Article
Obstetrics & Gynecology
Alan Wright, Peter von Dadelszen, Laura A. Magee, Argyro Syngelaki, Ranjit Akolekar, Dave Wright, Kypros H. Nicolaides
Summary: This study examined the effect of self-declared race on serum placental growth factor (PlGF) and sFlt-1/PlGF ratio and its impact on the prediction of pre-eclampsia (PE). The results showed that compared to white women, black, South Asian, East Asian, and mixed race women had higher mean PlGF levels and lower sFlt-1/PlGF ratios.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jean Michell Santoyo, Jose Antonio Noguera, Francisco Aviles, Juan Luis Delgado, Catalina de Paco-Matallana, Virginia Perez, Isabel Hernandez
Summary: Pre-eclampsia is related to future cardiovascular disease risk, and this study aims to investigate factors and biomarkers related to endothelial dysfunction in women at high risk of pre-eclampsia who do not develop the disease. The study found that arterial pressure and oxidative stress biomarkers were significantly increased in the high-risk pre-eclampsia group, while biomarkers of inflammation and endothelial function were also significantly elevated.
Review
Biochemistry & Molecular Biology
Nataliia Sergeevna Karpova, Olga Pavlovna Dmitrenko, Tatyana Sergeevna Budykina
Summary: One of the main causes of maternal and neonatal morbidity and mortality is pre-eclampsia, characterized by a high sFlt1/PlGF ratio. Pregestational diseases in mothers may increase the risk, but few studies have looked at the connection between maternal comorbidities and the sFlt1/PlGF ratio. This review summarizes the latest information on the association between maternal pregestational diseases and the ratio of sFlt1/PlGF, as well as the link between changes in pregnancy hormones/metabolites and a high sFlt1/PlGF ratio. Debate remains on the association between the ratio and maternal disorders, calling for further research.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Acoustics
J. Binder, E. Kalafat, P. Palmrich, P. Pateisky, A. Khalil
Summary: This study aimed to investigate the value of angiogenic marker assessment in women with chronic hypertension and suspected superimposed PE. The study found that adding angiogenic markers to the traditional diagnostic criteria significantly improved the prediction of adverse outcomes for both mothers and infants. Therefore, the assessment of angiogenic markers should be considered when evaluating pregnant women with chronic hypertension.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2022)
Article
Medicine, Research & Experimental
Qi Lang, Jinyan Wei, Mengran Tian, Shudan Wei, Xiangyuan Yu, Chaochao Zhao, Jun Zhang, Bo Huang
Summary: This study demonstrates that zinc gluconate (ZG) supplementation can ameliorate the early signs, adverse pregnancy outcomes, and pathogenic processes of PE in an animal model.
Article
Obstetrics & Gynecology
A. Peguero, L. Fernandez-Blanco, E. Mazarico, L. Benitez, A. Gonzalez, L. Youssef, F. Crispi, S. Hernandez, F. Figueras
Summary: Longitudinal changes in sFlt-1 levels improve the prediction of complications and interval to delivery in women with early-onset severe pre-eclampsia.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2021)
Article
Cell Biology
Lina Bergman, Karl Bergman, Eduard Langenegger, Ashley Moodley, Stephanie Griffith-Richards, Johan Wikstrom, David Hall, Lloyd Joubert, Philip Herbst, Sonja Schell, Teelkien van Veen, Michael Belfort, Stephen Y. C. Tong, Susan Walker, Roxanne Hastie, Catherine Cluver
Summary: This project aims to establish a pre-eclampsia biobank in South Africa, focusing on phenotyping severe disease and improving understanding, prediction, and potential drug evaluation of organ complications associated with the condition.
Review
Obstetrics & Gynecology
K. E. Eddy, J. P. Vogel, R. Zahroh, M. A. Bohren
Summary: This qualitative evidence synthesis identified key factors influencing the underutilization of MgSO4 for the prevention and treatment of pre-eclampsia and eclampsia, with themes such as provider competence, health system capability, and knowledge translation. Mapping facilitators and barriers within the COM-B behavior change theory framework highlighted the complex interplay between physical and psychological capability, social and physical opportunity, and motivation. The findings from this review can guide policy and guideline development to improve the appropriate use of MgSO4 in clinical care worldwide.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2022)
Article
Obstetrics & Gynecology
Terteel Elawad, Georgia Scott, Jeffrey N. Bone, Helen Elwell, Cristina Escalona Lopez, Veronique Filippi, Marcus Green, Asma Khalil, Mai-Lei W. Kinshella, Hiten D. Mistry, Kelly Pickerill, Reshma Shanmugam, Joel Singer, Rosemarie Townsend, Eleni Z. Tsigas, Marianne Vidler, Marie-Laure Volvert, Peter von Dadelszen, Laura A. Magee
Summary: The pre-eclampsia risk factors identified by clinical practice guidelines are inconsistent with the evidence, particularly for the strongest risk factor of obesity. There is a lack of distinction between risk factors identifiable in early pregnancy and those arising later. An update of the recommended strategies is needed.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jiangnan Pei, Zhenzhen Liu, Chengjie Wang, Nan Chu, Lei Liu, Yao Tang, Haiyan Liu, Qianqian Xiang, Haidong Cheng, Mingqing Li, Weirong Gu
Summary: SIRT1 plays a significant role in the pathogenesis of pre-eclampsia, with progesterone showing better efficacy than metformin in alleviating symptoms mediated by SIRT1 deficiency.
