Article
Medical Laboratory Technology
Fabio Angeli, Paolo Verdecchia, Stefano Savonitto, Sara Cavallini, Andrea Santucci, Stefano Coiro, Rocco Sclafani, Clara Riccini, Stefano De Servi, Claudio Cavallini
Summary: This study found that higher levels of sCD40L predict an increased risk of acute coronary events and coronary restenosis among patients with ACS or CCS undergoing PCI, but not of mortality.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Ewelina A. Dziedzic, Jakub S. Gasior, Agnieszka Tuzimek, Justyna Paleczny, Miroslaw Kwasny, Marek Dabrowski, Piotr Jankowski
Summary: This study assessed the zinc nutritional status in patients with coronary artery disease using inductively coupled plasma optical emission spectrometry. The results showed no association between zinc and the severity of coronary artery disease, and there were no significant differences in zinc levels between patients with acute coronary syndrome and stable coronary artery disease. However, a significant negative correlation was observed between zinc content and serum triglyceride concentration, and patients with type 2 diabetes mellitus had lower hair zinc content.
Review
Medicine, General & Internal
Arnav Katira, Ravish Katira
Summary: Colchicine may play a key role in the prevention of cardiovascular events in patients with stable and unstable coronary artery disease, as it is associated with a reduction in the rate of myocardial infarction and other major cardiovascular outcomes.
POSTGRADUATE MEDICAL JOURNAL
(2022)
Review
Cell Biology
Bradley Tucker, Kaivan Vaidya, Blake J. Cochran, Sanjay Patel
Summary: Periprocedural myocardial injury and myocardial infarction are common complications of percutaneous coronary intervention, associated with increased short- and long-term mortality. Inflammation levels before, during, and after the procedure are linked to higher rates of myonecrosis and future cardiovascular events. In addition to inflammation from underlying coronary disease, PCI itself triggers an acute inflammatory response.
Article
Medicine, General & Internal
Markus Malmberg, Jarmo Gunn, Paivi Rautava, Jussi Sipila, Ville Kyto
Summary: Patients with myocardial infarction have poorer short- and long-term outcomes compared to stable coronary artery disease patients after coronary artery bypass grafting (CABG). Higher risk of death continues also in stabilized first-year myocardial infarct survivors. Efficient secondary prevention and follow-up are important in the post-myocardial infarct population after CABG.
ANNALS OF MEDICINE
(2021)
Article
Medicine, Research & Experimental
Matej Strycek, Lukas Jaworski, Rostislav Polasek, Pavol Tomasov
Summary: Coronary artery perforation is a rare but potentially fatal complication of percutaneous coronary intervention. We report a case of massive main vessel coronary perforation in a patient with acute ST segment elevation myocardial infarction, which was successfully treated with a second drug-eluting stent. This unusual therapeutic approach was used to maintain blood flow to the large side branch.
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Ayman Elbadawi, Mohammed Elzeneini, Islam Y. Elgendy, Michael Megaly, Mohamed Omer, Ernesto Jimenez, Ravi K. Ghanta, Emmanouil S. Brilakis, Hani Jneid
Summary: This study used a nationwide database to analyze the trends and outcomes of isolated coronary artery bypass grafting after ST-elevation myocardial infarction. The results showed a decline in the use of this procedure, but no change in in-hospital mortality. A recent cohort study found that performing the grafting on day 2 had similar in-hospital mortality compared with day 3 or more, but lower rates of complications and shorter hospital stays.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2023)
Article
Cardiac & Cardiovascular Systems
Valentino Bianco, Arman Kilic, Thomas G. Gleason, Edgar Aranda-Michel, Yisi Wang, Forozan Navid, Ibrahim Sultan
Summary: The timing of coronary artery bypass grafting after acute myocardial infarction does not consistently affect postoperative outcomes. After adjusting for baseline patient characteristics, there was no statistically significant difference between timing cohorts for both mortality and major adverse cardiovascular and cerebrovascular event readmissions.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2021)
Article
Medicine, General & Internal
Yves Cottin, Rany Issa, Mourad Benalia, Basile Mouhat, Alexandre Meloux, Laura Tribouillard, Florence Bichat, Luc Rochette, Catherine Vergely, Marianne Zeller
Summary: The study found an association between serum OPG levels and coronary lesion complexity in patients with acute myocardial infarction, which was not influenced by factors such as hypercholesterolemia, cardiovascular history, and reduced glomerular filtration rate.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Marta Lozano-Prieto, David Adlam, Marcos Garcia-Guimaraes, Ancor Sanz-Garcia, Paula Vera-Tome, Fernando Rivero, Javier Cuesta, Teresa Bastante, Anna A. Baranowska-Clarke, Alicia Vara, Enrique Martin-Gayo, Miguel Vicente-Manzanares, Pilar Martin, Nilesh J. Samani, Francisco Sanchez-Madrid, Fernando Alfonso, Hortensia de la Fuente
Summary: The study found that specific miRNAs have significantly different expression in the plasma of SCAD and AT-AMI patients, and the combined expression of these four miRNAs can better distinguish between the two diseases. Functional analysis revealed an association of these miRNAs with blood vessel biology, TGF-beta pathway, and cytoskeletal traction force.
