Review
Endocrinology & Metabolism
Yu Feng Shang, Yi Yang Shen, Meng Chen Zhang, Min Chao Lv, Tong Ying Wang, Xue Qun Chen, Jun Lin
Summary: Saliva production and secretion are essential functions of the salivary glands, with multiple functions including moistening, digestion, mineralization, lubrication, and mucosal protection. Saliva undergoes dynamic changes in its chemical and physical properties during physiological and pathophysiological processes. The central nervous system regulates salivary secretion and function through various neurotransmitters and neuroreceptors. Salivary glands play a crucial role in innate and adaptive immunity and protection, and saliva contains potential biomarkers for monitoring and predicting health and disease in clinical practice and precision medicine.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Oncology
N. B. Pushpa, Kumar Satish Ravi, Prashant Durgapal
Summary: Despite the COVID-19 pandemic in 2020, the discovery of a new salivary gland became a hot topic in the medical community. The significance of this finding lies in its clinical relevance in radiotherapy of oropharyngeal carcinoma, but there are differing views due to the lack of substantial evidence. Efforts have been made to shed light on Tubarial glands with potential evidence.
RADIOTHERAPY AND ONCOLOGY
(2021)
Article
Multidisciplinary Sciences
Rabab Ahmed Rasheed, Azza Saleh Embaby, Fatma Alzahraa A. Elkhamisy, Mohamed Othman Mohamed, Arshad Mehmood Abbasi, Wael B. A. Ghaly, Mohamed M. A. Elshaer, Khalid S. Almaary, Mai A. M. Almoatasem
Summary: Diabetes and hyperglycemia can cause oxidative damage to tissues and organs, including the salivary glands. This study investigated the potential of ascorbic acid to protect the structure and function of the major salivary glands in diabetic patients. The results showed that ascorbic acid could improve histological and functional changes in the salivary glands, suggesting it could be used as an adjuvant medication for diabetes.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Fetta Guerrib, Caina Ning, Lourdes Mateos-Hernandez, Sabine Rakotobe, Yoonseong Park, Ondrej Hajdusek, Jan Perner, Marie Vancova, James J. Valdes, Ladislav Simo
Summary: Salivary glands are crucial for tick feeding success and pathogen transmission. Previous studies have shown that neuropeptidergic axons innervate saliva-producing acini in Ixodes scapularis salivary glands and release different neuropeptides. One of these neuropeptides, SIFamide, along with its receptor, has been found to control the acinar valve. In this study, a second SIFamide receptor, SIFa_R2, was identified and characterized in I. scapularis salivary glands.
INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2023)
Article
Multidisciplinary Sciences
S. Ghosh, M. Kumar, M. Santiana, A. Mishra, M. Zhang, H. Labayo, A. M. Chibly, H. Nakamura, T. Tanaka, W. Henderson, E. Lewis, O. Voss, Y. Su, Y. Belkaid, J. A. Chiorini, M. P. Hoffman, N. Altan-Bonnet
Summary: This study reveals a new transmission route for enteric viruses through salivary glands, finding that infected infants can transmit the viruses to their mothers' mammary glands through saliva, leading to an increase in secretory IgA antibodies in maternal milk.
Article
Oncology
Sarah Pringle, Floris J. Bikker, Wouter Vogel, Bernadette S. de Bakker, Ingrid Hofland, Bert van der Vegt, Hendrika Bootsma, Frans Kroese, Arjan Vissink, Matthijs Valstar
Summary: Based on histological and immunohistochemical analyses, the tubarial glands resemble salivary glands in terms of tissue and cellular expression, specifically resembling the palatal and labial glands.
RADIOTHERAPY AND ONCOLOGY
(2023)
Article
Multidisciplinary Sciences
Yeo-Jun Yoon, Donghyun Kim, Kwon Yong Tak, Seungyeon Hwang, Jisun Kim, Nam Suk Sim, Jae-Min Cho, Dojin Choi, Yongmi Ji, Junho K. Hur, Hyunki Kim, Jong-Eun Park, Jae-Yol Lim
Summary: In this study, the authors establish a protocol for long-term maintenance of murine and human salivary gland organoids exhibiting gland-specific gene expression, gland functions, and cellular diversity confirmed by scRNA-seq.
