☆ 4.7 Meeting Abstract

Extracellular vesicles mediate cardioprotection exerted by remote ischemic preconditioning in rats

CARDIOVASCULAR RESEARCH (2014)

Journal

CARDIOVASCULAR RESEARCH

Volume 103, Issue -, Pages -

Publisher

OXFORD UNIV PRESS

DOI: 10.1093/cvr/cvu091.114

Keywords

-

Categories

Cardiac & Cardiovascular Systems

Ask authors/readers for more resources

Protocol

Community support

Reagent

Community support

Authors

I am an author on this paper

Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.7

Not enough ratings

Secondary Ratings

Novelty

-

Significance

-

Scientific rigor

-

Rate this paper

Recommended

Article Cardiac & Cardiovascular Systems

Cardioprotection by remote ischemic conditioning is transferable by plasma and mediated by extracellular vesicles

Thomas Ravn Lassen, Jesper Just, Marie Vognstoft Hjortbak, Nichlas Riise Jespersen, Katrine Tang Stenz, Tingting Gu, Yan Yan, Junyi Su, Jakob Hansen, Rikke Baek, Malene Moller Jorgensen, Jens Randel Nyengaard, Steen Buus Kristiansen, Kim Ryun Drasbek, Jorgen Kjems, Hans Erik Botker

Summary: The study demonstrates that cardioprotection by RIC may be mediated by circulating EVs that accumulate in the injured myocardium. The EV miRNAs may promote cell survival during reperfusion, suggesting a potential mechanism for the protective effect.

BASIC RESEARCH IN CARDIOLOGY (2021)

Add to Collection

Article Biochemistry & Molecular Biology

Influence of Short and Long Hyperglycemia on Cardioprotection by Remote Ischemic Preconditioning-A Translational Approach

Katharina Feige, Sebastian Roth, Rene M'Pembele, Anna Galow, Sarah Koenig, Martin Stroethoff, Annika Raupach, Giovanna Lurati Buse, Alexander M. Mathes, Markus W. Hollmann, Ragnar Huhn, Carolin Torregroza

Summary: The adverse impact of common diseases like diabetes mellitus and acute hyperglycemia on morbidity and mortality from myocardial infarction (MI) has been well documented. The relationship between blood glucose and mortality appears linear, and this seems to be independent of a diagnosis of diabetes. This study investigates the influence of acute and prolonged hyperglycemia on the protective effect of transferred human RIPC-plasma and suggests that hyperglycemia might obstruct translation into the clinical setting.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Add to Collection

Article Cell Biology

Remote ischemic preconditioning prevents sarcolemmal-associated proteolysis by MMP-2 inhibition

Eliana P. Bin, Tamara Zaobornyj, Mariana Garces, Veronica D'Annunzio, Bruno Buchholz, Timoteo Marchini, Pablo Evelson, Ricardo J. Gelpi, Martin Donato

Summary: The rupture of the plasma membrane is the key point in cell death, which can be prevented by remote ischemic preconditioning through inhibiting MMP-2 activity. Besides, remote ischemic preconditioning also improves mitochondrial function, increasing membrane potential, ATP production and respiratory control.

MOLECULAR AND CELLULAR BIOCHEMISTRY (2023)

Add to Collection

Article Cell Biology

Myocardial remote ischemic preconditioning: from cell biology to clinical application

Martin Donato, Eliana P. Bin, Veronica D'Annunzio, Ricardo J. Gelpi

Summary: Remote ischemic preconditioning (rIPC) can protect the heart from ischemia/reperfusion injury by activating different signaling pathways. Factors such as age, comorbidities, medication, and anesthetic protocol may weaken the subcellular mechanisms of rIPC in patients. Further carefully designed studies are necessary to develop a clearer understanding of the pathways and mechanisms of early and late rIPC.

MOLECULAR AND CELLULAR BIOCHEMISTRY (2021)

Add to Collection

Article Multidisciplinary Sciences

Remote liver ischemic preconditioning attenuates myocardial ischemia/reperfusion injury in streptozotocin-induced diabetic rats

Xinhao Liu, Hui Chen, Zhibing Yan, Lei Du, Dou Huang, Wei Dong Gao, Zhaoyang Hu

Summary: This study evaluated the protective effects of liver ischemic preconditioning (RLIPC) on I/R injury in streptozotocin-induced type 1 diabetic rats. RLIPC significantly reduced infarct size and cardiac tissue damage, inhibited apoptosis, improved cardiac functions, and preserved cardiac morphology in diabetic hearts post I/R. Western blotting showed that RLIPC stimulated phosphorylation of ventricular GSK-3 beta and STAT-5, indicating its strong cardioprotective properties against myocardial I/R injury in diabetic hearts.

SCIENTIFIC REPORTS (2021)

Add to Collection

Article Immunology

Tumor extracellular vesicles mediate anti-PD-L1 therapy resistance by decoying anti-PD-L1

Jiming Chen, Jie Yang, Wenhui Wang, Danfeng Guo, Chengyan Zhang, Shibo Wang, Xinliang Lu, Xiaofang Huang, Pingli Wang, Gensheng Zhang, Jing Zhang, Jianli Wang, Zhijian Cai

Summary: PD-L1(+) tumor-derived extracellular vesicles (TEVs) cause resistance to anti-PD-L1 antibody therapy by decoying the antibody and being cleared by macrophages, resulting in insufficient blockade of tumor PD-L1.

CELLULAR & MOLECULAR IMMUNOLOGY (2022)

Add to Collection

Article Medicine, General & Internal

Cardioprotective Properties of Humoral Factors Released after Remote Ischemic Preconditioning in CABG Patients with Propofol-Free Anesthesia-A Translational Approach from Bedside to Bench

Katharina Feige, Carolin Torregroza, Milena Gude, Patrick Maddison, Martin Stroethoff, Sebastian Roth, Giovanna Lurati Buse, Markus W. Hollmann, Ragnar Huhn

Summary: The cardioprotective effect of remote ischemic preconditioning (RIPC) has been observed in experimental studies but not in clinical trials. Propofol is believed to have a negative impact on the release of humoral factors after RIPC. Furthermore, comorbidities may interact with the cardioprotective properties of RIPC. This study found that propofol-free RIPC did not lead to the release of cardioprotective humoral factors in male patients undergoing CABG surgery, regardless of the presence of diabetes mellitus.

JOURNAL OF CLINICAL MEDICINE (2022)

Add to Collection

Article Medicine, Research & Experimental

Remote ischemic preconditioning does not induce activation of Akt and STAT5 in the rat heart

Annika Raupach, Katharina Feige, Christian Reiter, Timo Brandenburger, Nicole Heinen, Andre Heinen, Markus W. Hollmann, Ragnar Huhn, Carolin Torregroza

Summary: The study found that RIPC did not induce the phosphorylation of AKT or STAT5 in a rat model, nor did it modulate the activation of AKT and STAT5 following I/R, suggesting that RIPC-induced cardioprotection may not be mediated by the activation of AKT or STAT5 at the investigated time points.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2021)

Add to Collection

Article Biochemistry & Molecular Biology

Modification of Ischemia/Reperfusion-Induced Alterations in Subcellular Organelles by Ischemic Preconditioning

Paramjit S. Tappia, Anureet K. Shah, Bram Ramjiawan, Naranjan S. Dhalla

Summary: Ischemia/reperfusion injury can compromise cardiac function recovery, but ischemic preconditioning (IP) can reduce oxidative stress and intracellular Ca2+ overload, improving cardiac function and providing cardioprotective effects.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Add to Collection

Review Pharmacology & Pharmacy

Challenges facing the clinical translation of cardioprotection: 35 years after the discovery of ischemic preconditioning

Claudia Penna, Stefano Comita, Francesca Tullio, Giuseppe Alloatti, Pasquale Pagliaro

Summary: Since the introduction of coronary reperfusion in the late 1970s, the translation of successful animal experiments on cardioprotection into clinical practice has been disappointing. Animal experiments are often lacking the risk factors, co-morbidities and co-medications characteristic of acute myocardial infarction patients. The long-term effects of additional cardioprotection, particularly regarding vessel protection, repair, inflammation, remodeling, and mortality, are not well-studied. Species differences, co-morbidities, vascular damage, inflammatory processes, and co-medications often limit the reproducibility and robustness of experimental studies. Future studies should focus on interventions with reliable preclinical data and recruit patients who have the potential to benefit from further cardioprotection.

