Article
Multidisciplinary Sciences
Chenglin Zou, Xun Tang, Tingting Guo, Tingting Jiang, Wenying Zhang, Jun Zhang
Summary: Cisplatin is an effective anti-tumor drug but can cause acute kidney injury (AKI). CTRP3, a new adipokine, has been found to have antioxidant, anti-inflammatory, and antiapoptotic properties. This study demonstrates that CTRP3 protects against cisplatin-induced AKI through the Nrf2/MAPK pathway.
Article
Biochemistry & Molecular Biology
Sang-Heon Kim, Jeong-Ah Jin, Hyung Joon So, Sung Hoon Lee, Tae-Wook Kang, Jae-Ung Lee, Dae Eun Choi, Jin Young Jeong, Yoon-Kyung Chang, Hyunsu Choi, Youngjun Lee, Young-Kwon Seo, Hong-Ki Lee
Summary: In this study, it was discovered that urine-derived stem cells (UDSCs) express Klotho protein more strongly than other mesenchymal stem cells (MSCs) and can suppress renal fibrosis by inhibiting transforming growth factor (TGF)-beta. This finding provides a potential new approach for treating chronic kidney disease (CKD).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Tao Yang, Wei Li, Anquan Peng, Jia Liu, Qin Wang
Summary: In this study, it was found that hypoxic BMSCs-derived exosomes (hypBMSC-Exo) could alleviate cisplatin-induced ototoxicity and had better therapeutic effects compared to BMSC-Exo. This may be achieved by up-regulating the expression of SOD1 and SOD2 to protect auditory function.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Samuel Bernardo-Bermejo, Elena Sanchez-Lopez, Maria Castro-Puyana, Ana B. Fernandez-Martinez, Francisco Javier Lucio-Cazana, Maria Luisa Marina
Summary: Apoptotic bodies (ABs), a type of extracellular vesicles, play a significant role in the pathogenesis of various diseases. This study used a non-targeted metabolomic approach to investigate the impact of different apoptotic stimuli (cisplatin or UV light) on the metabolites involved in apoptosis propagation. The results revealed stimulus-specific differences in metabolite abundances, suggesting that these metabolites may vary in their contribution to apoptosis depending on the apoptotic stimulus.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Yaqiong Yu, Yoko Uchida-Fukuhara, Yao Weng, Yuhan He, Mika Ikegame, Ziyi Wang, Kaya Yoshida, Hirohiko Okamura, Lihong Qiu
Summary: In this study, the roles of NRP1 and GAG-modifiable NRP1 in adipogenesis were explored in C3H10T1/2 cells. The expression of full-length NRP1 and GAG-modifiable NRP1 increased during adipogenic differentiation, and NRP1 knockdown repressed adipogenesis. JIP4 was found to be involved in adipogenesis by interacting with NRP1. Moreover, the non-GAG-modifiable NRP1 mutant greatly promoted adipogenic differentiation by activating the Akt and ERK1/2 pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Ali A. Shati, J. Alkabli, Mohammad Y. Alfaifi, Serag Eldin I. Elbehairi, Reda F. M. Elshaarawy, Waleed M. Serag, Yasser A. Hassan
Summary: This study compared the effects of bone marrow-derived mesenchymal stem cells (BMSCs) and crab chitosan nanoparticles (CCNPs) on renal fibrosis in cisplatin-induced kidney injury rats. The results showed that CCNPs and BMSC treatment had protective effects on renal function, with CCNPs administration showing more improvement of kidney damage resembling normal cells.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Anatomy & Morphology
Rui-ning Liang, De-qi Yan, Xing-ping Zhang, Xu Chen, Wen-hui Zhang, Hong -lin Jia
Summary: The objective of this experiment was to demonstrate the therapeutic effects of kidney-derived mesenchymal stem cells (MSCs) on cisplatin-induced kidney injury and renal cell apoptosis through the paracrine pathway. MSCs were isolated from the kidneys of young rats and characterized using molecular and immunofluorescence techniques. The self-renewal ability of kidney mesenchymal stem cells (KMSCs) was observed, and KMSCs at logarithmic growth stage were transplanted into rats via the tail vein. The results showed that KMSCs homed to the kidney tissues, reduced inflammation, and improved renal function. Pathological damage and apoptosis in rat kidneys induced by cisplatin were alleviated by KMSCs. The expression of pro-apoptotic and anti-apoptotic proteins in kidney tissues was also modulated by KMSCs. In conclusion, KMSCs have therapeutic effects against cisplatin-induced kidney injury in rats.
