Article
Biochemistry & Molecular Biology
Layla Panahipour, Azarakhsh Oladzad Abbasabadi, Anja Wagner, Klaus Kratochwill, Monika Pichler, Reinhard Gruber
Summary: This study evaluated the response of mesenchymal cells to acid lysates of bone allografts (ALBA) and found that the expression of IL11, AREG, and C11orf96 can serve as a bioassay reflecting the bioactivity of the bone allografts.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Engineering, Biomedical
Wenhao Wang, Jie Shen, Yuan Meng, Miaoman Ye, Shaozhang Lin, Qi Zhao, Le Wang, Kenneth M. C. Cheung, Shuilin Wu, Yufeng Zheng, Xuanyong Liu, Paul K. Chu, Kelvin W. K. Yeung, Zhi-Yong Zhang
Summary: Regardless of the advancement of synthetic bone substitutes, allograft-derived bone substitutes still dominate in the orthopaedic circle in the treatments of bone diseases. Nevertheless, the stringent devitalization process jeopardizes their osseointegration with host bone and therefore prone to long-term failure. Hence, improving osseointegration and transplantation efficiency remains important. The alteration of bone tissue microenvironment (TME) to facilitate osseointegration has been generally recognized.
BIOACTIVE MATERIALS
(2022)
Article
Orthopedics
Philipp W. Winkler, Nyaluma N. Wagala, Jonathan D. Hughes, James J. Irrgang, Freddie H. Fu, Volker Musahl
Summary: Meniscal allograft root tears were predominant, associated with younger patient age, and more often observed when using the suture-only fixation technique versus the bone block fixation technique. Torn meniscal allografts were associated with early surgical graft failure when compared with intact meniscal allografts, resulting in a significantly lower 1-year survival rate.
AMERICAN JOURNAL OF SPORTS MEDICINE
(2021)
Article
Multidisciplinary Sciences
Koen van de Ven, Josien Lanfermeijer, Harry van Dijken, Hiromi Muramatsu, Caroline Vilas Boas de Melo, Stefanie Lenz, Florence Peters, Mitchell B. Beattie, Paulo J. C. Lin, Jose A. Ferreira, Judith van den Brand, Debbie van Baarle, Norbert Pardi, Jorgen de Jonge
Summary: This study evaluated a novel T cell-inducing nucleoside-modified messenger RNA (mRNA) vaccine that encoded conserved proteins of an H1N1 influenza virus, and found that it induced broadly reactive T cells and enhanced protection against potential influenza viruses.
Article
Infectious Diseases
Debora C. Coraca-Huber, Stephan J. M. Steixner, Stevo Najman, Sanja Stojanovic, Ronja Finze, Denis Rimashevskiy, Dina Saginova, Mike Barbeck, Reinhard Schnettler
Summary: This study evaluated the efficacy of specially prepared human bone allografts as antibiotic carriers. The results showed that these allografts successfully loaded antibiotics and released high concentrations of antibiotics in vitro and in vivo. The susceptibility tests demonstrated strong antibacterial activity of the allografts against specific bacterial strains.
Editorial Material
Biochemical Research Methods
Hin Chu, Jasper Fuk-Woo Chan, Kwok-Yung Yuen
Summary: This article discusses the main animal models that have played a key role in our understanding of the immune and viral dynamics of SARS-CoV-2.
Article
Multidisciplinary Sciences
Suzanne M. Dufault, Stephanie K. Tanamas, Citra Indriani, Adi Utarini, Riris Andono Ahmad, Nicholas P. Jewell, Cameron P. Simmons, Katherine L. Anders
Summary: Dengue exhibits focal clustering, but the introduction of wMel strain can disrupt this clustering and reduce the incidence of dengue cases.
SCIENTIFIC REPORTS
(2022)
Editorial Material
Gastroenterology & Hepatology
Manal H. El-Sayed, Jordan J. Feld
Summary: Innovations in 2021 have shown promising progress in curbing HBV transmission and advancing our understanding of the immunology underlying lack of protection against HCV reinfection. Additionally, a vaccination trial for HCV was conducted.