VASCULAR PHARMACOLOGY (2022)

Add to Collection

Article Immunology

miR-142-5p Encapsulated by Serum-Derived Extracellular Vesicles Protects against Acute Lung Injury in Septic Rats following Remote Ischemic Preconditioning via the PTEN/PI3K/Akt Axis

Wenliang Zhu, Xiaopei Huang, Shi Qiu, Lingxiao Feng, Yue Wu, Huanzhang Shao

Summary: This study investigates the effects of miR-142-5p encapsulated by serum-derived extracellular vesicles (EVs) on septic acute lung injury (ALI) following remote ischemic preconditioning (RIPC). The results show that miR-142-5p can target PTEN to activate the PI3K/Akt signaling pathway, reducing pulmonary edema, neutrophil infiltration, and inflammatory cytokine release in ALI.

JOURNAL OF INNATE IMMUNITY (2022)

Add to Collection

Article Biology

The Role of Extracellular Vesicles in Ischemic Stroke Severity

Angelica Carandina, Chiara Favero, Roberto Maria Sacco, Mirjam Hoxha, Giuseppe Torgano, Nicola Montano, Valentina Bollati, Eleonora Tobaldini

Summary: This study found that specific subtypes of extracellular vesicles are associated with stroke severity and both short- and long-term outcomes. Extracellular vesicles could serve as a valid tool to improve risk stratification in patients with ischemic stroke and post-recanalization treatment monitoring.

BIOLOGY-BASEL (2022)

Add to Collection

Article Chemistry, Multidisciplinary

Extracellular Vesicles Mediate the Intercellular Exchange of Nanoparticles

Xian Wu, Tang Tang, Yushuang Wei, Katherine A. Cummins, David K. Wood, Hong-Bo Pang

Summary: This study develops a collagen-based three-dimension assay to quantify and understand the intercellular exchange of nanoparticles (NPs). The results demonstrate the significant role of extracellular vesicles (EVs) in NP transport, providing insights into the importance of EVs in NP delivery into complex tissues.

ADVANCED SCIENCE (2022)

Add to Collection

Article Hematology

Circulating platelet-derived extracellular vesicles are decreased after remote ischemic preconditioning in patients with coronary disease: A randomized controlled trial

Caroline J. Reddel, Gabrielle J. Pennings, Jerrett K. Lau, Vivien M. Chen, Leonard Kritharides

Summary: Remote ischemic preconditioning was found to decrease circulating levels of platelet-derived EVs in patients with coronary disease on antiplatelet therapy. This effect may be due to increased clearance/uptake of EVs or changes in production. Clinical variables could modify the effectiveness of RIPC.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2021)

Add to Collection

Article Engineering, Biomedical

Immunomodulatory effects exerted by extracellular vesicles from Staphylococcus epidermidis and Staphylococcus aureus isolated from bone-anchored prostheses

Magdalena Zaborowska, Forugh Vazirisani, Furqan A. Shah, Rininta Firdaus, Omar Omar, Karin Ekstrom, Margarita Trobos, Peter Thomsen

Summary: This study found that Staphylococcus aureus and Staphylococcus epidermidis isolated from osteomyelitis associated with septic loosening of orthopedic prostheses release extracellular vesicles (EVs) with potent cytolytic and immunomodulatory properties.

BIOMATERIALS (2021)

Add to Collection

Article Engineering, Chemical

Development of High-Fibre, Ready-to-Bake Flour Mixtures from Purple Wheat

Eszter Szoke-Trenyik, Jozsef Mihalko, Peter Sipos, Balazs P. Szabo

Summary: Nowadays, consumers are increasingly focused on healthy eating, however, insulin resistance and type 2 diabetes are impacting many individuals. Generally, people are paying more attention to consuming foods rich in fiber. In this study, we developed high-fiber ready-to-bake flour mixtures using purple wheat flour (white and wholemeal) and fortified them with inulin, chia seed flour, and psyllium husk flour. After determining the nutritional parameters of the raw materials, we conducted four sets of experiments to prepare bread rolls and test the final products. Ultimately, we developed three blends with the appropriate mixing ratios of enriching agents.

