Article
Medicine, Research & Experimental
Yi-Xing Yang, Huai-Peng Zhang, Chuang Li, Yuan Fu, Kui-Zheng He, Xin-Ming Liu, Hong-Jiang Wang, Kun Xia, Li Xu, Jiu-Chang Zhong, Mu-Lei Chen, Le-Feng Wang
Summary: This study investigated the safety and efficiency of drug eluting balloon (DEB) versus drug eluting stent (DES) in cancer patients with acute myocardial infarction (AMI). The results showed that DEB had a trend towards lower rate of major adverse cardiovascular events (MACE) compared with DES in this high-risk group.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Yi-Xing Yang, Kui-Zheng He, Jiang-Yuan Li, Yuan Fu, Chuang Li, Xin-Ming Liu, Hong-Jiang Wang, Mu-Lei Chen, Pi-Xiong Su, Li Xu, Le-Feng Wang
Summary: The present study investigated the safety and effectiveness of drug-eluting balloons (DEBs) in young patients with acute myocardial infarction (AMI). The results showed that patients treated with DEBs had a trend toward a lower incidence of device-oriented composite endpoint (DOCE) compared to those treated with drug-eluting stents (DESs). This suggests that DEBs might be a potential treatment option in young patients with AMI.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2023)
Review
Medicine, General & Internal
Baoyu Geng, Zhe Liu, Guangzhi Feng, Jun Jiang
Summary: This study is a high-quality systematic review and meta-analysis comparing the efficacy and safety of DCB and DES in patients with acute myocardial infarction. The results suggest that the use of DCB may be associated with a reduced risk of cardiovascular disease and death.
Article
Cardiac & Cardiovascular Systems
Yasushi Ino, Masahiro Takahata, Takashi Kubo, Amir Kh. M. Khalifa, Keisuke Satogami, Kosei Terada, Yuichi Ozaki, Yosuke Katayama, Akira Taruya, Shingo Ota, Teruaki Wada, Takashi Tanimoto, Yasutsugu Shiono, Manabu Kashiwagi, Akio Kuroi, Atsushi Tanaka
Summary: This study investigated the late vascular response after everolimus-eluting stent (EES) implantation assessed by optical coherence tomography (OCT) in patients with acute myocardial infarction (AMI) caused by calcified nodules (CN), by comparing with plaque rupture (PR) and plaque erosion (PE). The study found that patients with AMI caused by CN had worse late arterial healing response compared to those with PR and PE.
CIRCULATION JOURNAL
(2022)
Article
Cardiac & Cardiovascular Systems
Fumi Yamamoto, Masahiro Natsuaki, Shoichi Kuramitsu, Masanobu Ohya, Hiromasa Otake, Kazunori Horie, Futoshi Yamanaka, Hiroki Shiomi, Gaku Nakazawa, Kenji Ando, Kazushige Kadota, Shigeru Saito, Takeshi Kimura, Koichi Node
Summary: This study assessed the association between clinical presentation at index procedure and mortality in patients with second-generation drug-eluting stent thrombosis. The results showed that the cumulative 3-year incidence of all-cause death after the index ST events was similar between patients with acute coronary syndrome (ACS) and chronic coronary syndrome (CCS), but patients in the ACS group were more likely to have early ST and higher incidences of target lesion revascularization and recurrent ST compared to the CCS group.
JACC-CARDIOVASCULAR INTERVENTIONS
(2021)
Article
Medicine, General & Internal
Yong Hoon Kim, Ae-Young Her, Myung Ho Jeong, Byeong-Keuk Kim, Sung-Jin Hong, Seunghwan Kim, Chul-Min Ahn, Jung-Sun Kim, Young-Guk Ko, Donghoon Choi, Myeong-Ki Hong, Yangsoo Jang
Summary: In patients with AMI undergoing DES implantation, the efficacy of statin treatment varied according to baseline renal function. Although statin treatment was effective in reducing mortality, this beneficial effect was diminished with worsening baseline renal function.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, Research & Experimental
Matej Strycek, Lukas Jaworski, Rostislav Polasek, Pavol Tomasov
Summary: Coronary artery perforation is a rare but potentially fatal complication of percutaneous coronary intervention. We report a case of massive main vessel coronary perforation in a patient with acute ST segment elevation myocardial infarction, which was successfully treated with a second drug-eluting stent. This unusual therapeutic approach was used to maintain blood flow to the large side branch.