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
(2022)
Article
Immunology
Noy Pinto, Yehuda Klein, Eilon David, David Polak, Daniel Steinberg, Gilad Mizrahi, Yasmin Khoury, Yechezkel Barenholz, Stella Chaushu
Summary: In this study, the effect of endogenous lipid RvD1 on allograft osteointegration in alveolar bone regeneration was investigated. Repeated administrations of RvD1 were found to promote bone regeneration through enhancing osteoblasts' differentiation and reducing osteoclastogenesis. This suggests that RvD1 may be a potential therapeutic bioagent for osseous regeneration following allograft implantation.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Suwasin Udomkarnjananun, Kroonpong Iampenkhae
Summary: Infectious agents can directly infect the transplanted kidney, leading to a decline in function and reduced longevity. Common infections include bacterial pyelonephritis and BK virus infection, while adenovirus, JC virus, and cytomegalovirus can also cause significant dysfunctions. Histopathological features include inflammatory cell infiltration and viral nuclear inclusions or cytopathic changes. Confirmatory tests are available but may have limitations in developing countries. Differential diagnosis must consider T cell-mediated rejection. This review highlights the importance of recognizing diverse pathological alterations to facilitate further investigations and management.
Article
Medicine, General & Internal
Haley Wienkes, Kelley Vilen, Alexandra Lorentz, Daniel Gerlach, Xiong Wang, Amy Saupe, Richard Danila, Ruth Lynfield, Kirk Smith, Carlota Medus
Summary: This cohort study investigated transmission and infection of SARS-CoV-2 among vaccinated and unvaccinated attendees at an indoor wedding reception, identifying a Delta variant outbreak despite a high proportion of vaccinated attendees and finding that vaccination was associated with a reduced risk of infection.
Article
Biochemical Research Methods
Aurelien Marc, Romain Marlin, Flora Donati, Melanie Prague, Marion Kerioui, Cecile Herate, Marie Alexandre, Nathalie Dereuddre-bosquet, Julie Bertrand, Vanessa Contreras, Sylvie Behillil, Pauline Maisonnasse, Sylvie van der Werf, Roger Le Grand, Jeremie Guedj
Summary: By analyzing data from 78 non-human primates infected by different Variants of Concern (VoC), the researchers found that Omicron and Delta variants were associated with a longer and larger excretion of infectious particles, attributed to their enhanced capability to escape the immune response. While the Delta variant had a higher peak viral load, the Omicron variant did not show a similar effect. This suggests that the increased transmissibility of the Omicron variant is not due to higher viral load levels, but rather its ability to maintain high levels of infectious particles over time. These results highlight the importance of quantifying viral load and infectiousness to better understand the differences observed in the transmission patterns of VoCs.
PLOS COMPUTATIONAL BIOLOGY
(2023)
Article
Anatomy & Morphology
Bernette Maria Oosterlaken, Heiner Friedrich, Gijsbertus de With
Summary: Transmission electron microscopy (TEM) is an important analysis technique for visualizing (bio)macromolecules such as collagen fibers. The choice of washing solvent for collagen samples, whether water or ethanol, significantly influences the structure and appearance of the fibers under TEM. Washing with water maintains the hydrated collagen structure, while washing with ethanol can lead to fiber dehydration and aggregation.
MICROSCOPY RESEARCH AND TECHNIQUE
(2022)
Article
Polymer Science
Hadis Gharacheh, Murat Guvendiren
Summary: Composite hydrogel bioink, formulated by incorporating human allograft bone particles in a methacrylated alginate formulation, enhances osteogenesis of adult human mesenchymal stem cells (hMSCs) for bone tissue engineering. The bioink is suitable for extrusion-based 3D bioprinting, and in vitro studies show significantly enhanced osteogenic differentiation of hMSCs cultured within the bioprinted composite scaffolds.
Article
Materials Science, Biomaterials
Wen Zou, Xing Li, Na Li, Tianwei Guo, Yongfu Cai, Xiaoqin Yang, Jie Liang, Yong Sun, Yujiang Fan
Summary: Autogenous bone and biphasic calcium phosphate artificial bone exhibit similar and strong bone repair ability, but autogenous bone causes greater secondary damage to experimental animals; allogenic bone shows poor bone defect repair ability.
