Vascular endothelial growth factor receptors and the therapeutic targeting of angiogenesis in cancer: where do we go from here?

Phase 1 study of weekly anti-vascular endothelial growth factor receptor-1 (VEGFR-1) monoclonal antibody IMC-18F1 in patients with advanced solid malignancies

(2017) S. S. Krishnamurthi et al.   JOURNAL OF CLINICAL ONCOLOGY

VEGFR-1 Expressed by Malignant Melanoma-Initiating Cells Is Required for Tumor Growth

(2011) Natasha Y. Frank et al.   CANCER RESEARCH

DLL4-Notch Signaling Mediates Tumor Resistance to Anti-VEGF Therapy In Vivo

(2011) J.-L. Li et al.   CANCER RESEARCH

Foretinib (GSK1363089), an Orally Available Multikinase Inhibitor of c-Met and VEGFR-2, Blocks Proliferation, Induces Anoikis, and Impairs Ovarian Cancer Metastasis

(2011) M. Zillhardt et al.   CLINICAL CANCER RESEARCH

Upregulated stromal EGFR and vascular remodeling in mouse xenograft models of angiogenesis inhibitor–resistant human lung adenocarcinoma

(2011) Tina Cascone et al.   JOURNAL OF CLINICAL INVESTIGATION

Vascular endothelial growth factor receptor-1 in human cancer

(2010) Jonathan D. Schwartz et al.   CANCER

ZD6474, a dual tyrosine kinase inhibitor of EGFR and VEGFR-2, inhibits MAPK/ERK and AKT/PI3-K and induces apoptosis in breast cancer cells

(2010) Siddik Sarkar et al.   CANCER BIOLOGY & THERAPY

Cotargeting of VEGFR-1 and -3 and angiopoietin receptor Tie2 reduces the growth of solid human ovarian cancer in mice

(2010) H Sallinen et al.   CANCER GENE THERAPY

Interleukin-8 Mediates Resistance to Antiangiogenic Agent Sunitinib in Renal Cell Carcinoma

(2010) D. Huang et al.   CANCER RESEARCH

Direct and Differential Suppression of Myeloid-Derived Suppressor Cell Subsets by Sunitinib Is Compartmentally Constrained

(2010) Jennifer S. Ko et al.   CANCER RESEARCH

Molecular Mechanisms of Cardiovascular Toxicity of Targeted Cancer Therapeutics

(2010) Hui Cheng et al.   CIRCULATION RESEARCH

Vascular Endothelial Growth Factor Receptors VEGFR-2 and VEGFR-3 Are Localized Primarily to the Vasculature in Human Primary Solid Cancers

(2010) N. R. Smith et al.   CLINICAL CANCER RESEARCH

Effects of Anti-VEGF Treatment Duration on Tumor Growth, Tumor Regrowth, and Treatment Efficacy

(2010) A. Bagri et al.   CLINICAL CANCER RESEARCH

Biological Evidence for Dual Antiangiogenic-Antiaromatase Activity of the VEGFR Inhibitor PTK787/ZK222584 In vivo

(2010) S. Banerjee et al.   CLINICAL CANCER RESEARCH

Angiopoietin-2 Interferes with Anti-VEGFR2-Induced Vessel Normalization and Survival Benefit in Mice Bearing Gliomas

(2010) S.-S. Chae et al.   CLINICAL CANCER RESEARCH

Mechanisms of resistance to antiangiogenesis therapy

(2010) Faisal Azam et al.   EUROPEAN JOURNAL OF CANCER

Experimental treatment of oestrogen receptor (ER) positive breast cancer with tamoxifen and brivanib alaninate, a VEGFR-2/FGFR-1 kinase inhibitor: A potential clinical application of angiogenesis inhibitors

(2010) Roshani R. Patel et al.   EUROPEAN JOURNAL OF CANCER

Disease Course Patterns After Discontinuation of Bevacizumab: Pooled Analysis of Randomized Phase III Trials

(2010) David Miles et al.   JOURNAL OF CLINICAL ONCOLOGY

Anti-tumor effect of CT-322 as an Adnectin inhibitor of vascular endothelial growth factor receptor-2

(2010) Roni Mamluk et al.   mAbs

Tumour vascularization via endothelial differentiation of glioblastoma stem-like cells

(2010) Lucia Ricci-Vitiani et al.   NATURE

Fibroblast growth factor 2 regulates endothelial cell sensitivity to sunitinib

(2010) J C Welti et al.   ONCOGENE

Cytogenetic Abnormalities of Tumor-Associated Endothelial Cells in Human Malignant Tumors

(2009) Tomoshige Akino et al.   AMERICAN JOURNAL OF PATHOLOGY

Effects of VEGFR-3 phosphorylation inhibitor on lymph node metastasis in an orthotopic diffuse-type gastric carcinoma model

(2009) M Yashiro et al.   BRITISH JOURNAL OF CANCER

Accelerated Metastasis after Short-Term Treatment with a Potent Inhibitor of Tumor Angiogenesis

(2009) John M.L. Ebos et al.   CANCER CELL

Antiangiogenic Therapy Elicits Malignant Progression of Tumors to Increased Local Invasion and Distant Metastasis

(2009) Marta Pàez-Ribes et al.   CANCER CELL

Identification of Ligand-Induced Proteolytic Cleavage and Ectodomain Shedding of VEGFR-1/FLT1 in Leukemic Cancer Cells

(2009) N. Rahimi et al.   CANCER RESEARCH

Direct Evidence that Bevacizumab, an Anti-VEGF Antibody, Up-regulates SDF1 , CXCR4, CXCL6, and Neuropilin 1 in Tumors from Patients with Rectal Cancer

(2009) L. Xu et al.   CANCER RESEARCH

High VEGFR-3-positive Circulating Lymphatic/Vascular Endothelial Progenitor Cell Level Is Associated with Poor Prognosis in Human Small Cell Lung Cancer

(2009) K. Bogos et al.   CLINICAL CANCER RESEARCH

Human Hepatocellular Carcinoma Tumor-derived Endothelial Cells Manifest Increased Angiogenesis Capability and Drug Resistance Compared with Normal Endothelial Cells

(2009) Y.-Q. Xiong et al.   CLINICAL CANCER RESEARCH

VEGFR-2 silencing by small interference RNA (siRNA) suppresses LPA-induced epithelial ovarian cancer (EOC) invasion

(2009) Feng-qiang Wang et al.   GYNECOLOGIC ONCOLOGY

Vandetanib Versus Gefitinib in Patients With Advanced Non–Small-Cell Lung Cancer: Results From a Two-Part, Double-Blind, Randomized Phase II Study

(2009) Ronald B. Natale et al.   JOURNAL OF CLINICAL ONCOLOGY

VEGFR1-activity-independent metastasis formation

(2009) Michelle R. Dawson et al.   NATURE

An overview of small-molecule inhibitors of VEGFR signaling

(2009) S. Percy Ivy et al.   Nature Reviews Clinical Oncology

Serum Vascular Endothelial Growth Factor/Soluble Vascular Endothelial Growth Factor Receptor 1 Ratio Is an Independent Prognostic Marker in Pancreatic Cancer

(2009) Yu-Ting Chang et al.   PANCREAS

Targeting Vascular Endothelial Growth Factor in Renal Cell Carcinoma

(2009) Nilay S. Patel et al.   TUMOR BIOLOGY

VEGF165b, an antiangiogenic VEGF-A isoform, binds and inhibits bevacizumab treatment in experimental colorectal carcinoma: balance of pro- and antiangiogenic VEGF-A isoforms has implications for therapy

(2008) A H R Varey et al.   BRITISH JOURNAL OF CANCER

Blood Vessel Maturation and Response to Vascular-Disrupting Therapy in Single Vascular Endothelial Growth Factor-A Isoform-Producing Tumors

(2008) G. M. Tozer et al.   CANCER RESEARCH

Vascular Endothelial Growth Factor (VEGF)-A165b Is a Weak In vitro Agonist for VEGF Receptor-2 Due to Lack of Coreceptor Binding and Deficient Regulation of Kinase Activity

(2008) H. Kawamura et al.   CANCER RESEARCH

Targeting the EGFR, VEGFR, and PDGFR on colon cancer cells and stromal cells is required for therapy

(2008) Toshio Kuwai et al.   CLINICAL & EXPERIMENTAL METASTASIS

Hematogenous Metastasis in Gastric Cancer Requires Isolated Tumor Cells and Expression of Vascular Endothelial Growth Factor Receptor-1

(2008) K. Mimori et al.   CLINICAL CANCER RESEARCH

The VEGF receptor Flt-1 spatially modulates Flk-1 signaling and blood vessel branching

(2008) Nicholas C. Kappas et al.   JOURNAL OF CELL BIOLOGY

Effect of Interleukin-8 Gene Silencing With Liposome-Encapsulated Small Interfering RNA on Ovarian Cancer Cell Growth

(2008) William M. Merritt et al.   JNCI-Journal of the National Cancer Institute

Examining the acute effects of cediranib (RECENTIN, AZD2171) treatment in tumor models: a dynamic contrast-enhanced MRI study using gadopentate

(2008) Daniel P. Bradley et al.   MAGNETIC RESONANCE IMAGING

Differential response of primary tumor versus lymphatic metastasis to VEGFR-2 and VEGFR-3 kinase inhibitors cediranib and vandetanib

(2008) T. P. Padera et al.   MOLECULAR CANCER THERAPEUTICS

Sorafenib in Advanced Hepatocellular Carcinoma

(2008) Josep M. Llovet et al.   NEW ENGLAND JOURNAL OF MEDICINE

Basic Science Review: Current Insights on the Biology and Clinical Aspects of VEGF Regulation

(2008) Daniel M. Birk et al.   Vascular and Endovascular Surgery