Article
Cardiac & Cardiovascular Systems
Yuichi Saito, Kazuya Tateishi, Masato Kanda, Yuki Shiko, Yohei Kawasaki, Yoshio Kobayashi, Takahiro Inoue
Summary: This study reveals that there is an inverse relationship between the volume of primary, elective, and total PCI performed in hospitals and in-hospital mortality in patients with acute MI undergoing primary PCI. Additionally, a lower ratio of primary to total PCI volume is associated with higher in-hospital mortality, suggesting it as an indicator of quality of care for acute MI.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Medical Laboratory Technology
Fabio Angeli, Paolo Verdecchia, Stefano Savonitto, Sara Cavallini, Andrea Santucci, Stefano Coiro, Rocco Sclafani, Clara Riccini, Stefano De Servi, Claudio Cavallini
Summary: This study found that higher levels of sCD40L predict an increased risk of acute coronary events and coronary restenosis among patients with ACS or CCS undergoing PCI, but not of mortality.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2022)
Review
Cell Biology
Bradley Tucker, Kaivan Vaidya, Blake J. Cochran, Sanjay Patel
Summary: Periprocedural myocardial injury and myocardial infarction are common complications of percutaneous coronary intervention, associated with increased short- and long-term mortality. Inflammation levels before, during, and after the procedure are linked to higher rates of myonecrosis and future cardiovascular events. In addition to inflammation from underlying coronary disease, PCI itself triggers an acute inflammatory response.
Article
Health Care Sciences & Services
Nebojsa Antonijevic, Predrag Mitrovic, Nikola Gosnjic, Dejan Orlic, Sasa Kadija, Tanja Ilic Mostic, Nebojsa Savic, Ljubica Birovljev, Zaklina Lekovic, Dragan Matic
Summary: This case report presents the first reported case of surgery in a pregnant woman treated with dual antiplatelet therapy without discontinuation of ticagrelor. Despite insufficient platelet inhibition of ticagrelor and moderate inhibition of aspirin, a caesarean section was performed for the patient due to the need for emergency surgery, with local hemostatic measures to prevent excessive bleeding.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Kah Yong Peck, Nick Andrianopoulos, Diem Dinh, Louise Roberts, Stephen J. Duffy, Martin Sebastian, David Clark, Angela Brennan, Ernesto Oqueli, Andrew E. Ajani, Christopher M. Reid, Melanie Freeman, Andrew W. Teh
Summary: The study showed that in patients undergoing percutaneous coronary intervention for acute coronary syndrome, the use of beta blockers was associated with lower mortality rates, especially in patients with lower left ventricular ejection fraction.
Article
Medicine, General & Internal
Ratna Andriyati, Doni Firman, Yovi Kurniawati, Amir Aziz Alkatiri, Raymond Pranata, Hary Sakti Muliawan, Vienna Rossimarina, Sunarya Soerianata
Summary: In this study, 400 patients with STEMI were analyzed to compare the 2-year clinical outcomes of BP-DES and DP-DES in PPCI. The results showed that BP-DES were associated with lower incidence of MACE and ST within 2 years of follow-up. Subgroup analysis revealed that BP-DES were also linked to lower cardiac deaths compared to DP-DES.
POSTGRADUATE MEDICAL JOURNAL
(2021)
Article
Public, Environmental & Occupational Health
Luke P. Dawson, Luke Burchill, Jessica O'Brien, Diem Dinh, Stephen J. Duffy, Dion Stub, Angela Brennan, David Clark, Ernesto Oqueli, Chin Hiew, Melanie Freeman, Christopher M. Reid, Andrew E. Ajani
Summary: This study assessed differences in patient characteristics, presentations, and outcomes among Indigenous and non-Indigenous Australians undergoing PCI in urban and larger regional centers in Victoria, Australia. Indigenous patients were found to be younger, more likely to have comorbidities, but had similar procedural success and complication rates as non-Indigenous patients.
LANCET GLOBAL HEALTH
(2021)
Article
Cardiac & Cardiovascular Systems
Johanne Silvain, Michel Zeitouni, Valeria Paradies, Huili L. Zheng, Gjin Ndrepepa, Claudio Cavallini, Dimitri N. Feldman, Samin K. Sharma, Julinda Mehilli, Sebastiano Gili, Emanuele Barbato, Giuseppe Tarantini, Sze Y. Ooi, Clemens von Birgelen, Allan S. Jaffe, Kristian Thygesen, Gilles Montalescot, Heerajnarain Bulluck, Derek J. Hausenloy
Summary: The prognostic importance of cardiac procedural myocardial injury and myocardial infarction (MI) in chronic coronary syndrome (CCS) patients undergoing elective percutaneous coronary intervention (PCI) is still debated. Post-PCI cTn elevation of >= 5 x 99th percentile URL used to define Type 4a MI is associated with increased 1-year mortality in CCS patients with normal baseline cTn levels.
