Article
Biochemistry & Molecular Biology
Juergen Pfeffermann, Peter Pohl
Summary: Millions of years of evolution have resulted in proteinaceous water channels with excellent selectivity and transport rates near the diffusion limit. However, a recent claim in Science suggests that artificial channels are much faster and nearly as selective. The deflation kinetics of vesicles with channels or channel elements contradict this claim as they do not demonstrate facilitated water transport. By pointing out flaws in data processing, we show that individual vesicles cannot shrink with two different kinetics simultaneously and that deflation within the dead time of the instrument cannot be detected. Furthermore, after analyzing the achievable limits of single-channel water permeability, we conclude that it is unlikely to surpass the optimized performance of natural aquaporins while maintaining near-perfect selectivity.
Article
Multidisciplinary Sciences
Yasunori Saitoh, Namiki Mitani-Ueno, Keisuke Saito, Kengo Matsuki, Sheng Huang, Lingli Yang, Naoki Yamaji, Hiroshi Ishikita, Jian-Ren Shen, Jian Feng Ma, Michihiro Suga
Summary: The authors have shown the crystal structure of rice Lsi1 and identified a unique hydrophilic selectivity filter composed of five residues. This structure provides a solid basis for the highly selective activity of Lsi1 in silicon uptake, contributing to secure and sustainable rice production.
NATURE COMMUNICATIONS
(2021)
Review
Biochemistry & Molecular Biology
Fabio Herrera, Olga Bondarenko, Sergii Boryshpolets
Summary: Fish spermatozoa adapt to environmental changes to maintain cell structure and functional integrity, which is essential for their motility and successful fertilization. Specific water channels may play a role in cell volume regulation and motility. Changes in external osmolality can impact sperm function and quality.
FISH PHYSIOLOGY AND BIOCHEMISTRY
(2021)
Article
Plant Sciences
Mengmeng Liu, Janusz J. Zwiazek
Summary: This study found that the oxidative burst had a decisive impact on the hydraulic recovery of plants upon re-aeration after root hypoxia. The gradual recovery of root hydraulic conductivity (Lpr) was accompanied by up-regulation of aquaporins and activation of antioxidant enzymes. The ability of plants to recover from waterlogging was partly determined by their ability to handle oxidative stress caused by both hypoxia event and the burst of reactive oxygen species (ROS).
ENVIRONMENTAL AND EXPERIMENTAL BOTANY
(2022)
Article
Agriculture, Dairy & Animal Science
Caterina Squillacioti, Nicola Mirabella, Giovanna Liguori, Giuseppe Germano, Alessandra Pelagalli
Summary: This study investigated the localization and expression of AQP7, AQP8, and AQP9 in the efferent ductules and epididymal regions of normal and cryptorchid dogs. The results showed regional tissue distributions of these Aquaporins, with evidence of their upregulation in the caput and downregulation in the cauda region of the canine cryptorchid epididymis. This suggests the involvement of AQPs in luminal microenvironment modifications associated with cryptorchidism.
Article
Pharmacology & Pharmacy
Henry Danahay, Sarah Lilley, Kathryn Adley, Holly Charlton, Roy Fox, Martin Gosling
Summary: Niclosamide and benzbromarone have been considered as clinical candidates for the treatment of airway diseases due to their activity as inhibitors of the calcium activated chloride channel TMEM16A. However, this study reveals that both compounds have off-target effects and also questions the classification of niclosamide as a TMEM16A blocker. The study further suggests a potential role of TMEM16A in the regulation of epithelial ion transport and mucus secretion in the airway.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Plant Sciences
Xiaoyu Han, Jinfeng Wang, Linsen Zhang
Summary: This study examines the hydraulic performance of five apple rootstocks under drought stress and finds that leaf water potential and photosynthesis significantly decrease under drought stress. Aquaporins are closely related to the hydraulic conductance of rootstocks under drought stress. The drought resistance of dwarfing rootstocks is associated with the rapid recovery of water-related traits.
