Journal
CELL BIOLOGY INTERNATIONAL
Volume 38, Issue 11, Pages 1337-1343Publisher
WILEY
DOI: 10.1002/cbin.10320
Keywords
autophagy; MSCs; mTOR; neuronal differentiation
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Funding
- National Natural Science Foundation of China [81071114]
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Autophagy is involved in cell differentiation. We present evidence that autophagy is activated during -mercaptoethanol (-ME)-induced neuronal differentiation of bone marrow mesenchymal stem cells (MSCs), in which mammalian target of rapamycin (mTOR) signaling is important. mTOR activity declined after being transported from the nucleus to the cytoplasm. Using 3-methyladenine (3-MA) and rapamycin to regulate the activity of mTOR, it was found that the efficiency of neuronal differentiation was affected.
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