Article
Gastroenterology & Hepatology
Lucas Wauters, Matthias Ceulemans, Dennis Frings, Maarten Lambaerts, Alison Accarie, Joran Toth, Raf Mols, Patrick Augustijns, Gert De Hertogh, Lukas Van Oudenhove, Jan Tack, Tim Vanuytsel
Summary: This study found that the numbers of eosinophils and immune cells in the duodenum, as well as permeability, were significantly higher in patients with functional dyspepsia, and decreased after PPI therapy. In contrast, immune cells and permeability increased in healthy volunteers on PPIs.
Article
Gastroenterology & Hepatology
Chuan-Guo Guo, Feifei Zhang, Joseph T. Wu, Ka-Shing Cheung, Bofei Li, Simon Y. K. Law, Wai K. Leung
Summary: The study found a decreasing trend in upper gastrointestinal bleeding and a slight increase in lower gastrointestinal bleeding over time, especially in the elderly population. Prescriptions of PPIs and aspirin were found to be increasing and had different associations with the incidences of UGIB and LGIB.
UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
(2021)
Article
Biochemistry & Molecular Biology
Lucas Wauters, Raul Y. Tito, Matthias Ceulemans, Maarten Lambaerts, Alison Accarie, Leen Rymenans, Chloe Verspecht, Joran Toth, Raf Mols, Patrick Augustijns, Jan Tack, Tim Vanuytsel, Jeroen Raes
Summary: The study found differential mucus-associated genera between FD patients and controls, with Streptococcus positively correlating with duodenal eosinophils in controls. While short-term PPI therapy effects were unrelated to changes in the gut microbiota for FD patients, increased Streptococcus in controls was associated with duodenal PPI effects, even after long-term therapy withdrawal in FD stoppers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Pharmacology & Pharmacy
Hyo-Jeong Ahn, So-Ryoung Lee, Eue-Keun Choi, Tae-Min Rhee, Soonil Kwon, Seil Oh, Gregory Y. H. Lip
Summary: This meta-analysis found that proton-pump inhibitor (PPI) cotherapy in oral anticoagulant (OAC)-treated patients is associated with a lower risk of gastrointestinal bleeding (GIB). This protective effect is independent of ethnic group and OAC type, except for edoxaban. PPI cotherapy may be particularly beneficial for patients with high risk of GIB.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2022)
Review
Medicine, General & Internal
Siddharth Gosavi, Gokul Krishnan, Raviraja Acharya
Summary: Antiplatelet agents are widely used for the prevention of cardiovascular events, but can cause gastrointestinal bleeding. The choice of agent, timing of therapy, underlying indications, and coadministration of proton pump inhibitors should be considered to prevent the risk of bleed and rebleed incidents. Balancing the risks of cardiovascular events from stopping antiplatelet therapy is also important. This review focuses on aspirin and clopidogrel and provides guidance on the management of acute upper and lower gastrointestinal bleeding, stopping and restarting of agents, and measures to prevent recurrence.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2023)
Article
Gastroenterology & Hepatology
Riccardo Marmo, Marco Soncini, Cristina Bucci, Angelo Zullo
Summary: The study found no significant difference in the prevalence of HRS on ulcers between patients receiving or not receiving pre-endoscopic PPI therapy, but a higher prevalence of non-ulcer bleeding lesions in patients treated with PPI. PPI therapy was not an independent factor affecting HRS prevalence, while timing to endoscopy was inversely correlated with HRS prevalence in UGIB patients.
DIGESTIVE AND LIVER DISEASE
(2021)
Article
Cardiac & Cardiovascular Systems
So-Ryoung Lee, Soonil Kwon, Eue-Keun Choi, Jin-Hyung Jung, Kyung-Do Han, Seil Oh, Gregory Y. H. Lip
Summary: The study found that PPI co-therapy was significantly associated with a reduced risk of major GIB in Asian patients with atrial fibrillation who were treated with oral anticoagulants (OACs) and had a prior history of upper GIB, particularly in patients treated with rivaroxaban and warfarin.
