Dual renin-angiotensin system inhibition for prevention of renal and cardiovascular events: do the latest trials challenge existing evidence?

ALTITUDE Trial and Dual RAS Blockade: The Alluring but Soft Science of the Surrogate End Point

(2013) Franz H. Messerli et al.   AMERICAN JOURNAL OF MEDICINE

Meta-analysis: Effect of Monotherapy and Combination Therapy with Inhibitors of the Renin–Angiotensin System on Proteinuria in Renal Disease

(2013) Regina Kunz et al.   ANNALS OF INTERNAL MEDICINE

Systematic Review: Comparative Effectiveness of Angiotensin-Converting Enzyme Inhibitors or Angiotensin II–Receptor Blockers for Ischemic Heart Disease

(2013) William L. Baker   ANNALS OF INTERNAL MEDICINE

Effect of Telmisartan on Renal Outcomes

(2013) Johannes F.E. Mann   ANNALS OF INTERNAL MEDICINE

Is there benefit in dual renin– angiotensin–aldosterone system blockade? No, yes and maybe: A guide for the perplexed

(2013) Jencia Wong   Diabetes & Vascular Disease Research

Effect of Aliskiren on Postdischarge Mortality and Heart Failure Readmissions Among Patients Hospitalized for Heart Failure

(2013) Mihai Gheorghiade et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

To RAS or Not to RAS? The Evidence for and Cautions with Renin-Angiotensin System Inhibition in Patients with Diabetic Kidney Disease

(2013) Wendy L. St. Peter et al.   PHARMACOTHERAPY

The Safety and Short-Term Efficacy of Aliskiren in the Treatment of Immunoglobulin A Nephropathy – A Randomized Cross-Over Study

(2013) Cheuk-Chun Szeto et al.   PLoS One

Diabetes mellitus y riesgos del bloqueo dual del sistema renina-angiotensina-aldosterona

(2013) Ferrán Catalá-López et al.   REVISTA ESPANOLA DE CARDIOLOGIA

Efficacy and safety of dual blockade of the renin-angiotensin system: meta-analysis of randomised trials

(2013) H. Makani et al.   BMJ-British Medical Journal

What is a preferred angiotensin II receptor blocker-based combination therapy for blood pressure control in hypertensive patients with diabetic and non-diabetic renal impairment?

(2012) Samir G Mallat   Cardiovascular Diabetology

Combinations of Renin-Angiotensin-Aldosterone System Antagonists:True Advantages?

(2012) Franco Veglio et al.   CURRENT PHARMACEUTICAL DESIGN

The Effect of Direct Renin Inhibition Alone and in Combination With ACE Inhibition on Endothelial Function, Arterial Stiffness, and Renal Function in Type 1 Diabetes

(2012) D. Z. I. Cherney et al.   DIABETES CARE

Aliskiren, ALTITUDE, and the implications for ATMOSPHERE

(2012) John J.V. McMurray et al.   EUROPEAN JOURNAL OF HEART FAILURE

Additive renoprotective effects of aliskiren on angiotensin receptor blocker and calcium channel blocker treatments for type 2 diabetic patients with albuminuria

(2012) Masanori Abe et al.   HYPERTENSION RESEARCH

Combination therapy an ACE inhibitor and an angiotensin receptor blocker for IgA nephropathy: a meta-analysis

(2012) J. Cheng et al.   INTERNATIONAL JOURNAL OF CLINICAL PRACTICE

Inhibition of the renin–angiotensin–aldosterone system

(2012) Massimo Volpe et al.   JOURNAL OF HYPERTENSION

Dual inhibition of the renin–angiotensin system in high-risk diabetes and risk for stroke and other outcomes

(2012) Johannes F.E. Mann et al.   JOURNAL OF HYPERTENSION

Cardiorenal End Points in a Trial of Aliskiren for Type 2 Diabetes

(2012) Hans-Henrik Parving et al.   NEW ENGLAND JOURNAL OF MEDICINE

Beneficial Effects on Arterial Stiffness and Pulse-Wave Reflection of Combined Enalapril and Candesartan in Chronic Kidney Disease - A Randomized Trial

(2012) Marie Frimodt-Møller et al.   PLoS One

The safety of combining angiotensin-converting-enzyme inhibitors with angiotensin-receptor blockers in elderly patients: a population-based longitudinal analysis

(2011) F. A. McAlister et al.   CANADIAN MEDICAL ASSOCIATION JOURNAL

Cardiovascular and Renal Outcomes With Telmisartan, Ramipril, or Both in People at High Renal Risk

(2011) Sheldon W. Tobe et al.   CIRCULATION

Hyperkalemia and Renal Function During Monotherapy and Dual Renin-Angiotensin Blockade in the Community Setting

(2011) Daniel Kurnik et al.   CLINICAL THERAPEUTICS

Effect of the direct renin inhibitor aliskiren on left ventricular remodelling following myocardial infarction with systolic dysfunction

(2011) Scott D. Solomon et al.   EUROPEAN HEART JOURNAL

Neurohumoral effects of aliskiren in patients with symptomatic heart failure receiving a mineralocorticoid receptor antagonist: the Aliskiren Observation of Heart Failure Treatment study

(2011) Bertram Pitt et al.   EUROPEAN JOURNAL OF HEART FAILURE

Suppression of aldosterone mediates regression of left ventricular hypertrophy in patients with hypertension

(2011) Anne-Catherine Pouleur et al.   JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM

Combination inhibition of the renin–angiotensin system: is more better?