Article
Medicine, General & Internal
Tobias F. S. Pustjens, Marijke J. C. Timmermans, Saman Rasoul, Arnoud W. J. van't Hof
Summary: The study found that NSTE-ACS patients with MVD undergoing MV-PCI and CO-PCI had similar mortality rates at long-term follow-up, but the MV-PCI group showed improved event-free survival in terms of fewer coronary reinterventions.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Tae-Min Rhee, Hyung-Kwan Kim, Bong-Seong Kim, Kyung-Do Han, Hyun-Jung Lee, In-Chang Hwang, Heesun Lee, Jun-Bean Park, Yeonyee E. Yoon, Yong-Jin Kim, Goo-Yeong Cho
Summary: Limited data are available on the long-term outcomes in HCM patients with significant CAD requiring revascularization. This study showed that HCM patients who underwent coronary revascularization had a significantly higher risk of cardiovascular death, SCD, ischemic stroke, and heart failure compared to the non-HCM control group.
SCIENTIFIC REPORTS
(2023)
Article
Cardiac & Cardiovascular Systems
Joseph Hadaya, Yas Sanaiha, Zachary Tran, Peter Downey, Richard J. Shemin, Peyman Benharash
Summary: This study evaluated the impact of timing of coronary artery bypass grafting (CABG) on mortality and resource utilization in patients with acute coronary syndrome. The study found comparable in-hospital mortality for CABG performed on days 1-3 and 4-7, with higher rates on day 0 and after day 7. Additionally, CABG performed on days 4-7 had higher hospitalization costs. High-performing hospitals had similar CABG timing but lower mortality compared to others.
ANNALS OF THORACIC SURGERY
(2022)
Article
Endocrinology & Metabolism
Gilles Lemesle, Etienne Puymirat, Laurent Bonello, Tabassome Simon, Philippe-Gabriel Steg, Jean Ferrieres, Francois Schiele, Laurent Fauchier, Patrick Henry, Guillaume Schurtz, Sandro Ninni, Nicolas Lamblin, Christophe Bauters, Nicolas Danchin
Summary: This study aimed to investigate the relationship between diabetes mellitus (DM) status and the risk of heart failure (HF) occurrence in patients with coronary artery disease (CAD). The results showed that patients with DM had a significantly higher risk of HF, whether in the acute myocardial infarction (MI) phase or the chronic stable phase. Therefore, it is crucial to prevent HF occurrence in CAD patients with DM.