PHYSIOLOGIA PLANTARUM
(2023)
Article
Plant Sciences
Miguel Barcelo-Anguiano, Jose I. Hormaza, Juan M. Losada
Summary: This study combined fluorescence and electron microscopy to explore the vascular anatomy of phloem tissue in tapering branches of mango trees, revealing variations in phloem anatomy in different years that led to an exponential increase in conductivity towards the base of the tree. The findings suggest that the pipe model theory applied to the phloem continuous tubing system is a good approach to understanding hydraulic transport in fruit trees.
HORTICULTURE RESEARCH
(2021)
Article
Chemistry, Physical
Danmin Huang, Yangkun Huang, Shuqin Zheng, Mei Tu, Lingxiang Jiang
Summary: This study investigates the dynamics of host-guest systems using direct imaging and tracking in a colloid-in-tube system. The findings reveal that the thermal motion of the host tube leads to various anomalies in guest particle dynamics, which has implications for host-guest systems embedded in thermal fluctuations.
Biographical-Item
Computer Science, Interdisciplinary Applications
Gheorghe Benga
Summary: Petre T. Frangopol, a brilliant Romanian scientist, is acknowledged for his contributions to the development of Scientometrics in Romania. His achievements in various fields have been widely recognized, and he is also remembered as a man of great character and an unforgettable friend.
Article
Chemistry, Multidisciplinary
Michael Falato, Ruth Chan, Liao Y. Chen
Summary: In this study, the affinity of AQP7 for glycerol was computed using unbiased equilibrium molecular dynamics simulations. The results showed that the computed affinity values depend on the system size. By calculating the dissociation constant, a lower bound for the AQP7-glycerol affinity was obtained, indicating that the affinity is stronger than previously predicted.
Review
Medicine, General & Internal
Julian Prangenberg, Elke Doberentz, Burkhard Madea
Summary: Forensic pathologists often face unclear causes of death, and immunohistochemical analysis has become increasingly important in clarifying such uncertainties. Studies have focused on aquaporins, a family of water channels, and their role in transporting water and small molecules like glycerol, with potential applications in forensic investigations.
FRONTIERS IN MEDICINE
(2021)
Article
Plant Sciences
Alicia Pou, Charles Hachez, Valentin Couvreur, Laurie C. Maistriaux, Ahmed Ismail, Francois Chaumont
Summary: The regulation of root nitrogen acquisition through mass flow involves the coordinated regulation of root hydraulic properties and stomatal conductance. This study examined the short-term effect of high nitrogen availability on hydraulic parameters and aquaporin regulation in maize genotypes. Results showed that some genotypes had a rapid increase in root hydraulic conductivity under high nitrogen treatment, while others did not. There was a significant correlation between root hydraulic conductivity and cortex cell hydraulic conductivity. However, gas exchange parameters showed genotype-specific variations that were not always correlated with root hydraulic parameters. The protein abundance of plasma membrane PIP aquaporins was correlated with the rapid variation in root hydraulic conductivity in one genotype, suggesting posttranslational mechanisms in the regulation of root hydraulic parameters in response to high nitrogen.
PHYSIOLOGIA PLANTARUM
(2022)
Article
Plant Sciences
Adi Yaaran, Eyal Erez, Carl Procko, Menachem Moshelion
Summary: Genetic modifications of leaf cells' sensitivity to abscisic acid reveal their roles in leaf hydraulic regulation. Transgenic Arabidopsis plants insensitive to ABA in their bundle sheath and mesophyll cells showed increased leaf hydraulic conductance and transpiration under optimal conditions. Tissue-specific regulation of water permeability by ABA may be influenced by whole-leaf hydraulics and transpiration.
Article
Veterinary Sciences
Veronica Mollica Govoni, Claudio Pigoli, Eleonora Brambilla, Felipe Augusto Ruiz Sueiro, Rafael Torres Neto, Renee Laufer-Amorim, Juliany Gomes Quitzan, Valeria Grieco, Carlos Eduardo Fonseca-Alves
Summary: This study evaluated Caveolin-1, GATA-3, and Ki67 immunostaining in canine bladder urothelial carcinoma (UC) samples and found that Caveolin-1 and GATA-3 expression could be promising markers for bladder UC aggressiveness.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Entomology
Daniel C. B. de Barros, Alex Junji Shinohara, Marcelo P. Camilli, Sergio A. A. Santos, Luis A. Justulin, Ricardo de Oliveira Orsi
Summary: The study found that supplementation of inorganic Fe in the feed of bees significantly impacts the morphology of mandibular glands in Apis mellifera, resulting in a significant reduction in the area and height of secretory cells of the glands.
