Article
Pharmacology & Pharmacy
Boyu Xia, Qi Li, Jingjing Wu, Xiaomei Yuan, Fei Wang, Xu Lu, Chao Huang, Koulong Zheng, Rongrong Yang, Le Yin, Kun Liu, Qingsheng You
Summary: Sinomenine has cardioprotective effects in a mouse model of myocardial ischemia-reperfusion injury by attenuating oxidative stress, inflammation, and apoptosis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Yingying Liu, Yanzhen Tan, Guojie Cao, Lei Shi, Yujie Song, Wenju Shan, Miao Zhang, Panpan Li, Haitao Zhou, Bing Zhang, Yang Sun, Wei Yi
Summary: This study demonstrates that bergenin attenuates myocardial apoptosis and oxidative damage induced by MI/R through the SIRT1 signaling pathway. Bergenin significantly reduces cardiomyocyte apoptosis and ROS production, and improves cardiac function in vitro and in vivo.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Qi Xiao, Yuan Liu, XingJian Zhang, ZhongZhong Liu, JianSheng Xiao, QiFa Ye, BiQi Fu
Summary: Mild hypothermia protects the liver from ischemia reperfusion-induced injury by upregulating RBM3 expression, reducing p38 and JNK signaling pathway activation, oxidative stress injury, and apoptosis.
Article
Immunology
Shixia Zhang, Jilang Tang, Chen Sun, Nuannuan Zhang, Xiaqing Ning, Xueqin Li, Jiaqi Wang
Summary: Dexmedetomidine (DEX) protects the liver against ischemia-reperfusion injury (IRI) by reducing oxidative stress, endoplasmic reticulum stress (ERS), and apoptosis. DEX increases antioxidant activity and reduces oxidative damage in BRL-3A cells. It also inhibits MAPK signaling pathway activation and ERS to prevent cell apoptosis. Animal studies confirm that DEX alleviates histopathological injury and improves liver function.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Qi Li, Boyu Xia, Jingjing Wu, Xiaomei Yuan, Xu Lu, Chao Huang, Hongcheng Gu, Koulong Zheng, Qingsheng You, Kun Liu
Summary: The study demonstrates that administration of indole-3-carbinol (I3C) protects the heart from myocardial ischemia/reperfusion injury (MIRI) through its anti-apoptotic, antioxidant, and anti-inflammatory effects.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Pharmacology & Pharmacy
Meng Sun, Rong Wang, Rui Xia, Zhengyuan Xia, Zhilin Wu, Tingting Wang
Summary: Mechanisms contributing to myocardial ischemia-reperfusion (I/R) injury are complex, but Dexmedetomidine (DEX) shows potential in ameliorating this injury in diabetic states. DEX activates the PI3K/Akt and associated GSK-3 beta pathway, alleviates endoplasmic reticulum stress, and inhibits apoptosis. Additionally, DEX up-regulates autophagy, reduces ROS production, and inhibits inflammation via HMGB1 pathways, leading to the protection against diabetic myocardial I/R injury.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jing Zhang, Yuecheng Sun, Wentao Song, Anshan Shan
Summary: This study found that exposure to phoxim at low levels can cause bioaccumulation with neurotoxicity, oxidative stress, tissue damage, and abnormal nutrient metabolism. Vitamin E was found to alleviate phoxim-induced nephrotoxicity by inhibiting mitochondrial apoptosis.
Article
Immunology
Qiwen Yu, Sanyang Chen, Hongwei Tang, Xiaodan Zhang, Ruolin Tao, Zhiping Yan, Jihua Shi, Wenzhi Guo, Shuijun Zhang
Summary: Veratric acid (VA) has protective effects against liver ischemia/reperfusion (I/R) injury by activating the Nrf2 signaling pathway, leading to increased expression of Nrf2, HO-1, and NQO-1 proteins, which helps alleviate oxidative stress and apoptosis, thus reducing liver damage.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Eyup Sari, Dilek Dilli, Irfan Tasoglu, Hasan Akduman, Nihat Yumusak, Naim Boran Tumer, Salih Salar
Summary: Melatonin and spirulina have protective effects against multiorgan damage induced by ischemia/reperfusion injury in a rat model, reducing oxidative tissue damage and apoptosis. Their antioxidant properties contribute to increasing total antioxidant capacity and reducing oxidative stress index, myeloperoxidase, tumor necrosis factor-alfa, and malondialdehyde levels.
JOURNAL OF FOOD BIOCHEMISTRY
(2022)
Article
Biotechnology & Applied Microbiology
Yu Zheng, Yingying Tao, Xiaobo Zhan, Qi Wu
Summary: The NR4A1/LKB1/AMPK axis is a new protective pathway involved in hepatocyte ischemia-reperfusion injury (IRI). It can improve cell viability, reduce oxidative stress and inflammation through negative regulation on the LKB1/AMPK pathway, while inducing apoptosis and autophagy.
Article
Immunology
Ya-lin Zhu, Jie Huang, Xue-ying Chen, Jian Xie, Qing Yang, Jia-feng Wang, Xiao-ming Deng
Summary: SEI alleviates renal injury induced by ischemia reperfusion with anti-inflammatory, anti-endoplasmic reticulum stress, anti-oxidative, and anti-apoptotic effects.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Tao Zheng, Jun Yang, Jing Zhang, Chaojun Yang, Zhixing Fan, Qi Li, Yuhong Zhai, Haiyin Liu, Jian Yang
Summary: The study found that downregulation of miR-327 could inhibit oxidative stress and apoptosis induced by H/R and TBHP in vitro experiments. Additionally, the downregulation enhanced the expression of fibroblast growth factor 10 (FGF10), activated p-PI3K and p-Akt, and promoted the translocation of Nrf2.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Medicine, Research & Experimental
Kuan-Hung Chen, Han-Tan Chai, Chih-Hung Chen, Chi-Ruei Huang, John Y. Chiang, Pei-Hsun Sung, Yi-Ching Chu, Hon-Kan Yip
Summary: The study demonstrated that combined CsA and Mel were superior to either CsA or Mel alone in protecting the brain against ischemia-reperfusion injury. The combination treatment showed significant reductions in neuronal damage and various biomarkers expressions in both cell and animal experiments.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Plant Sciences
Xiaoqi Zhao, Yutong Liu, Lei Wang, Chaolong Yan, Han Liu, Wenxin Zhang, Hongting Zhao, Chen Cheng, Zhipeng Chen, Tianze Xu, Kuanyu Li, Jing Cai, Tong Qiao
Summary: Oridonin exhibits a protective effect on hindlimb ischemia-reperfusion injury, possibly through Nrf2-mediated oxidative stress and NLRP3-mediated inflammasome activation.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Letter
Neurosciences
Shitao Lv, Haiyan Yang, Pengcheng Jing, Haiying Song
Summary: Alpha-tocopherol has shown antioxidant, anti-inflammatory, and anti-apoptotic abilities in rat brain tissue, mitigating nerve damage caused by cerebral ischemia-reperfusion injury.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)