Article
Biotechnology & Applied Microbiology
Guodong Liu, Honggang Mao, Yan Liu, Zun Zhang, Si Ha, Xiaoyan Zhang
Summary: This study reveals that miR-148b-3p is underexpressed in osteosarcoma (OS) and its overexpression can inhibit the growth, migration, and invasion of OS cells while inducing apoptosis. miR-148b-3p targets SOS1 and its anti-tumor effect is reversed by SOS1. Additionally, the study demonstrates that overexpressing miR-148b-3p can significantly reduce tumor growth in a mouse model.
Article
Oncology
Zhendan Zhao, Zhiling Wang, Pengling Wang, Shujie Liu, Yingwei Li, Xingsheng Yang
Summary: The study identified EPDR1 as a tumor-suppressor gene negatively regulated by miR-429 in EOC development, inhibiting proliferation, migration, and invasion of cancer cells through the PI3K/AKT pathway. The miR-429/EPDR1 axis may offer novel therapeutic targets for personalized treatment of EOC patients in the future.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Mei Shi, Xiuyun Chen, Hui Li, Lixia Zheng
Summary: The research shows that Delta-TT may have detrimental effects on trophoblasts by downregulating miR-429 and upregulating ZEB1. Clinical samples indicate higher miR-429 expression and lower ZEB1 expression in preeclamptic placentas compared to normal placentas, with a negative correlation between the two.
Review
Medicine, Research & Experimental
Seyede Fatemeh Hosseini, Setareh Javanshir-giv, Hanieh Soleimani, Homa Mollaei, Farzad Sadri, Zohreh Rezaei
Summary: MicroRNA production in tumorigenesis is dysregulated by various processes, leading to dysfunctional and dysregulated miRNAs. These miRNAs have been identified as potential biomarkers for human cancer, although further evaluation is necessary. The miR-28 family, especially miR-28-5p and miR-28-3p, play essential roles in various cancers and can serve as diagnostic biomarkers for prognosis and early detection of cancers.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Cell Biology
Qiudan Zhang, Chenming Zhong, Qianqian Yan, Ling-hui Zeng, Wei Gao, Shiwei Duan
Summary: miR-874 is frequently dysregulated in various cancers and non-cancer diseases, and its dysfunction is closely associated with the diagnosis, prognosis, and efficacy of chemotherapy drugs. It participates in ceRNA networks and regulates multiple signaling pathways involved in tumor cell processes. miR-874 has the potential to serve as a diagnostic and prognostic biomarker in cancer and has implications for clinical applications.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Medicine, Research & Experimental
Zhichao Wang, Wenjie Xie, Hongzai Guan
Summary: MicroRNAs are small non-coding RNAs that interact with their target mRNAs to degrade them or inhibit translation. Dysregulation of miRNAs is associated with various human cancers and plays a role in the development of cancer pathology. MiR-328 has been implicated in multiple human cancers and considered a key regulator. It is involved in biological processes such as cell proliferation, apoptosis, invasion, migration, and epithelial-mesenchymal transition. This review combines basic and clinical studies to demonstrate that miR-328 promotes tumorigenesis and metastasis in human cancer and discusses its diagnostic, prognostic, and therapeutic value.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Yang Li, Min Liu, Shuting Yang, Ashley M. Fuller, T. S. Karin Eisinger-Mathason, Shuying Yang
Summary: This study identifies RGS12 as a novel tumor suppressor in osteosarcoma through inhibiting the YAP-TEAD1-Ezrin signaling pathway and provides evidence that targeting RGS12 may be a therapeutic strategy for osteosarcoma.
Article
Medicine, General & Internal
Ya-Zeng Huang, Jun Zhang, Jian-Jian Shen, Ting-Xiao Zhao, You-Jia Xu
Summary: The study revealed that miR-296-5p acts as a tumor suppressor in OS by targeting SND1, providing a potential novel therapeutic target for OS treatment.