PROCESSES (2023)

Add to Collection

Review Engineering, Chemical

Dough Rheological Properties and Macronutrient Bioavailability of Cereal Products Fortified through Legume Proteins

Chaima Neji, Jyoti Semwal, Endre Mathe, Peter Sipos

Summary: Cereal products are important sources of protein, but their nutritional quality may be poor due to imbalanced amino acid content. Combining legume proteins with cereals can enhance their nutritional value, but the cereal processing industry needs to address this possibility. However, incorporating legume protein concentrates and isolates may also affect the functionality and bioavailability of some cereal constituents.

PROCESSES (2023)

Add to Collection

Article Oncology

BRAF RNA is prognostic and widely expressed in lung adenocarcinoma

David Dora, Imre Voros, Zoltan V. Varga, Peter Takacs, Vanda Teglasi, Judit Moldvay, Zoltan Lohinai

Summary: The expression of BRAF RNA in lung adenocarcinoma is increased and associated with tumor necrosis, immune checkpoint biology, and outcomes. Further research on targeting the overexpressed BRAF pathway in lung adenocarcinoma is recommended.

TRANSLATIONAL LUNG CANCER RESEARCH (2023)

Add to Collection

Article Biology

Single-cell transcriptomics reveal extracellular vesicles secretion with a cardiomyocyte proteostasis signature during pathological remodeling

Eric Schoger, Federico Bleckwedel, Giulia Germena, Cheila Rocha, Petra Tucholla, Izzatullo Sobitov, Wiebke Moebius, Maren Sitte, Christof Lenz, Mostafa Samak, Rabea Hinkel, Zoltan V. Varga, Zoltan Giricz, Gabriela Salinas, Julia C. Gross, Laura C. Zelarayan

Summary: In a study on the hypertrophy of cardiomyocytes, it was found that aberrant Wnt activation leads to a proteostasis signature in extracellular vesicles and transcriptomic profiling, indicating early patho-physiological states. Aberrant Wnt activation has been observed in failing cardiomyocytes. Further analysis shows enrichment of extracellular vesicles related processes in hearts with Wnt activation, and the identification of differentially enriched proteins including proteasome constituents, chaperones, and cardiac proteins. These findings suggest that the secretion of extracellular vesicles with a proteostasis signature plays a role in the early adaptation of cardiomyocytes and may have diagnostic and prognostic implications.

COMMUNICATIONS BIOLOGY (2023)

Add to Collection

Editorial Material Engineering, Chemical

Special Issue: Processing Foods: Process Optimization and Quality Assessment

Peter Sipos, Milivoj Radojcin

PROCESSES (2023)

Add to Collection

Article Agronomy

Assessment of Bioactive Profile of Sorghum Brans under the Effect of Growing Conditions and Nitrogen Fertilization

Robert Nagy, Eszter Muranyi, Piroska Birone Molnar, Judit Szepesi, Zoltan Gyori, Szilvia Veres, Judit Remenyik, Peter Sipos

Summary: This study evaluated the bioactive profiles and antioxidant potentials of brans from six sorghum varieties using spectrophotometric methods. Results showed that the bran of red varieties contained a higher amount of polyphenols and tannins and exhibited higher antioxidant capacities than the bran of white varieties, with the exception of one red genotype. Two red varieties had the highest total polyphenol contents. In conclusion, red-colored varieties are a good source of polyphenols and the environmental conditions greatly affect the bioactive profile of sorghum.

AGRICULTURE-BASEL (2023)

Add to Collection

Article Engineering, Chemical

The Relationship between Rehydration Time and Tenderness at Different Rehydrating Water Temperatures in Freeze-Dried Pork Loin

Zoltan Repas, Jozsef Prokisch, Zoltan Gyori, Peter Sipos

Summary: This study investigates the preparation parameters of freeze-dried meat for fast rehydration and restoration of original tenderness in low-temperature environments. The results show that with proper preparation, meat can be quickly rehydrated and restored to ideal tenderness within a short period of time.

