Article
Cardiac & Cardiovascular Systems
Christina Christersson, Tomasz Baron, Frank Flachskampf, Lars Lindhagen, Bertil Lindahl, Agneta Siegbahn
Summary: A proportion of ACS patients will experience progressive remodeling of the LV. This study identified important biomarkers associated with reduced LV function early and 1 year after ACS, providing insights into the biological processes involved in long-term heart failure after ACS.
JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH
(2023)
Article
Medicine, Research & Experimental
Xuan Wang, Yi Hu, Hao Luan, Chaodi Luo, Tingting Zheng, Gang Tian
Summary: This study investigated the predictive value of fibrinogen-to-albumin ratio (FAR) for left ventricular systolic dysfunction (LVSD) in patients with acute coronary syndromes (ACS). The results showed a significant association between FAR and LVSD, indicating that FAR is an important predictor for LVSD.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Patoomporn Prasatthong, Sariya Meephat, Siwayu Rattanakanokchai, Juthamas Khamseekaew, Sarawoot Bunbupha, Parichat Prachaney, Putcharawipa Maneesai, Poungrat Pakdeechote
Summary: Galangin showed potential in alleviating signs of metabolic syndrome and cardiac abnormalities in rats under a high-fat diet, possibly through suppressing inflammation and oxidative stress and restoring gene expression related to these disorders.
Article
Cardiac & Cardiovascular Systems
Hong Wang, Rongrong Wang, Junping Tian
Summary: This study found a correlation between admission serum calcium and left ventricular dysfunction in patients with acute coronary syndrome (ACS). Lower serum calcium levels were associated with elevated B-type natriuretic peptide (BNP) and reduced left ventricular ejection fraction (LVEF). However, no significant correlation was found between low serum calcium and left ventricular systolic dysfunction in ACS patients.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Health Care Sciences & Services
Federico Marin, Michele Pighi, Federico Zucchelli, Alessandro Ruzzarin, Giulio Russo, Cristina Aurigemma, Enrico Romagnoli, Valeria Ferrero, Anna Piccoli, Roberto Scarsini, Gabriele Pesarini, Carlo Trani, Francesco Burzotta, Flavio Luciano Ribichini
Summary: This study aims to assess the predictors and prognostic role of left ventricle ejection fraction (LVEF) recovery after Impella-supported PCI in patients with acute myocardial infarction (AMI). The study found that complete functional revascularization is an independent predictor of LVEF recovery, and the recovery of LV function is associated with improved prognosis.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Nick S. R. Lan, Bu B. Yeap, P. Gerry Fegan, Gillian Green, James M. Rankin, Girish Dwivedi
Summary: Sodium-glucose cotransporter 2 inhibitors have shown potential to improve heart failure outcomes, but their effects on left ventricular function post-ACS in patients with type 2 diabetes were unclear. A prospective observational study found that initiating empagliflozin therapy after ACS in T2D patients was associated with favorable changes in LV diastolic function parameters, suggesting the potential benefits of adding empagliflozin to ACS therapy in this patient population.
INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING
(2021)
Article
Cardiac & Cardiovascular Systems
Jacob Sama, Dhananjay Vaidya, Monica Mukherjee, Marlene Williams
Summary: Depression is associated with heart failure independent of traditional cardiovascular disease risk factors. Enhanced platelet activation may play a role in this relationship. However, the presence of LV dysfunction is similar in depressed and non-depressed patients, suggesting alternative factors contribute to poor cardiovascular outcomes in depressed patients independent of LV function post ACS.
JOURNAL OF THROMBOSIS AND THROMBOLYSIS
(2021)
Article
Cell Biology
Friedrich Reusswig, Amin Polzin, Meike Klier, Matthias Achim Dille, Aysel Ayhan, Marcel Benkhoff, Celina Lersch, Anika Prinz, Simone Gorressen, Jens Walter Fischer, Malte Kelm, Margitta Elvers
Summary: Platelets play a crucial role in thrombosis and inflammation after acute myocardial infarction (AMI). Acute thrombocytopenia can reduce infarct size and improve cardiac function, while chronic thrombocytopenia does not have a protective effect on heart function.
