Article
Biochemistry & Molecular Biology
Lisandra Flores-Aldama, Daniel Bustos, Deny Cabezas-Bratesco, Wendy Gonzalez, Sebastian E. Brauchi
Summary: TRPV5 and TRPV6 are calcium-selective ion channels that play a crucial role in maintaining systemic calcium homeostasis. These channels are regulated by intracellular calcium, which induces inactivation. The inactivation of TRPV5 and TRPV6 can be divided into fast and slow phases, with the fast inactivation being unique to TRPV6. By utilizing various techniques, including structural analyses and mutagenesis, we have identified specific amino acids and interactions that govern the inactivation kinetics of mammalian TRPV5 and TRPV6 channels. Additionally, we propose that the association between the intracellular HLH domain and the TRP domain helix contributes to the faster inactivation kinetics observed in mammalian TRPV6 channels.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Genetics & Heredity
Vinayak Khattar, Lingyun Wang, Ji-Bin Peng
Summary: TRPV6 is a calcium-selective channel that plays critical roles in cellular calcium transport, maintaining low calcium environment, and certain biological processes. Its function and expression are regulated by vitamin D, dietary calcium, and physiological conditions. Loss of function and aberrant expression of TRPV6 are associated with various human diseases.
Review
Chemistry, Multidisciplinary
Hai-tao Yu, Juan Zhen, Ji-yan Leng, Lu Cai, Hong-lei Ji, Bradley B. Keller
Summary: Cadmium is a significant environmental pollutant linked to various health issues, while zinc has been shown to alleviate cadmium toxicity through mechanisms like direct competition for cellular uptake and induction of protective mechanisms. Future research directions on the role of zinc and metal transporters in reducing cadmium toxicity are discussed in this review.
ACTA PHARMACOLOGICA SINICA
(2021)
Article
Environmental Sciences
Mateusz Okrutniak, Irena M. Grzes
Summary: The study revealed significant differences in the accumulation of zinc and cadmium in worker ants from different colonies at the same site, with up to three-fold and six-fold differences detected. The results indicate a high level of colony-specific metal accumulation capacity in L. niger in the study area. These findings may suggest potential for incorporating between-colony variation in metal accumulation into bioindication protocols for more accurate assessments of environmental contamination.
ENVIRONMENTAL POLLUTION
(2021)
Article
Environmental Sciences
Zunxin Wang, Yang Li, Mingsong Liu, Ying Yang, Rui Wang, Siyuan Chen, Zongmei Liu, Feiyu Yan, Xinhong Chen, Junguo Bi, Zhiyao Dong, Feibing Wang
Summary: This study investigated the effects of nitrogen (N), zinc (Zn), and 24-epibrassionlide (EBL) alone and in combination on the growth and physiological characteristics of Cd and Zn in rice plants under Cd stress. The results showed that N and its combination with Zn or EBL promoted rice growth and yield, and the N + EBL treatment had the highest yield increase. In addition, the application of N, Zn, EBL, and their combined treatments reduced the Cd uptake in different parts of the rice plant and increased Cd distribution in cell walls, leading to decreased Cd concentration in grains.
Article
Cell Biology
Tibor Rohacs, Edwin C. Fluck, Jose J. De Jesus-Perez, Vera Y. Moiseenkova-Bell
Summary: Transient Receptor Potential Vanilloid 5 and 6 (TRPV5 and TRPV6) are Ca2+ selective epithelial ion channels that share high sequence homology due to recent gene duplication in mammals. Both channels are constitutively active and undergo Ca2+-induced inactivation, regulated by endogenous cofactors and binding of calmodulin. Recent cryo electron microscopy and X-ray crystallography structures provide detailed information for TRPV5 and TRPV6, focusing on their mechanisms of inhibition, activation, and modulation.
Article
Plant Sciences
Moez Maghrebi, Elena Baldoni, Giorgio Lucchini, Gianpiero Vigani, Giampiero Vale, Gian Attilio Sacchi, Fabio Francesco Nocito
Summary: The study found that there are distinct differences in the ways Capataz and Beirao handle Cd at different concentrations. The Cd root retention in Capataz increased with external Cd concentration, while Beirao had higher Cd root retention compared to Capataz and was independent of Cd concentration. Additionally, the expression levels of genes related to Cd transport varied between the two rice accessions.