EUROPEAN HEART JOURNAL
(2021)
Article
Medicine, General & Internal
Yehua Wang, Larisa H. Cavallari, Joshua D. Brown, Cameron D. Thomas, Almut G. Winterstein
Summary: A retrospective cohort study was conducted to describe the trends and determinants of initial P2Y12 inhibitor choice and switching in patients undergoing PCI for ACS. It was found that the preference for prasugrel and ticagrelor as initial therapy has increased over time, while deescalation (switch to clopidogrel) has also become more common. Baseline bleeding risk was associated with initial treatment choice, but had limited association with deescalation.
Article
Medicine, General & Internal
Tobias F. S. Pustjens, Marijke J. C. Timmermans, Saman Rasoul, Arnoud W. J. van't Hof
Summary: The study found that NSTE-ACS patients with MVD undergoing MV-PCI and CO-PCI had similar mortality rates at long-term follow-up, but the MV-PCI group showed improved event-free survival in terms of fewer coronary reinterventions.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Sang Jin Ha, Se-Jun Park, Bora Lee, Hyesung Moon, Bo Young Kim
Summary: This study examined the short-and long-term prognosis of patients with and without rheumatoid arthritis (RA) who underwent percutaneous coronary intervention (PCI). The results showed that compared to non-RA patients, RA patients had a shorter median survival time from major adverse cardiovascular events (MACE) and were at an increased risk of MACE in the long-term.
Review
Medicine, General & Internal
Seung-Hyun Kim, Michael Behnes, Kambis Mashayekhi, Alexander Bufe, Markus Meyer-Gessner, Ibrahim El-Battrawy, Ibrahim Akin
Summary: Studies have shown a clear association between coronary chronic total occlusion (CTO) and adverse clinical outcomes, especially in patients with acute myocardial infarction (AMI). However, the prognostic impact of CTO-percutaneous coronary intervention (PCI) during AMI remains controversial due to the higher risk of complications compared to non-occlusive coronary lesions.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Jangho Park, Sangwoo Park, Yong-Giun Kim, Soe Hee Ann, Hyun Woo Park, Jon Suh, Jae-Hyung Roh, Young-Rak Cho, Seungbong Han, Gyung-Min Park
Summary: An analysis of National Health Insurance data in Korea showed that pre-existing depression does not have a significant impact on mortality in patients with established coronary artery disease undergoing PCI. However, younger patients with angina and depression may have a higher risk of all-cause mortality.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Lorenzo Azzalini, Milan Seth, Devraj Sukul, Javier A. Valle, Edouard Daher, Brett Wanamaker, Michael T. Tucciarone, Anwar Zaitoun, Ryan D. Madder, Hitinder S. Gurm
Summary: The COVID-19 pandemic has affected the temporal trends and outcomes of patients undergoing percutaneous coronary intervention (PCI) in Michigan, leading to a reduction in PCI volume and an increase in risk-adjusted mortality. COVID-19 positive patients experienced worse outcomes.
Article
Cardiac & Cardiovascular Systems
Mohammed M. N. Meah, Tobin Joseph, Wern Yew Ding, Matthew Shaw, Jonathan Hasleton, Nick D. Palmer, Periaswamy Velavan, Suneil K. Aggarwal
Summary: The study aimed to compare mortality in nonagenarians undergoing primary percutaneous coronary intervention (PPCI) versus medical management for myocardial infarction. The findings suggest that nonagenarians who underwent PPCI had lower mortality rates compared to those managed medically, indicating PPCI may be beneficial in this age group.
BMC CARDIOVASCULAR DISORDERS
(2021)
Article
Cardiac & Cardiovascular Systems
Antonio J. Vallejo-Vaz, Sarah Bray, Guillermo Villa, Julia Brandts, Gaia Kiru, Jennifer Murphy, Maciej Banach, Stefano De Servi, Dan Gaita, Ioanna Gouni-Berthold, G. Kees Hovingh, Jacek J. Jozwiak, J. Wouter Jukema, Robert Gabor Kiss, Serge Kownator, Helle K. Iversen, Vincent Maher, Luis Masana, Alexander Parkhomenko, Andre Peeters, Piers Clifford, Katarina Raslova, Peter Siostrzonek, Stefano Romeo, Dimitrios Tousoulis, Charalambos Vlachopoulos, Michal Vrablik, Alberico L. Catapano, Neil R. Poulter, Kausik K. Ray
Summary: In patients with atherosclerotic cardiovascular disease (ASCVD), achieving European Society of Cardiology/European Atherosclerosis Society (ESC/EAS) LDL-C goals may result in an additional 2% absolute risk reduction (ARR) over 10 years compared to the American College of Cardiology/American Heart Association (ACC/AHA) approach.
