Id proteins in the vasculature: from molecular biology to cardiopulmonary medicine

Id proteins are critical downstream effectors of BMP signaling in human pulmonary arterial smooth muscle cells

(2013) Jun Yang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Anti-Inflammatory and Antiatherogenic Role of BMP Receptor II in Endothelial Cells

(2013) Chan Woo Kim et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

FK506 activates BMPR2, rescues endothelial dysfunction, and reverses pulmonary hypertension

(2013) Edda Spiekerkoetter et al.   JOURNAL OF CLINICAL INVESTIGATION

Inhibition of Bone Morphogenetic Protein Signaling Reduces Vascular Calcification and Atherosclerosis

(2012) Matthias Derwall et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Stalk Cell Phenotype Depends on Integration of Notch and Smad1/5 Signaling Cascades

(2012) Iván M. Moya et al.   DEVELOPMENTAL CELL

Id proteins synchronize stemness and anchorage to the niche of neural stem cells

(2012) Francesco Niola et al.   NATURE CELL BIOLOGY

B-Cell Aortic Homing and Atheroprotection Depend on Id3

(2011) Amanda C. Doran et al.   CIRCULATION RESEARCH

Using a structural and logics systems approach to infer bHLH–DNA binding specificity determinants

(2011) Federico De Masi et al.   NUCLEIC ACIDS RESEARCH

ID family protein expression and regulation in hypoxic pulmonary hypertension

(2010) Jonathan W. Lowery et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Endothelial cells are activated during hypoxia via endoglin/ALK-1/SMAD1/5 signaling in vivo and in vitro

(2010) Fei Tian et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Inhibition of Id proteins by a peptide aptamer induces cell-cycle arrest and apoptosis in ovarian cancer cells

(2010) D S Mern et al.   BRITISH JOURNAL OF CANCER

Using the Transcription Factor Inhibitor of DNA Binding 1 to Selectively Target Endothelial Progenitor Cells Offers Novel Strategies to Inhibit Tumor Angiogenesis and Growth

(2010) A. S. Mellick et al.   CANCER RESEARCH

Smad-Dependent and Smad-Independent Induction of Id1 by Prostacyclin Analogues Inhibits Proliferation of Pulmonary Artery Smooth Muscle Cells In Vitro and In Vivo

(2010) Jun Yang et al.   CIRCULATION RESEARCH

Id3 Is a Novel Atheroprotective Factor Containing a Functionally Significant Single-Nucleotide Polymorphism Associated With Intima–Media Thickness in Humans

(2010) Amanda C. Doran et al.   CIRCULATION RESEARCH

Developmental ablation of Id1 and Id3 genes in the vasculature leads to postnatal cardiac phenotypes

(2010) Qingshi Zhao et al.   DEVELOPMENTAL BIOLOGY

Inductive angiocrine signals from sinusoidal endothelium are required for liver regeneration

(2010) Bi-Sen Ding et al.   NATURE

A novel interplay between Epac/Rap1 and mitogen-activated protein kinase kinase 5/extracellular signal-regulated kinase 5 (MEK5/ERK5) regulates thrombospondin to control angiogenesis

(2009) R. C. Doebele et al.   BLOOD

Inhibitor of differentiation 4 (Id4) is a potential tumor suppressor in prostate cancer

(2009) Jason PW Carey et al.   BMC CANCER

Smooth muscle cell differentiation from human bone marrow: Variations in cell type specific markers and Id gene expression in a new model of cell culture

(2009) Karine Tréguer et al.   CELL BIOLOGY INTERNATIONAL

Altered Bone Morphogenetic Protein and Transforming Growth Factor-β Signaling in Rat Models of Pulmonary Hypertension

(2009) Lu Long et al.   CIRCULATION

Angiotensin II Induces a Region-Specific Hyperplasia of the Ascending Aorta Through Regulation of Inhibitor of Differentiation 3

(2009) A. Phillip Owens et al.   CIRCULATION RESEARCH

BMP type II receptor regulates positioning of outflow tract and remodeling of atrioventricular cushion during cardiogenesis

(2009) Hideyuki Beppu et al.   DEVELOPMENTAL BIOLOGY

Novel crosstalk to BMP signalling: cGMP-dependent kinase I modulates BMP receptor and Smad activity

(2009) Raphaela Schwappacher et al.   EMBO JOURNAL

Cellular and Molecular Basis of Pulmonary Arterial Hypertension

(2009) Nicholas W. Morrell et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Inhibitor of DNA binding-1 promotes the migration and proliferation of endothelial progenitor cells in vitro

(2009) Hong Wang et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Interaction of Inhibitor of DNA binding 3 (Id3) with Gut-enriched Krüppel-like factor (GKLF) and p53 regulates proliferation of vascular smooth muscle cells

(2009) Kerstin Wassmann et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Targeting Id protein interactions by an engineered HLH domain induces human neuroblastoma cell differentiation

(2009) R Ciarapica et al.   ONCOGENE

Cross Talk between Id1 and Its Interactive Protein Dril1 Mediate Fibroblast Responses to Transforming Growth Factor-β in Pulmonary Fibrosis

(2008) Ling Lin et al.   AMERICAN JOURNAL OF PATHOLOGY

Smad3 mediates immediate early induction of Id1 by TGF-β

(2008) Yao-Yun Liang et al.   CELL RESEARCH

Mutations in Bone Morphogenetic Protein Type II Receptor Cause Dysregulation of Id Gene Expression in Pulmonary Artery Smooth Muscle Cells

(2008) Jun Yang et al.   CIRCULATION RESEARCH

Id-1 Induces Proteasome-dependent Degradation of the HBX Protein

(2007) Ming-Tat Ling et al.   JOURNAL OF MOLECULAR BIOLOGY