Journal
CELL CYCLE
Volume 7, Issue 1, Pages 24-27Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/cc.7.1.5232
Keywords
Skp2; E2F; Rb; cyclin E; cdk2; G(1) phase
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Funding
- NATIONAL CANCER INSTITUTE [R01CA072639] Funding Source: NIH RePORTER
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [P01HL062250] Funding Source: NIH RePORTER
- NCI NIH HHS [CA72639] Funding Source: Medline
- NHLBI NIH HHS [HL62250] Funding Source: Medline
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The identification of Skp2 as a direct E2F target has allowed us to document the existence of a positive feedback loop comprised of Rb-E2F, Skp2, p27 and cyclin E-cdk2. We have termed this set of regulatory molecules the Skp2 autoinduction loop. Interference with this loop selectively regulates cell cycle progression through the restriction point. We describe here how the Skp2 autoinduction loop may interact with other regulatory controls on the restriction point, and how the reciprocal relationship between Rb and Skp2 may affect signal transduction to the cell cycle and thinking about the role of Skp2 overexpression in cancers.
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