Article
Biophysics
Yuanlin Zhang, Ehsan Ranaei Pirmardan, Hua Jiang, Aliaa Barakat, Ali Hafezi-Moghadam
Summary: Diabetic retinopathy (DR) is a severe organ manifestation of diabetes that can lead to irreversible vision decline. Researchers developed an adhesive fluorescent nanoprobe with high brightness, which selectively targeted vascular endothelial growth factor receptor 2 (VEGFR-2) in diabetic microvessels. In vivo results showed that the nanoprobes adhered to retinal microvessels and were visualized as bright spots, indicating their potential for early diagnosis of DR.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Medicine, Research & Experimental
Ishfaq Ahmad Rather, Nadeem Khan, Ajay Singh Kushwah, Gurunath Surampalli, Manish Kumar
Summary: This study evaluated the potential of Hon in treating diabetic nephropathy (DN) and the possible molecular mechanisms. The results showed that Hon had a positive effect in attenuating the symptoms of DN and improving renal function, possibly by attenuating endoplasmic reticulum stress and the Rock pathway.
Article
Multidisciplinary Sciences
Mengwei Li, Limei Zhang, Xinyan Liu, Guoqiang Wang, Jian Lu, Jifeng Guo, Hongjie Wang, Jinpeng Xu, Yi Zhang, Na Li, You Zhou
Summary: This study found that low-intensity exercise training can improve the heart function and structure of spontaneously hypertensive rats by inhibiting the RhoA/ROCK signaling pathway, providing further evidence for this protective effect.
SCIENTIFIC REPORTS
(2022)
Article
Pharmacology & Pharmacy
Xiaojing Yang, Wu Luo, Li Li, Xiang Hu, Mingjiang Xu, Yi Wang, Jianpeng Feng, Jianchang Qian, Xinfu Guan, Yunjie Zhao, Guang Liang
Summary: This study demonstrated that inhibiting CDK9 can reduce inflammatory cytokines and fibrogenic genes in the kidneys of diabetic mice, leading to improved renal function. Deficiency in CDK9 can also prevent glucose-induced inflammatory and fibrogenic proteins, suggesting CDK9 as a potential therapeutic target for diabetic nephropathy.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2021)
Article
Cell Biology
Michael H. Radke, Victor Badillo-Lisakowski, Thiago Britto-Borges, Dieter A. Kubli, Rene Juettner, Pragati Parakkat, Jacobo Lopez Carballo, Judith Huettemeister, Martin Liss, Arne Hansen, Christoph Dieterich, Adam E. Mullick, Michael Gotthardt
Summary: HFpEF is a prevalent and deadly heart disease for which no targeted therapy has been established. Research has shown that ASOs targeting the cardiac splice factor RBM20 can improve cardiac function and alleviate symptoms of heart failure. Experimental evidence demonstrates that this approach can promote the expression of compliant titin isoforms over a period of 2 months and has been validated in human heart tissue.
SCIENCE TRANSLATIONAL MEDICINE
(2021)
Editorial Material
Cardiac & Cardiovascular Systems
Olufunke O. Arishe, R. Clinton Webb
Summary: This editorial discusses a study on the effects of VE-PTP inhibition on endothelial dysfunction and hypertension in patients with diabetes.
CARDIOVASCULAR RESEARCH
(2021)
Review
Peripheral Vascular Disease
Ferdinand A. C. le Noble, Jean-Jacques Mourad, Bernard I. Levy, Harry A. J. Struijker-Boudier
Summary: Drugs inhibiting VEGF have been widely used in cancer treatment, but they often cause cardiovascular side effects, with hypertension being the most frequently observed. This review explores the mechanism behind VEGF inhibitor-induced hypertension, focusing on microvascular rarefaction, which is supported by evidence from experimental and clinical studies.
Article
Biochemistry & Molecular Biology
Luqing Song, Tao Wu, Li Zhang, Jin Wan, Zheng Ruan
Summary: The phenolic acid CGA can protect the intestinal barrier by inhibiting ROCK/MLCK signaling pathways and relieving ER stress. Three other substances were also found to stabilize intestinal homeostasis.