(2011) Michelle W. Krause et al.   KIDNEY INTERNATIONAL

Angiotensin-converting enzyme inhibitors, angiotensin receptor blockers and combined therapy in patients with micro- and macroalbuminuria and other cardiovascular risk factors: a systematic review of randomized controlled trials

(2011) A. Maione et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Role of the Intrarenal Renin-Angiotensin-Aldosterone System in Chronic Kidney Disease

(2010) Helmy M. Siragy et al.   AMERICAN JOURNAL OF NEPHROLOGY

Changes of Matrix Metalloproteinase-9 Level Is Associated With Left Ventricular Remodeling Following Acute Myocardial Infarction Among Patients Treated With Trandolapril, Valsartan or Both

(2010) Sakiko Miyazaki et al.   CIRCULATION JOURNAL

Patients with acute coronary syndromes and elevated levels of natriuretic peptides: the results of the AVANT GARDE-TIMI 43 Trial

(2010) Benjamin M. Scirica et al.   EUROPEAN HEART JOURNAL

Of fads, fashion, surrogate endpoints and dual RAS blockade

(2010) F. H. Messerli et al.   EUROPEAN HEART JOURNAL

Effects of Telmisartan Added to Angiotensin-Converting Enzyme Inhibitors on Mortality and Morbidity in Hemodialysis Patients With Chronic Heart Failure

(2010) Gennaro Cice et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Meta-Analysis of Combined Therapy with Angiotensin Receptor Antagonists versus ACE Inhibitors Alone in Patients with Heart Failure

(2010) Andrea Kuenzli et al.   PLoS One

Reappraisal of European guidelines on hypertension management: a European Society of Hypertension Task Force document

(2009) Giuseppe Mancia et al.   BLOOD PRESSURE

Effect of the Direct Renin Inhibitor Aliskiren, the Angiotensin Receptor Blocker Losartan, or Both on Left Ventricular Mass in Patients With Hypertension and Left Ventricular Hypertrophy

(2009) Scott D. Solomon et al.   CIRCULATION

Design of Combination Angiotensin Receptor Blocker and Angiotensin-Converting Enzyme Inhibitor for Treatment of Diabetic Nephropathy (VA NEPHRON-D)

(2009) L. F. Fried et al.   Clinical Journal of the American Society of Nephrology

Renal Effects of Aliskiren Compared With and in Combination With Irbesartan in Patients With Type 2 Diabetes, Hypertension, and Albuminuria

(2009) F. Persson et al.   DIABETES CARE

The Sudden Demise of Dual Renin-Angiotensin System Blockade or the Soft Science of the Surrogate End Point

(2009) Franz H. Messerli   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Albuminuria and Kidney Function Independently Predict Cardiovascular and Renal Outcomes in Diabetes

(2009) T. Ninomiya et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Feasibility of combined treatment with enalapril and candesartan in advanced chronic kidney disease

(2009) M. Frimodt-Moller et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Effects of Dual Blockade of Renin-Angiotensin System on Concentric Left Ventricular Hypertrophy in Essential Hypertension: a Randomized, Controlled Pilot Study

(2008) A. M. Grandi et al.   AMERICAN JOURNAL OF HYPERTENSION

Antiproteinuric Response to Dual Blockade of the Renin-Angiotensin System in Primary Glomerulonephritis: Meta-analysis and Metaregression

(2008) Fausta Catapano et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

Effects of the Oral Direct Renin Inhibitor Aliskiren in Patients With Symptomatic Heart Failure

(2008) John J.V. McMurray et al.   Circulation-Heart Failure

Dual renin–angiotensin system blockade: In patients with single functioning kidney and proteinuria

(2008) N.R. Robles et al.   European Journal of Internal Medicine

Safety and Tolerability of Angiotensin-Converting Enzyme Inhibitor Versus the Combination of Angiotensin-Converting Enzyme Inhibitor and Angiotensin Receptor Blocker in Patients With Left Ventricular Dysfunction: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

(2008) Rachid Lakhdar et al.   JOURNAL OF CARDIAC FAILURE

Renal outcomes with telmisartan, ramipril, or both, in people at high vascular risk (the ONTARGET study): a multicentre, randomised, double-blind, controlled trial

(2008) Johannes FE Mann et al.   LANCET

Aliskiren Combined with Losartan in Type 2 Diabetes and Nephropathy

(2008) Hans-Henrik Parving et al.   NEW ENGLAND JOURNAL OF MEDICINE

Effect of a Multifactorial Intervention on Mortality in Type 2 Diabetes

(2008) Peter Gæde et al.   NEW ENGLAND JOURNAL OF MEDICINE