Review
Chemistry, Medicinal
Magdolna Nagy, Paola E. J. van der Meijden, Julia Glunz, Leon Schurgers, Esther Lutgens, Hugo ten Cate, Stefan Heitmeier, Henri M. H. Spronk
Summary: This review focuses on the important factors of atherosclerosis contributing to the pathophysiology of peripheral arterial disease (PAD). The role of thrombo-inflammation and hypercoagulability in vascular diseases, including PAD, is discussed. The current antithrombotic treatments and potential new targets for the development of new treatments are also examined.
Article
Cardiac & Cardiovascular Systems
Hasan K. Siddiqi, Peter Libby, Paul M. Ridker
Summary: SARS-CoV-2 causes multi-system dysfunction, with emerging evidence indicating that endothelial injury plays a crucial role. Therapies targeting vascular system dysfunction may be important in treating SARS-CoV-2 infection and its long-lasting effects.
TRENDS IN CARDIOVASCULAR MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Giuseppe Miceli, Maria Grazia Basso, Giuliana Rizzo, Chiara Pintus, Antonino Tuttolomondo
Summary: Peripheral artery disease (PAD) is a clinical manifestation of atherosclerosis with significant impact on the economy and global health. The contribution of the coagulation system to atherosclerosis formation and PAD development is increasingly recognized, influencing therapeutic approaches.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Janina Krug, Magdalena L. Bochenek, Rajinikanth Gogiraju, Dagmar Laubert-Reh, Karl J. Lackner, Thomas Muenzel, Philipp S. Wild, Christine Espinola-Klein, Katrin Schaefer
Summary: This study found that circulating sEPCR levels may serve as biomarkers of endothelial dysfunction, including angiogenesis, in individuals older than 35 years, and progressive loss of endothelial protein C receptors might be involved in the development and progression of PAD.
Article
Dermatology
Aishwarya Raja, Jamie Karch, Allen F. Shih, Henriette De La Garza, Antonio Jesus De Zepeda Diaz, Mayra B. C. Maymone, Tania J. Phillips, Eric Secemsky, Neelam Vashi
Summary: In this article, the epidemiology of peripheral vascular disease, its association with cutaneous symptoms, and the diagnosis and evaluation of cutaneous features of vascular disorders are reviewed. With the increasing prevalence of peripheral vascular disease globally, it is crucial for dermatologists to accurately recognize and diagnose cutaneous manifestations and direct individuals to receive appropriate care and treatment.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2023)
Article
Hematology
Ellen G. Driever, Marta Magaz, Jelle Adelmeijer, Fanny Turon, Anna Baiges, Pol Olivas, Valeria Perez-Campuzano, Virginia Hernandez-Gea, Annabel Blasi, Juan-Carlos Garcia-Pagan, Ton Lisman
Summary: This study aimed to determine whether the portal vein (PV) has specific proinflammatory/hypercoagulable characteristics by comparing plasma sampled in the PV, hepatic vein (HV), and the systemic circulation. The results showed that although there were slightly higher levels of inflammatory markers in the PV, there was no clear proinflammatory or prothrombotic environment in the PV of cirrhotic patients. Multiple markers were found to be lower in the HV compared to the PV and systemic circulation, indicating that the liver plays a role in the clearance of these markers.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2022)
Review
Pharmacology & Pharmacy
Shigang Lin, Ruoran Lin, Hongkun Zhang, Qingbo Xu, Yangyan He
Summary: This review focuses on the functional changes of peripheral arterial cells and the mechanisms of PAD pathogenesis. It summarizes the progress of current clinical treatment and potential therapeutic methods for PAD, and provides insights for future perspectives.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Caitlin W. Hicks, Courtenay M. Holscher, Peiqi Wang, Chen Dun, Christopher J. Abularrage, James H. Black III, Kim J. Hodgson, Martin A. Makary
Summary: The study aimed to describe physician practice patterns and factors associated with the use of atherectomy during index revascularization for femoropopliteal peripheral artery disease. Results showed a wide distribution of physician practice patterns with atherectomy, and identified independent characteristics such as treatment type, patient diabetes, physician gender, practice time, specialties, procedure volume, and work settings.