NATURE COMMUNICATIONS
(2022)
Article
Medicine, Research & Experimental
Railson O. Ferreira, Walessa A. B. Araga, Leonardo O. Bittencourt, Luanna P. M. Fernandes, Karolyny M. Balbinot, Sergio M. Alves-Junior, Joao de Jesus V. Pinheiro, Cristiane do Socorro Ferraz Maia, Maria E. Crespo-Lopez, Rafael Rodrigues Lima
Summary: This study found that alcohol consumption during pregnancy significantly decreased total protein concentration and amylase activity in the saliva of offspring rats, leading to oxidative stress and morphological changes in the parotid and submandibular glands.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Endocrinology & Metabolism
L. Meme, M. Di Girolamo, A. Alushi, P. Rasicci, D. Marcattili, M. Capogreco, E. E. Carli
Summary: The article aims to analyze different approaches to solve the symptoms of chronic gland inflammation, specifically focusing on the high risk of relapse. Minor salivary glands, present in most oral cavities, play a vital role in moistening and lubricating oral tissues, as well as protecting against bacterial activity.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2022)
Article
Biochemistry & Molecular Biology
Douglas Nesadal de Souza, Eugen Mendes Nesadal de Souza, Marlus da Silva Pedrosa, Fernando Neves Nogueira, Alyne Simoes, Jose Nicolau
Summary: The study found that sodium tungstate can reduce blood glucose levels in STZ-induced diabetic rats, restore the activity of the antioxidant enzyme system, and reduce lipid peroxidation levels in the glands.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2021)
Article
Food Science & Technology
Chandra Sekhar Arigela, Giribabu Nelli, Siew Hua Gan, Kuttulebbai Nainamohamed Salam Sirajudeen, Kumarathevan Krishnan, Nurhanan Abdul Rahman, Visweswara Rao Pasupuleti
Summary: Bitter gourd honey (BGH) shows potential anti-oxidative, anti-inflammatory, and anti-apoptotic effects in the treatment of diabetes, reducing liver and kidney damage and increasing levels of antioxidant enzymes.
Review
Oncology
Laura D. Locati, Renata Ferrarotto, Lisa Licitra, Marco Benazzo, Lorenzo Preda, Davide Farina, Gemma Gatta, Davide Lombardi, Piero Nicolai, Vincent Vander Poorten, Melvin Lee Kiang Chua, Barbara Vischioni, Giuseppe Sanguineti, Patrizia Morbini, Isabel Fonseca, Davide Sozzi, Anna Merlotti, Ester Orlandi
Summary: Salivary gland cancers are rare malignancies of the head and neck region, with diagnosis based on histology and molecular profiling. Treatment consists of surgery, radiotherapy, and systemic therapy. Recent discussions and insights from a conference have provided updates on the research and future challenges in salivary gland cancers.
FRONTIERS IN ONCOLOGY
(2023)
Article
Medicine, Research & Experimental
Shen-Sui Li, Chen-Zhou Wu, Bo-Wen Zhang, Ling Qiu, Wen Chen, Yi-Hang Yuan, Xing-Chen Liu, Chun-Jie Li, Long-Jiang Li
Summary: The study demonstrated that NGF expression is upregulated after radiotherapy and plays a protective role in salivary glands by reducing radiation-induced cell apoptosis and protecting against damage. NGF protects salivary glands from radiation-induced apoptosis by de-phosphorylating JNK kinase rather than promoting AKT phosphorylation.
Review
Health Care Sciences & Services
Matteo Pellegrini, Federica Pulicari, Paolo Zampetti, Andrea Scribante, Francesco Spadari
Summary: This article describes modern major and minor salivary gland biopsy techniques and evaluates the indications and complications of other salivary gland biopsy techniques. A comparison was made between ultrasound-guided fine-needle aspiration biopsy and ultrasound-guided core needle biopsy in the oncological field, and intra-operative frozen sections were presented as an additional intraoperative diagnostic method.
