Journal
CELL
Volume 142, Issue 4, Pages 513-515Publisher
CELL PRESS
DOI: 10.1016/j.cell.2010.08.003
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Funding
- NIGMS NIH HHS [R01 GM099321] Funding Source: Medline
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The epidermal growth factor receptor (EGFR) regulates cell proliferation in many tissues. A new structure of the Drosophila EGFR presented by Alvarado et al. (2010) reveals an asymmetric dimer with the ligand bound to only one subunit. The structure provides a rationale for the receptor's negative cooperativity and necessitates a reconsideration of models for activation of human EGFR.
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