Article
Radiology, Nuclear Medicine & Medical Imaging
Suzanne M. Wong, Phoebe Luo, Benjamin Keunen, Samuel Pichardo, James M. Drake, Adam C. Waspe
Summary: An adaptive targeting algorithm was developed for real-time correction of misplanned hyperthermia treatments, improving the accuracy and precision of MRgHIFU therapy.
Article
Radiology, Nuclear Medicine & Medical Imaging
Anastasia Antoniou, Nikolas Evripidou, Leonidas Georgiou, Antreas Chrysanthou, Cleanthis Ioannides, Christakis Damianou
Summary: This study presents the development and evaluation of a tumor-bearing tissue phantom model for testing MRgFUS ablation protocols and equipment. The results suggest that the proposed tumor phantom model is a simple and inexpensive tool for preclinical MRgFUS ablation studies.
Article
Multidisciplinary Sciences
Chien-Feng Judith Huang, Win-Li Lin, San-Chao Hwang, Ching Yao, Hsu Chang, Yung-Yaw Chen, Li-Wei Kuo
Summary: This study introduces a wireless inductively coupled surface (WICS) coil design for MRgHIFU ablation on a clinical 3 T MRI system. Ex vivo and in vivo experiments were performed to evaluate the temperature accuracy improvement of the WICS coil.
SCIENTIFIC REPORTS
(2022)
Review
Engineering, Biomedical
Vismaya S. Bachu, Jayanidhi Kedda, Ian Suk, Jordan J. Green, Betty Tyler
Summary: HIFU is an emerging and increasingly useful modality in the treatment of cancer and other diseases, using high-energy ultrasound pulses to target specific areas while minimizing damage to surrounding tissues. Its wide applications across various tumor types and organ systems, along with its potential future pathways, highlight the growing importance of this technology in biomedical fields.
ANNALS OF BIOMEDICAL ENGINEERING
(2021)
Article
Oncology
Yi Zhao, Shuang Luo, Yanglu Liu, Yuchun He, Xiaofang Liu, Guohua Huang, Jia He
Summary: This study compared the clinical efficacy of High intensity-focused ultrasound (HIFU) for different types of adenomyosis. The results showed that HIFU treatment was effective for all types of adenomyosis, with better therapeutic outcomes for type III patients compared to the other three types.
INTERNATIONAL JOURNAL OF HYPERTHERMIA
(2023)
Article
Oncology
S. Ambrogio, R. M. Baesso, F. Bosio, F. Fedele, K. Ramnarine, B. Zeqiri, P. Miloro
Summary: This study presents a new HIFU test object that provides temperature measurement in a reference material compatible with MR and ultrasound. The test object demonstrated stability and validity during a 12-month testing period, making it a useful tool for evaluating device performance. The study also highlighted potential limitations of existing QA and monitoring methods, emphasizing the importance of temperature monitoring along the entire acoustic path.
INTERNATIONAL JOURNAL OF HYPERTHERMIA
(2022)
Review
Biochemistry & Molecular Biology
Loreto B. Feril, Rodney L. Fernan, Katsuro Tachibana
Summary: High-intensity focused ultrasound (HIFU) is a non-invasive method of ablating malignant tumors, with growing interest in its clinical application for breast cancer treatment. Despite technical challenges and limited clinical studies, HIFU is considered safe and potentially the preferred treatment option for most breast cancer patients in the future.
CURRENT MEDICINAL CHEMISTRY
(2021)
Article
Immunology
Qin Zhong, Fei Tang, Tingting Ni, Yanping Chen, Yuncong Liu, Jing Wu, Wen Zhou, Zhiyu Feng, Xiaokai Lu, Shisheng Tan, Yu Zhang
Summary: This study retrospectively analyzed the outcomes of 153 patients with residual/recurrent cervical cancer in a previously irradiated field who received HIFU treatment. The results showed that HIFU treatment can improve local control rate and extend survival with minimal adverse events.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Engineering, Environmental
Tianzhi Liu, Qian Wan, Chao Zou, Mengjie Chen, Gang Wan, Xin Liu, Hangrong Chen
Summary: This study demonstrates the sophisticated combination of smart mesoporous nanocarriers and the MR-FUS technique for precise regulation of drug release kinetics. Utilizing temperature control and phase transition mechanisms, the efficiency of multi-modal drug release is enhanced, showing significant tumor growth inhibition in in vivo experiments.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Qinghua Yang, Xiaoying Zhang
Summary: This study aimed to evaluate the efficacy and safety of HIFU for the ablation of RAE. The results showed that HIFU effectively and safely ablated 65 lesions in 56 patients with only 1 case of recurrence during an 84-month follow-up.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2023)
Article
Urology & Nephrology
Alexis Rompre-Brodeur, Gautier Marcq, Come Tholomier, Ioana Fugaru, Oleg Loutochin, Maurice Anidjar, Franck Bladou
Summary: This study evaluated the role of systematic control biopsies following HIFU-PGA treatment for Cs-PCa patients, finding residual Cs-PCa in up to a third of patients within one year of systematic control biopsy. Systematic control biopsies should be offered to all patients regardless of PSA kinetics or control mpMRI results based on our early experience.
