Cardioprotection by the TSPO ligand 4′-chlorodiazepam is associated with inhibition of mitochondrial accumulation of cholesterol at reperfusion

Rationale and Design of the ‘MITOCARE’ Study: A Phase II, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Assess the Safety and Efficacy of TRO40303 for the Reduction of Reperfusion Injury in Patients Undergoing Percutaneous Coronary Intervention for Acute Myocardial Infarction

(2012) MITOCARE Study Group   CARDIOLOGY

Pathways of cholesterol oxidation via non-enzymatic mechanisms

(2011) Luigi Iuliano   CHEMISTRY AND PHYSICS OF LIPIDS

A carbon monoxide-releasing molecule (CORM-3) uncouples mitochondrial respiration and modulates the production of reactive oxygen species

(2011) Luisa Lo Iacono et al.   FREE RADICAL BIOLOGY AND MEDICINE

Metabolic consequences of mitochondrial coenzyme A deficiency in patients with PANK2 mutations

(2011) Valerio Leoni et al.   MOLECULAR GENETICS AND METABOLISM

The cellular and molecular origin of reactive oxygen species generation during myocardial ischemia and reperfusion

(2011) Koen Raedschelders et al.   PHARMACOLOGY & THERAPEUTICS

TNF-alpha induced PMN apoptosis in whole human blood: Protective effect of SSR180575, a potent and selective peripheral benzodiazepine ligand

(2010) N. Leducq-Alet et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A pore way to die: the role of mitochondria in reperfusion injury and cardioprotection

(2010) Andrew P. Halestrap   BIOCHEMICAL SOCIETY TRANSACTIONS

Peripheral benzodiazepine receptor ligand Ro5-4864 inhibits isoprenaline-induced cardiac hypertrophy in rats

(2010) Amardeep Jaiswal et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

4′-Chlorodiazepam, a translocator protein (18 kDa) antagonist, improves cardiac functional recovery during postischemia reperfusion in rats

(2010) Junjie Xiao et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

TRO40303, a New Cardioprotective Compound, Inhibits Mitochondrial Permeability Transition

(2010) S. Schaller et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Melatonin protects against heart ischemia-reperfusion injury by inhibiting mitochondrial permeability transition pore opening

(2009) Giuseppe Petrosillo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Regulation and pharmacology of the mitochondrial permeability transition pore

(2009) D. B. Zorov et al.   CARDIOVASCULAR RESEARCH

Oxysterols and mechanisms of apoptotic signaling: implications in the pathology of degenerative diseases☆

(2009) Sinéad Lordan et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Oxysterols: Sources, cellular storage and metabolism, and new insights into their roles in cholesterol homeostasis

(2009) Andrew J. Brown et al.   MOLECULAR ASPECTS OF MEDICINE

Side effects of oxysterols: cytotoxicity, oxidation, inflammation, and phospholipidosis

(2008) A. Vejux et al.   BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH

Mitochondrial Cholesterol Contributes to Chemotherapy Resistance in Hepatocellular Carcinoma

(2008) J. Montero et al.   CANCER RESEARCH

Effects of 4'-chlorodiazepam on cellular excitation-contraction coupling and ischaemia-reperfusion injury in rabbit heart

(2008) D. A. Brown et al.   CARDIOVASCULAR RESEARCH

Cholesterol, Reactive Oxygen Species, and the Formation of Biologically Active Mediators

(2008) Robert C. Murphy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cardioprotective Effect of Morphine and a Blocker of Glycogen Synthase Kinase 3 , SB216763 [3-(2,4-Dichlorophenyl)-4(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione], via Inhibition of the Mitochondrial Permeability Transition Pore

(2008) F. N. Obame et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS