Enhanced binding of calmodulin to the ryanodine receptor corrects contractile dysfunction in failing hearts

Aberrant interaction of calmodulin with the ryanodine receptor develops hypertrophy in the neonatal cardiomyocyte

(2011) Jaya P. Gangopadhyay et al.   BIOCHEMICAL JOURNAL

Defective calmodulin binding to the cardiac ryanodine receptor plays a key role in CPVT-associated channel dysfunction

(2010) Xiaojuan Xu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Intracellular translocation of calmodulin and Ca2+/calmodulin-dependent protein kinase II during the development of hypertrophy in neonatal cardiomyocytes

(2010) Jaya Pal Gangopadhyay et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Dissociation of calmodulin from cardiac ryanodine receptor causes aberrant Ca2+ release in heart failure

(2010) Makoto Ono et al.   CARDIOVASCULAR RESEARCH

Catecholaminergic Polymorphic Ventricular Tachycardia Is Caused by Mutation-Linked Defective Conformational Regulation of the Ryanodine Receptor

(2010) Hitoshi Uchinoumi et al.   CIRCULATION RESEARCH

Dantrolene, a Therapeutic Agent for Malignant Hyperthermia, Markedly Improves the Function of Failing Cardiomyocytes by Stabilizing Interdomain Interactions Within the Ryanodine Receptor

(2009) Shigeki Kobayashi et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Interaction of the Lys3614–Asn3643calmodulin-binding domain with the Cys4114-Asn4142region of the type 1 ryanodine receptor is involved in the mechanism of Ca2+/agonist-induced channel activation

(2008) Jaya P. Gangopadhyay et al.   BIOCHEMICAL JOURNAL

Defective domain-domain interactions within the ryanodine receptor as a critical cause of diastolic Ca2+ leak in failing hearts

(2008) H. Tateishi et al.   CARDIOVASCULAR RESEARCH

Identification of Target Domains of the Cardiac Ryanodine Receptor to Correct Channel Disorder in Failing Hearts

(2008) Takeshi Yamamoto et al.   CIRCULATION