JOURNAL OF UROLOGY
(2021)
Article
Engineering, Manufacturing
Weidong Liu, Benxin Wu
Summary: While micromachining SiC remains challenging, HIFU-based UWLM process shows potential in improving machining rate and quality, and solves issues in laser machining process through in-situ ultrasound cleaning effect.
JOURNAL OF MANUFACTURING PROCESSES
(2023)
Article
Physiology
Shangying Hu, Yuhang Liu, Rongsheng Chen, Zhibo Xiao
Summary: The combination of MRI and USg-HIFU shows clinical value in diagnosing and treating abdominal wall endometriosis. MRI is useful for identifying lesion location, size, and treatment efficacy, with higher ablation rates associated with better remission and lower recurrence rates.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Brian H. H. Lang, Yu-Cho Woo, Keith Wan-Hang Chiu
Summary: The study demonstrated that the combination of high-intensity focused ultrasound (HIFU) ablation with percutaneous ethanol injection (PEI) was significantly more effective in treating benign thyroid nodules over a 6-month period compared to HIFU ablation alone. Importantly, this combined approach did not compromise patient safety and comfort.
EUROPEAN RADIOLOGY
(2021)
Article
Acoustics
Shaojian Mo, Jinyun Chen, Rong Zhang, Chao Yang, Ting Wang, Li Chen, Wenzhi Chen
Summary: This study aimed to evaluate the feasibility, safety, and therapeutic effects of high-intensity focused ultrasound ablation (HIFUA) in the treatment of post-operative recurrent desmoid tumors. The results showed that HIFUA can be used as an effective minimally invasive therapy for the local control of post-operative recurrent desmoid tumors.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2022)
Letter
Medicine, General & Internal
Pieter Vermeersch, Frederic Cotton, Dieter De Smet, Geert Martens, Matthijs Oyaert, Etienne Cavalier
ACTA CLINICA BELGICA
(2022)
Article
Clinical Neurology
Salem Hannoun, Gabriel Kocevar, Pekes Codjia, Delphine Maucort-Boulch, Francois Cotton, Sandra Vukusic, Francoise Durand-Dubief, Dominique Sappey-Marinier
Summary: Longitudinal analysis of T1-weighted images in multiple sclerosis patients over 4 years showed no significant signal intensity increases in the dentate nuclei and subcortical gray matter structures with cumulative administration of the macrocyclic gadolinium-based contrast agent, gadoterate meglumine.
CLINICAL NEURORADIOLOGY
(2022)
Article
Medicine, General & Internal
Axelle Gilles, Sebastian Vermeersch, Pieter Vermeersch, Fleur Wolff, Frederic Cotton, Sebastien Tilleux, David Cassiman
Summary: Acute hepatic porphyrias are a group of rare and severe diseases with limited treatment options, impacting an estimated 11-34 patients in Belgium. An expert consensus statement on the current status of AHP in Belgium was drafted by EPNet centers in collaboration with Alnylam Pharmaceuticals. This statement provides an overview of AHP pathophysiology, clinical manifestations, burden of disease, epidemiology, treatments, and proposed organization of care.
ACTA CLINICA BELGICA
(2022)
Article
Clinical Neurology
Salem Hannoun, Gabriel Kocevar, Pekes Codjia, Berardino Barile, Francois Cotton, Francoise Durand-Dubief, Dominique Sappey-Marinier
Summary: The study aimed to determine if T1/T2 ratio measurements can accurately detect cerebral white matter microstructural damage in RRMS patients compared to healthy controls. Results showed significant differences between RRMS and HC in both DTI and T1/T2 ratio measurements, highlighting the potential clinical use of T1/T2 ratio in evaluating WM abnormalities in the brain.
JOURNAL OF NEUROIMAGING
(2022)
Article
Clinical Neurology
Alexandre Bani-Sadr, Marie-Camille Ruitton-Allinieu, Jean-Christophe Brisset, Francois Ducray, Bastien Joubert, Geraldine Picard, Francois Cotton
Summary: This study aimed to determine whether diffusion-weighted imaging (DWI) can help distinguish early-stage autoimmune (AI) encephalitis from herpes simplex virus (HSV) encephalitis. By comparing the MRIs of patients from a multi-center cohort of AI encephalitis and a single-center of HSV encephalitis, it was found that restricted diffusion lesions in the medial temporal lobe are a characteristic of HSV encephalitis and can aid in distinguishing it from early-stage AI encephalitis.