Article
Nutrition & Dietetics
Natnicha Promyos, Pornpimol Panprathip Phienluphon, Naruemon Wechjakwen, Jirayu Lainampetch, Pattaneeya Prangthip, Karunee Kwanbunjan
Summary: Oxidative stress and defective antioxidant defenses, specifically lower concentrations of superoxide dismutase (SOD) and catalase (CAT) activities, may contribute to the risk of type 2 diabetes (T2D). This study found that individuals with lower SOD and CAT activities had a higher risk of T2D, while the relationship between vitamin A and vitamin E concentrations and T2D risk was not significant. Factors like physical activity, total cholesterol, and triglyceride levels might mediate the association between SOD/CAT and T2D risk.
Article
Biochemistry & Molecular Biology
Douglas Nesadal de Souza, Eugen Mendes Nesadal de Souza, Marlus da Silva Pedrosa, Fernando Neves Nogueira, Alyne Simoes, Jose Nicolau
Summary: The study found that sodium tungstate can reduce blood glucose levels in STZ-induced diabetic rats, restore the activity of the antioxidant enzyme system, and reduce lipid peroxidation levels in the glands.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2021)
Letter
Virology
Marlus da Silva Pedrosa, Carla Renata Sipert, Fernando Neves Nogueira
JOURNAL OF MEDICAL VIROLOGY
(2021)
Letter
Dentistry, Oral Surgery & Medicine
Marlus da Silva Pedrosa, Carla Renata Sipert, Fernando Neves Nogueira
Letter
Dermatology
Sandra Bastos Rezende, Luana Campos, Luiz Felipe Palma, Ricardo Yudi Tateno, Alyne Simoes, Maria Cristina Macedo, Roberto Luiz da Silva
PHOTODERMATOLOGY PHOTOIMMUNOLOGY & PHOTOMEDICINE
(2021)
Letter
Dermatology
Luana Campos, Sandra Bastos Rezende, Alyne Simoes, Geise Silva Grigio, Pedro Amoedo Fernandes, Maria Cristina de Almeida Macedo, Roberto Luiz da Silva
PHOTODERMATOLOGY PHOTOIMMUNOLOGY & PHOTOMEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Andre Guaraci DeVito-Moraes, Victor Di Donato Marques, Luciana Chagas Caperuto, Flavia Kazue Ibuki, Fernando Neves Nogueira, Carlos Eduardo Francci, Carla Roberta de Oliveira Carvalho
Summary: The parotid gland, as the largest salivary gland, plays a significant role in saliva production. Research has shown that insulin has acute effects on intracellular pathways in the parotid glands. These findings are important for understanding salivary gland issues in diabetic individuals.
CELL BIOCHEMISTRY AND BIOPHYSICS
(2022)
Article
Oncology
Luana Campos, Sandra Bastos Rezende, Luiz Felipe Palma, Andressa Matucci Hotsumi, Ricardo Yudi Tateno, Alyne Simoes, Larissa Yukari Okada, Maria Cristina Macedo
Summary: The study reported a clinical case of using antimicrobial photodynamic therapy to successfully treat extensive oral pseudomembranous candidiasis in a patient undergoing HCT. The results indicate that aPDT is highly effective for cases of oral candidiasis not responsive to micafungin.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Claudia C. Cotomacio, Caio C. Calarga, Bianca K. Yshikawa, Victor E. Arana-Chavez, Alyne Simoes
Summary: In the treatment of 5-fluorouracil-induced oral mucositis in hamsters, the PBMT protocol with low energy (0.24 J) showed better results in reducing inflammatory biomarkers and promoting tissue repair compared to higher energy protocols (1 and 1.2 J). Group ChLI, with less energy, exhibited faster repair rates and lower inflammatory biomarker concentrations than group Ch.
