Targeted mutagenesis tools for modelling psychiatric disorders

One-Step Generation of Mice Carrying Mutations in Multiple Genes by CRISPR/Cas-Mediated Genome Engineering

(2013) Haoyi Wang et al.   CELL

Direct production of mouse disease models by embryo microinjection of TALENs and oligodeoxynucleotides

(2013) B. Wefers et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RNA-Guided Human Genome Engineering via Cas9

(2013) P. Mali et al.   SCIENCE

Multiplex Genome Engineering Using CRISPR/Cas Systems

(2013) L. Cong et al.   SCIENCE

ZFN, TALEN, and CRISPR/Cas-based methods for genome engineering

(2013) Thomas Gaj et al.   TRENDS IN BIOTECHNOLOGY

Recent advances in targeted genome engineering in mammalian systems

(2012) Ning Sun et al.   Biotechnology Journal

TALE nucleases: tailored genome engineering made easy

(2012) Claudio Mussolino et al.   CURRENT OPINION IN BIOTECHNOLOGY

Advances in targeted genome editing

(2012) Pablo Perez-Pinera et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Generation of Rag1-knockout immunodeficient rats and mice using engineered meganucleases

(2012) Séverine Ménoret et al.   FASEB JOURNAL

Recombinase-mediated cassette exchange (RMCE) — A rapidly-expanding toolbox for targeted genomic modifications

(2012) Soeren Turan et al.   GENE

Targeting of >1.5 Mb of Human DNA into the Mouse X Chromosome Reveals Presence of cis -Acting Regulators of Epigenetic Silencing

(2012) Christine Yang et al.   GENETICS

Beyond knockouts: cre resources for conditional mutagenesis

(2012) Stephen A. Murray et al.   MAMMALIAN GENOME

The mammalian gene function resource: the international knockout mouse consortium

(2012) Allan Bradley et al.   MAMMALIAN GENOME

In vivo genome editing using a high-efficiency TALEN system

(2012) Victoria M. Bedell et al.   NATURE

RNA-mediated programmable DNA cleavage

(2012) Rodolphe Barrangou   NATURE BIOTECHNOLOGY

A toolbox of Cre-dependent optogenetic transgenic mice for light-induced activation and silencing

(2012) Linda Madisen et al.   NATURE NEUROSCIENCE

Genetic architectures of psychiatric disorders: the emerging picture and its implications

(2012) Patrick F. Sullivan et al.   NATURE REVIEWS GENETICS

Vika/vox, a novel efficient and specific Cre/loxP-like site-specific recombination system

(2012) Madina Karimova et al.   NUCLEIC ACIDS RESEARCH

Modeling disease mutations by gene targeting in one-cell mouse embryos

(2012) M. Meyer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Efficient TALEN-mediated gene knockout in livestock

(2012) D. F. Carlson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Supporting conditional mouse mutagenesis with a comprehensive cre characterization resource

(2012) Caleb S. Heffner et al.   Nature Communications

Modelling Human Regulatory Variation in Mouse: Finding the Function in Genome-Wide Association Studies and Whole-Genome Sequencing

(2012) Jean-François Schmouth et al.   PLoS Genetics

Animal Models of Psychiatric Disorders That Reflect Human Copy Number Variation

(2012) Jun Nomura et al.   NEURAL PLASTICITY

CRISPR-Cas Systems in Bacteria and Archaea: Versatile Small RNAs for Adaptive Defense and Regulation

(2011) Devaki Bhaya et al.   Annual Review of Genetics

A BACwards glance at neurodegeneration: molecular insights into disease fromLRRK2,SNCAandMAPTBAC-transgenic mice

(2011) Sara J. Johnson et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

TAL effectors are remote controls for gene activation

(2011) Heidi Scholze et al.   CURRENT OPINION IN MICROBIOLOGY

Quantitative Prediction of Human Pregnane X Receptor and Cytochrome P450 3A4 Mediated Drug-Drug Interaction in a Novel Multiple Humanized Mouse Line

(2011) M. Hasegawa et al.   MOLECULAR PHARMACOLOGY

Human Artificial Chromosomes for Gene Delivery and the Development of Animal Models

