Journal
CARDIOVASCULAR JOURNAL OF AFRICA
Volume 24, Issue 7, Pages 286-289Publisher
CLINICS CARDIVE PUBL PTY LTD
DOI: 10.5830/CVJA-2013-055
Keywords
natriuretic peptides; prognostic values; NT-pro-BNP
Categories
Funding
- European Social Funds by means of the Seetoral Operational Programme for the Development of the Human Resources [POSDRU/6/1.5/S/26]
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B-type natriuretic peptide (BNP) is a member of a four-natriuretic peptide family that shares a common 17-peptide ring structure. The N-terminal fragment (NT-pro-BNF) is biologically inert, but both are secreted in the plasma in equimolar quantities and both have been evaluated for use in the management of congestive heart failure. BNP and NT-pro-BNP are frequently used in the diagnosis of congestive heart failure and distinguishing between patients with dyspnoea of cardiac or pulmonary origin. Values of NT-pro-BNP are affected by age or the presence of one or several co-morbidities such as chronic renal failure, type 2 diabetes, and acute coronary syndrome. 'Normal' values of these peptides also vary depending on the type of test used, The performance characteristics of these tests vary depending on the patients on whom they are used and the manufacturer. For this reason, the determination of reference values for this peptide represents such a challenge.
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