DIABETES & METABOLISM
(2022)
Article
Cell Biology
Chang Chen, Yequn Chen, Jiaxin Xiao, Yanhong Zhang, Zhaorui Yang, Peixuan Yang, Nan Lu, Kaihong Yi, Xiaojun Chen, Shaoxin Chen, Mary Clare O'Gara Msc, Michael O'Meara, Shu Ye, Xuerui Tan
Summary: There is an association between impaired fasting glucose level and a predisposition to severe coronary artery disease indicated by triple vessel disease or myocardial infarction.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Peripheral Vascular Disease
Giuseppe De Luca, Magdy Algowhary, Berat Uguz, Dinaldo C. Oliveira, Vladimir Ganyukov, Zan Zimbakov, Miha Cercek, Lisette Okkels Jensen, Poay Huan Loh, Lucian Calmac, Gerard Roura Ferrer, Alexandre Quadros, Marek Milewski, Fortunato Scotto Di Uccio, Clemens von Birgelen, Francesco Versaci, Jurrien Ten Berg, Gianni Casella, Aaron Wong Sung Lung, Petr Kala, Jose Luis Diez Gil, Xavier Carrillo, Maurits Dirksen, Victor M. Becerra-Munoz, Michael Kang-Yin Lee, Dafsah Arifa Juzar, Rodrigo de Moura Joaquim, Ciro De Simone, Davor Milicic, Periklis Davlouros, Nikola Bakraceski, Filippo Zilio, Luca Donazzan, Adriaan Kraaijeveld, Gennaro Galasso, Lux Arpad, Lucia Marinucci, Vincenzo Guiducci, Maurizio Menichelli, Alessandra Scoccia, Aylin Hatice Yamac, Kadir Ugur Mert, Xacobe Flores Rios, Tomas Kovarnik, Michal Kidawa, Jose Moreu, Vincent Flavien, Enrico Fabris, Inigo Lozano Martinez-Luengas, Marco Boccalatte, Francisco Bosa Ojeda, Carlos Arellano-Serrano, Gianluca Caiazzo, Giuseppe Cirrincione, Hsien-Li Kao, Juan Sanchis Fores, Luigi Vignali, Helder Pereira, Stephane Manzo-Silbermann, Santiago Ordonez, Alev Arat Ozkan, Bruno Scheller, Heidi Lehtola, Rui Teles, Christos Mantis, Ylitalo Antti, Joao Antonio Brum Silveira, Ivan Bessonov, Rodrigo Zoni, Stefano Savonitto, George Kochiadakis, Dimitrios Alexopoulos, Carlos E. Uribe, John Kanakakis, Benjamin Faurie, Gabriele Gabrielli, Alejandro Gutierrez Barrios, Juan Pablo Bachini, Alex Rocha, Frankie Chor-Cheung Tam, Alfredo Rodriguez, Antonia Anna Lukito, Anne Bellemain-Appaix, Gustavo Pessah, Giuliana Cortese, Guido Parodi, Mohammed Abed Burgadha, Elvin Kedhi, Pablo Lamelas, Harry Suryapranata, Matteo Nardin, Monica Verdoia
Summary: This study aimed to evaluate the impact of SARS-CoV-2 positivity on in-hospital outcome and 30-day mortality in STEMI patients undergoing primary PCI. The results showed that SARS-CoV-2 positive patients had more complications and higher mortality post procedure, indicating the association between SARS-CoV-2 positivity and impaired reperfusion with negative prognostic consequences.
Article
Cardiac & Cardiovascular Systems
Ramesh Nadarajah, Peter Ludman, Yolande Appelman, Salvatore Brugaletta, Andrzej Budaj, Hector Bueno, Kurt Huber, Vijay Kunadian, Sergio Leonardi, Maddalena Lettino, Dejan Milasinovic, Chris P. Gale
Summary: The aim of this study is to identify international patterns in the management of NSTEMI and compare them with the 2015 ESC Guidelines. By collecting data from 3620 NSTEMI patients in 287 centers across 59 countries, this study will provide unique insights into the contemporary management of NSTEMI patients.
EUROPEAN HEART JOURNAL-QUALITY OF CARE AND CLINICAL OUTCOMES
(2023)
Article
Cardiac & Cardiovascular Systems
Francesco Costa, Claudio Montalto, Mattia Branca, Sung-Jin Hong, Hirotoshi Watanabe, Anna Franzone, Pascal Vranckx, Joo-Yong Hahn, Hyeon-Cheol Gwon, Fausto Feres, Yangsoo Jang, Giuseppe De Luca, Elvin Kedhi, Davide Cao, Philippe Gabriel Steg, Deepak L. Bhatt, Gregg W. Stone, Antonio Micari, Stephan Windecker, Takeshi Kimura, Myeong-Ki Hong, Roxana Mehran, Marco Valgimigli
Summary: The study evaluated the impact of an abbreviated dual antiplatelet therapy (DAPT) regimen in high bleeding risk patients after percutaneous coronary intervention (PCI), using existing evidence. It found that a shorter DAPT duration (1-3 months) reduced bleeding and cardiovascular mortality without increasing ischemic events in these patients.