CHINESE MEDICAL JOURNAL
(2021)
Article
Medicine, Research & Experimental
Aiqing Zhao, Wanlin Liu, Xiaolong Cui, Na Wang, Yuxin Wang, Liang Sun, Huiqin Xue, Lishuan Wu, Shuxia Cui, Yun Yang, Rui Bai
Summary: TUSC7 is downregulated in osteosarcoma tissues and cell lines, and its overexpression inhibits cell proliferation, migration, and invasion while promoting apoptosis. TUSC7 exerts its role in OS cells by sponging miR-181a, thereby mediating its tumor suppressor function through the miR-181a/RASSF6 axis, potentially representing a new therapeutic target for osteosarcoma.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Mingyang Jiang, Yiji Jike, Kaicheng Liu, Fu Gan, Ke Zhang, Mingjing Xie, Junlei Zhang, Chuanliang Chen, Xiaochong Zou, Xiaohong Jiang, Yongheng Dai, Weikui Chen, Yue Qiu, Zhandong Bo
Summary: MiR-144-3p induces ferroptosis by negatively regulating the expression of ZEB1, thereby inhibiting the proliferation, migration, and invasion of osteosarcoma (OS) cells.
Article
Oncology
Manuel Ruh, Marc P. Stemmler, Isabell Frisch, Kathrin Fuchs, Ruthger van Roey, Julia Kleemann, Maike Roas, Harald Schuhwerk, Rebecca L. Eccles, Abbas Agaimy, Daniel Baumhoer, Geert Berx, Fabian Mueller, Thomas Brabletz, Simone Brabletz
Summary: Osteosarcoma, a mesenchyme-derived malignancy, is often associated with overexpression of the EMT-TF ZEB1, which blocks osteoblastic differentiation. Depletion of ZEB1 induces differentiation of osteosarcoma cells. Overexpression of ZEB1 in osteosarcoma is frequently linked to silencing of the imprinted DLK-DIO3 locus, but epigenetic reactivation of this locus reduces ZEB1 expression and sensitizes to standard treatment.
JOURNAL OF PATHOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Chen Wu, Xinfang Hou, Shuai Li, Suxia Luo
Summary: Gastric cancer is the fifth most common malignant cancer globally, and the long noncoding RNA ZEB1-AS1 plays a critical role in ferroptosis in gastric cancer cells. This study investigated the efficacy of ZEB1-AS1 on ferroptosis in gastric cancer cells. Various assays were used to analyze cell growth, viability, RNA and protein expression, levels of Fe2+, malondialdehyde (MDA), and lipid reactive oxygen species (ROS), as well as the mechanism of action.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2023)
Article
Pharmacology & Pharmacy
Asmaa M. Elfiky, Rania Hassan Mohamed, Fatma El-Zahraa Abd EL-Hakam, Mohamed A. Yassin, Mahmoud ElHefnawi
Summary: This study demonstrated the potential of LA-PAMAM carrier for targeted delivery of tumor suppressor miR-218 as a therapeutic candidate for HCC. The combination of hyperbranched polyamidoamine and lactobionic acid efficiently suppressed HepG2 cell proliferation and down-regulated the oncogenic HOXA1 target.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Review
Pathology
Huldani Huldani, Shadia Hamoud Alshahrani, Yasir Qasim Almajidi, Rosario Mireya Romero-Parra, Ahmed Hjazi, Hashem O. Alsaab, Khulood H. Oudaha, Beneen M. Hussien, Muhja Ahmed, Seyed Reza Hosseini Fard
Summary: Noncoding RNAs, such as microRNAs, play important roles in regulating cellular functions by targeting specific genes. MiR-495-3p has been identified as a crucial player in cancer pathogenesis and has potential as a prognostic and diagnostic biomarker, as well as a modifier of cancer cell chemotherapy resistance.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Article
Oncology
Bangmin Wang, Xin Wang, Po Li, Xiaoying Niu, Xiaoxiao Liang, Guancong Liu, Zhiyong Liu, Hong Ge
Summary: ELFN1-AS1 is highly expressed in osteosarcoma and can be transferred to macrophages via exosomes, inducing M2 macrophage polarization and promoting osteosarcoma progression.
FRONTIERS IN ONCOLOGY
(2022)