JOURNAL OF NEURORADIOLOGY
(2023)
Letter
Hematology
Anne-Sophie Adam, Melanie Vaes, Frederic Cotton, Beatrice Gulbis
INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY
(2023)
Letter
Rehabilitation
Shams Ribault, Ahmed Adham, Francois Cotton, Lisette Arsenault, Ludovic Delporte, Nicolas Chatron, Gaetan Lesca, Patrick Edery, Gilles Rode
ANNALS OF PHYSICAL AND REHABILITATION MEDICINE
(2022)
Article
Engineering, Biomedical
Baptiste Pialot, Celestine Lachambre, Antonio Lorente Mur, Lionel Augeul, Lorena Petrusca, Adrian Basarab, Francois Varray
Summary: In this study, a new denoising method called the Coherence Factor Mask (CFM) is proposed for ultrafast power Doppler (UPD) imaging. The CFM filter combines singular value decomposition (SVD) and spatiotemporal coherence information to effectively reduce electronic noise and improve image quality. Experimental results show that the CFM filter outperforms standard UPD and other existing denoising methods.
PHYSICS IN MEDICINE AND BIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Nicolas Duchateau, Magalie Viallon, Lorena Petrusca, Patrick Clarysse, Nathan Mewton, Loic Belle, Pierre Croisille
Summary: We propose a new method to characterize myocardial injury at a pixel resolution using statistical tools from computational anatomy. Our study demonstrated the feasibility of this method in a randomized clinical trial, and showed its potential to reveal subtle differences in lesion patterns.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Lorena Petrusca, Pierre Croisille, Lionel Augeul, Michel Ovize, Nathan Mewton, Magalie Viallon
Summary: This study aimed to investigate the mechano-transduction effects induced by shock waves therapy as a non-invasive cardioprotective approach in treating acute myocardial infarction. The results showed that shock waves therapy can reduce the ischemia-reperfusion lesion size and improve left ventricular function.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Computer Science, Interdisciplinary Applications
Valentine Wargnier-Dauchelle, Thomas Grenier, Francoise Durand-Dubief, Francois Cotton, Michael Sdika
Summary: The lack of interpretability of deep learning hinders its use in critical fields like medicine. This paper proposes a new weakly supervised method for interpretable healthy vs pathological classification and anomaly detection, which includes a new loss function and constrained training to reveal pathological structures and provide more accurate classification and anomaly detection.
IEEE TRANSACTIONS ON MEDICAL IMAGING
(2023)
Article
Clinical Neurology
Florent Cluse, Tanguy Fenouil, Sandra Vukusic, Francois Ducray, Francois Cotton, Romain Marignier, Francoise Durand-Dubief
Summary: This study described the clinical, radiological, pathological, and follow-up characteristics of 13 pseudocystic inflammatory demyelinating lesions (PIDLs) in 9 MS patients. PIDLs often occurred at first event, were often asymptomatic, and showed distinctive MRI features. Biopsies revealed classical features of active MS except for unusual edema. The easily recognizable MRI features of PIDLs could help avoid biopsy.
MULTIPLE SCLEROSIS JOURNAL
(2023)
Article
Acoustics
Baptiste Pialot, Lionel Augeul, Lorena Petrusca, Francois Varray
Summary: This study introduces a simplified and accelerated algorithm called pSVD for filtering tissue and noise in UPD images. pSVD significantly decreases the running time of SVD without impacting the quality of UPD images.
Article
Cardiac & Cardiovascular Systems
Manon Desgres, Bruna Lima Correa, Lorena Petrusca, Gwennhael Autret, Chloe Pezzana, Celine Marigny, Chloe Guillas, Valerie Bellamy, Jose Vilar, Marie-Cecile Perier, Florent Dingli, Damarys Loew, Camille Humbert, Jerome Larghero, Guillaume Churlaud, Nisa Renault, Pierre Croisille, Albert Hagege, Jean-Sebastien Silvestre, Philippe Menasche
Summary: Intravenously-injected extracellular vesicles derived from cardiac progenitor cells (EV-CPC) have cardio-protective effects which may provide a new therapeutic option for chemotherapy-induced cardiomyopathy (CCM).
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Manon Desgres, Lorena Petrusca, Gwennhael Autret, Chloe Pezzana, Celine Marigny, Ashley Peuffier, Valerie Bellamy, Pierre Croisille, Albert Hagege, Bertrand Tavitian, Jean-Sebastien Silvestre, Philippe Menasche