Journal
CARDIOVASCULAR RESEARCH
Volume 91, Issue 1, Pages 16-26Publisher
OXFORD UNIV PRESS
DOI: 10.1093/cvr/cvr012
Keywords
Extracellular matrix; Balloon angioplasty and stenting; Extracellular response; Collagen synthesis and processing
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Events contributing to restenosis after coronary interventions include platelet aggregation, inflammatory cell infiltration, growth factor release, and accumulation of smooth muscle cells (SMCs) and extracellular matrix (ECM). The ECM is composed of various collagen subtypes and proteoglycans and over time constitutes the major component of the mature restenotic plaque. The pathophysiology of collagen accumulation in the ECM during arterial restenosis is reviewed. Factors regulating collagen synthesis and degradation, including various cytokines and growth factors involved in the process, may be targets for therapies aimed at prevention of in-stent restenosis.
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