in protein breakdown, muscle mass preservation, and function.
MOLECULAR METABOLISM
(2022)
Review
Biochemistry & Molecular Biology
Dina Aweida, Shenhav Cohen
Summary: Protein degradation is essential for cellular integrity, with autophagy and the UPS being the main systems responsible for protein breakdown. Recent studies show that even complex protein structures can be efficiently degraded in vivo, with AAA-ATPases playing a crucial role in the disassembly process.
Article
Biochemistry & Molecular Biology
Daniela Aravena-Canales, Jorge E. Aedo, Alfredo Molina, Juan Antonio Valdes
Summary: This study revealed that cortisol plays a complex regulatory role in the expression of atrogenes in rainbow trout skeletal muscle, with both early downregulation and later upregulation observed. Membrane-initiated cortisol action was found to regulate murf1 gene expression in rainbow trout myotubes, while having no significant effect on atrogin-1.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY
(2021)
Article
Cell Biology
Qin Feng, Wenkai Xia, Zhong Feng, Yujun Tan, Yongxia Zhang, Deshan Liu, Guimin Zhang
Summary: The mechanism of accelerated aging in thyrotoxicosis mice was investigated in this study. Excess thyroxine led to cardiac hypertrophy, decreased hepatic synthetic capacity, and decreased hepatic and renal metabolic capacity. The main cause of organ senescence was identified as proteotoxicity, which resulted from intensified oxidative phosphorylation, excessive ribosome production, and impaired splicing and ubiquitin proteasome system function. This research provides a convenient and suitable animal model for studying aging mechanisms and antiaging drugs.
JOURNAL OF CELLULAR PHYSIOLOGY
(2023)
Article
Food Science & Technology
Young-Sool Hah, Won Keong Lee, Sangyeob Lee, Jin-Hee Seo, Eun Ji Kim, Yeong-in Choe, Sang Gon Kim, Jun-Il Yoo
Summary: Sarcopenia, the loss of muscular mass and strength with aging, leads to functional impairment, increased risk of falls and fractures, and loss of independence. Coumestrol has been found to inhibit skeletal muscle loss, but its protective mechanism is poorly understood. This study investigated the protective effect of coumestrol against dexamethasone-induced muscle atrophy using in vitro and in vivo analyses. The results suggest that coumestrol may attenuate dexamethasone-induced muscle atrophy by blocking the ubiquitin-proteasome pathway through suppressing AMPK-FoxO1/3 signaling. Therefore, coumestrol could be a potential treatment for aging sarcopenia.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Review
Physiology
Lionel A. Tintignac, Hans-Rudolf Brenner, Markus A. Rueegg
PHYSIOLOGICAL REVIEWS
(2015)
Article
Biochemistry & Molecular Biology
Maitea Guridi, Lionel A. Tintignac, Shuo Lin, Barbara Kupr, Perrine Castets, Markus A. Rueegg
Article
Biochemistry & Molecular Biology
Maitea Guridi, Lionel A. Tintignac, Shuo Lin, Barbara Kupr, Perrine Castets, Markus A. Rueegg
Article
Cardiac & Cardiovascular Systems
Laetitia Mazelin, Baptiste Panthu, Anne-Sophie Nicot, Edwige Belotti, Lionel Tintignac, Geoffrey Teixeira, Qing Zhang, Valerie Risson, Dominique Baas, Emilie Delaune, Genevieve Derumeaux, Daniel Taillandier, Theophile Ohlmann, Michel Ovize, Yann-Gael Gangloff, Laurent Schaeffer
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2016)
Article
Cell Biology
Maitea Guridi, Barbara Kupr, Klaas Romanino, Shuo Lin, Denis Falcetta, Lionel Tintignac, Markus A. Ruegg
Article
Cell Biology
Perrine Castets, Shuo Lin, Nathalie Rion, Sabrina Di Fulvio, Klaas Romanino, Maitea Guridi, Stephan Frank, Lionel A. Tintignac, Michael Sinnreich, Markus A. Rueegg
Article
Clinical Neurology
Thorsten Schaefer, Archana Ramadoss, Severina Leu, Lionel Tintignac, Cristobal Tostado, Andrea Bink, Christoph Schurch, Joelle Mueller, Jonas Scharer, Giusi Moffa, Philippe Demougin, Suzette Moes, Christoph Stippich, Simona Falbo, Heike Neddersen, Heiner Bucher, Stephan Frank, Paul Jeno, Claudia Lengerke, Marie-Francoise Ritz, Luigi Mariani, Jean-Louis Boulay
Article
Multidisciplinary Sciences
Laurence Pessemesse, Lionel Tintignac, Emilie Blanchet, Fabienne Cortade, Elodie Jublanc, Remi Demangel, Guillaume Py, Chamroeun Sar, Gerard Cabello, Chantal Wrutniak-Cabello, Francois Casas
SCIENTIFIC REPORTS
(2019)
Article
Geriatrics & Gerontology
Alexander S. Ham, Kathrin Chojnowska, Lionel A. Tintignac, Shuo Lin, Alexander Schmidt, Daniel J. Ham, Michael Sinnreich, Markus A. Rueegg
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2020)
Article
Biology
Nathalie Bouquier, Enora Moutin, Lionel A. Tintignac, Amandine Reverbel, Elodie Jublanc, Michael Sinnreich, Yan Chastagnier, Julien Averous, Pierre Fafournoux, Chiara Verpelli, Tobias Boeckers, Gilles Carnac, Julie Perroy, Vincent Ollendorff
Article
Medicine, Research & Experimental
Simona Reinhold, Desiree Yeginsoy, Alexa Hollinger, Atanas Todorov, Lionel Tintignac, Michael Sinnreich, Caroline Kiss, Caroline E. Gebhard, Balazs Kovacs, Bianca Gysi, Lara Imwinkelried, Martin Siegemund
Article
Multidisciplinary Sciences
Daniel J. Ham, Anastasiya Borsch, Shuo Lin, Marco Thurkauf, Martin Weihrauch, Judith R. Reinhard, Julien Delezie, Fabienne Battilana, Xueyong Wang, Marco S. Kaiser, Maitea Guridi, Michael Sinnreich, Mark M. Rich, Nitish Mittal, Lionel A. Tintignac, Christoph Handschin, Mihaela Zavolan, Markus A. Ruegg
NATURE COMMUNICATIONS
(2020)
Article
Biology
Anastasiya Borsch, Daniel J. Ham, Nitish Mittal, Lionel A. Tintignac, Eugenia Migliavacca, Jerome N. Feige, Markus A. Ruegg, Mihaela Zavolan
Summary: This study utilized phenotypic measurements and RNA-Seq data from mice, rats, and humans to assess the relevance of rodent models for human muscle aging. The findings suggest that rodents can recapitulate some aspects of human sarcopenia, such as mitochondrial changes and inflammatory responses. Additionally, phenotypic measurements like muscle mass were found to be better indicators of muscle health than chronological age in aging-related molecular data analysis.
COMMUNICATIONS BIOLOGY
(2021)
Article
Food Science & Technology
Rim Nassar, Barbara Vernus, Gilles Carnac, Gilles Fouret, Benedicte Goustard, Francois Casas, Lionel Tintignac, Isabelle Cassar-Malek, Brigitte Picard, Iban Seiliez, Thomas Brioche, Christelle Koechlin-Ramonatxo, Christelle Bertrand-Gaday, Aline Hamade, Fadia Najjar, Beatrice Chabi, Anne Bonnieu
Summary: Myostatin deficiency leads to increased protein degradation in post-mortem muscle, primarily through enhanced calpain activity. Autophagy, ubiquitin-proteasome, and caspase systems are not upregulated in this process.
Article
Biology
Marco S. Kaiser, Giulia Milan, Daniel J. Ham, Shuo Lin, Filippo Oliveri, Kathrin Chojnowska, Lionel A. Tintignac, Nitish Mittal, Christian E. Zimmerli, David J. Glass, Mihaela Zavolan, Markus A. Rueegg
Summary: Muscle size is regulated by the PI3K-PKB/Akt-mTORC1-FoxO pathway, which controls protein synthesis and breakdown. Paradoxically, while mTORC1 activity is necessary for muscle hypertrophy, its constant activation promotes protein breakdown through the UPS. This study highlights the importance of mTORC1-mediated PKB/Akt inhibition and the role of the UPS in muscle atrophy and proteome integrity.
COMMUNICATIONS BIOLOGY
(2022)