Article
Engineering, Environmental
Muhammad Nafees, Adiba Khan Sehrish, Sarah Owdah Alomrani, Linlin Qiu, Aasim Saeed, Shoaib Ahmad, Shafaqat Ali, Hongyan Guo
Summary: The accumulation of cadmium and antibiotics in edible plants and fertile soil is a worldwide problem. This study investigated the potential of zinc oxide nanoparticles to alleviate the toxicity of both cadmium and antibiotics and promote spinach growth.
JOURNAL OF HAZARDOUS MATERIALS
(2024)
Article
Environmental Sciences
Jianjun Qin, Jing Wang, Jian Long, Jing Huang, Shengshuang Tang, Hongbo Hou, Peiqin Peng
Summary: This study investigates the extraction of biomass enriched with heavy metals using Napier grass biochar and the separation of heavy metals. The results show the feasibility of obtaining K-rich fertilizer with low risk of heavy metals and biochar with good application prospect.
JOURNAL OF ENVIRONMENTAL MANAGEMENT
(2022)
Article
Engineering, Chemical
Xiang Liu, Shixing Wang, Zhengwu Peng, Gengwei Zhang, Qihao Gui, Libo Zhang
Summary: Currently, removing cadmium (II) from zinc sulfate electrolytes using zinc powder presents several problems, such as increased consumption of the zinc powder and poor removal performance. To overcome this limitation, ultrasound is used to assist the replacement of the zinc powder. The ultrasonic-assisted replacements significantly reduce reaction time, temperature, and the required amount of zinc powder, resulting in improved replacement rate and reduced consumption.
SEPARATION AND PURIFICATION TECHNOLOGY
(2023)
Review
Nutrition & Dietetics
Theoharris Frangos, Wolfgang Maret
Summary: Zinc and cadmium play crucial roles in osteoarthritis and rheumatoid arthritis, affecting the immune system, inflammation, and metabolism. The mutations in proteins involved in zinc homeostasis and cadmium exposure through inhalation may contribute to joint destruction.
Article
Multidisciplinary Sciences
Brian J. Earley, Ciro Cubillas, Kurt Warnhoff, Raheel Ahmad, Alan Alcantar, Maximilian D. Lyon, Daniel L. Schneider, Kerry Kornfeld
Summary: This study demonstrates that cadmium can regulate transcription by mimicking the physiological role of zinc, affecting the high zinc response. By analyzing related genes, specific resistance pathways for high zinc and cadmium, as well as a shared pathway, have been identified.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Electrochemistry
Ozlem Uguz Neli, Oezlem Budak, Atif Koca
Summary: Cadmium zinc sulfoselenide (CdZnSSe) and reduced graphene oxide-cadmium zinc sulfoselenide (RGO)-CdZnSSe composite-based photoelectrodes were fabricated using a facile, simultaneous co-electrodeposition method for the first time. The rCV technique allowed for homogeneous decoration of CdZnSSe particles among RGO sheets, resulting in improved photoelectrochemical performance in hydrogen evolution. The Cd0.8Zn0.2S0.2Se0.8 photodecoration demonstrated the highest photocurrent density (4.08 mA cm-2), which was further increased to 5.00 mA cm-2 by decorating with RGO. The proposed rCV technique showed superiority in fabricating well-controlled RGO-CdZnSSe composite photoelectrodes.
ELECTROCHIMICA ACTA
(2023)
Article
Agronomy
Michael Tavarez, Michael A. Grusak, Renuka P. Sankaran
Summary: Cadmium is a toxic heavy metal that can be transferred into the food chain through rice consumption. Understanding the interactions between zinc and cadmium is crucial for controlling cadmium accumulation in rice and increasing zinc transfer. Previous studies have yielded conflicting results about these interactions. This study aimed to investigate the effects of external cadmium and zinc on the uptake and translocation of both minerals in rice with different grain cadmium concentrations.
Article
Plant Sciences
Seyyedeh Atefeh Mousavi, Neda Dalir, Rasoul Rahnemaie, Rainer Schulin
Summary: This study found that exogenous methionine could reduce Cd accumulation in valerian roots, while increasing Cd uptake in the shoots. The addition of phosphate affected root Cd contents due to increased apoplastic Cd binding. However, in the presence of methionine, the phosphate effect on root Cd accumulation was mainly due to increased symplastic mot Cd allocation.