Article
Physiology
Karla R. Castro, Karen M. Prado, Aline R. Lorenzon, Mara S. Hoshida, Eliane A. Alves, Rossana P. V. Francisco, Marcelo Zugaib, Aldilane L. X. Marques, Elaine C. O. Silva, Eduardo J. S. Fonseca, Alexandre U. Borbely, Mariana M. Veras, Estela Bevilacqua
Summary: This study found that serum factors in pregnant women with preeclampsia may impact placental morphology, viability, and secreted functional factors, while triggering endoplasmic reticulum stress and unfolded protein responses. The study also revealed molecular differences between preeclampsia and control groups.
FRONTIERS IN PHYSIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Zhen-Ling Liu, Huan-Huan Chen, Li-Li Zheng, Li-Ping Sun, Lei Shi
Summary: Angiogenesis is a complex process regulated by various molecules and plays a crucial role in tumor growth and metastasis. Targeted therapeutic research based on these molecules has led to the emergence of promising anti-angiogenic strategies in cancer therapy.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2023)
Article
Immunology
Chiara Agostinis, Gabriella Zito, Miriam Toffoli, Isabel Peterlunger, Livia Simoni, Andrea Balduit, Erica Curtolo, Alessandro Mangogna, Beatrice Belmonte, Davide Vacca, Federico Romano, Tamara Stampalija, Tiziana Salviato, Federica Defendi, Nicoletta Di Simone, Uday Kishore, Giuseppe Ricci, Roberta Bulla
Summary: C1q is essential in pregnancy, and its deficiency can lead to pregnancy failure. Anti-C1q autoantibodies are present in various diseases and in the general population. Recent evidence suggests an increased risk of PE in women undergoing ART. This study found that PE patients have lower levels of anti-C1q, and ART pregnancies showed similar levels of C1q and anti-C1q compared to PE patients. The findings suggest an immunological dysfunction at the fetal-maternal interface in ART pregnancies, with C1q deposition in placentae. Anti-C1q may have a physiological role in pregnancy.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Obstetrics & Gynecology
Nerolen Soobryan, Ajit Kumar, Jagidesa Moodley, Irene Mackraj
Summary: This study investigated the angiogenic, metabolic, and immunoregulatory profiles in hypertensive and normotensive pregnancies, revealing distinct characteristics in the spectrum of HDP in terms of angiogenic profile.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2022)
Article
Obstetrics & Gynecology
Isaac Ajadi, Kaminee Maduray, Simeon Eche, Premjith Gathiram, Irene Mackraj
Summary: This study found significantly lower serum PlGF, ET-1, and eNOS levels in PE women with HIV, while sFlt-1 levels were increased.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2021)
Article
Andrology
Sapna Ramdin, Thajasvarie Naicker, Virushka Pillay, Sanil D. Singh, Sooraj Baijnath, Blessing N. Mkhwanazi, Nalini Govender
Summary: The study found that the AVP-induced rat model of PE is reliable in mimicking the pathological changes associated with PE development in humans, providing important insights into the pathophysiology of PE.
SYSTEMS BIOLOGY IN REPRODUCTIVE MEDICINE
(2022)
Article
Psychiatry
Martins Nweke, Mshunqane Nombeko, Nalini Govender, Aderonke O. Akineplu
Summary: This systematic scoping review examined rehabilitative interventions for HIV-associated neurocognitive disorder (HAND) from 2009 to 2019. The study found limited rehabilitative options for HAND, with cognitive training and physical activity interventions showing potential effectiveness but requiring further research.
ADVANCES IN MENTAL HEALTH
(2022)
Article
Infectious Diseases
Martins Nweke, Mshunqane Nombeko, Nalini Govender, Aderonke O. Akinpelu, Adesola Ogunniyi
Summary: This study found that a 12-week aerobic exercise program can improve the quality of life of people with HIV-associated neurocognitive disorder (HAND) who are receiving antiretroviral therapy (ART), particularly in physical and psychological aspects. Exercise also helps reduce depression levels. However, to sustain the benefits, long-term physical exercise may be necessary for patients.
BMC INFECTIOUS DISEASES
(2022)
Article
Multidisciplinary Sciences
Martins Nweke, Mshunqane Nombeko, Nalini Govender, Aderonke O. Akinpelu, Maryjane Ukwuoma
Summary: This study evaluated the impact of HIV-associated neurocognitive disorder (HAND) on medication adherence, activities of daily living (ADL), quality of life, and frailty. The findings suggest that cognitive impairment is associated with poorer medication adherence, but does not significantly affect ADL and quality of life.