Article
Immunology
Lei Wu, Chao Rong, Qing Zhou, Xin Zhao, Xue-Mei Zhuansun, Shan Wan, Mao-Min Sun, Shou-Li Wang
Summary: This study showed that BM-MSCs attenuated cisplatin-induced renal fibrosis by regulating the miR-146a-5p/Tfdp2 axis in mRTECs. This provides a new direction for the treatment of chronic kidney diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Lina N. Zaripova, Angela Midgley, Stephen E. Christmas, Michael W. Beresford, Clare Pain, Eileen M. Baildam, Rachel A. Oldershaw
Summary: Mesenchymal stem cells (MSCs) have potential as immunosuppressants for treating autoimmune and autoinflammatory diseases. They can reduce inflammation and promote tissue regeneration. However, during the inflammatory process, MSCs become impaired and lose their immunomodulatory activity. Despite challenges and risks, MSCs show promise in the treatment of severe diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cell & Tissue Engineering
Rodrigo N. Riedel, Antonio Perez-Perez, Victor Sanchez-Margalet, Cecilia L. Varone, Julieta L. Maymo
Summary: The COVID-19 pandemic, caused by the SARS-CoV-2 virus, has led to significant social, economic, and health challenges globally. Stem cells, particularly human amniotic membrane cells, have shown promising potential as a therapeutic approach for COVID-19 due to their immunoregulatory and anti-inflammatory properties.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Public, Environmental & Occupational Health
Jun-Jun Wei, Li Tang, Liang-Liang Chen, Zhen-Hua Xie, Yu Ren, Hong-Gang Qi, Jiang-Yong Lou, Guo-Bin Weng, Shu-Wei Zhang
Summary: The study demonstrates that MSCs can protect against TGF-beta 1-induced HK-2 cell EMT by increasing HGF level and decreasing TGF-beta 1 level. However, HGF plays a critical role in this process.
IRANIAN JOURNAL OF PUBLIC HEALTH
(2021)
Article
Biochemistry & Molecular Biology
Maysa A. Mobasher, Eman Ibrahim Ahmed, Nora Y. Hakami, Mousa O. Germoush, Nabil S. Awad, Dina M. Khodeer
Summary: This study found that the combination of licorice extract (GGE) and bone marrow mesenchymal stem cells (BM-MSCs) can protect the liver from cisplatin-induced damage and promote hepatocyte regeneration. The combination treatment reduces the expression levels of inflammatory and apoptotic signals, improves liver function, and alleviates oxidative damage. The results suggest that GGE has a protective effect against oxidative liver damage, and BM-MSCs have promising regenerative potential.
Review
Cell Biology
Chunfeng Xu, Mingjie Wang, Behrouz Zandieh-Doulabi, Wei Sun, Lingfei Wei, Yuelian Liu
Summary: BMP-2, while potentially useful in repairing bone defects after OS resection, has limited application due to concerns about its tumorigenicity. Studies are focusing on understanding the impact of BMSCs' response to BMP-2 on OS development to pave the way for safer and broader clinical use of BMP-2 in the future.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Sanshiro Kanazawa, Hiroyuki Okada, Dan Riu, Yo Mabuchi, Chihiro Akazawa, Junichi Iwata, Kazuto Hoshi, Atsuhiko Hikita
Summary: This study demonstrates the important role of c-Mpl signal in the proliferation and differentiation ability of mesenchymal stem cells (MSCs), which are maintained through co-culture with hematopoietic stem cells (HSCs). Furthermore, the study suggests the existence of a hematopoietic-mesenchymal signal and highlights the significance of HSC state in the stability of MSC properties.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Dong Hoon Kwak, Ji Hye Park, Eul Sig Choi, Seong Hyun Park, Seo-Yeon Lee, Seoul Lee
Summary: This study analyzed the role of gangliosides in the osteogenesis of Lmna dysfunctional MSCs. The results showed that ganglioside GD1a played an important role in enhancing osteogenic differentiation in Lmna-mutated MSCs.
