HIF-1α activation results in actin cytoskeleton reorganization and modulation of Rac-1 signaling in endothelial cells

Localized RhoA GTPase activity regulates dynamics of endothelial monolayer integrity

(2013) Robert Szulcek et al.   CARDIOVASCULAR RESEARCH

Regulation of adherens junctions by Rho GTPases and p120-catenin

(2012) Andre Menke et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

The updated biology of hypoxia-inducible factor

(2012) Samantha N Greer et al.   EMBO JOURNAL

Hypoxia-inducible factor as a therapeutic target for cardioprotection

(2012) Sang-Ging Ong et al.   PHARMACOLOGY & THERAPEUTICS

HIF–prolyl hydroxylases and cardiovascular diseases

(2012) Sucharita Sen Banerjee et al.   TOXICOLOGY MECHANISMS AND METHODS

Phosphatidylinositol 3′-kinase signaling pathway is essential for Rac1-induced hypoxia-inducible factor-1α and vascular endothelial growth factor expression

(2011) Yan Xue et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Inhibition of Rho kinases increases directional motility of microvascular endothelial cells

(2011) Johannes Breyer et al.   BIOCHEMICAL PHARMACOLOGY

Targeting tumour angiogenesis with small molecule inhibitors of hypoxia inducible factor

(2011) Ida Karin Nordgren et al.   CHEMICAL SOCIETY REVIEWS

Current Insights into the Role of HIF-1 in Cutaneous Wound Healing

(2011) E. Andrikopoulou et al.   CURRENT MOLECULAR MEDICINE

Hypoxia-Inducible Factor-1 in Arterial Disease: A Putative Therapeutic Target

(2011) Veeru Kasivisvanathan et al.   Current Vascular Pharmacology

Inhibition of hypoxia-induced retinal neovascularization in mice with short hairpin RNA targeting Rac1, possibly via blockading redox signaling

(2011) Xiong-Ze Zhang et al.   EXPERIMENTAL EYE RESEARCH

Inhibition of prolyl hydroxylases by dimethyloxaloylglycine after stroke reduces ischemic brain injury and requires hypoxia inducible factor-1α

(2011) Molly E. Ogle et al.   NEUROBIOLOGY OF DISEASE

Regulation of vimentin intermediate filaments in endothelial cells by hypoxia

(2010) Tiegang Liu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

From Vessel Sprouting to Normalization

(2010) Cathy Coulon et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Hypoxia-inducible factor-1-dependent mechanisms of vascularization and vascular remodelling

(2010) S. Rey et al.   CARDIOVASCULAR RESEARCH

Role of GTPases in control of microvascular permeability

(2010) V. Spindler et al.   CARDIOVASCULAR RESEARCH

Chronic Inhibition of Hypoxia-inducible Factor Prolyl 4-hydroxylase Improves Ventricular Performance, Remodeling, and Vascularity After Myocardial Infarction in the Rat

(2010) Weike Bao et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

The role of HIF prolyl hydroxylases in tumour growth

(2010) Terhi Jokilehto et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Inhibition of Prolyl Hydroxylases Increases Erythropoietin Production in ESRD

(2010) W. M. Bernhardt et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Inhibition of Rho-dependent kinases ROCK I/II activates VEGF-driven retinal neovascularization and sprouting angiogenesis

(2009) Jens Kroll et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Inhibition of Prolyl Hydroxylase Domain-Containing Protein Suppressed Lipopolysaccharide-Induced TNF-α Expression

(2009) Kotaro Takeda et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Shear stress preconditioning modulates endothelial susceptibility to circulating TNF-α and monocytic cell recruitment in a simplified model of arterial bifurcations

(2009) Iwona Cicha et al.   ATHEROSCLEROSIS

Endothelial deletion of hypoxia-inducible factor-2  (HIF-2 ) alters vascular function and tumor angiogenesis

(2009) N. Skuli et al.   BLOOD

Tumor Vasculature Is Regulated by PHD2-Mediated Angiogenesis and Bone Marrow-Derived Cell Recruitment

(2009) Denise A. Chan et al.   CANCER CELL

Heterozygous Deficiency of PHD2 Restores Tumor Oxygenation and Inhibits Metastasis via Endothelial Normalization

(2009) Massimiliano Mazzone et al.   CELL

PAKing up to the endothelium

(2009) Eva Maria Galan Moya et al.   CELLULAR SIGNALLING

The role of hypoxia in atherosclerosis

(2009) Lillemor Mattsson Hultén et al.   CURRENT OPINION IN LIPIDOLOGY

FoxO Proteins Mediate Hypoxic Induction of Connective Tissue Growth Factor in Endothelial Cells

(2009) Jana Samarin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Endothelial oxygen sensors regulate tumor vessel abnormalization by instructing phalanx endothelial cells

(2009) Katrien De Bock et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Prolyl hydroxylase inhibitors increase neoangiogenesis and callus formation following femur fracture in mice

(2009) Xing Shen et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Recent advances in three-dimensional multicellular spheroid culture for biomedical research

(2008) Ruei-Zhen Lin et al.   Biotechnology Journal

Role and regulation of prolyl hydroxylase domain proteins

(2008) G-H Fong et al.   CELL DEATH AND DIFFERENTIATION

Biology of HIF-1α

(2008) A Weidemann et al.   CELL DEATH AND DIFFERENTIATION

Biology of hypoxia-inducible factor-2α in development and disease

(2008) S A Patel et al.   CELL DEATH AND DIFFERENTIATION

An essential role for Rac1 in endothelial cell function and vascular development

(2008) Wenfu Tan et al.   FASEB JOURNAL

HIF Activation Protects From Acute Kidney Injury

(2008) A. Weidemann et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The actin cytoskeleton in endothelial cell phenotypes

(2008) Nutan Prasain et al.   MICROVASCULAR RESEARCH