NLRP3, a Potential Therapeutic Target for Type 2 Diabetes?

T Cell–Derived IL-22 Amplifies IL-1β–Driven Inflammation in Human Adipose Tissue: Relevance to Obesity and Type 2 Diabetes

(2014) Elise Dalmas et al.   DIABETES

Toll-like receptors and NLRP3 as central regulators of pancreatic islet inflammation in type 2 diabetes

(2014) Clara Westwell-Roper et al.   IMMUNOLOGY AND CELL BIOLOGY

Rosuvastatin Alleviates Diabetic Cardiomyopathy by Inhibiting NLRP3 Inflammasome and MAPK Pathways in a Type 2 Diabetes Rat Model

(2013) Beibei Luo et al.   CARDIOVASCULAR DRUGS AND THERAPY

Variants of NLRP3 gene are associated with insulin resistance in Chinese Han population with type-2 diabetes

(2013) Yingying Zheng et al.   GENE

Cathepsin B Contributes to Autophagy-related 7 (Atg7)-induced Nod-like Receptor 3 (NLRP3)-dependent Proinflammatory Response and Aggravates Lipotoxicity in Rat Insulinoma Cell Line

(2013) Shali Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Upregulated NLRP3 Inflammasome Activation in Patients With Type 2 Diabetes

(2012) Hye-Mi Lee et al.   DIABETES

The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance

(2011) Bolormaa Vandanmagsar et al.   NATURE MEDICINE

Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes

(2010) Seth L Masters et al.   NATURE IMMUNOLOGY