Journal
CELL BIOLOGY INTERNATIONAL
Volume 37, Issue 6, Pages 633-637Publisher
WILEY-BLACKWELL
DOI: 10.1002/cbin.10069
Keywords
light emitting diodes (LEDs); melanoma; mitochondrial membrane potential (m); monochromatic visible light; superoxide
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Funding
- Grants-in-Aid for Scientific Research [25740018] Funding Source: KAKEN
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We have investigated the effect of visible light on animal cells using light-emitting diodes to emit monochromatic visible light (red, yellow, green and blue light). To explore the relevant mechanism of apoptosis, we assessed the intracellular superoxide anion production and mitochondrial membrane potential (m) of B16F1 and B16F10 murine melanoma cells after monochromatic light irradiation. Blue light caused m depolarization subsequent to elevation of intracellular superoxide production. However, red and yellow light had no affect on both cell lines. Green light induced m collapse only in B16F1 melanoma cells. m is a key indicator of mitochondrial function, therefore its disruption causes mitochondria-dependent apoptosis. Thus, blue light causes mitochondrial dysfunction and subsequent cell death.
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