Article
Parasitology
N. B. Terenina, N. D. Kreshchenko, N. Mochalova, M. A. Nikoghosyan, R. A. Petrosyan, S. O. Movsesyan
Summary: This study investigated the presence and localization of the neurotransmitter serotonin in the nervous system of the lancet fluke using immunocytochemical technique and confocal laser scanning microscopy. The results showed the presence of serotonin-immunopositive components in various parts of the nervous system, suggesting the involvement of the serotonergic nervous system in the regulation of attachment organs and reproductive system functions in the lancet fluke.
VETERINARY PARASITOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Raluca Ioana Teleanu, Adelina-Gabriela Niculescu, Eugenia Roza, Oana Vladacenco, Alexandru Mihai Grumezescu, Daniel Mihai Teleanu
Summary: This paper describes the role of neurotransmitters and their link to relevant neurological conditions. It also provides an overview of detection methods and considerations for modulating neurotransmitters to restore homeostasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Microbiology
Abu Amar M. Al Mamun, Kouhei Kishida, Peter J. Christie
Summary: Bacterial type IV secretion systems can translocate both DNA and various proteins to recipient cells, with the transferred proteins playing a role in suppressing the SOS response in recipient cells. These findings highlight a new biological function for conjugative protein translocation and suggest its potential impact on bacterial communication, physiology, and evolution.
Article
Biochemistry & Molecular Biology
Jinjing Jia, Guangtao Xu, Dongsheng Zhu, Hongjun Liu, Xiansi Zeng, Li Li
Summary: This review highlights the significance of the thioredoxin system in CNS diseases and suggests that it may be a promising therapeutic target. The article also proposes future directions for research in developing effective inducers of Trx and specific inhibitors of TXNIP for the treatment of CNS diseases.
ANTIOXIDANTS & REDOX SIGNALING
(2023)
Review
Food Science & Technology
Brett J. Deters, Mir Saleem
Summary: Glutamine can positively impact gut health by supporting the gut microbiome, gut mucosal wall integrity, and modulating inflammatory responses. The gut-brain connection, modulated by the vagus nerve, can impact the brain's neurochemical environment, potentially influencing conditions such as depression. Supplementing with glutamine may offer adjunctive nutritional support in cases of depression by promoting proper gut health and function.
FOOD SCIENCE AND HUMAN WELLNESS
(2021)
Review
Oncology
Cristian Scheau, Carmen Draghici, Mihaela Adriana Ilie, Mihai Lupu, Iulia Solomon, Mircea Tampa, Simona Roxana Georgescu, Ana Caruntu, Carolina Constantin, Monica Neagu, Constantin Caruntu
Summary: Melanoma is an aggressive and fatal malignant tumor, with early diagnosis being curable but advanced stages having high mortality rates. Studies have focused on neuroendocrine factors' role in melanoma development, but there are still unknown features to uncover. Investigating how neuroendocrine factors influence melanoma's clinical course may lead to new biomedical research areas and therapeutic approaches.
Review
Biology
Leonid L. Moroz, Daria Y. Romanova, Andrea B. Kohn
Summary: Transmitter signalling is the universal chemical language of the nervous system, with origins possibly in secretory cells capable of volume chemical transmission and behavior integration. Different neurotransmitters may have been recruited relatively early or late in animal evolution.
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2021)
Article
Neurosciences
Tri Huu Doan, Yuma Sato, Masayuki Matsumoto, Tadachika Koganezawa
Summary: The lateral habenula regulates autonomic cardiovascular responses through activation of different neural pathways including cardiac parasympathetic nerves and cardiovascular sympathetic nerves. The stimulation effects of lateral habenula are likely mediated by 5-HT1A and 5-HT2 receptors, while other 5-HT receptors do not affect its actions.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Environmental Sciences
Hanan A. Edres, Nabil M. Taha, Mohamed A. Lebda, Mohamed S. Elfeky
Summary: The study revealed that ACR exposure induced oxidative damage in the brain, leading to altered neurotransmitters and pathological brain lesions. Allicin and melatonin mitigated ACR-induced brain damage by restoring redox balance, enhancing neurotransmitters, reducing DNA damage, and providing anti-inflammatory effects.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Elena Kotsyuba, Vyacheslav Dyachuk
Summary: This study investigated the effects of hypoxia on the central nervous system of scallops and found that hypoxia can affect the expression and dynamics of neurotransmitters and the distribution of neurotransmitter enzymes. The study also revealed that hypoxia may have a weak influence on the number of neurons but does not affect the expression of certain peptides.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Monica Montagnani, Lucrezia Bottalico, Maria Assunta Potenza, Ioannis Alexandros Charitos, Skender Topi, Marica Colella, Luigi Santacroce
Summary: Several studies have shown that the gut microbiota has an influence on behavior, and changes in the immune system associated with symptoms of depression or anxiety disorder may be reflected in corresponding changes in the gut microbiota. However, there is currently no accurate epidemiological evidence explaining the connection between central nervous system (CNS) pathology and intestinal dysbiosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Fisheries
Tianxu Zhang, Sihan Wang, Yanzhang Jiang, Haishui Zhou, Mingyang Sun, Zhaoyang Ning, Weijie Mu
Summary: This study focused on the cloning and expression of GRP94 and HSP90 beta genes in Phoxinus lagowskii during cold stress. Both genes were found to be highly expressed in various tissues, and their expression levels showed different patterns in response to acute and long-term cold stress. GRP94 showed significantly high expression in the brain during long-term cold stress, suggesting a protective role in brain tissue.