CARDIOVASCULAR DRUGS AND THERAPY
(2023)
Article
Cardiac & Cardiovascular Systems
M. T. H. M. Henkens, J. F. van Ast, A. S. J. M. te Riele, A. C. Houweling, A. S. Amin, R. Nijveldt, M. L. Antoni, X. Li, S. M. T. Wehrens, J. H. von der Thusen, K. Damman, E. N. ter Horst, O. C. Manintveld, R. Y. Abma-Schouten, H. W. M. Niessen, H. H. W. Sillje, J. W. Jukema, P. A. Doevendans
Summary: The Netherlands Heart Tissue Bank (NHTB) is a non-profit biobank that aims to enhance cardiovascular disease-related research by providing a collection of healthy and diseased human cardiac tissue and clinical data. This initiative addresses the limitations of current animal and in vitro models in understanding the pathophysiological processes underlying cardiac diseases.
NETHERLANDS HEART JOURNAL
(2023)
Article
Medicine, General & Internal
Edith M. Heintjes, Anastassia Anastassopoulou, Josephina Kuiper, Aikaterini Bilitou, Fernie J. A. Penning-van Beest, Ron M. C. Herings, Maarten J. Postma, J. Wouter Jukema
Summary: This study aimed to investigate the treatment patterns, LDL-C levels and healthcare resource utilization of patients with hypercholesterolaemia or mixed dyslipidaemia at high or very high cardiovascular risk in the Netherlands in 2018. The findings revealed suboptimal treatment with the majority of patients receiving statin monotherapy and only a small percentage receiving combination therapy. Alternative treatment strategies are required to further lower cardiovascular risk.
CURRENT MEDICAL RESEARCH AND OPINION
(2023)
Article
Biochemistry & Molecular Biology
Tariq O. Faquih, N. Ahmad Aziz, Sarah L. Gardiner, Ruifang Li-Gao, Renee de Mutsert, Yuri Milaneschi, Stella Trompet, J. Wouter Jukema, Frits R. Rosendaal, Astrid van Hylckama Vlieg, Ko Willems van Dijk, Dennis O. Mook-Kanamori
Summary: Based on the data from three European cohorts, this study found that non-pathogenic CAG repeat sizes below 36 in the HTT gene are associated with abnormal metabolite levels, which may be mediated through lower BMI.
HUMAN MOLECULAR GENETICS
(2023)
Article
Cardiac & Cardiovascular Systems
Gali Albalak, Marjon Stijntjes, David van Bodegom, J. Wouter Jukema, Douwe E. Atsma, Diana van Heemst, Raymond Noordam
Summary: Morning physical activity is associated with lower risks of incident cardiovascular diseases, irrespective of total physical activity.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Alberico L. Catapano, Raffaele De Caterina, J. Wouter Jukema, Robert Klempfner, Ulf Landmesser, Francois Schiele, Alessandro Sionis
Summary: The ACS EuroPath III project was conducted to improve LDL-C management for post-ACS patients. Five areas of improvement were identified, including developing a standardized GP discharge letter and treatment algorithm.
CLINICAL CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Gregory G. Schwartz, Michael Szarek, Deepak L. Bhatt, Vera A. Bittner, Maja Bujas-Bobanovic, Rafael Diaz, Sergio Fazio, Zlatko Fras, Shaun G. Goodman, Robert A. Harrington, J. Wouter Jukema, Garen Manvelian, Robert Pordy, Kausik K. Ray, Michel Scemama, Harvey D. White, Ph Gabriel Steg
Summary: Long-term placebo-controlled trials have shown clinical benefits that persist after the end of the trial. This study aims to investigate whether similar effects can be seen with short-term very low low-density lipoprotein cholesterol (LDL-C) levels achieved using statin and proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor therapy.
EUROPEAN HEART JOURNAL
(2023)
Article
Geriatrics & Gerontology
Dennis van Erck, Michel Terbraak, Christine D. D. Dolman, Peter J. M. Weijs, Jose P. Henriques, Ronak Delewi, Lotte Verweij, Patricia Jepma, Wilma J. M. Scholte Op Reimer, Josje D. D. Schoufour
Summary: Referral rates for home-based cardiac rehabilitation (HBCR) are low among older and frailer patients due to healthcare professionals' low expectations. This study aimed to determine adherence to HBCR in referred old and frail patients, and explore any differences in baseline characteristics between adherent and nonadherent patients.