Article
Endocrinology & Metabolism
Vladimira Fejfarova, Jiri Matuska, Edward Jude, Pavlina Pithova, Milan Flekac, Karel Roztocil, Veronika Woskova, Michal Dubsky, Alexandra Jirkovska, Robert Bem, Jitka Husakova, Vera Lanska
Summary: The study aimed to enhance the diagnosis of peripheral arterial disease (PAD) in diabetic foot patients using a transcutaneous oximetry (TcPO2) stimulation test. Results showed that stimulation test could effectively detect the disease conditions in patients.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Yan Qiu, Stanley Buffonge, Raina Ramnath, Sophie Jenner, Sarah Fawaz, Kenton P. Arkill, Chris Neal, Paul Verkade, Stephen J. White, Melanie Hezzell, Andrew H. J. Salmon, M-Saadeh Suleiman, Gavin Welsh, Rebecca R. Foster, Paolo Madeddu, Simon C. Satchell
Summary: Diabetic cardiomyopathy is a serious complication of diabetes that is characterized by diastolic dysfunction and can progress to heart failure. This study suggests that damage to the endothelial glycocalyx in the coronary microcirculation may contribute to increased microvascular permeability and impaired cardiac function in diabetes.
Article
Physiology
Andrew M. Roberts, Nayeem Z. Moulana, Rekha Jagadapillai, Lu Cai, Evelyne Gozal
Summary: The study suggests that diabetes mellitus affects pulmonary microcirculation through reducing nitric oxide bioavailability, increasing precapillary arteriolar tone, and causing endothelial injury. These findings may potentially lead to ventilation-perfusion abnormalities and exacerbate systemic diabetes complications.
JOURNAL OF APPLIED PHYSIOLOGY
(2021)
Article
Cell Biology
Hang Xing, Zhiqi Zhang, Guangbin Shi, Yixin He, Yi Song, Yuhong Liu, Elizabeth O. Harrington, Frank W. Sellke, Jun Feng
Summary: Diabetes is associated with coronary endothelial dysfunction, which can be partly attributed to persistent oxidative stress and mitochondrial generation of reactive oxygen species. Inhibition of small-conductance Ca2+-activated K+ channels in diabetes contributes to the downregulation of endothelial function. Chronic administration of the mitochondria-targeted antioxidant mito-Tempo shows promising results in improving coronary endothelial function and SK channel activity in diabetic mice, suggesting that targeting mROS may be a novel strategy for treating vascular complications in diabetes.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Ekaterina K. Selivanova, Anastasia A. Shvetsova, Lyubov D. Shilova, Olga S. Tarasova, Dina K. Gaynullina
Summary: Intrauterine growth restriction (IUGR) can lead to cardiovascular consequences in adulthood, affecting vasomotor control and increasing the risk of cardiac disorders by altering the expression of vasoactive factors like NO and Rho-kinase.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Jianchang Qian, Fei Zhuang, Yujing Chen, Xinrong Fan, Jun Wang, Zhe Wang, Yi Wang, Mingjiang Xu, Aleksandr Samorodov, Valentin N. Pavlov, Guang Liang
Summary: The study reveals that the MD2 inhibitor C30 has therapeutic effects on diabetic cardiomyopathy by inhibiting p38MAPK and activating AMPK pathway, resulting in improved cardiac function and reduced cardiomyocyte apoptosis and cardiac fibrosis.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2022)
Review
Cardiac & Cardiovascular Systems
Rajan Rehan, Andy Yong, Martin Ng, James Weaver, Rajesh Puranik
Summary: The coronary microcirculation is crucial in regulating coronary blood flow to meet the changing metabolic demands of the myocardium. Coronary microvascular dysfunction (CMD) refers to the remodeling of the coronary microcirculation, and it plays a role in the pathogenesis of various cardiovascular diseases. CMD is often overlooked in clinical practice despite recent diagnostic advancements, but it holds potential for the development of new therapeutic targets. This review explores the diagnosis and pathogenic role of CMD, its prognostic significance, and the current therapeutic landscape.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Neurosciences
