Journal
CATALYSIS COMMUNICATIONS
Volume 54, Issue -, Pages 11-16Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.catcom.2014.05.007
Keywords
Acetaminophen; Amides; Self-catalyzed; Oximation; Beckmann rearrangement
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Funding
- Ca' Foscari University of Venice
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High yielding amination of ketones and benzaldehyde in acid-less conditions has been conducted on several ketones to achieve amides and nitriles. The reactivity of the selected substrates showed to depend on both oximation and Beckmann rearrangement reaction rates. Oximation allows the in-situ production of hydrochloric acid that enables Beckmann rearrangement of the mime to form the corresponding amide or nitrile. It is noteworthy that, using this one-pot synthetic approach, N-acetyl-4-aminophenol (acetaminophen drug), can be easily synthesized starting from 4-hydroxy-acetophenone in high yield. Acetanilide and epsilon-caprolactam can be also efficiently synthesized employing this synthetic procedure. (C) 2014 Elsevier B.V. All rights reserved.
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