ARCHIVES OF ORAL BIOLOGY
(2021)
Article
Oncology
Paula Sachet, Breno Amaral Rocha, Fabianne Soares Lima, Marlus da Silva Pedrosa, Andre Guollo, Mario Rodrigues de Melo Filho, Martinho Campolina Rebello Horta, Alyne Simoes
Summary: This study describes the clinical presentation and specificities of three cases in which aPDT and PBMT were used to manage orofacial lesions in patients with COVID-19. The laser protocols were effective, with improvement of the orofacial lesions within a few days.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2022)
Article
Optics
Luana Campos, Gabriela Campos Magliano, Andressa Matucci Hotsumi, Daniele de Paula Faria, Alexandre Teles Garcez, Fernando Godoy, Victor Elias Arana-Chavez, Alyne Simoes
Summary: Radioactive iodine treatment causes damage to the salivary glands, but photobiomodulation therapy can alleviate tissue damage.
Article
Biochemical Research Methods
Claudia C. Cotomacio, Bianca K. Yshikawa, Caio C. Calarga, Victor E. Arana-Chavez, Alyne Simoes
Summary: This study aims to compare the effects of simultaneous irradiation with the isolated application of photobiomodulation therapy (PBMT) on oral mucositis (OM). The results showed that red laser and infrared laser irradiation can effectively reduce the grade of OM, accelerate the tissue repair process, decrease the expression of inflammatory factors, and increase the concentration of collagen fibers.
JOURNAL OF BIOPHOTONICS
(2023)
Article
Health Care Sciences & Services
Fernando Rodrigues Carvalho, Rafael Queiroz Barros, Alyne Simoes Goncalves, Sabrina Pinho Muragaki, Ana Clara Fagundes Pedroni, Karolyne Dias Carvalho Moschella Oliveira, Patricia Moreira Freitas
Summary: This study investigated the impact of photobiomodulation therapy (PBMT) on temporomandibular disorders (TMDs) symptoms. The results showed that PBMT could reduce orofacial/cervical skull pain, decrease the number of painful points, and increase maximum mouth opening. This treatment approach is clinically relevant and should be taken into consideration by professionals treating TMDs.
Article
Dentistry, Oral Surgery & Medicine
Bruna Oliveira Perestrelo, Polliane Morais de Carvalho, Douglas Nesadal Souza, Mara Junqueira Carneiro, Joao Pedro Goncalves Cirino, Patricia Oliveira Carvalho, Alexandra Christine Helena Frankland Sawaya, Lila Missae Oyama, Fernando Neves Nogueira
Summary: This study found that replacing water with chamomile tea can prevent oxidative stress in the salivary glands of diabetic rats, and it exhibits hypoglycemic and antioxidant effects.
BRAZILIAN ORAL RESEARCH
(2022)
Article
Dentistry, Oral Surgery & Medicine
Marlus da Silva Pedrosa, Tomaz Alves, Juliana Garuba Rahhal, Fernando Neves Nogueira, Carla Renata Sipert
Summary: In this study, the cytotoxicity of various commercial reparative endodontic cements on human periodontal ligament stem cells (hPDLSCs) was compared. The results showed that Biodentine, Bio-C Repair, and MTA Repair HP were able to induce cell proliferation, while Cimmo HD and White MTA exhibited higher cytotoxicity on the stem cells.
PESQUISA BRASILEIRA EM ODONTOPEDIATRIA E CLINICA INTEGRADA
(2022)
Review
Biochemistry & Molecular Biology
Kumaresan Ramanathan, Minale Fekadie, Giri Padmanabhan, Henok Gulilat
Summary: Long noncoding RNAs (lncRNAs) play critical roles in kidney disease development and their dysregulation can lead to various disease processes. Understanding the function and potential application of lncRNAs in kidney disease may provide new diagnostic and therapeutic opportunities. This review provides an overview of lncRNA characteristics, function, and specific studies related to kidney disease treatment.
CELL BIOCHEMISTRY AND FUNCTION
(2024)