Article
Cell Biology
Atousa Namjoo, Ali Salimi, Pardis Saeedi, Raheleh Halabian, Asgar Emamgholi
Summary: The study showed that preconditioning with Nisin can enhance the survival and proliferation ability of MSCs, reduce cell apoptosis, and have anti-apoptotic effects on the cells. However, further research is needed on the protective properties of this strategy and its mechanism in stem cell therapy.
CELL AND TISSUE BANKING
(2022)
Review
Oncology
Mehdi Rabiee Valashedi, Amirsadegh Nikoo, Nima Najafi-Ghalehlou, Kazuo Tomita, Yoshikazu Kuwahara, Tomoaki Sato, Amaneh Mohammadi Roushandeh, Mehryar Habibi Roudkenar
Summary: Ferroptosis is a non-apoptotic mode of regulated cell death driven by excessive accumulation of toxic lipid peroxides and iron overload. It has been found to have great potential in inhibiting tumor growth and metastasis, as well as overcoming drug resistance. Thus, targeting ferroptosis could be a promising approach in cancer treatment.
CURRENT CANCER DRUG TARGETS
(2022)
Article
Biochemistry & Molecular Biology
Fatemeh Amiri, Ali Asghar Kiani, Marzie Bahadori, Mehryar Habibi Roudkenar
Summary: The study investigated co-culturing HSCs with MSC spheres under hypoxic condition, which not only increased cellular yield but also upregulated the expression of self-renewal and homing genes.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Reza Moazamiyanfar, Raheleh Halabian, Marzieh Ghollasi, Delaram Poormoghadam, Maliheh Entezari, Seyed Ehsan Endorami
Summary: Tissue engineering utilizes living cells to restore, maintain, or enhance tissues and organs. This study found that surface-modified nanofibrous scaffolds coated with platelet-rich plasma significantly enhanced the proliferation and neural differentiation of hiPSCs, showing promising potential for neural tissue engineering in vivo.
NEUROCHEMICAL RESEARCH
(2022)
Article
Otorhinolaryngology
Saghi Jani Kargar Moghaddam, Amaneh Mohammadi Roushandeh, Mehryar Habibi Roudkenar, Shadman Nemati, Nima Najafi-Ghalehlou, Toofan Pakzad, Masoud Hamidi
Summary: This study aimed to investigate the clinical significance of vascular endothelial growth factor (VEGF), latent membrane protein 1 (LMP1), and tumor necrosis factor-alpha (TNF-alpha) as biomarkers for nasopharyngeal carcinoma (NPC) and evaluate their correlations in a specific region of Iran.
INTERNATIONAL ARCHIVES OF OTORHINOLARYNGOLOGY
(2023)
Article
Virology
Jafar Salimian, Ali Ahmadi, Jafar Amani, Gholamreza Olad, Raheleh Halabian, Ali Saffaei, Masoud Arabfard, Mojtaba Nasiri, Shahram Nazarian, Hassan Abolghasemi, Gholamhossein Alishiri
Summary: The study evaluated the safety and immunogenicity of a recombinant receptor-binding domain (RBD)-based protein subunit vaccine (Noora vaccine) against COVID-19. The vaccine showed acceptable safety without severe adverse events and significant seroconversion in both humoral and cellular immunity.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Review
Cell Biology
Chia Bamshad, Nima Najafi-Ghalehlou, Zahra Pourmohammadi-Bejarpasi, Kazuo Tomita, Yoshikazu Kuwahara, Tomoaki Sato, Alireza Feizkhah, Amaneh Mohammadi Roushnadeh, Mehryar Habibi Roudkenar
Summary: Mitochondria play a crucial role in ageing and neurodegenerative disorders. This review examines the functions of mitochondria and the pathways contributing to mitochondrial dysfunction. It also discusses the therapeutic effects of mitophagy and highlights the experiments involving mitochondrial transfer in animal models of neurodegenerative disorders.
Article
Cell & Tissue Engineering
Fariba Sadraei, Marzieh Ghollasi, Fatemeh Khakpai, Raheleh Halabian, Hora Jalali Tehrani
Summary: This study investigates the effect of Nisin on the differentiation of bone marrow mesenchymal stem cells into osteocytes. The results demonstrate that cell proliferation and differentiation significantly increased in samples pretreated with Nisin on the PLLA Nano scaffolds.