PROCESSES (2023)

Add to Collection

Article Pharmacology & Pharmacy

Antineoplastic drugs inducing cardiac and vascular toxicity - An update

Serena Barachini, Sandra Ghelardoni, Zoltan V. Varga, Radwa A. Mehanna, Maria Magdalena Montt-Guevara, Peter Ferdinandy, Rosalinda Madonna

Summary: With the improvement in cancer prognosis, there has been an increase in survival rate among cancer survivors. However, the use of anti-neoplastic drugs has led to an increase in morbidity among these survivors due to cardiovascular complications. These complications include arrhythmias, myocardial ischemia, heart failure, arterial hypertension, thromboembolic events, and accelerated atherosclerosis. The drugs not only target cancer cells but also affect normal cells within the cardiovascular system, leading to toxicity.

VASCULAR PHARMACOLOGY (2023)

Add to Collection

Meeting Abstract Pharmacology & Pharmacy

Novel G-protein coupled receptor targets for heart failure with reduced ejection fraction identified by next generation sequencing and validated by droplet digital PCR in a rat model

Nabil V. Sayour, Viktoria E. Toth, Regina N. Nagy, Noemi Nagy, Csaba Bodor, Imre Voros, Tamas G. Gergely, Barnabas Varadi, Bence Agg, Mihaly Ruppert, Tamas Radovits, Aniko Gorbe, Peter Ferdinandy, Zoltan V. Varga

BRITISH JOURNAL OF PHARMACOLOGY (2023)

Add to Collection

Meeting Abstract Pharmacology & Pharmacy

Gene expression alterations of different SARS-CoV-2 host factors in heart failure patients

Viktoria E. Toth, Tamas G. Gergely, Aniko Gorbe, Zsofia Onodi, Agota Apati, Przemyslaw Leszek, Tamas Radovits, Bela Merkely, Peter Ferdinandy, Zoltan V. Varga

BRITISH JOURNAL OF PHARMACOLOGY (2023)

Add to Collection

Meeting Abstract Pharmacology & Pharmacy

Transcriptomic analysis and comparative characterization of rat H9C2, human AC16 and murine HL-1 cardiac cell line

Barnabas Varadi, Zsofia Onodi, Tamas Visnovitz, Bernadett Kiss, Szabolcs Hambalko, Anna Koncz, Bence Agg, Viktoria Eva Toth, Regina Norma Nagy, Tamas Gergely, Dorottya Gergely, Andras Makkos, Csilla Pelyhe, Nora Varga, Dora Ree, Agota Apati, Przemyslaw Leszek, Tamas Kovacs, Bandor Nagy, Peter Ferdinandy, Edit Iren Buzas, Aniko Gorbe, Zoltan Giricz, Zoltan V. Varga

BRITISH JOURNAL OF PHARMACOLOGY (2023)

Add to Collection

Meeting Abstract Pharmacology & Pharmacy

Teaching pharmacology on Instagram - two years of experience at the Semmelweis University, Budapest, Hungary

David A. . Karadi, Zoltan V. Varga

BRITISH JOURNAL OF PHARMACOLOGY (2023)

Add to Collection

Meeting Abstract Pharmacology & Pharmacy

Angiotensin II receptor type 1 antagonism enhances the antiallodynic effect of morphine in a rodent model of neuropathic pain

David A. . Karadi, Anna R. Galambos, Nariman Essmat, Kornel Kiraly, Imre Voros, Edina Szucs, Zoltan V. Varga, Mahmoud Al-Khrasani

BRITISH JOURNAL OF PHARMACOLOGY (2023)

Add to Collection

Meeting Abstract Pharmacology & Pharmacy

Role of inflammasome activation in monocytes with hypercholesterolemia

Regina N. Nagy, Zsofia Gulyas-Onodi, Peter Ferdinandy, Aniko Gorbe, Zoltan V. Varga

BRITISH JOURNAL OF PHARMACOLOGY (2023)

Add to Collection

Meeting Abstract Pharmacology & Pharmacy

Effects of Blunting Annexin A1 Expression in Small Cell Lung Cancer Cell Lines

Agnes Paal, Akos Takacs, Zoltan V. Varga, Istvan Petak, Aniko Gorbe, Peter Ferdinandy, David Dora

BRITISH JOURNAL OF PHARMACOLOGY (2023)

Add to Collection

No Data Available

© Peeref 2019-2024. All rights reserved.