JOURNAL OF APICULTURAL RESEARCH
(2021)
Review
Entomology
Marcelo P. Camilli, Daniel C. B. de Barros, Luis A. Justulin, Marcos L. P. Tse, Ricardo de Oliveira Orsi
Summary: This study found that during dearth periods, honey bee workers fed protein-enriched feed showed significantly increased area and height of secretory MG cells. The feed with 23% CP had the greatest impact on the height of secretory cells in the MG.
JOURNAL OF APICULTURAL RESEARCH
(2021)
Article
Plant Sciences
Gabriela Bueno, Stefanni Liliane Chavez Rico, Larissa Lucena Perico, Rie Ohara, Vinicius Peixoto Rodrigues, Maycon Tavares Emilio-Silva, Renata Assuncao, Lucia Regina Machado da Rocha, Domingos Savio Nunes, Michele Aparecida Besten, Gustavo Heiden, Ana Carolina Lima Camargo, Luis Antonio Justulin, Clelia Akiko Hiruma-Lima
Summary: The study demonstrated that the essential oil from Baccharis trimera has protective and healing effects on gastric ulcers by decreasing myeloperoxidase activity, increasing vascular endothelial growth factor expression, and reducing matrix metalloproteinase-2 activity.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Medicine, Research & Experimental
Lucas Silva Cortes, Henrique Spaulonci Silveira, Luiz Antonio Lupi, Talita de Mello Santos, Marilia Martins Cavariani, Raquel Fantin Domeniconi, Leticia Barbosa Gaiotte, Diego Augusto de Morais Oliveira, Luis Antonio Justulin, Luiz Gustavo de Almeida Chuffa
Summary: Maternal low protein diet significantly affects the nutritional parameters, estrous cycle, ovarian histomorphometry, and reproductive health of offspring, without altering the levels of intracellular regulatory molecules in adulthood.
Article
Cell Biology
Luiz M. F. Portela, Sergio A. A. Santos, Flavia B. Constantino, Ana C. L. Camargo, Ketlin T. Colombelli, Matheus N. Fioretto, Caroline N. Barquilha, Larissa L. Perico, Clelia A. Hiruma-Lima, Wellerson R. Scarano, Elena Zambrano, Luis A. Justulin
Summary: The study found that protein malnutrition in dams during gestation and lactation led to decreased testosterone levels and increased estrogen levels in elderly offspring, along with increased oxidative stress and potential promotion of prostate carcinogenesis.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2021)
Article
Orthopedics
Alexandre Zuccon, Hamilton Da Rosa Pereira, Sergio Alexandre Alcantara dos Santos, Sergio Luis Felisbino, Luis Antonio Justulin Junior, Daniele Cristina Cataneo
Summary: Histological analysis revealed significant increase in cellularity in the round ligament of unstable hips, while significantly greater collagen occupancy was observed in the control side. However, there were no significant differences in zymography, and biomechanical tests showed similarities in maximal strength and deformation between the unstable side and the control side.
ACTA ORTOPEDICA BRASILEIRA
(2022)
Article
Cell Biology
Joyce R. Zapaterini, Antonio R. B. Fonseca, Lucas T. Bidinotto, Ketlin T. Colombelli, Andre L. D. Rossi, Laura Kass, Luis A. Justulin, Luis F. Barbisan
Summary: This study found that maternal malnutrition, especially a low-protein diet, has adverse effects on the development of mammary cancer in female offspring. It was found that low-protein diet can cause delays in mammary gland development and abnormal gene expression in DNA repair and replication pathways, making female offspring more susceptible to chemically induced mammary cancer.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Environmental Sciences
Alexandre M. B. Cavalca, Ariana M. Aquino, Francielle C. Mosele, Luis A. Justulin, Flavia K. Delella, Jodi A. Flaws, Wellerson R. Scarano
Summary: This study found that a mixture of phthalates may increase the proliferation and migration of tumor cells, as well as modulate tumor behavior, but these effects were less pronounced in benign cells. Benign cells are able to develop effective mechanisms or more resistance against the insult.