Article
Medicine, Research & Experimental
Kecheng Zhang, Guangren Gao, Yanjiao Guo, Jing Liang, Chunyan Li, Peitian Han, Lijie Wang, Zijian Wang, Wenzhou Wang, Wenhui Li
Summary: This study revealed a close relationship between changes in Gal-3 levels and left ventricular function of patients with acute coronary syndrome after PCI treatment. Gal-3 levels were found to be correlated with LVEDD and LVEF. Therefore, Gal-3 can be used as an indicator for early diagnosis and disease treatment.
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
(2021)
Article
Hematology
Niema Kazem, Felix Hofer, Lorenz Koller, Andreas Hammer, Christian Hengstenberg, Alexander Niessner, Patrick Sulzgruber
Summary: In patients aged 65 and older, lymphocyte fraction, neutrophil fraction, and neutrophil-to-lymphocyte ratio were strongly and independently associated with mortality, indicating their potential as prognostic markers. Conversely, no significant effects were observed in patients under 65 years old. These findings suggest age-specific cellular immunity markers can aid in identifying high-risk individuals and informing proper secondary prevention strategies after ACS.
THROMBOSIS AND HAEMOSTASIS
(2021)
Article
Cardiac & Cardiovascular Systems
Roland Klingenberg, Soheila Aghlmandi, Lorenz Raeber, Alexander Akhmedov, Baris Gencer, David Carballo, David Nanchen, Heiner C. Bucher, Nicolas Rodondi, Francois Mach, Stephan Windecker, Ulf Landmesser, Arnold von Eckardstein, Christian W. Hamm, Thomas F. Luescher, Christian M. Matter
Summary: This study found that the novel biomarker CCN1 can predict adverse outcomes in patients with acute coronary syndromes, adding incremental value to the GRACE risk score, suggesting distinct underlying molecular mechanisms.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Review
Cell Biology
Kyoko Komai, Nicholas K. Kawasaki, Jason K. Higa, Takashi Matsui
Summary: Ferroptosis is an iron-dependent form of regulated cell death characterized by dysfunction of the GPX4 antioxidant system. Inhibiting ferroptosis restores cardiac function and provides protection against I/R injury.
Article
Cardiac & Cardiovascular Systems
Jan Traub, Paula Schuermann, Dominik Schmitt, Tobias Gassenmaier, Georg Fette, Stefan Frantz, Stefan Stoerk, Niklas Beyersdorf, Valerie Boivin-Jahns, Roland Jahns, Ulrich Hofmann, Anna Frey
Summary: This study analyzed the relationships between BMI, other components of metabolic syndrome, and inflammatory markers with left ventricular geometry, function, and infarct size after ST-elevation MI. The results showed that BMI, HbA1c, and peak CRP were independent predictors of worse LVEF early after MI, while only peak CRP predicted worse LVEF at later stages.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Article
Multidisciplinary Sciences
Michal Kukla, Tomasz Menzyk, Marcin Dembinski, Marek Winiarski, Aleksander Garlicki, Monika Bociaga-Jasik, Magdalena Skonieczna, Dorota Hudy, Barbara Maziarz, Beata Kusnierz-Cabala, Lubomir Skladany, Ivica Grgurevic, Malgorzata Wojcik-Bugajska, Tomasz Grodzicki, Dominika Stygar, Tomasz Rogula
Summary: Chemerin and omentin levels were significantly decreased in COVID-19 patients compared to healthy controls, but did not correlate with disease severity. Elevated GGT activity may be the only predictive factor for a more severe COVID-19 course.
SCIENTIFIC REPORTS
(2021)
Article
Cardiac & Cardiovascular Systems
Tobias Harm, Alexander Bild, Kristina Dittrich, Andreas Goldschmied, Jeremy Nestele, Madhumita Chatterjee, Xiaoqing Fu, Kyra Kolb, Tatsiana Castor, Oliver Borst, Tobias Geisler, Dominik Rath, Michael LaeMmerhofer, Meinrad Gawaz
Summary: The study revealed significant changes in the platelet lipidome in ACS patients, with a particular up-regulation of glycerophospholipids. These lipid alterations may play a role in the pathophysiology of ACS.
CARDIOVASCULAR RESEARCH
(2022)