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2021)
Article
Urology & Nephrology
Manuel A. Anderegg, Giuseppe Albano, Daniela Hanke, Christine Deisl, Dominik E. Uehlinger, Simone Brandt, Rajesh Bhardwaj, Matthias A. Hediger, Daniel G. Fuster
Summary: NHA2 plays a critical role in kidney function and blood pressure homeostasis, affecting WNK4-NCC pathway; NHA2 knockout mice showed reduced blood pressure and attenuated response to diuretics; NHA2 regulates blood pressure homeostasis in the kidney by influencing WNK4-NCC pathway.
KIDNEY INTERNATIONAL
(2021)
Article
Oncology
Palanivel Kandasamy, Inti Zlobec, Damian T. Nydegger, Jonai Pujol-Gimenez, Rajesh Bhardwaj, Senji Shirasawa, Toshiyuki Tsunoda, Matthias A. Hediger
Summary: Oncogenic KRAS mutations in colorectal cancer cells upregulate specific amino acid transporters (AATs) resulting in increased uptake of amino acids such as glutamine and leucine. The activation of mTOR and enhanced cell proliferation in KRAS mutant CRC cells is mediated through YAP1 transcriptional coactivator and the upregulation of AATs.
MOLECULAR ONCOLOGY
(2021)
Article
Multidisciplinary Sciences
Pulak Kar, Yu-Ping Lin, Rajesh Bhardwaj, Charles J. Tucker, Gary S. Bird, Matthias A. Hediger, Carina Monico, Nader Amin, Anant B. Parekh
Summary: Eukaryotic cells confine second messengers to spatially restricted subcompartments to avoid conflicting outcomes. The smallest signaling unit, Ca2+ nanodomain, is formed when Ca2+ channels open. NFAT1 tethered to scaffolding protein AKAP79 is activated by local Ca2+ entry, providing a mechanism to selectively recruit a transcription factor.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Chemistry, Medicinal
Jonai Pujol-Gimenez, Marion Poirier, Sven Buehlmann, Celine Schuppisser, Rajesh Bhardwaj, Mahendra Awale, Ricardo Visini, Sacha Javor, Matthias A. Hediger, Jean-Louis Reymond
Summary: Researchers discovered the first inhibitor of ZIP8, showing that this target is druggable, through screening a library of molecules in a database.
Article
Biotechnology & Applied Microbiology
Sami Havukainen, Jonai Pujol-Gimenez, Mari Valkonen, Matthias A. Hediger, Christopher P. Landowski
Summary: Through research, a protein from Trichoderma reesei was identified as a potential L-arabinose transporter. This transporter has high affinity for L-arabinose and low affinity for D-xylose, with slight inhibition by D-glucose. The discovery may lead to improvements in pentose-utilizing yeast strains.
MICROBIAL CELL FACTORIES
(2021)
Article
Medicine, Research & Experimental
Marianela G. Dalghi, Wily G. Ruiz, Dennis R. Clayton, Nicolas Montalbetti, Stephanie L. Daugherty, Jonathan M. Beckel, Marcelo D. Carattino, Gerard Apodaca
Summary: The study reveals that the urothelium functions in a sex- and circadian rhythm-dependent manner to link urothelial PIEZO1/2 channel-driven mechanotransduction to normal voiding function and behavior. In the absence of these signals, bladder dysfunction occurs.
Review
Physiology
Manuel A. Anderegg, Gergely Gyimesi, Tin Manh Ho, Matthias A. Hediger, Daniel G. Fuster
Summary: This review summarizes the structure, function, and expression regulation of the SLC9B subfamily members, focusing primarily on the better-studied SLC9B paralog, NHA2. The potential of the SLC9B subfamily as drug targets is also reviewed.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Cell Biology
Bartlomiej Augustynek, Gergely Gyimesi, Jan Dernic, Matthias Sallinger, Giuseppe Albano, Gabriel J. Klesse, Palanivel Kandasamy, Herwig Grabmayr, Irene Frischauf, Daniel G. Fuster, Christine Peinelt, Matthias A. Hediger, Rajesh Bhardwaj
Summary: This study reveals potential differences in the gating mechanism of Orai channels among different Orai paralogs and highlights the importance of specific mutations in influencing the channel's activation state. These findings contribute to a better understanding of the functional characteristics of Orai channels.
Article
Multidisciplinary Sciences
Gergely Gyimesi, Matthias A. Hediger
Summary: Researchers have identified a new set of SLC-like protein families in the human genome, shedding light on the functional and structural diversity of solute carrier (SLC) proteins. This research provides a foundation for future studies on the biological function and natural substrates of these under-explored SLC transporters, as well as the development of new therapeutic applications.