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Josep Gomez-Lara, Loreto Oyarzabal, Luis Ortega-Paz, Salvatore Brugaletta, Rafael Romaguera, Neus Salvatella, Gerard Roura, Fernando Rivero, Lara Fuentes, Fernando Alfonso, Imanol Otaegui, Bert Vandeloo, Beatriz Vaquerizo, Manel Sabate, Josep Comin-Colet, Joan-Antoni Gomez-Hospital
Summary: This study investigated the impact of different stents on endothelial function, finding variations in vasomotor responses and neointimal healing between devices, but no significant differences in endothelial dysfunction issues.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Health Care Sciences & Services
Li-Nien Chien, Chun-Chao Chen, Ya-Hui Chang, Fa-Chang Yu, Chen-Ting Tsai, Hung-Yi Liu, Hung- Yeh, Chao-Feng Lin
Summary: This population-based retrospective cohort study aimed to investigate whether the use of new-generation drug-eluting stent (NG-DES) during an undefined duration of dual antiplatelet therapy (DAPT) can reduce the risk of hospitalization for heart failure (HHF) in patients with ST-elevation myocardial infarction (STEMI). The results showed that NG-DES implantation was associated with a lower risk of HHF compared to bare-metal stent (BMS) implantation after 5 years.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Chao-Feng Lin, Ya-Hui Chang, Fa-Chang Yu, Chen-Ting Tsai, Chun-Chao Chen, Hung-Yi Liu, Li-Nien Chien
Summary: This study investigated the impact of NG-DES and BMS implantation on the risk of heart failure hospitalization in NSTEMI patients. The results showed that compared to BMS, NG-DES implantation was associated with a lower risk of heart failure after 5 years.
Article
Medicine, General & Internal
Yong Hoon Kim, Ae-Young Her, Myung Ho Jeong, Byeong-Keuk Kim, Sung-Jin Hong, Seung-Jun Lee, Chul-Min Ahn, Jung-Sun Kim, Young-Guk Ko, Donghoon Choi, Myeong-Ki Hong, Yangsoo Jang
Summary: This study compared the 2-year clinical outcomes of different reperfusion strategies in patients with non-ST-elevation myocardial infarction and chronic kidney disease undergoing newer-generation drug-eluting stent implantation. The results suggest that culprit-only percutaneous coronary intervention (C-PCI) may be a better reperfusion option for these patients compared to multivessel PCI, complete revascularization, and incomplete revascularization. Further large-scale randomized studies are needed to confirm these findings.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Yong Hoon Kim, Ae-Young Her, Myung Ho Jeong, Byeong-Keuk Kim, Sung-Jin Hong, Seung-Jun Lee, Chul-Min Ahn, Jung-Sun Kim, Young-Guk Ko, Donghoon Choi, Myeong-Ki Hong, Yangsoo Jang
Summary: The study compared the 2-year major clinical outcomes between STEMI and NSTEMI patients who are current smokers treated with PCI, and found no significant difference in outcomes. Further research is needed to confirm these results.
Article
Medicine, General & Internal
Sungmin Lim, Eun Ho Choo, Ik Jun Choi, Kwan Yong Lee, Su Nam Lee, Byung-Hee Hwang, Chan Joon Kim, Mahn-Won Park, Jong-Min Lee, Chul Soo Park, Hee-Yeol Kim, Ki-Dong Yoo, Doo Soo Jeon, Ho Joong Youn, Wook Sung Chung, Min Chul Kim, Myung Ho Jeong, Hyeon Woo Yim, Youngkeun Ahn, Kiyuk Chang
Summary: This study evaluated long-term clinical outcomes in 1-year AMI survivors with newer-generation drug-eluting stents implanted since 2010. Uncontrolled systolic blood pressure, serum low-density lipoprotein cholesterol levels, and non-fatal cardiovascular events within 1 year after the index procedure were strongly associated with adverse clinical outcomes. The risks of adverse cardiovascular events and death remained high in AMI patients more than 1 year after PCI, emphasizing the importance of controlling risk factors and monitoring for recurrent events.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Ji Woong Roh, Seung-Jun Lee, Byeong-Keuk Kim, Sung-Jin Hong, Hee-Yeol Kim, Chul-Min Ahn, Deok-Kyu Cho, Jung-Sun Kim, Young-Guk Ko, Donghoon Choi, Myeong-Ki Hong, Yangsoo Jang
Summary: The effects of ticagrelor-based dual antiplatelet therapy on ACS patients with CKD varied according to CKD stage. Among CKD patients without ESRD, ticagrelor-based DAPT reduced MACCE risk without increasing bleeding risks compared with clopidogrel-based DAPT.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Peripheral Vascular Disease
Tomomi Hasebe, Naoyuki Hasebe
Summary: Despite advancements in cardiovascular medicine, myocardial infarction (MI) remains a major concern for younger patients, with plaque rupture or erosion being the most common cause, often related to obesity and metabolic syndrome. The prevention and treatment of metabolic syndrome-related risk factors are crucial for primary prevention of cardiovascular disease, particularly MI, in younger patients.
