Journal
CELL BIOCHEMISTRY AND FUNCTION
Volume 28, Issue 4, Pages 258-265Publisher
WILEY
DOI: 10.1002/cbf.1645
Keywords
binaphthyl diselenide; selenium; 2-NP; antioxidant; hepatic damage; liver
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Funding
- TWAS
- CNPq
- FAPERGS
- CAPES
- CAPES/SAUX
- VITAE
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Organoselenides have been documented as promising pharmacological agents against a number of diseases associated with oxidative stress Here we have investigated, for the first time, the potential antioxidant activity of binaphthyl diselenide ((NapSe)(2), 50 mg kg(-1) p o) against the 2-nitropropane (2-NP)-induced hepatoxicity in rats, using different end points of toxicity (liver histopathology, plasma aspart ate aminotransferase (AST), alanine aminotransferase (ALT) and creatinine) In addition. in view of the association of oxidative stress with 2-NP exposure. hepatic lipid peroxidation, ascorbic acid levels, delta-aminolevulinate dehydratase (delta-ALA-D) and catalase (CAT) activities were evaluated 2-NP caused an increase of AST. ALT and hepatic lipid peroxidation 2-NP also caused hepatic histopathological alterations and delta-ALA-D inhibition (Nap Se), (50 mg kg(-1)) prevented 2-NP-induced changes in plasmatic ALT and AST activities and also prevented changes in hepatic histology, delta-ALA-D and lipid peroxidation Results presented here indicate that the protective mechanism of (NapSe)(2) against 2-NP hepatotoxicity is possibly linked to its antioxidant activity Copyright (C) 2010 John Wiley & Sons, Ltd
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