Journal
CELL BIOLOGY INTERNATIONAL
Volume 39, Issue 3, Pages 283-290Publisher
WILEY-BLACKWELL
DOI: 10.1002/cbin.10390
Keywords
Bmi-1; glioma; invasion; migration; p16
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Funding
- National Natural Science Foundation of China [81072072]
- Xuzhou Medical College [09KJZ18]
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Bmi-1 is involved in the development of several human cancers; however, its significance in glioma progression remains largely unknown. We report that downregulation of Bmi-1 clearly reduces glioma cell migration and invasion. Downregulation of Bmi-1 promotes the expression of the tumor suppressor p16, which is important in glioma cell motility. Reduction in glioma cell invasion due to downregulation of Bmi-1 could be rescued by p16 downregulation. These results show that Bmi-1 contributes to the motility of glioma cells by regulating the expression of p16.
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