CARDIOVASCULAR DRUGS AND THERAPY
(2022)
Article
Gastroenterology & Hepatology
Shih-Cheng Yang, Cheng-Kun Wu, Wei-Chen Tai, Chih-Ming Liang, Chih-Chien Yao, Keng-Liang Wu, Chien-Ning Hsu, Seng-Kee Chuah
Summary: The study found no significant difference in short-term major adverse cardiovascular events (MACE) and upper gastrointestinal bleeding (UGIB) recurrence between clopidogrel and aspirin in patients at risk of bleeding. However, clopidogrel use was associated with a significantly increased risk of mortality within 90 days of follow-up.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Pharmacology & Pharmacy
Toshihiko Kakiuchi
Summary: In this study, the success rate of eradicating H. pylori with VPZ-based regimens was compared between adults and children, and it was found that the success rate was lower in children, possibly due to higher enzymatic activity and shorter intestinal transit times. It is important to maintain a higher intragastric pH and reduce diarrhea to ensure the effectiveness of the therapy. Therefore, VPZ, which can suppress stomach acids more strongly, is considered a more relevant treatment for H. pylori eradication.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Britta Lotstedt, Debra Boyer, Gary Visner, Dawn Freiberger, Margot Lurie, Madeline Kane, Courtney DiFilippo, Joakim Lundeberg, Monica Narvaez-Rivas, Kenneth Setchell, Eric Alm, Rachel Rosen
Summary: This study investigated the relationship between delays in gastrointestinal motility and the diversity and composition of gastric, oropharyngeal, and lung microbiomes in pediatric lung transplant recipients. The results showed that lung transplant recipients had reduced microbial diversity in gastric fluid and oropharynx compared to patients who did not undergo lung transplantation, especially in patients with delayed gastric emptying. The study also found low microbial overlap between lung and gastric samples within patients, indicating high individual variation between lung transplant recipients.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2021)
Article
Medicine, General & Internal
Shakira Yoosuf, Caitlin G. Barrett, Konstantinos Papamichael, Sarah E. Madoff, Satya Kurada, Joshua Hansen, Jocelyn A. Silvester, Amelie Therrien, Prashant Singh, Melinda Dennis, Daniel A. Leffler, Ciaran P. Kelly
Summary: Pancreatic enzyme supplements (PES) did not improve symptoms in patients with non-responsive celiac disease (NRCD). The study aimed to assess the efficacy of PES for improvement of gastrointestinal symptoms in NRCD patients.
FRONTIERS IN MEDICINE
(2023)
Letter
Gastroenterology & Hepatology
Jian Zhao, Kun Huang, Bowen Hu
Summary: This article is linked to Li et al papers.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Review
Critical Care Medicine
Hasan M. Al-Dorzi, Yaseen M. Arabi
Summary: The incidence of stress-induced clinically important gastrointestinal bleeding in critically ill patients seems to be decreasing. Early enteral nutrition and proton pump inhibitors may be effective in preventing gastrointestinal bleeding, but questions remain regarding which patients are likely to benefit the most.
CURRENT OPINION IN CRITICAL CARE
(2021)
Article
Cardiac & Cardiovascular Systems
Masanobu Ishii, Takashi Kawai, Kenichi Tsujita, Ataru Igarashi, Manabu Suzuki, Hisato Deguchi, Jovelle Fernandez
Summary: This study assessed the cost-effectiveness of vonoprazan compared with PPIs in patients taking low-dose aspirin for secondary prevention of CV events. The results showed that vonoprazan was dominant against esomeprazole and more cost-effective than lansoprazole.
CIRCULATION JOURNAL
(2023)
Article
Medicine, General & Internal
Chris Hawkey, Anthony Avery, Carol A. C. Coupland, Colin Crooks, Jennifer Dumbleton, F. D. Richard Hobbs, Denise Kendrick, Michael Moore, Clive Morris, Gregory Rubin, Murray Smith, Diane Stevenson
Summary: This study aimed to investigate whether eradication of Helicobacter pylori would protect against aspirin-associated peptic ulcer bleeding. The results showed a significant reduction in bleeding risk during the first 2.5 years after H. pylori eradication, but this advantage diminished with longer follow-up.