Journal
CELL
Volume 174, Issue 6, Pages 1339-1341Publisher
CELL PRESS
DOI: 10.1016/j.cell.2018.08.035
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- NIA NIH HHS [F32 AG059358] Funding Source: Medline
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Partial loss of TANK-binding kinase 1 (TBK1) causes amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Xu et al. identify the role of TBK1 in suppressing neuroinflammation and apoptosis by its inhibition of the receptor-interacting serine/threonine-protein kinase 1 (RIPK1) and elucidate how aging and genetic susceptibility together cause neuroinflammation.
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