Toru Kawada, Yusuke Sata, Tsuyoshi Akiyama, Shuji Shimizu, Takashi Sonobe, James T. Pearson, Masaru Sugimachi
AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL
(2020)
Letter
Cardiac & Cardiovascular Systems
Feby Savira, Amanda J. Edgley, Beat M. Jucker, Robert N. Willette, Henry Krum, Darren J. Kelly, Andrew R. Kompa, Bing H. Wang
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Letter
Cardiac & Cardiovascular Systems
Feby Savira, Andrew R. Kompa, Amanda J. Edgley, Beat M. Jucker, Robert N. Willette, Darren J. Kelly, Bing H. Wang
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Article
Medicine, Research & Experimental
James T. Pearson, Hamish P. Thambyah, Mark T. Waddingham, Tadakatsu Inagaki, Vijayakumar Sukumaran, Jennifer P. Ngo, Connie P. C. Ow, Takashi Sonobe, Yi Ching Chen, Amanda J. Edgley, Yutaka Fujii, Cheng-Kun Du, Dong-Yun Zhan, Keiji Umetani, Darren J. Kelly, Hirotsugu Tsuchimochi, Mikiyasu Shirai
Summary: A high salt intake exacerbates insulin resistance and induces hypertension due to systemic perivascular inflammation, oxidative-nitrosative stress, and endothelial dysfunction. Treatment with ACE inhibitors and ARBs can alleviate inflammation and redox stress, but only partially restore endothelial function in mesenteric vessels. In male Goto-Kakizaki (GK) and Wistar rats, combination of high salt intake and insulin resistance leads to coronary microvessel endothelial dysfunction, which was restored by CAR and MET treatment, despite ongoing inflammation and oxidative-nitrosative stress.
Article
Medicine, Research & Experimental
Feby Savira, Andrew R. Kompa, Ruth Magaye, Xin Xiong, Li Huang, Beat M. Jucker, Robert N. Willette, Darren J. Kelly, Bing H. Wang
Summary: The study showed that Indoxyl sulfate (IS) impairs endothelium-dependent vasorelaxation and endothelial cell migration, while inhibition of apoptosis signal regulating kinase 1 (ASK1) can alleviate these effects and promote autocrine interleukin 8 (IL-8) pro-angiogenic signaling.
Article
Pharmacology & Pharmacy
Takashi Sonobe, Tsuyoshi Akiyama, James T. Pearson
Summary: This study used microdialysis technique to investigate the contribution of carrier-mediated 5-HT efflux to the elevation of interstitial 5-HT levels in the heart during myocardial ischemia. The results showed that reverse transport of 5-HT via SERT, caused by impaired ion gradients, plays a significant role in the increase of interstitial 5-HT during ischemia. Pharmacological agents such as sodium cyanide, ouabain, and reserpine were found to induce a rise in 5-HT levels in the dialysate, suggesting the presence of carrier-mediated 5-HT efflux in the heart.
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
(2021)
Article
Multidisciplinary Sciences
Ryotaro Asano, Takeshi Ogo, Yoshiaki Morita, Akiyuki Kotoku, Tatsuo Aoki, Kyoko Hirakawa, Sayuri Nakayama, Jin Ueda, Akihiro Tsuji, Mark T. Waddingham, Yasutoshi Ohta, Tetsuya Fukuda, Keiko Ohta-Ogo, Hatsue Ishibashi-Ueda, Teruo Noguchi, Satoshi Yasuda
Summary: The study found that native T1 values of the right ventricular free wall were significantly higher in patients with pulmonary arterial hypertension compared to controls, and were better correlated with right ventricular elastance, ventricular-arterial uncoupling, and serum brain natriuretic peptide levels. Additionally, baseline RVT1 was an accurate predictor of reduced right ventricular ejection fraction at 12-month follow-up and independently associated with composite events of death or hospitalization. This suggests that native T1 mapping in the right ventricular free wall may be an effective prognostic method for pulmonary arterial hypertension.