(2011) Yasuhiro Kazuki et al.   MOLECULAR THERAPY

A conditional knockout resource for the genome-wide study of mouse gene function

(2011) William C. Skarnes et al.   NATURE

Genomically humanized mice: technologies and promises

(2011) Anny Devoy et al.   NATURE REVIEWS GENETICS

A Resource of Cre Driver Lines for Genetic Targeting of GABAergic Neurons in Cerebral Cortex

(2011) Hiroki Taniguchi et al.   NEURON

Multiple new site-specific recombinases for use in manipulating animal genomes

(2011) A. Nern et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glutamatergic and Dopaminergic Neurons Mediate Anxiogenic and Anxiolytic Effects of CRHR1

(2011) D. Refojo et al.   SCIENCE

Inducible activation of Cre recombinase in adult mice causes gastric epithelial atrophy, metaplasia, and regenerative changes in the absence of “floxed” alleles

(2010) Won Jae Huh et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Hematopoietic Origin of Pathological Grooming in Hoxb8 Mutant Mice

(2010) Shau-Kwaun Chen et al.   CELL

TAL effectors: finding plant genes for disease and defense

(2010) Adam J Bogdanove et al.   CURRENT OPINION IN PLANT BIOLOGY

ROSA26Flpo deleter mice promote efficient inversion of conditional gene traps in vivo

(2010) Christopher S. Raymond et al.   GENESIS

Genetic Fate Mapping Reveals That the Caudal Ganglionic Eminence Produces a Large and Diverse Population of Superficial Cortical Interneurons

(2010) G. Miyoshi et al.   JOURNAL OF NEUROSCIENCE

PhiC31 integrase facilitates genetic approaches combining multiple recombinases

(2010) Claudio Monetti et al.   METHODS

Production of p53 gene knockout rats by homologous recombination in embryonic stem cells

(2010) Chang Tong et al.   NATURE

Gene targeting by homologous recombination in mouse zygotes mediated by zinc-finger nucleases

(2010) M. Meyer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CRISPR/Cas, the Immune System of Bacteria and Archaea

(2010) P. Horvath et al.   SCIENCE

Mouse Embryonic Stem Cells, but Not Somatic Cells, Predominantly Use Homologous Recombination to Repair Double-Strand DNA Breaks

(2010) Elisia D. Tichy et al.   STEM CELLS AND DEVELOPMENT

TAL effector-DNA specificity

(2010) Heidi Scholze et al.   Virulence

Homing endonucleases: from basics to therapeutic applications

(2009) Maria J. Marcaida et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Dre recombinase, like Cre, is a highly efficient site-specific recombinase in E. coli, mammalian cells and mice

(2009) K. Anastassiadis et al.   Disease Models & Mechanisms

Direct Hematological Toxicity and Illegitimate Chromosomal Recombination Caused by the Systemic Activation of CreERT2

(2009) A. Y. Higashi et al.   JOURNAL OF IMMUNOLOGY

An anatomic gene expression atlas of the adult mouse brain

(2009) Lydia Ng et al.   NATURE NEUROSCIENCE

A robust and high-throughput Cre reporting and characterization system for the whole mouse brain

(2009) Linda Madisen et al.   NATURE NEUROSCIENCE

Linking Genetically Defined Neurons to Behavior through a Broadly Applicable Silencing Allele

(2009) Jun Chul Kim et al.   NEURON

Split-Cre Complementation Indicates Coincident Activity of Different Genes In Vivo

(2009) Johannes Hirrlinger et al.   PLoS One

Split-CreERT2: Temporal Control of DNA Recombination Mediated by Split-Cre Protein Fragment Complementation

(2009) Johannes Hirrlinger et al.   PLoS One

Breaking the Code of DNA Binding Specificity of TAL-Type III Effectors

(2009) J. Boch et al.   SCIENCE

A Simple Cipher Governs DNA Recognition by TAL Effectors

(2009) M. J. Moscou et al.   SCIENCE

Germline Competent Embryonic Stem Cells Derived from Rat Blastocysts

(2008) Ping Li et al.   CELL

Tamoxifen modulates apoptosis in multiple modes of action in CreER mice

(2008) Hirohide Takebayashi et al.   GENESIS

Redefining the serotonergic system by genetic lineage

(2008) Patricia Jensen et al.   NATURE NEUROSCIENCE

Suitability of tamoxifen-induced mutagenesis for behavioral phenotyping

(2007) M.A. Vogt et al.   EXPERIMENTAL NEUROLOGY