Editorial Material
Immunology
Alexandros Galaras, Mihalis Verykokakis
Summary: New research reveals molecular mechanisms underlying sex-based differences in antiviral immune responses.
Article
Clinical Neurology
Christopher L. Taylor
Summary: The history of neurosurgery at UT Southwestern Medical Center in Dallas, Texas, includes key milestones such as the establishment of the academic neurosurgical practice, the expansion of training programs, and the emphasis on excellence in patient care and surgical outcomes. Under the leadership of various chairs, the program grew significantly, with a focus on community engagement and policy leadership. Through continuous development and integration with other medical services, the center has become a leading institution in academic neurosurgery.
JOURNAL OF NEUROSURGERY
(2021)
Article
Pharmacology & Pharmacy
Shavron Hada, Urmila Burlakoti, Ki Hyun Kim, Ji Soo Han, Min Ji Kim, Nam Ah Kim, Seong Hoon Jeong
Summary: Arginine and its derivatives have varying effects on protein aggregation. Arginine and arginine ethyl ester can reduce the stability of IgG, while acetyl arginine can efficiently suppress the formation of subvisible particles.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Engineering, Environmental
Li Wang, Jianbo Liu, Adrian Oehmen, Chencheng Le, Yikun Geng, Yan Zhou
Summary: The research indicates that using butyrate as a carbon source may enhance the performance of the enhanced biological phosphorus removal (EBPR) process, particularly benefiting polyphosphate accumulating organisms (PAOs) in warm climates. However, it also negatively affects glycogen accumulating organisms (GAOs), leading to a decrease in biomass concentration and microbial diversity in GAO cultures.
Article
Biochemistry & Molecular Biology
Irem Avcilar-Kucukgoze, Brittany MacTaggart, Anna Kashina
Summary: Protein arginylation is an important posttranslational modification that transfers the amino acid Arg from tRNA to proteins and peptides. Our study demonstrates that the availability of free Arg is a potentially rate-limiting factor for arginylation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Editorial Material
Biochemistry & Molecular Biology
Alessa L. Henneberg, Christiane A. Opitz
Summary: A recent study has revealed that hepatocellular carcinoma cells suppress the urea cycle enzymes and depend on the uptake of exogenous arginine and GCN2 kinase-induced cell-cycle arrest for survival. These findings present new possibilities for combination therapy in liver cancer.
Article
Horticulture
Xiangli Sun, Zebin Yuan, Bo Wang, Liping Zheng, Jianzhong Tan
Summary: This study demonstrated that exogenous putrescine (Put) supplementation can enhance the synthesis of endogenous arginine (Arg) and polyamines (PAs), while reducing the decomposition rate of PAs in Anthurium andraeanum seedlings under chilling stress. On the other hand, supplementation of D-arginine (D-Arg) and/or difluoromethylornithine (DFMO) inhibited the synthesis of endogenous Arg and its conversion to Put, accelerating the decomposition of PAs. Transcriptional analysis confirmed the differential expression of genes involved in these pathways, supporting the observed physiological effects.
SCIENTIA HORTICULTURAE
(2021)
Article
Biochemistry & Molecular Biology
Sven Wijngaarden, Chunsong Yang, Carlos Vela-Rodriguez, Lari Lehtio, Herman S. Overkleeft, Bryce M. Paschal, Dmitri V. Filippov
Summary: This study reveals that the DTX3L/PARP9 complex recognizes the androgen receptor through dual ADP-ribosylation, and the oligomerization of the complex is crucial for peptide binding.
ACS CHEMICAL BIOLOGY
(2023)
Review
Chemistry, Physical
Galina Gayda, Nataliya Stasyuk, Andriy Zakalskiy, Mykhailo Gonchar, Evgeny Katz
Summary: L-Arginine is a semi-essential amino acid that plays important roles in human health. Its metabolism generates various biochemical products and it is used in clinical diagnostics, disease prevention/treatment, and quality assessment of food and beverages. Electrochemical biosensors based on Arg-degrading enzymes are considered promising tools for Arg assay.
CURRENT OPINION IN ELECTROCHEMISTRY
(2022)
Review
Nutrition & Dietetics
Jun-Yi Li, Yan-Chao Guo, Hai-Feng Zhou, Tian-Tian Yue, Fa-Xi Wang, Fei Sun, Wen-Zhu Wang
Summary: The pathogenesis of inflammatory bowel disease (IBD) is related to genetic susceptibility, enteric dysbiosis, and chronic inflammation. Arginine supplementation may be a promising therapeutic strategy for IBD, but dosage adjustment is necessary.
Article
Multidisciplinary Sciences
Fernando P. Canale, Camilla Basso, Gaia Antonini, Michela Perotti, Ning Li, Anna Sokolovska, Julia Neumann, Michael J. James, Stefania Geiger, Wenjie Jin, Jean-Philippe Theurillat, Kip A. West, Daniel S. Leventhal, Jose M. Lora, Federica Sallusto, Roger Geiger
Summary: Engineered bacteria were developed to convert ammonia to l-arginine in tumors, increasing intratumoral l-arginine concentrations, T cell infiltration, and synergistic effects with PD-L1 blocking antibodies in tumor clearance. These results indicate that microbial therapies can enhance immunotherapy efficacy by modulating the tumor microenvironment.
Article
Multidisciplinary Sciences
Fatlum Hajredini, Ranajeet Ghose
Summary: By comparing the catalytic mechanisms of BY-kinases and NTPases, the study reveals the enzymatic activity differences between them, providing a theoretical basis for bacteria to reuse ancient domains to achieve tyrosine phosphorylation.
Article
Biochemistry & Molecular Biology
Daniela B. Surrer, Martin F. Fromm, Renke Maas, Joerg Koenig
Summary: This study reveals an unknown link between NaCT/Nact transporter protein and L-arginine and its cardiovascular important derivatives, and demonstrates that arginine and its derivatives are substrates of NaCT/Nact. This finding is of significance for further investigation into the role of arginine and its derivatives in energy metabolism and brain development.
Review
Medicine, General & Internal
Jin-Shou Yang, Cheng-Cheng Wang, Jiang-Dong Qiu, Bo Ren, Lei You
Summary: PDAC is an extremely malignant disease with a low survival rate, with arginine metabolism playing a crucial role in its development and progression. Arginine deprivation is considered a potential therapy, but drug resistance may develop during treatment. Arginase 1 may be a potential target for cancer immunotherapy.
CHINESE MEDICAL JOURNAL
(2021)
Article
Computer Science, Software Engineering
Javier E. Santos, Alex Gigliotti, Abhishek Bihani, Christopher Landry, Marc A. Hesse, Michael J. Pyrcz, Masa Prodanovic
Summary: MPLBM-UT is a lattice-Boltzmann library specifically designed for single- and two-phase flow simulations in porous media. It provides a comprehensive set of tools and interfaces that allow users to perform simulations and visualize results with ease.