4.7 Review

Calcium signaling in the cochlea - Molecular mechanisms and physiopathological implications

Journal

CELL COMMUNICATION AND SIGNALING
Volume 10, Issue -, Pages -

Publisher

BMC
DOI: 10.1186/1478-811X-10-20

Keywords

Hearing; Inner ear; Transducer adaptation; Ca2+ channels; Cadherin 23; Protocadherin 15; Plasma-membrane Ca2+-ATPase; Prestin; Intracellular stores; Calcium release; Mitochondria; Ribbon synapse; Adenosine-5 '-triphosphate; Inositol 1,4,5-trisphosphate; Connexin 26; Connexin 30; Deafness; Mouse models

Categories

Funding

  1. MIUR PRIN [2009CCZSES]
  2. Telethon [GGP09137]

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Calcium ions (Ca2+) regulate numerous and diverse aspects of cochlear and vestibular physiology. This review focuses on the Ca2+ control of mechanotransduction and synaptic transmission in sensory hair cells, as well as on Ca2+ signalling in non-sensory cells of the developing cochlea.

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