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Nutrition & Dietetics
Shusuke Iwata, Ryusuke Yoshida, Shingo Takai, Keisuke Sanematsu, Noriatsu Shigemura, Yuzo Ninomiya
Summary: This study found that adrenomedullin enhances sugar sensing in mouse taste cells, potentially impacting caloric sensing and food intake.
Article
Medicine, Research & Experimental
Elham Sajadi, Javad Sajedianfard, Saeid Hosseinzadeh, Mahnaz Taherianfard
Summary: This study investigates the association between insulin resistance and Alzheimer's disease, and explores the effect of insulin and cinnamon extract on glucose transporter gene expression and spatial memory in a rat model of AD.
IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES
(2023)
Article
Biochemical Research Methods
Liam Lang, Giancarlo La Camera, Alfredo Fontanini
Summary: This study reveals that the mouse gustatory cortex plays a role in taste-guided decision-making. The neural activity in the gustatory cortex exhibits metastable dynamics, which sequentially encode sensory, abstract cue, and decision information during the decision-making process. Perturbations of the metastable dynamics differentially impact network performance, explaining the counterintuitive effect of optogenetic manipulation on mouse behavior.
PLOS COMPUTATIONAL BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Kate J. Claycombe-Larson, Amy Bundy, Elizabeth Black Lance, Diane C. Darland, Shanon L. Casperson, James N. Roemmich
Summary: This study found that postnatal diet has a greater impact on offspring adiposity and BA numbers than maternal diet. Additionally, offspring exercise can counter the increase in G9a triggered by maternal and postnatal high-fat diets by inducing KDM4C.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Article
Physiology
Stuart A. McCaughey
Summary: The gene Tas1r3 codes for the T1R3 protein, which combines with T1R2 to form a sweet taste receptor. Tas1r3 influences sweet taste preferences in mice, showing that sweet taste transduction initially occurs through T1R3-independent mechanisms before involving the T1R2/T1R3 receptor leading to spatially distinct responses.
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
(2021)
Article
Cell Biology
Marin E. Nelson, Soren Madsen, Kristen C. Cooke, Andreas M. Fritzen, Ida H. Thorius, Stewart W. C. Masson, Luke Carroll, Fiona C. Weiss, Marcus M. Seldin, Meg Potter, Samantha L. Hocking, Daniel J. Fazakerley, Amanda E. Brandon, Senthil Thillainadesan, Alistair M. Senior, Gregory J. Cooney, Jacqueline Stockli, David E. James
Summary: Insulin resistance can occur independently in skeletal muscle and adipose tissue, highlighting the importance of tissue-specific investigation in understanding metabolic diseases.
Article
Dentistry, Oral Surgery & Medicine
Masae Ueda, Tetsuya Goto, Kayoko N. Kuroishi, Kaori K. Gunjigake, Erina Ikeda, Shinji Kataoka, Mitsushiro Nakatomi, Takashi Toyono, Yuji Seta, Tatsuo Kawamoto
ARCHIVES OF ORAL BIOLOGY
(2016)
Article
Anatomy & Morphology
Hiroki Takagi, Yuji Seta, Shinji Kataoka, Mitsushiro Nakatomi, Takashi Toyono, Tatsuo Kawamoto
ANATOMICAL SCIENCE INTERNATIONAL
(2018)
Article
Developmental Biology
Kotono Kibe, Mitsushiro Nakatomi, Shinji Kataoka, Takashi Toyono, Yuji Seta
GENE EXPRESSION PATTERNS
(2018)
Article
Cell Biology
Takeshi Kotani, Takashi Toyono, Yuji Seta, Ayae Kitou, Shinji Kataoka, Kuniaki Toyoshima
CELL AND TISSUE RESEARCH
(2013)
Article
Behavioral Sciences
Ayae Kito-Shingaki, Yuji Seta, Takashi Toyono, Shinji Kataoka, Yasuaki Kakinoki, Yuchio Yanagawa, Kuniaki Toyoshima
Article
Endocrinology & Metabolism