JACC-CARDIOVASCULAR INTERVENTIONS
(2021)
Article
Medicine, Research & Experimental
Bo Rim Kim, Leerang Lim, YoungRok Choi, Nam-Joon Yi, Kwang-Woong Lee, Kyung-Suk Suh, Kyung-Sang Yu, Jin Young Sohn, Raewon Jeong, Jaeseong Oh, Ho Geol Ryu
Summary: This study investigated the appropriate method of antithrombin-III (AT-III) concentrate administration after liver transplantation to maintain plasma AT-III activity within the target range. The study randomized 130 adult patients into intermittent and continuous groups, and found that the continuous group had a higher rate of target attainment within 72 hours.
CTS-CLINICAL AND TRANSLATIONAL SCIENCE
(2023)
Article
Medicine, General & Internal
Daniel P. Zalewski, Karol P. Ruszel, Andrzej Stepniewski, Dariusz Galkowski, Marcin Feldo, Janusz Kocki, Anna Bogucka-Kocka
Summary: This study compared the miRNA expression profiles of patients with lower extremity artery disease (LEAD), abdominal aortic aneurysm (AAA), and chronic venous disease (CVD) to identify similarities and differences in miRNA-dependent regulatory mechanisms. The functional analysis revealed associations with inflammation, cellular differentiation, motility, and death. The findings provide new insights into the pathogenesis of LEAD, AAA, and CVD.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Malika Aid, Kathryn E. Stephenson, Ai-ris Y. Collier, Joseph P. Nkolola, James V. Michael, Steven E. Mckenzie, Dan H. Barouch
Summary: Thrombosis with thrombocytopenia syndrome (TTS) is a rare but potentially severe adverse event following immunization with adenovirus vector-based COVID-19 vaccines. Transcriptomic and proteomic profiling reveals that TTS patients show robust upregulation of platelet, coagulation, and immune pathways after receiving the initial dose of Ad26.COV2.S. A second immunization or a reduced initial dose of Ad26.COV2.S induces lower activation of these pathways.
NATURE COMMUNICATIONS
(2023)
Article
Medicine, General & Internal
Christoph Fisser, Corina Armbruester, Clemens Wiest, Alois Philipp, Maik Foltan, Dirk Lunz, Karin Pfister, Roland Schneckenpointner, Christof Schmid, Lars S. Maier, Thomas Mueller, Matthias Lubnow
Summary: This study aimed to investigate the prevalence and risk factors of arterial and venous complications in patients requiring peripheral venoarterial extracorporeal membrane oxygenation (VA ECMO) and assess complications associated with decannulation. The study found a 27% prevalence of venous complications and a 37% prevalence of arterial complications. The location of cannulation and NIRS monitoring were associated with complication occurrence. Complications associated with decannulation were similar between percutaneous and surgical approaches.
FRONTIERS IN MEDICINE
(2022)
Article
Hematology
Usha S. Perepu, Isaac Chambers, Abdul Wahab, Patrick Ten Eyck, Chaorong Wu, Sanjana Dayal, Grerk Sutamtewagul, Steven R. Bailey, Lori J. Rosenstein, Steven R. Lentz
Summary: In hospitalized adults with severe COVID-19, standard prophylactic dose and intermediate dose enoxaparin did not significantly differ in preventing death or thrombosis at 30 days. The occurrence of arterial or venous thrombosis was slightly higher than the rate of major bleeding.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2021)
Article
Materials Science, Biomaterials
Ruibo Yang, Wenkai Liu, Ao Wang, Xiaobo Deng, Yuan Feng, Qiao Zhang, Zhen Li, Feng Luo, Jiehua Li, Hong Tan
Summary: A novel SMPU was developed with full hard segments on the main chains and hydrophilic tertiary amine soft segments on the side chains, which when immersed in water, dramatically separated the segments to form densely packed hard domains, leading to improved Young's modulus and shape recovery ratio. Additionally, the hydrophilic side chains migrated to the surface driven by the segmental rearrangement in water, promoting adhesion and growth of vascular endothelial cells while inhibiting coagulation system activation. The unique structural design provided SMPUs with sufficient mechanical strength and hemocompatibility for potential use in self-expanding vascular stents.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Review
Gastroenterology & Hepatology
Alberto Zanetto, Patrick Northup, Lara Roberts, Marco Senzolo
Summary: Hospitalised patients with decompensated cirrhosis experience a rebalanced haemostasis, but this balance can easily be disrupted, leading to bleeding. Acute kidney injury, bacterial infections/sepsis, and progression to acute-on-chronic liver failure further increase the risk of bleeding. Unfortunately, there is no single laboratory method to accurately assess bleeding risk and guide preventive measures. Understanding the haemostatic alterations during acute illness could improve the management of these patients.
JOURNAL OF HEPATOLOGY
(2023)