Article
Biochemistry & Molecular Biology
Jose A. Inia, Geurt Stokman, Elsbet J. Pieterman, Martine C. Morrison, Aswin L. Menke, Lars Verschuren, Martien P. M. Caspers, Martin Giera, J. Wouter Jukema, Anita M. van den Hoek, Hans M. G. Princen
Summary: Patients with metabolic syndrome are often prescribed statins to prevent cardiovascular disease, but their effects on NASH are lacking. This study found that atorvastatin can significantly reduce hepatic steatosis, inflammation, and fibrosis, as well as prevent cholesterol crystal formation and NLRP3 inflammasome activation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Genetics & Heredity
Amar D. Levens, Melina C. den Haan, J. Wouter Jukema, Mette Heringa, Wilbert B. van den Hout, Dirk Jan A. R. Moes, Jesse J. Swen
Summary: Tailoring antiplatelet therapy based on CYP2C19 pharmacogenetic testing can improve cardiovascular outcomes and reduce healthcare costs. To evaluate the feasibility of CYP2C19-guided de-escalation of prasugrel/ticagrelor to clopidogrel, a proof-of-concept study was conducted in community pharmacies. The study found that community pharmacies are a suitable location for point-of-care PGx testing and the majority of patients and pharmacists view it as valuable.
Review
Cardiac & Cardiovascular Systems
Nina Ajmone Marsan, Francesca Graziani, Maria Chiara Meucci, Hoi W. Wu, Rosa Lillo, Jeroen J. Bax, Francesco Burzotta, Massimo Massetti, J. Wouter Jukema, Filippo Crea
Summary: Cardiomyopathies and valvular heart diseases often coexist and have shared etiology, leading to important prognostic and therapeutic implications. Understanding their pathophysiological mechanisms and improving the classification of these diseases could lead to a different approach in clinical management and personalized treatment.
NATURE REVIEWS CARDIOLOGY
(2023)
Letter
Cardiac & Cardiovascular Systems
Shaun G. Goodman, Philippe Gabriel Steg, Yann Poulouin, Deepak L. Bhatt, Vera A. Bittner, Rafael Diaz, Genevieve Garon, Robert A. Harrington, J. Wouter Jukema, Garen Manvelian, Wanda Stipek, Michael Szarek, Harvey D. White, Gregory G. Schwartz
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Medicine, General & Internal
Elma J. Peters, Sanne ten Berg, Margriet Bogerd, Marijke J. C. Timmermans, Adriaan O. Kraaijeveld, Jeroen J. H. Bunge, Koen Teeuwen, Erik Lipsic, Krischan D. Sjauw, Robert-Jan M. van Geuns, Admir Dedic, Eric A. Dubois, Martijn Meuwissen, Peter Danse, Niels J. W. Verouden, Gabe Bleeker, Jose M. Montero Cabezas, Irlando A. Ferreira, Annemarie E. Engstrom, Wim K. Lagrand, Luuk C. Otterspoor, Alexander P. J. Vlaar, Jose P. S. Henriques
Summary: Cardiogenic shock complicating acute myocardial infarction is associated with high morbidity and mortality. Patients who did not survive had lower blood pressure, increased heart rate, blood lactate, and blood glucose levels. The presence of diabetes, multivessel coronary artery disease, and prior coronary events also increased the risk of mortality.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Jussi Schultz, Inge J. van den Hoogen, Jurrien H. Kuneman, Michiel A. de Graaf, Vasileios Kamperidis, Alexander Broersen, J. Wouter Jukema, Antonis Sakellarios, Sotirios Nikopoulos, Konstantina Tsarapatsani, Katerina Naka, Lampros Michalis, Dimitrios Fotiadis, Teemu Maaniitty, Antti Saraste, Jeroen J. Bax, Juhani Knuuti
Summary: This study evaluated CCTA-based ESS values in coronary arteries without atherosclerosis and identified factors affecting ESS values. The findings showed that ESS was highest in the left anterior descending artery and lower in men compared to women, even after adjusting for lumen diameter. ESS values were also highest in small segments and had a correlation with the distance from the ostium.
INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING
(2023)
Review
Geriatrics & Gerontology
Michelle H. Zonneveld, Denise Abbel, Saskia le Cessie, J. Wouter Jukema, Raymond Noordam, Stella Trompet
Summary: This systematic review examined the association between cardiac troponin, cognitive function, and dementia. The findings suggest that elevated troponin is associated with cognitive impairment, increased risk of dementia, and higher prevalence of dementia hospitalization, specifically due to vascular dementia.