Aya Fukuda, Tetsuya Goto, Kayoko N. Kuroishi, Kaori K. Gunjigake, Shinji Kataoka, Shigeru Kobayashi, Kazunori Yamaguchi
Article
Endocrinology & Metabolism
Satomi Nagao, Tetsuya Goto, Shinji Kataoka, Takashi Toyono, Takaaki Joujima, Hiroshi Egusa, Hirofumi Yatani, Shigeru Kobayashi, Kenshi Maki
Article
Medicine, Research & Experimental
Yuki Hirata, Takashi Toyono, Shoichiro Kokabu, Yui Obikane, Shinji Kataoka, Mitsushiro Nakatomi, Chihiro Masaki, Ryuji Hosokawa, Yuji Seta
BIOMEDICAL RESEARCH-TOKYO
(2019)
Article
Dentistry, Oral Surgery & Medicine
T. Joujima, M. Oda, M. Sasaguri, M. Habu, S. Kataoka, Y. Miyamura, N. Wakasugi-Sato, S. Matsumoto-Takeda, O. Takahashi, S. Kokuryo, T. Sago, D. Yoshiga, T. Tanaka, Y. Morimoto
INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY
(2020)
Article
Dentistry, Oral Surgery & Medicine
T. Shikayama, J. Fujita-Yoshigaki, M. Sago-Ito, M. Nakamura-Kiyama, M. Naniwa, S. Hitomi, I Ujihara, S. Kataoka, N. Yada, W. Ariyoshi, M. Usui, K. Nakashima, K. Ono
ARCHIVES OF ORAL BIOLOGY
(2020)
Article
Cell Biology
Chia-Chien Hsu, Yuji Seta, Kae Matsuyama, Shinji Kataoka, Mitsushiro Nakatomi, Takashi Toyono, Kaori K. Gunjigake, Kayoko N. Kuroishi, Tatsuo Kawamoto
Summary: This study revealed that Mash1-positive precursor cells differentiate into type III taste bud cells, but not into most type II cells. Additionally, Mash1-expressing cells can differentiate into PLC beta 2-positive cells, which have a shorter lifespan compared to other taste bud cells.
CELL AND TISSUE RESEARCH
(2021)
Article
Dentistry, Oral Surgery & Medicine
Jinsil Park, Mitsushiro Nakatomi, Masaaki Sasaguri, Manabu Habu, Osamu Takahashi, Daigo Yoshiga, Kae Matsuyama, Shinji Kataoka, Takashi Toyono, Yuji Seta, Heiko Peters, Kazuhiro Tominaga
Summary: This study investigated the impact of gene-environment interaction on cleft palate, revealing that the combination of Msx1 heterozygosity and hypoxic stress induced a higher incidence of cleft palate. The downregulation of Bmp4 and decreased cell proliferation were identified as key factors contributing to cleft palate formation. Individuals with MSX1 mutations may need to take extra precautions during pregnancy to minimize exposure to environmental risks.
CLEFT PALATE-CRANIOFACIAL JOURNAL
(2021)
Article
Dentistry, Oral Surgery & Medicine
Yui Obikane, Takashi Toyono, Shoichiro Kokabu, Kae Matsuyama, Shinji Kataoka, Mitsushiro Nakatomi, Ryuji Hosokawa, Yuji Seta
Summary: This study investigated the transcriptional regulation of Tas1r1 by Myod1, revealing that Myod1 forms a heterodimer with Tcf12 and collaborates with Klf5 to bind to E-box1 and activate Tas1r1 expression during myogenic differentiation.
JOURNAL OF ORAL BIOSCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Saori Shibuya, Mitsushiro Nakatomi, Kaori Kometani-Gunjigake, Kayoko Nakao-Kuroishi, Kae Matsuyama, Shinji Kataoka, Takashi Toyono, Yuji Seta, Tatsuo Kawamoto
Summary: Optimal Msx1 gene is crucial for mandibular tip development, and its deficiency leads to rare abnormalities in the median cleft of the lower lip and cleft chin. The study found that the expression of Msx1 gene is reduced in the mandibular tip, resulting in incomplete fusion of the mandibular processes and failure to restore during development. In addition, the absence of the Msx1 gene also causes division of Meckel's cartilage and surrounding soft tissues. The results suggest that the Msx1 gene is indispensable for proper mandibular tip development.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Dentistry, Oral Surgery & Medicine
Kae Matsuyama, Yuji Seta, Shinji Kataoka, Mitsushiro Nakatomi, Takashi Toyono, Tatsuo Kawamoto
JOURNAL OF ORAL BIOSCIENCES
(2017)