REGENERATIVE BIOMATERIALS
(2021)
Article
Orthopedics
Shady Mahmoud, Faisal Hamad, Muhammad Riaz, Ghalib Ahmed, Mohammad Al Ateeq, Talal Ibrahim
INTERNATIONAL ORTHOPAEDICS
(2015)
Article
Orthopedics
Salah Al-Burdeni, Yousef Abuodeh, Talal Ibrahim, Ghalib Ahmed
INTERNATIONAL ORTHOPAEDICS
(2015)
Article
Orthopedics
Talal Ibrahim, Muhammad Riaz, Abdelsalam Hegazy
INTERNATIONAL ORTHOPAEDICS
(2015)
Article
Orthopedics
Talal Ibrahim, Osama M. S. Aldahamsheh, Abdelsalam Hegazy, Hassan M. K. Ghomrawi
INTERNATIONAL ORTHOPAEDICS
(2018)
Article
Orthopedics
Talal Ibrahim, Abdelsalam Hegazy, Safa I. S. Abulhail, Hassan M. K. Ghomrawi
JOURNAL OF PEDIATRIC ORTHOPAEDICS
(2017)
Review
Orthopedics
Nedal AlKhatib, Manaf H. Younis, Abdelsalam Hegazy, Talal Ibrahim
INTERNATIONAL ORTHOPAEDICS
(2019)
Article
Orthopedics
Nedal Alkhatib, Fadi Bouri, Abdelsalam Hegazy, Talal Ibrahim
JOURNAL OF PEDIATRIC ORTHOPAEDICS-PART B
(2018)
Article
Orthopedics
I. A. Mukhtar, K. M. Yaghmour, A. F. Ahmed, T. Ibrahim
JOURNAL OF CHILDRENS ORTHOPAEDICS
(2018)
Article
Orthopedics
Manaf H. Younis, Karim Mahmoud, Alaa Kawas, Talal Ibrahim
JOURNAL OF PEDIATRIC ORTHOPAEDICS-PART B
(2019)
Article
Orthopedics
Isam Moghamis, Yousef Abuodeh, Ali Darwiche, Talal Ibrahim, Mohammad Al Ateeq Al Dosari, Ghalib Ahmed
INTERNATIONAL ORTHOPAEDICS
(2020)
Article
Orthopedics
Aissam Elmherig, Abdulaziz F. Ahmed, Abdelsalam Hegazy, John E. Herzenberg, Talal Ibrahim
JOURNAL OF PEDIATRIC ORTHOPAEDICS
(2020)
Article
Critical Care Medicine
Aissam Elmhiregh, Abdulaziz F. Ahmed, Abdul Majid Dabboussi, Ghalib Ahmed, Husham Abdelrahman, Talal Ibrahim
Summary: This study aimed to evaluate the effect of obesity on outcomes following operative treatment of fractures in obese polytrauma patients. The results showed that obesity was associated with increased hospital and ICU length of stay, as well as higher rates of ICU admission and mechanical ventilation. This highlights the importance of optimizing trauma care for obese polytrauma patients.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2022)
Review
Orthopedics
Talal Ibrahim, Matthew Ball, Muhammad Riaz, Mohamed Kenawey
Summary: This study investigated the association between avascular necrosis (AVN) rate and time to surgery in unstable slipped capital femoral epiphysis (SCFE). The results showed higher AVN rates when surgery was performed between 24 hours to 7 days, while lower rates were seen with surgery <= 24 hours and >7 days. Overall, the evidence was inconclusive regarding the association between AVN rate and time to surgery.
JOURNAL OF PEDIATRIC ORTHOPAEDICS
(2022)
Review
Orthopedics
Osama Z. Alzobi, Ashraf T. Hantouly, Mohamed Kenawey, Talal Ibrahim
Summary: A meta-analysis of randomized controlled trials found that below-elbow cast treatment for displaced distal forearm fractures in children was more effective than above-elbow cast treatment. Below-elbow cast resulted in a lower risk of loss of fracture reduction and re-manipulation without increasing cast-related complications. Therefore, below-elbow cast should be the preferred treatment for pediatric distal forearm fractures.
JOURNAL OF CHILDRENS ORTHOPAEDICS
(2023)
Article
Surgery
Talal Ibrahim, David G. Little