AQUACULTURE REPORTS
(2023)
Article
Chemistry, Medicinal
Hany H. Arab, Ali Khames, Shuruq E. Alsufyani, Azza A. K. El-Sheikh, Amany M. Gad
Summary: The study investigated the neuroprotective potential of magnesium sulfate in a rat model of chronic-restraint stress (CRS)-induced depression-like behavioral disturbance and the underlying molecular mechanisms. The results demonstrated that magnesium sulfate attenuated the depression-like behavioral outcomes and histopathological changes in the brain by dampening inflammation, ER stress, and the associated PERK/GRP78/CHOP pathway. These findings suggest the promising neuroprotective/antidepressant actions of magnesium sulfate in CRS.
Review
Medicine, Research & Experimental
Meihua Jin, Chun Wang, Yifeng Xu, Zijing Zhang, Xueyan Wu, Runfa Ye, Qinggao Zhang, Donghe Han
Summary: This review tracks and summarizes studies from the past eight years, elucidating the pharmacological effects of Salidroside on inflammation, oxidative stress, apoptosis, autophagy, and neuronal regeneration, as well as assessing its regulatory effect on various signaling pathways.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Pharmacology & Pharmacy
Maximilian Hirschenberger, Nicole Stadler, Maximilian Fellermann, Konstantin M. J. Sparrer, Frank Kirchhoff, Holger Barth, Panagiotis Papatheodorou
Summary: CRISPA is a novel, transient, and non-viral Cas9 delivery strategy based on the translocation machinery of the Bacillus anthracis anthrax toxin, PA. By shuttling Cas9 variants through channels formed by PA into the cytosol of human cells, CRISPA successfully delivers Cas9 into specific cells for genome editing. This approach has the potential to be optimized for cell type-selective delivery of Cas9, making it a promising step towards safe translation of the CRISPR/Cas9 technology into clinics.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cell Biology
Grace Ampem, Alexandra Junginger, Haidong Yu, Lajos Balogh, Julianna Thuroczy, Marion E. Schneider, Tamas Roeszer
CELL AND TISSUE RESEARCH
(2019)
Article
Medicine, Research & Experimental
Haidong Yu, Sedat Dilbaz, Jonas Cossmann, Anh Cuong Hoang, Victoria Diedrich, Annika Herwig, Akiko Harauma, Yukino Hoshi, Toru Moriguchi, Kathrin Landgraf, Antje Koerner, Christina Lucas, Susanne Brodesser, Lajos Balogh, Julianna Thuroczy, Gopal Karemore, Michael Scott Kuefner, Edwards A. Park, Christine Rapp, Jeffrey Bryant Travers, Tames Roeszer
JOURNAL OF CLINICAL INVESTIGATION
(2019)
Article
Immunology
Florian Olde Heuvel, Sarah Holl, Akila Chandrasekar, Zhenghui Li, Yibin Wang, Rida Rehman, Philip Foerstner, Daniela Sinske, Annette Palmer, Diana Wiesner, Albert Ludolph, Markus Huber-Lang, Borna Relja, Thomas Wirth, Tamas Roeszer, Bernd Baumann, Tobias Boeckers, Bernd Knoell, Francesco Roselli
BRAIN BEHAVIOR AND IMMUNITY
(2019)
Editorial Material
Endocrinology & Metabolism
Tamas Roeszer
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Cell Biology
Anh Cuong Hoang, Haidong Yu, Tamas Roeszer
Summary: The study identified gene networks in developing iWAT and BAT in mice, showing similarities and differences in gene expression related to immune responses and antiviral factors. It also revealed a metabolic shift in postnatal iWAT from thermogenesis and lipolysis towards fat storage. Additionally, differences were found in the signals for thermogenic fat differentiation between early postnatal life and adulthood.
