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SnapShot: PTEN signaling pathways

CELL (2008)

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CELL

Volume 133, Issue 3, Pages 550-U15

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CELL PRESS

DOI: 10.1016/j.cell.2008.04.023

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OTUD1 stabilizes PTEN to inhibit the PI3K/AKT and TNF-alpha/NF-kappaB signaling pathways and sensitize ccRCC to TKIs

Wentao Liu, Bin Yan, Haixin Yu, Jiannan Ren, Mou Peng, Liang Zhu, Yinhuai Wang, Xin Jin, Lu Yi

Summary: This study investigates the clinicopathological role of the OTUD family in ccRCC and identifies that the OTUD1-PTEN axis suppresses tumor growth and regulates the resistance of renal cancer to TKIs.

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Multiple signaling pathways are essential for synapse formation induced by synaptic adhesion molecules

Xian Jiang, Richard Sando, Thomas C. Sudhof

Summary: The study revealed that interference with microtubules or actin filaments, JNKs, PKA, or AKT signaling pathways can affect heterologous synapse formation, with JNK and PKA inhibitors suppressing both pre- and postsynaptic specialization formation, while AKT inhibitors only impairing postsynaptic specialization formation. By targeting PTEN, an enzyme regulating AKT activation, to postsynaptic sites, a decrease in excitatory synapse function was observed, indicating a multifaceted and multistage kinase network underlying heterologous synapse formation.

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Canagliflozin alleviates valproic acid-induced autism in rat pups: Role of PTEN/PDK/PPAR-γ signaling pathways

Mariam A. Elgamal, Dina M. Khodeer, Basel A. Abdel-Wahab, Ibrahim Abdel Aziz Ibrahim, Abdullah R. Alzahrani, Yasser M. Moustafa, Azza A. Ali, Norhan M. El-Sayed

Summary: This study investigated the protective effect of Canagliflozin against the VPA-induced model of autism. The results showed that Canagliflozin effectively counteracted histopathological changes in the brain tissues, improved social and stereotypic behaviors, and reduced hyperlocomotion activity.

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Regulation of follicular activation signaling pathways by in vitro inhibition of YAP/TAZ activity in mouse ovaries

Melody Devos, Joana Dias Nunes, Nathalie Donfack Jiatsa, Isabelle Demeestere

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Dysregulation of PI3K and Hippo signaling pathways synergistically induces chronic pancreatitis via CTGF upregulation

Takeshi Tamura, Takahiro Kodama, Katsuhiko Sato, Kazuhiro Murai, Teppei Yoshioka, Minoru Shigekawa, Ryoko Yamada, Hayato Hikita, Ryotaro Sakamori, Hirofumi Akita, Hidetoshi Eguchi, Randy L. Johnson, Hideki Yokoi, Masashi Mukoyama, Tomohide Tatsumi, Tetsuo Takehara

Summary: The dysregulation of PI3K and Hippo signaling pathways induces chronic pancreatitis via upregulation of CTGF.

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Regulatory role of microRNAs on PTEN signaling

Soudeh Ghafouri-Fard, Atefe Abak, Hamed Shoorei, Mahdi Mohaqiq, Jamal Majidpoor, Arezou Sayad, Mohammad Taheri

Summary: PTEN gene encodes a tumor suppressor protein that regulates the PI3K/AKT signaling, and its expression is influenced by various transcription factors and miRNAs, playing key roles in cancer therapy.

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Neurodevelopmental disorders and cancer networks share pathways, but differ in mechanisms, signaling strength, and outcome

Bengi Ruken Yavuz, M. Kaan Arici, Habibe Cansu Demirel, Chung-Jung Tsai, Hyunbum Jang, Ruth Nussinov, Nurcan Tuncbag

Summary: Epidemiological studies show that individuals with neurodevelopmental disorders are more likely to develop certain types of cancer. While these disorders and cancer share proteins, pathways, and mutations, they differ in clinical outcomes. The key factor determining clinical outcome is signaling strength, with strong signaling promoting cell proliferation in cancer and moderate signaling affecting differentiation in neurodevelopmental disorders.

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Signaling Pathways Regulating Thermogenesis

Chihiro Tabuchi, Hei Sook Sul

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PI3K/PTEN/AKT Signaling Pathways in Germ Cell Development and Their Involvement in Germ Cell Tumors and Ovarian Dysfunctions

Massimo De Felici, Francesca Gioia Klinger

Summary: Several studies have demonstrated that the PI3K/PTEN/AKT signaling pathways play critical roles in regulating ovarian function, including primordial germ cell development and maintenance of the ovarian primordial follicle reserve. Dysregulation of these pathways may contribute to the development of certain types of germ cell tumors and ovarian dysfunctions.

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NGF-p75 signaling coordinates skeletal cell migration during bone repair

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The function of Foxo1 in spermatogonia development is independent of PI3K/PTEN signaling

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Adipokine Signaling Pathways in Osteoarthritis

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Thioredoxin Signaling Pathways in Cancer

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SIAH2 regulates colorectal cancer tumorigenesis via PI3K/ATK signaling pathway

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Summary: SIAH2 acts as an oncogene in colorectal cancer, promoting tumor proliferation, migration, and invasion. It activates the PI3K/AKT signaling pathway and is regulated by PTEN loss.

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LUZP1 Controls Cell Division, Migration and Invasion Through Regulation of the Actin Cytoskeleton

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SMALL (2023)

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STAT3/LKB1 controls metastatic prostate cancer by regulating mTORC1/CREB pathway

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SnapShot: PTEN signaling pathways

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