Journal
CELL BIOLOGY INTERNATIONAL
Volume 33, Issue 5, Pages 578-585Publisher
WILEY
DOI: 10.1016/j.cellbi.2009.02.006
Keywords
Filopodia; Overexpression; Adhesion; Migration
Categories
Funding
- National Natural Science Foundation of China [30670689]
- Program for New Century Excellent Talents in University [NCET-07-0173]
- Specialized Research Fund for the Doctoral Program of High Education [20060200008]
- Ministry of Education of China
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Myosin X (Myo X), an unconventional myosin with a tail homology 4-band 4.1/ezrin/radixin/moesin (MyTH4-FERM) tail, is expressed ubiquitously in various mammalian tissues. In addition to the full-length Myo X (Myo X FL), a headless form is synthesized in the brain. So far, little is known about the function of this motor-less Myo X. In this study, the role of the headless Myo X was investigated in immortalized gonadotropin-releasing hormone (GnRH) neuronal cells, NLT. NLT cells overexpressing the headless Myo X formed fewer focal adhesions and spread more slowly than the wild-type NLT cells and GFP-expressing NLT cells. In chemomigration assays, the NLT cells overexpressing the headless Myo X migrated shorter distances and had fewer migratory cells compared with the control NLT cells. (C) 2009 International Federation for Cell Biology. Published by Elsevier Ltd. All rights reserved.
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