EUROPEAN HEART JOURNAL
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Antonio Landi, Anna Giulia Pavon, Marco Valgimigli
Article
Pharmacology & Pharmacy
Pasquale Paolisso, Luca Bergamaschi, Felice Gragnano, Emanuele Gallinoro, Arturo Cesaro, Celestino Sardu, Niya Mileva, Alberto Foa, Matteo Armillotta, Angelo Sansonetti, Sara Amicone, Andrea Impellizzeri, Giuseppe Esposito, Morici Nuccia, Oreglia Jacopo Andrea, Gianni Casella, Ciro Mauro, Dobrin Vassilev, Nazzareno Galie, Gaetano Santulli, Raffaele Marfella, Paolo Calabro, Carmine Pizzi, Emanuele Barbato
Summary: In T2DM patients presenting with AMI, the use of SGLT2-I was associated with better in-hospital and long-term prognosis compared to non-SGLT2-I users.
PHARMACOLOGICAL RESEARCH
(2023)
Review
Cardiac & Cardiovascular Systems
Claudio Montalto, Francesco Costa, Sergio Leonardi, Antonio Micari, Jacopo A. Oreglia, Pascal Vranckx, Davide Capodanno, Jurrien ten Berg, Renato D. Lopes, Marco Valgimigli
Summary: In patients with concomitant indication to oral anticoagulation, shortening dual antiplatelet therapy duration can reduce bleeding risk without increasing major adverse cardiovascular events.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR PHARMACOTHERAPY
(2023)
Article
Cardiac & Cardiovascular Systems
Antonio Landi, Marco Valgimigli
Article
Cardiac & Cardiovascular Systems
Antonio Landi, Dik Heg, Enrico Frigoli, Pascal Vranckx, Stephan Windecker, Patrick Siegrist, Guillaume Cayla, Adrian Wlodalczak, Stephane Cook, Ivan Gomez-Blazquez, Yair Feld, Park Seung-Jung, Martin Mates, Chaim Lotan, Sengottuvelu Gunasekaran, Mamoru Nanasato, Rajiv Das, Henning Kelbaek, Emmanuel Teiger, Javier Escaned, Yuki Ishibashi, Gilles Montalescot, Hitoshi Matsuo, Dragan Debeljacki, Pieter C. Smits, Marco Valgimigli
Summary: This study investigated the clinical outcomes and treatment selection of antiplatelet therapy (APT) after percutaneous coronary intervention (PCI). The results showed that there was no difference in net adverse clinical outcomes and major adverse cardiac and cerebral events between abbreviated and standard APT at 15 months, but abbreviated APT had a lower risk of bleeding.
JACC-CARDIOVASCULAR INTERVENTIONS
(2023)
Article
Cardiac & Cardiovascular Systems
Antonio Landi, Adrian Wlodarczak, Ralph Tolg, Henning Kelbaek, Jacek Legutko, Stefano Galli, Matthieu G. Godin, Gabor G. Toth, Thibault Lhermusier, Benjamin Honton, Peter Laurenz Dietrich, Francis Stammen, Bert Ferdinande, Johanne Silvain, Davide Capodanno, Guillaume Cayla, Marco Valgimigli
Summary: The BIOFLOW-DAPT trial is investigating the safety of the Orsiro Mission stent compared to the Resolute Onyx stent in high bleeding risk patients. Patients are initially treated with one month of dual antiplatelet therapy (aspirin and a P2Y(12) inhibitor), followed by single antiplatelet therapy. The primary endpoint is the occurrence of cardiac death, myocardial infarction, and stent thrombosis within one year.
JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Marco Valgimigli, Victor Aboyans, Dominick Angiolillo, Dan Atar, Davide Capodanno, Sigrun Halvorsen, Stefan James, Peter Juni, Vijay Kunadian, Antonio Landi, Sergio Leonardi, Roxana Mehran, Gilles Montalescot, Eliano Pio Navarese, Josef Niebauer, Angelo Oliva, Raffaele Piccolo, Susanna Price, Robert F. Storey, Heinz Voeller, Pascal Vranckx, Stephan Windecker, Keith A. A. Fox
Summary: Multiple guidelines and consensus papers have been used to address the role of antithrombotic strategies in patients with established coronary artery disease (CAD). To update clinicians on the best antithrombotic strategies for these patients, the authors conducted a consensus initiative. They systematically reviewed and performed meta-analyses using both direct and indirect comparisons to inform their recommendations.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR PHARMACOTHERAPY
(2023)
Article
Cardiac & Cardiovascular Systems
Marco Valgimigli, Adrian Wlodarczak, Ralph Toelg, Bela Merkely, Henning Kelbaek, Jacek Legutko, Stefano Galli, Matthieu Godin, Gabor G. Toth, Thibault Lhermusier, Benjamin Honton, Peter Laurenz Dietrich, Francis Stammen, Bert Ferdinande, Johanne Silvain, Davide Capodanno, Guillaume Cayla
Summary: This study aimed to compare the safety and effectiveness of biodegradable-polymer sirolimus-eluting stents with durable-polymer zotarolimus-eluting stents in patients at high bleeding risk receiving abbreviated dual antiplatelet therapy after percutaneous coronary intervention (PCI). The results showed that the use of biodegradable-polymer sirolimus-eluting stents was noninferior to the use of durable-polymer zotarolimus-eluting stents in terms of the composite outcome of death from cardiac causes, myocardial infarction, or stent thrombosis at 1 year.
Review
Cardiac & Cardiovascular Systems
Thomas A. Meijers, Adel Aminian, Marco Valgimigli, Joseph Dens, Pierfrancesco Agostoni, Juan F. Iglesias, Gabriele L. Gasparini, Arnold H. Seto, Shigeru Saito, Sunil V. Rao, Niels van Royen, Emmanouil S. Brilakis, Maarten A. H. van Leeuwen
Summary: The outcomes of chronic total occlusion percutaneous coronary intervention have significantly improved in the past decade, with a focus on improving procedural safety. Vascular access site bleeding is a common complication, and various strategies have been implemented to reduce its occurrence. This state-of-the-art review provides an overview of the current evidence on optimal vascular access strategies for chronic total occlusion percutaneous coronary intervention.
CIRCULATION-CARDIOVASCULAR INTERVENTIONS
(2023)
Article
Cardiac & Cardiovascular Systems
Alessandro Spirito, Marco Valgimigli, Davide Cao, Usman Baber, Shamir R. Mehta, C. Michael Gibson, Gabriel P. Steg, Samin K. Sharma, Ridhima Goel, Kurt Huber, Vijay Kunadian, Javier Escaned, Anna Franzone, Han Yaling, Timothy Collier, Upendra Kaul, Ran Kornowski, Mitchell Krucoff, David Moliterno, Samantha Sartori, Ruth Owen, Zhongjie Zhang, George D. Dangas, Adnan Kastrati, Dominick J. Angiolillo, David J. Cohen, Pascal Vranckx, Stephan Windecker, Stuart Pocock, Roxana Mehran
Summary: BP-BES is associated with lower risk of major adverse cardiovascular events and target-vessel failure compared to other current generation LES in ACS patients.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Mohil Garg, Hector M. Garcia-Garcia, Andrea Teira Calderon, Jaytin Gupta, Shrayus Sortur, Molly B. Levine, Andrea Picchi, Gennaro Sardella, Marianna Adamo, Enrico Frigoli, Ugo Limbruno, Stefano Rigattieri, Roberto Diletti, Giacomo Boccuzzi, Marco Zimarino, Marco Contarini, Filippo Russo, Paolo Calabro, Giuseppe Ando, Ferdinando Varbella, Stefano Garducci, Cataldo Palmieri, Carlo Briguori, Jorge Sanz Sanchez, Marco Valgimigli
JACC-CARDIOVASCULAR INTERVENTIONS
(2023)
Article
Cardiac & Cardiovascular Systems
Francesco Pergolini, Laura Sofia Cardelli, Giorgia Arnone, Gaetano Barbato, Letizia Riva, Andrea Zini, Gianni Casella
Summary: The search for silent atrial tachyarrhythmias is crucial in patients with embolic stroke of undetermined source. We present a case of a 76-year-old female patient with recurrent ischemic stroke, who underwent prolonged ECG monitoring based on predictors of atrial fibrillation (AF). The monitoring revealed long-lasting AF triggered by atrial tachycardia and a direct correlation between AF and new cerebral stroke.
GIORNALE ITALIANO DI CARDIOLOGIA
(2023)