Article
Physiology
Mark T. Waddingham, Hirotsugu Tsuchimochi, Takashi Sonobe, Ryotaro Asano, Huiling Jin, Connie P. C. Ow, Daryl O. Schwenke, Rajesh Katare, Kohki Aoyama, Keiji Umetani, Masato Hoshino, Kentaro Uesugi, Mikiyasu Shirai, Takeshi Ogo, James T. Pearson
Summary: Majority of the conventional techniques used for investigating the pathogenesis of cardiovascular disease in animal models do not allow for microlevel assessment of in situ cardiomyocyte and microvascular functions. Thus, it has been challenging to determine whether cardiac dysfunction in complex multiorgan disease states originates from microvascular dysfunction or cardiomyocytes. This study describes the use of synchrotron radiation microangiography to assess the vasodilator effects of hexarelin and its ability to prevent right ventricle dysfunction in pulmonary hypertension. The findings reveal the potential of synchrotron-based imaging approaches in understanding cardiac and coronary functions in vivo.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Neurosciences
Takashi Sonobe, Hirotsugu Tsuchimochi, Hisashi Maeda, James T. Pearson
Summary: In type 2 diabetes, endothelium-dependent hyperpolarization (EDH)-mediated vasodilation is reduced, leading to impaired blood flow redistribution during exercise. Low-intensity exercise training can enhance the role of KCa channels in the endothelium-dependent vasodilatory mechanisms, thereby improving vascular and blood flow responses in diabetic patients.
JOURNAL OF PHYSIOLOGY-LONDON
(2022)
Article
Peripheral Vascular Disease
Takeshi Tokudome, Kentaro Otani, Yuanjie Mao, Lars Jorn Jensen, Yuji Arai, Takahiro Miyazaki, Takashi Sonobe, James T. Pearson, Tsukasa Osaki, Naoto Minamino, Junji Ishida, Akiyoshi Fukamizu, Hayato Kawakami, Daisuke Onozuka, Kunihiro Nishimura, Mikiya Miyazato, Hirohito Nishimura
Summary: This study revealed the crucial role of vascular endothelial NPR1 in ANP-mediated blood pressure regulation. ANP lowers blood pressure by activating potassium channels and modulating G-protein signaling pathways in endothelial cells. Furthermore, ANP's blood pressure regulation depends on RGS2 in the acute phase but is independent of RGS2 in the chronic phase.
Article
Physiology
Takashi Sonobe, Tsuyoshi Akiyama, James T. Pearson
Summary: This study investigated the roles of the serotonin transporter (SERT) and plasma membrane monoamine transporter (PMAT) in the uptake and metabolism of serotonin (5-HT) in the heart. The results showed that both SERT and PMAT regulate the levels of 5-HT in the myocardium through uptake, but 5-HT uptake via PMAT leads to metabolism by monoamine oxidase (MAO).
JOURNAL OF PHYSIOLOGICAL SCIENCES
(2022)
Article
Physiology
Mark T. Waddingham, Vasco Sequeira, Diederik W. D. Kuster, Elisa Dal Canto, M. Louis Handoko, Frances S. de Man, Denielli da Silva Goncalves Bos, Coen A. Ottenheijm, Shengyi Shen, Robbert J. Van Der Pijl, Jolanda Van Der Velden, Walter J. Paulus, Etto C. Eringa
Summary: The study found that oral treatment with geranylgeranylacetone (GGA) can lower cardiomyocyte stiffness and improve left ventricular diastolic dysfunction in the cardiometabolic syndrome.
PHYSIOLOGICAL REPORTS
(2023)
Meeting Abstract
Peripheral Vascular Disease
James Pearson, Huiling Jin, Mark Waddingham, Takashi Sonobe, Hisashi Maeda, Jennifer Ngo, Connie Ow, Vijayakumar Sukumaran, Takeshi Ogo, Mikiyasu Shirai, Hirotsugu Tsuchimochi, Hatsue-Ishibash Ueda
JOURNAL OF HYPERTENSION
(2021)