Journal
CELL
Volume 153, Issue 1, Pages 11-12Publisher
CELL PRESS
DOI: 10.1016/j.cell.2013.03.015
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Funding
- Cancer Research UK [11567] Funding Source: researchfish
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Human synovial sarcoma is caused by a chromosome translocation, which fuses DNA encoding SSX to that encoding the SS18 protein. Kadoch and Crabtree now show that the resulting cellular transformation stems from disruption of the normal architecture and function of the human SWI/SNF (BAF) complex.
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