Review
Cell Biology
Tamas Roeszer
Summary: The safe removal of apoptotic cells by macrophages is crucial for tissue health, but in the case of adipocyte apoptosis, the clearance process can lead to inflammation and metabolic diseases. Metabolites released by apoptotic cells and produced by macrophages during digestion of apoptotic cells control macrophage immune functions.
Article
Multidisciplinary Sciences
Timm Amendt, Gabriele Allies, Antonella Nicolo, Omar El Ayoubi, Marc Young, Tamas Roszer, Corinna S. Setz, Klaus Warnatz, Hassan Jumaa
Summary: Hormone production is crucial for maintaining metabolic homeostasis. This study found that antibody-deficient mice and immunodeficiency patients have lower blood glucose concentrations. The presence of insulin-specific IgG antibodies in total IgG preparations and healthy individuals' serum is necessary for restoring blood glucose physiology. Autoreactive IgM antibodies recognizing insulin play a key role in regulating blood glucose and metabolism.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Biochemistry & Molecular Biology
Tamas Roeszer
Summary: Breastfeeding is a unique behavior of mammals, providing heat and metabolic fuel for offspring. The lipid signals in breast milk play a crucial role in infant lipid metabolism and metabolic development.
Article
Biochemistry & Molecular Biology
Tamas Roeszer
Article
Cell Biology
Tamas Roeszer
Summary: Adipose tissue macrophages (ATMs) play critical roles in metabolic inflammation, insulin resistance, adipose tissue fibrosis, and obesity-related immune disorders. While most research on ATMs has focused on adult obesity, it is important to note that ATMs are present and active in newborns and infants, with potential lifelong impacts.
JOURNAL OF LEUKOCYTE BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Gergely Balazs, Andras Balajthy, Istvan Seri, Thomas Hegyi, Tibor Ertl, Tamas Szabo, Tamas Roszer, Agnes Papp, Jozsef Balla, Tamas Gall, Gyorgy Balla
Summary: Less invasive surfactant administration techniques, such as LISA-nCPAP, are becoming increasingly significant in the treatment of extremely premature newborns. This review focuses on the short- and long-term complications associated with prematurity and discusses various preventative and therapeutic approaches to improve outcomes. Adjuvant interventions, including optimized cardiopulmonary transition and the use of angiogenic growth factors, show promise in enhancing morbidity-free survival. Additionally, the potential benefits of corticosteroids, caffeine, insulin, thyroid hormones, antioxidants, N-acetylcysteine, and immunomodulatory components of mother's milk are explored.
Article
Cell Biology
Kornel Z. Varga, Katalin Gyurina, Adam Radvanyi, Tibor Pal, Laszlo Sasi-Szabo, Haidong Yu, Eniko Felszeghy, Tamas Szabo, Tamas Roeszer
Summary: Innate immune signaling in adipocytes can affect systemic metabolism. DNA sensing in the cytoplasm of adipocytes can stimulate thermogenic adipocyte differentiation and protect against obesity. However, DNA efflux from adipocyte mitochondria may lead to tissue dysfunction and insulin resistance. This study found that the signal transduction molecule STING can trigger autophagy in adipocytes, thereby protecting them from excessive IFN-I response.
Article
Endocrinology & Metabolism
Anh Cuong Hoang, Laszlo Sasi-Szabo, Tibor Pal, Tamas Szabo, Victoria Diedrich, Annika Herwig, Kathrin Landgraf, Antje Koerner, Tamas Roeszer
Summary: This study reveals that mitochondrial RNA in young adipocytes can trigger thermogenesis, and vitamin D suppresses the interferon response to this RNA, reducing the risk of obesity.
Editorial Material
Pharmacology & Pharmacy
Tamas Roeszer
CURRENT OPINION IN PHARMACOLOGY
(2020)
Article
Biochemical Research Methods
Grace Ampem, Tamas Roeszer
NUCLEAR RECEPTORS: METHODS AND EXPERIMENTAL PROTOCOLS
(2019)