SCIENTIFIC REPORTS
(2022)
Correction
Infectious Diseases
Martins Nweke, Nombeko Mshunqane, Nalini Govender, Aderonke O. Akinpelu, Adesola Ogunniyi
BMC INFECTIOUS DISEASES
(2022)
Article
Rehabilitation
Martins Nweke, Mshunqane Nombeko, Nalini Govender, Aderonke Akinpelu, Maryjane Ukwuoma, Adesola Ogunniyi
Summary: This study investigated the effects of aerobic exercise on HIV-associated neurocognitive disorder (HAND). The results showed that moderate-intensity aerobic exercise could significantly reduce working memory deficit and attention deficit, indicating a positive impact on cognitive abilities.
CLINICAL REHABILITATION
(2022)
Correction
Multidisciplinary Sciences
Martins Nweke, Nombeko Mshunqane, Nalini Govender, Aderonke O. Akinpelu, Maryjane Ukwuoma
SCIENTIFIC REPORTS
(2022)
Correction
Health Care Sciences & Services
Martins Nweke, Nombeko Mshunqane, Nalini Govender, Aderonke Akinpelu, Adesola Ogunniyi
JMIR RESEARCH PROTOCOLS
(2022)
Article
Obstetrics & Gynecology
S. Ramphal, N. Govender, S. Singh, O. P. Khaliq, T. Naicker
Summary: This study provides a semi-qualitative histopathological report of dual SARS-CoV-2 and HIV infected placentae in the third trimester of Advanced Abdominal Pregnancy (AAP), showing significant pathological changes in infected placentae, especially in the group infected with both SARS-CoV-2 and HIV.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY-X
(2022)
Article
Obstetrics & Gynecology
Zamahlabangane Mtshali, Nalini Govender, Thajasvarie Naicker
Summary: This study investigates the role of circulating TGF-beta in HIV-associated pregnancy. The results show a significant downregulation of TGF-beta 3 in HIV-positive pregnant women. TGF-beta 3 is positively correlated with gestational age, birth weight, and CD4 count. These findings provide important insights into the mechanisms of HIV infection complicated by preeclampsia.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2022)
Article
Reproductive Biology
Rebecca Reddy, Virushka Pillay, Sooraj Baijnath, Sanil D. Singh, Sapna Ramdin, Thajasvarie Naicker, Nalini Govender
Summary: This study compares three different mating techniques in Sprague-Dawley rats, using pregnancy rate as the main indicator of success. It provides recommendations for timed-pregnancy experiments to achieve an appropriate sample size for the study of human pregnancy disorders. Factors such as implementing a preconditioning phase, determining the estrous cycle, using two mating strategies (Lee-Boot and Whitten effect), female-to-male mating ratios, and cohabitation duration should be considered to improve the mating success rate.
REPRODUCTIVE BIOLOGY
(2022)
Article
Psychology, Clinical
Trishka Govender, Nalini Govender, Poovendhree Reddy
Summary: The study reveals a significant association between food insecurity and risky sexual behaviors among university students, including engaging in transactional sex for money or basic material needs, and having multiple sexual partners. It suggests the need for interventions targeting the alleviation of food insecurity to reduce participation in risky sexual behaviors among university students.
INTERNATIONAL JOURNAL OF SEXUAL HEALTH
(2022)
Article
Public, Environmental & Occupational Health
Lauren Chetty, Nalini Govender, Poovendhree Reddy
Summary: The study found a low prevalence rate of TM usage in T2DM patients, with Indians being the most frequent users. Most users used TM in conjunction with prescribed medication and typically acquired TM knowledge from family members.
ADVANCES IN PUBLIC HEALTH
(2022)
Article
Medicine, General & Internal
Martins Nweke, Nombeko Mshunqane, Nalini Govender, Aderonke O. Akinpelu, Adesola Ogunniyi
Summary: This study aimed to determine the standard scores for neuropsychological tests used to detect neurocognitive disorders among individuals living with HIV in Nigeria. The results showed that gender had an impact on certain tests, while education affected most of the test results. Additionally, the scores for IHDS-MS and DST remained relatively stable, which is unfavorable in assessing the severity of cognitive impairment.
NIGERIAN POSTGRADUATE MEDICAL JOURNAL
(2022)
Review
Integrative & Complementary Medicine
Rebecca Reddy, Sooraj Baijnath, Roshila Moodley, Jagidesa Moodley, Thajasvarie Naicker, Nalini Govender
Summary: In resource-limited settings like South Africa, traditional medicine plays an important role in the treatment of pregnancy-induced hypertension. This narrative review aims to evaluate the potential use of indigenous medicinal plants from South Africa in managing hypertension during pregnancy, offering a new natural pharmaceutical option to reduce maternal and neonatal mortality and morbidity.
JOURNAL OF AYURVEDA AND INTEGRATIVE MEDICINE
(2022)
