PI3K Inhibitors in Cardiovascular Disease

Involvement of Phosphoinositide 3-Kinase γ in Angiogenesis and Healing of Experimental Myocardial Infarction in Mice

(2010) Mauro Siragusa et al.   CIRCULATION RESEARCH

Bone morphogenetic protein 4 mediates myocardial ischemic injury through JNK-dependent signaling pathway

(2010) Alok S. Pachori et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

PPAR-α activation protects the type 2 diabetic myocardium against ischemia-reperfusion injury: involvement of the PI3-Kinase/Akt and NO pathway

(2009) Aliaksandr A. Bulhak et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

High expression level of Toll-like receptor 2 on monocytes is an important risk factor for arteriosclerotic disease

(2009) So Kuwahata et al.   ATHEROSCLEROSIS

PI3K inhibitors for cancer treatment: where do we stand?

(2009) Sauveur-Michel Maira et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Phosphoinositide 3-kinase is a novel target of piceatannol for inhibiting PDGF-BB-induced proliferation and migration in human aortic smooth muscle cells

(2009) Keun Hwa Choi et al.   CARDIOVASCULAR RESEARCH

Role of the Phosphatidylinositol 3-Kinase/Protein Kinase B Pathway in Regulating Alternative Splicing of Tissue Factor mRNA in Human Endothelial Cells

(2009) Andreas Eisenreich et al.   CIRCULATION JOURNAL

Cdc2-Like Kinases and DNA Topoisomerase I Regulate Alternative Splicing of Tissue Factor in Human Endothelial Cells

(2009) Andreas Eisenreich et al.   CIRCULATION RESEARCH

Tissue factor: beyond coagulation in the cardiovascular system

(2009) Alexander Breitenstein et al.   CLINICAL SCIENCE

Antiangiogenic effect of ZSTK474, a novel phosphatidylinositol 3-kinase inhibitor

(2009) Dexin Kong et al.   EUROPEAN JOURNAL OF CANCER

Fine tuning the immune response with PI3K

(2009) David A. Fruman et al.   IMMUNOLOGICAL REVIEWS

Toll-like receptor agonists induce inflammation and cell death in a model of head and neck squamous cell carcinomas

(2009) Camilla Rydberg et al.   IMMUNOLOGY

Non-redundant Roles of Phosphoinositide 3-Kinase Isoforms α and β in Glycoprotein VI-induced Platelet Signaling and Thrombus Formation

(2009) Karen Gilio et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of Phosphoinositide 3-Kinase β in Glycoprotein VI-mediated Akt Activation in Platelets

(2009) Soochong Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lewis y antigen promotes the proliferation of ovarian carcinoma-derived RMG-I cells through the PI3K/Akt signaling pathway

(2009) Juanjuan Liu et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

High-Affinity αvβ3 Integrin Targeted Optical Probe as a New Imaging Biomarker for Early Atherosclerosis: Initial Studies in Watanabe Rabbits

(2009) Julie Heroux et al.   MOLECULAR IMAGING AND BIOLOGY

Ticagrelor versus Clopidogrel in Patients with Acute Coronary Syndromes

(2009) Lars Wallentin et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Stimulation of CD147 Induces MMP-9 Expression through ERK and NF-κB in Macrophages: Implication for Atherosclerosis

(2009) Ju-Young Kim et al.   Immune Network

Multi-Hit Inhibition of Circulating and Cell-Associated Components of the Toll-Like Receptor 4 Pathway by Oxidized Phospholipids

(2008) Elena von Schlieffen et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Enhanced expression of vascular cell adhesion molecule-1 by corticotrophin-releasing hormone contributes to progression of atherosclerosis in LDL receptor-deficient mice

(2008) Yuqing Wu et al.   ATHEROSCLEROSIS

Inflammation and Plaque Vulnerability

(2008) Prediman K. Shah   CARDIOVASCULAR DRUGS AND THERAPY

Genetic and Pharmacological Targeting of Phosphoinositide 3-Kinase-γ Reduces Atherosclerosis and Favors Plaque Stability by Modulating Inflammatory Processes

(2008) Anne Fougerat et al.   CIRCULATION

Heart Disease and Stroke Statistics—2009 Update

(2008) et al.   CIRCULATION

Phosphatidylinositol-3-Kinase-γ Is Integral to Homing Functions of Progenitor Cells

(2008) Emmanouil Chavakis et al.   CIRCULATION RESEARCH

Advantages of a selective β-isoform phosphoinositide 3-kinase antagonist, an anti-thrombotic agent devoid of other cardiovascular actions in the rat

(2008) Sharelle A. Sturgeon et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Angiogenesis selectively requires the p110α isoform of PI3K to control endothelial cell migration

(2008) Mariona Graupera et al.   NATURE

Taming the PI3K team to hold inflammation and cancer at bay

(2008) Emilio Hirsch et al.   PHARMACOLOGY & THERAPEUTICS

Phosphoinositide 3-Kinase γ Gene Knockout Impairs Postischemic Neovascularization and Endothelial Progenitor Cell Functions

(2007) Paolo Madeddu et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Upregulation of tissue factor expression and thrombogenic activity in human aortic smooth muscle cells by irradiation, rapamycin and paclitaxel

(2007) Andreas Eisenreich et al.   INTERNATIONAL IMMUNOPHARMACOLOGY