ENVIRONMENTAL TOXICOLOGY
(2022)
Article
Environmental Sciences
Helga Caputo Nunes, Samara Costa Tavares, Heloisa Vicente Garcia, Maira Smaniotto Cucielo, Sergio Alexandre Alcantara dos Santos, Mirian Carolini Esgoti Aal, Marjorie Assis de Golim, Luis Antonio Justulin Jr, Amanda Oliveira Ribeiro, Elenice Deffune, Wellerson Rodrigo Scarano, Flavia Karina Delella
Summary: Chemical contamination is an important factor to consider in cell therapy strategy design. This study found that BPA and TCDD can significantly reduce cell viability and affect adipogenic differentiation and DNA damage.
ENVIRONMENTAL TOXICOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Nilton J. Santos, Ana Carolina Lima Camargo, Hernandes F. Carvalho, Luis Antonio Justulin, Sergio Luis Felisbino
Summary: The study identified nine dysregulated membrane and secreted proteins in prostate cancer, along with interactions between validated miRNAs and target genes. These findings contribute to understanding the biology, disease progression, and patient outcomes of prostate cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Sergio Alexandre Alcantara Santos, Luiz Marcos Frediani Portela, Ana Carolina Lima Camargo, Flavia Bessi Constantino, Ketlin Thassiani Colombelli, Matheus Naia Fioretto, Renato Mattos, Bruno Evaristo de Almeida Fantinatti, Michela Alessandra Denti, Silvano Piazza, Sergio Luis Felisbino, Elena Zambrano, Luis Antonio Justulin
Summary: This study describes the deregulation of two miRNAs in the prostate of rats born to dams fed with a low protein diet. Integrative analysis of transcriptomic and proteomic data reveals potential molecular mechanisms involved in prostate cancer. Imbalance of the testosterone/estrogen ratio in the offspring rats highlights the importance of improving maternal healthcare.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Ericka Patricia da Silva, Georgia da Silva Feltran, Sergio Alexandre Alcantara dos Santos, Rodrigo Cardoso de Oliveira, Rahyza I. F. Assis, Luis Antonio Justulin Junior, Denise Carleto Andia, Willian F. Zambuzzi, Alexandra Latini, Rodrigo A. Foganholi da Silva
Summary: Diabetes mellitus (DM) is a chronic metabolic disease characterized by increased blood glucose and insulin dysfunction. The relationship between DM and bone fragility, cognitive deficits, and increased risk of dementia needs further understanding. A study found that chronic hyperglycemia negatively affected bone biology and compromised the balance of the bone-brain endocrine axis.
Editorial Material
Cell Biology
Luis A. Justulin, Elena Zambrano, Thomas P. Ong, Susan E. Ozanne
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Cell Biology
Jessica Silvino Valente, Erika Stefani Perez, Bruna Tereza Thomazini Zanella, Tassiana Gutierrez de Paula, Sergio Alexandre Alcantara dos Santosl, Bruno Oliveira da Silva Duran, Robson Francisco Carvalho, Luis Antonio Justulin, Bruno Evaristo de Almeida Fantinatti, Maeli Dal-Pai-Silva
Summary: The study revealed that maternal protein restriction affects the morphological and molecular characteristics of skeletal muscle in aging rats, with changes in oxidative muscle fiber size and gene expression levels, as well as alterations in fiber frequency in glycolytic muscle.
HISTOLOGY AND HISTOPATHOLOGY
(2021)
Article
Entomology
Daniel C. B. de Barros, Marcelo P. Camilli, Gabriel M. Martineli, Aime A. Longuini, Samir M. Kadri, Luis A. Justulin, Ricardo O. Orsi
Summary: The study showed that organic zinc supplementation positively influenced development of the mandibular glands in honey bees, with the 75 ppm treatment showing the best results. In contrast, the inorganic zinc supplementation had similar results to the control group, but the 75 ppm treatment demonstrated the worst development of the mandibular glands.
BULLETIN OF INSECTOLOGY
(2021)