HYPERTENSION RESEARCH
(2022)
Article
Cardiac & Cardiovascular Systems
Yong-Joon Lee, Jae Young Cho, Seng Chan You, Yong-Ho Lee, Kyeong Ho Yun, Yun-Hyeong Cho, Won-Yong Shin, Sang Wook Im, Woong Chol Kang, Yongwhi Park, Sung Yoon Lee, Seung-Jun Lee, Sung-Jin Hong, Chul-Min Ahn, Byeong-Keuk Kim, Young-Guk Ko, Donghoon Choi, Myeong-Ki Hong, Yangsoo Jang, Jung-Sun Kim
Summary: This study evaluated the effect of moderate-intensity statin with ezetimibe combination therapy versus high-intensity statin monotherapy among patients with diabetes mellitus and atherosclerotic cardiovascular disease. The study found that the combination therapy had similar outcomes in terms of cardiovascular events compared to the monotherapy, but had a higher rate of intolerance-related discontinuation or dose reduction. However, the combination therapy was more effective in achieving lower LDL cholesterol levels.
EUROPEAN HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Jiwon Seo, Yoo Jin Hong, Uuganbayar Batbayar, Dae-Young Kim, Iksung Cho, Young-Jin Kim, Geu-Ru Hong, Jong-Won Ha, Chi Young Shim
Summary: This study found that quantitative assessment of functional tricuspid regurgitation by CMR is independently associated with adverse clinical outcomes in patients with heart failure with reduced ejection fraction.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2023)
Article
Cardiac & Cardiovascular Systems
Dae-Young Kim, Jiwon Seo, Iksung Cho, Geu-Ru Hong, Jong-Won Ha, Chi Young Shim
Summary: This study investigates the prognostic implication of mitral valve disease and its progression in East Asian patients with HCM. The presence and progression of MR are associated with a poor prognosis in patients with HCM.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
Jung-Joon Cha, Ngoc-Luu Nguyen, Cong Tran, Won-Yong Shin, Seul-Gee Lee, Yong-Joon Lee, Seung-Jun Lee, Sung-Jin Hong, Chul-Min Ahn, Byeong-Keuk Kim, Young-Guk Ko, Donghoon Choi, Myeong-Ki Hong, Yangsoo Jang, Jinyong Ha, Jung-Sun Kim
Summary: This study aimed to evaluate and compare the diagnostic accuracy of machine learning fractional flow reserve (ML-FFR) based on optical coherence tomography (OCT) with wire-based FFR. OCT and FFR data were obtained for 356 individual coronary lesions in 130 patients. The ML-FFR showed good diagnostic performance in predicting FFR irrespective of the coronary territory, highlighting its potential in clinical practice.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Medicine, General & Internal
Sung-Jin Hong, Yong-Joon Lee, Seung-Jun Lee, Bum-Kee Hong, Woong Chol Kang, Jong-Young Lee, Jin-Bae Lee, Tae-Hyun Yang, Junghan Yoon, Chul-Min Ahn, Jung-Sun Kim, Byeong-Keuk Kim, Young-Guk Ko, Donghoon Choi, Yangsoo Jang, Myeong-Ki Hong
Summary: This study compared the effectiveness of initial statin treatment with high-intensity statins versus a treat-to-target strategy in patients with coronary artery disease. The results showed that the treat-to-target strategy of achieving an LDL-C level between 50 and 70 mg/dL was noninferior to high-intensity statin therapy in terms of clinical outcomes over a 3-year period.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
Sang-Hyup Lee, Yong -Joon Lee, Jung Ho Heo, Seung-Ho Hur, Hyun Hee Choi, Kyung-Jin Kim, Ju Han Kim, Keun-Ho Park, Jung Hee Lee, Yu Jeong Choi, Seung-Jun Lee, Sung-Jin Hong, Chul-Min Ahn, Byeong-Keuk Kim, Young-Guk Ko, Donghoon Choi, Myeong-Ki Hong, Yangsoo Jang, Jung-Sun Kim
Summary: This study compared the cardiovascular effects and tolerability of combination therapy with moderate-intensity statins and ezetimibe versus high-intensity statin monotherapy in elderly patients. The results showed no significant difference in the occurrence of cardiovascular events between the two treatment groups among patients aged ≥75 years and <75 years, but the combination therapy group had lower rates of adverse reactions. Therefore, combination therapy with moderate-intensity statins and ezetimibe has similar cardiovascular effects and greater tolerability in elderly patients.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Multidisciplinary Sciences
Bom Lee, Teklay Gebrehaweria Baraki, Byung Gyu Kim, Yong-Joon Lee, Seung-Jun Lee, Sung-Jin Hong, Chul-Min Ahn, Dong-Ho Shin, Byeong-Keuk Kim, Young-Guk Ko, Donghoon Choi, Myeong-Ki Hong, Yangsoo Jang, Jung-Sun Kim
Summary: This study evaluated the impact of various stent expansion indices on clinical outcomes and identified optimal stent implantation criteria using optical coherence tomography (OCT). It found that minimal stent area (MSA) was negatively correlated with the risk of adverse events, while overall volumetric stent expansion was associated with greater risk. Categorical criteria, such as MSA<5.0 mm(2), MSA/distal reference lumen area<90%, and stent expansion by linear model>= 65.0%, were independently associated with adverse events.