Article
Physiology
Sophia N. Verouti, Jonai Pujol-Gimenez, Paola Bermudez-Lekerika, Laeticia Scherler, Rajesh Bhardwaj, Aurelien Thomas, Sebastien Lenglet, Mark Siegrist, Willy Hofstetter, Daniel G. Fuster, Matthias A. Hediger, Genevieve Escher, Bruno Vogt
Summary: The metal ion transporter ZIP8 has been found to play a significant role in blood pressure regulation and glucose homeostasis. The SNP variant A391T (rs13107325) of ZIP8 is associated with reduced arterial blood pressure and insulin resistance, but not with body weight and plasma lipid composition. This research also suggests that ZIP8 is involved in the cellular uptake of zinc, cadmium, and iron.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Physiology
Nicolas Montalbetti, Aneta J. Przepiorski, Shujie Shi, Shaohu Sheng, Catherine J. Baty, Joseph C. Maggiore, Marcelo D. Carattino, Thitinee Vanichapol, Alan J. Davidson, Neil A. Hukriede, Thomas R. Kleyman
Summary: This study examines the functional expression of key ion channels in kidney organoids derived from pluripotent stem cells. It demonstrates the presence of large-conductance Ca2+-activated K+ (BKCa) channels, renal outer medullary K+ (ROMK, Kir1.1) channels, and epithelial Na+ channels (ENaC) in different cell populations within the organoids. These findings suggest that human kidney organoids can functionally produce important distal nephron K+ and Na+ channels.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2022)
Article
Physiology
Dennis R. Clayton, Wily G. Ruiz, Marianela G. Dalghi, Nicolas Montalbetti, Marcelo D. Carattino, Gerard Apodaca
Summary: The study reveals that PDGFRA(+) interstitial cells in the bladder wall are fibroblasts and that there are multiple, regionally distinct populations of these cells.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2022)
Article
Physiology
Nicolas Montalbetti, Marianela G. Dalghi, Sheldon Bastacky, Dennis R. Clayton, Wily G. Ruiz, Gerard Apodaca, Marcelo D. Carattino
Summary: This study suggests that bacterial infection can cause sensitization of bladder sensory neurons, leading to bladder overactivity and pelvic pain.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2022)
Article
Physiology
Nicolas Montalbetti, Marcelo D. Carattino
Summary: Our study suggests that protons and their corresponding acid-sensing ion channel receptors are part of a mechanism operating at bladder afferent terminals to regulate their function, and the loss of this regulatory mechanism leads to the hyperactivation of nociceptive pathways and pain development in the context of chemical-induced cystitis.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2021)
Meeting Abstract
Urology & Nephrology
Nicolas Montalbetti, Marianela Dalghi, Gerard Apodaca, Marcelo Carattino
NEUROUROLOGY AND URODYNAMICS
(2021)
Article
Cell Biology
Dominic Tscherrig, Rajesh Bhardwaj, Daniel Biner, Jan Dernic, Daniela Ross-Kaschitza, Christine Peinelt, Matthias A. Hediger, Martin Lochner
Summary: Changes in Ca2+ levels regulate many physiological functions, and the endoplasmic reticulum is the major Ca2+ store in cells. Store-operated calcium entry (SOCE) is a refilling process that involves protein-protein interactions between Ca2+ sensing STIM in the ER and Orai proteins in the plasma membrane, forming selective Ca2+ channels. Abnormal SOCE is associated with diseases and cancers, making STIM and Orai important therapeutic targets. Novel GSK-7975A-based molecular probes have been developed for studying SOCE in different cells and settings.
Article
Cell Biology
Nicola Fameli, Cornelis van Breemen, Klaus Groschner
Summary: The study provides evidence for the importance of junctional membrane architecture in cellular function. Through modeling and prediction, it is shown that nano-scale membrane spacing plays a crucial role in junctional ER Ca2+ refilling and signaling efficiency. Additionally, interactions between Ca2+ and the phospholipid membrane surface are suggested to support interfacial Ca2+ transport and receptor targeting. This research introduces a new concept in pathophysiology.
Article
Cell Biology
Satomi Ohtsuka, Yumi Miyai, Hiroyuki Mima, Masaki Magari, Yoichi Chiba, Futoshi Suizu, Hiroyuki Sakagami, Masaki Ueno, Hiroshi Tokumitsu
Summary: This study characterized the splice variants of mouse CaMKKI3/2 and found that CaMKKI3-3 and I3-3x were functionally active and likely to be bona fide CaMKIV kinases involved in the regulation of spermiogenesis.