REGENERATIVE THERAPY
(2022)
Article
Cell Biology
Shima Norozi, Mrazieh Ghollasi, Ali Salimi, Raheleh Halabian, Mohsen Shahrousvad
Summary: Mesenchymal stem cells can promote bone repair, especially when used with nano scaffolds/particles. The cytotoxic concentration of Zinc oxide nanoparticles and Polyurethane was evaluated using the MTT and Acridine Orange assay. Results showed that 1% PU scaffold and ZnO NPs boosted the osteogenic differentiation of adipose tissue-derived MSCs, suggesting their potential as a new bone tissue engineering matrix.
CELL AND TISSUE BANKING
(2023)
Article
Environmental Sciences
Murteza Jaafaryneya, Jafar Amani, Raheleh Halabian
Summary: This study aimed to screen and characterize explosive biodegradable Actinomycetes from water, wastewater, and sludge. Actinomycetes isolates from 80 environmental samples were recovered and identified. The results showed that the isolates can degrade and consume 50-80% of RDX and TNT as their sole carbon and energy source. Seeking and screening untapped ecosystems that possess unexplored Actinomycetes will increase the chances of discovering microorganisms capable of degrading TNT and RDX for bioremediation.
WATER AND ENVIRONMENT JOURNAL
(2023)
Article
Biotechnology & Applied Microbiology
Reza Esfandiary, Pardis Saeedi, Parvaneh Saffarian, Raheleh Halabian, Abbas Ali Imani Fooladi
Summary: This study investigated the use of antibiotics to enhance the antimicrobial effects of mesenchymal stem cells (MSCs) against methicillin-resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa. Preconditioning MSCs with antibiotics at optimal concentrations improved their ability to inhibit bacterial growth and enhance bacterial clearance. The findings suggest that preconditioned MSCs could be a potential adjuvant treatment for antibiotic-resistant infections.
FOLIA MICROBIOLOGICA
(2023)
Article
Toxicology
Vahid Jamshidi, Raheleh Halabian, Pardis Saeedi, Hasan Bagheri, Bibi Fatemeh Nobakht Motlagh Ghoochani
Summary: This study aimed to investigate the effects of natural (Crocin) and synthetic (Dexamethasone) antioxidants on the efficacy of mesenchymal stem cells (MSCs). The results showed that Crocin and Dexamethasone significantly increased the survival rate of MSCs and A549 cells treated with MSCs. Additionally, they reduced apoptosis and reactive oxygen species (ROS) production, and had an impact on the cytokine levels in treated A549 cells.
TOXICOLOGY RESEARCH
(2023)
Review
Chemistry, Medicinal
Shahroukh Abdoullahi, Abolfazl Jahangiri, Raheleh Halabian
Summary: Despite advancements in the prevention, diagnosis, and treatment of colorectal cancer, refractory tumor cells still pose challenges leading to low survival rates and metastasis. Therefore, finding effective and harmless novel molecules for the treatment of colorectal cancer is crucial. Studies have shown that peptides derived from herbal and bacterial sources have antitumor activity with better tolerability and fewer side effects, making them promising candidates for cancer treatment.
REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY
(2022)
Article
Pharmacology & Pharmacy
Zahra Pourmohammadi-Bejarpasi, Reza Sabzevari, Amaneh Mohammadi Roushandeh, Ammar Ebrahimi, Mohammadreza Mobayen, Ali Jahanian-Najafabadi, Abbas Darjani, Mehryar Habibi Roudkenar
Summary: This study utilized combination therapy of Lcn2-engineered MSCs and Metadichol to treat excision wounds in a rat model. The results showed that the combination therapy improved wound healing rate and accelerated the process.
ADVANCED PHARMACEUTICAL BULLETIN
(2022)
Review
Cell & Tissue Engineering
Nima Najafi-Ghalehlou, Alireza Feizkhah, Mohammadreza Mobayen, Zahra Pourmohammadi-Bejarpasi, Shima Shekarchi, Amaneh Mohammadi Roushandeh, Mehryar Habibi Roudkenar
Summary: This article introduces the important role of regenerative medicine in disease treatment, particularly the use of medical biowaste as a novel means to repair or replace injured or diseased cells, organs, and tissues. It also discusses the applications and challenges of biowaste in routine clinical practices, and calls for research to bridge the gap between clinical and basic science in order to further explore the potential applications of medical biowaste.
STEM CELL REVIEWS AND REPORTS
(2022)