SCIENTIFIC REPORTS
(2023)
Article
Cardiac & Cardiovascular Systems
Byung Gyu Kim, Sung-Jin Hong, Byeong-Keuk Kim, Yong-Joon Lee, Seung-Jun Lee, Chul-Min Ahn, Dong-Ho Shin, Jung-Sun Kim, Young-Guk Ko, Donghoon Choi, Myeong-Ki Hong, Yangsoo Jang
Summary: This study aimed to evaluate the BMI-dependent effect of ticagrelor monotherapy after 3-month DAPT compared with 12-month DAPT on clinical outcomes in patients with ACS. The results showed consistent effects of ticagrelor monotherapy after 3-month DAPT on major clinical outcomes, regardless of BMI.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Medicine, General & Internal
Jong -Il Park, Seung-Jun Lee, Bum-Kee Hong, Yun-Hyeong Cho, Won-Yong Shin, Sang-Wook Lim, Woong-Chol Kang, Yongwhi Park, Sung-Yoon Lee, Yong-Joon Lee, Sung-Jin Hong, Chul-Min Ahn, Byeong-Keuk Kim, Young-Guk Ko, Donghoon Choi, Myeong-Ki Hong, Yangsoo Jang, Jung-Sun Kim
Summary: This study analyzed the effects of ezetimibe combination therapy with moderate-intensity statins in patients with atherosclerotic cardiovascular disease following percutaneous coronary intervention. The results showed that the combination therapy did not increase the risk of cardiovascular events and was effective in reducing low-density lipoprotein cholesterol levels.
Article
Medicine, General & Internal
Seung-Jun Lee, Woong Chol Kang, Jong-Young Lee, Jin-Bae Lee, Tae-Hyun Yang, Junghan Yoon, Yong-Joon Lee, Sung-Jin Hong, Chul-Min Ahn, Jung-Sun Kim, Byeong-Keuk Kim, Young-Guk Ko, Donghoon Choi, Bum-Kee Hong, Yangsoo Jang, Myeong-Ki Hong, LODESTAR Investigators
Summary: For patients with coronary artery disease and diabetes mellitus, achieving target LDL-C levels is comparable to high-intensity statin therapy in terms of 3-year clinical efficacy and safety outcomes.
Article
Endocrinology & Metabolism
Yong-Joon Lee, Sang-Hyup Lee, Seng Chan You, Yong-ho Lee, Seung-Jun Lee, Sung-Jin Hong, Chul-Min Ahn, Byeong-Keuk Kim, Young-Guk Ko, Donghoon Choi, Myeong-Ki Hong, Yangsoo Jang, Jung-Sun Kim
Summary: The study evaluated the safety and efficacy of a moderate-intensity statin with ezetimibe combination therapy versus high-intensity statin monotherapy in patients with metabolic syndrome (MetS) and atherosclerotic cardiovascular disease. The combination therapy showed comparable cardiovascular benefits with lower drug intolerance and low-density lipoprotein cholesterol levels compared to monotherapy, but no significant difference in new-onset diabetes.
DIABETES OBESITY & METABOLISM
(2023)
Article
Cardiac & Cardiovascular Systems
Seung-Jun Lee, Jung-Joon Cha, Woong Gil Choi, Wang-Soo Lee, Jin-Ok Jeong, Seonghoon Choi, Yoon-Haeng Cho, Woojung Park, Chang-Hwan Yoon, Yong-Joon Lee, Sung-Jin Hong, Chul-Min Ahn, Byeong-Keuk Kim, Young-Guk Ko, Donghoon Choi, Myeong-Ki Hong, Yangsoo Jang, Soon Jun Hong, Jung-Sun Kim
Summary: The study aimed to evaluate the outcomes of a moderate-intensity statin with ezetimibe combination in patients with very high risk (VHR) and non-VHR of atherosclerotic cardiovascular disease (ASCVD). The results showed no significant difference in the primary end point between combination therapy and high-intensity statin monotherapy in both VHR and non-VHR patients. Additionally, the combination therapy group had significantly lower levels of low-density lipoprotein cholesterol (LDL-C) compared to the high-intensity statin group, and was associated with greater changes in LDL-C levels and a higher proportion of patients with LDL-C levels below 70 mg/dL. The discontinuation or dose reduction of lipid-lowering drugs due to intolerance occurred less frequently in the combination therapy group.