Article
Multidisciplinary Sciences
William T. N. Culp, Eric G. Johnson, Michelle A. Giuffrida, Robert B. Rebhun, James K. Cawthra, Heidi A. Schwanz, Jenna H. Burton, Michael S. Kent
Summary: This study describes the use of a novel drug-eluting microsphere in transarterial chemoembolization for dogs with non-resectable hepatic neoplasia. The results show significant reduction in tumor volume and improvement in clinical signs.
Article
Immunology
Fei Song, Cheng-Gui Wang, Jia-Zhen Mao, Tian-Lun Wang, Xiao-Liang Liang, Chen-Wei Hu, Yu Zhang, Lu Han, Zhong Chen
Summary: This study analyzed PANoptosis-associated genes in hepatocellular carcinoma (HCC) and identified 69 differentially expressed genes (HPAN_DEGs) in HCC. Three HCC subtypes were discovered, and the role of these genes in tumor growth, immune infiltration, and drug resistance was investigated. The findings provide valuable insights for personalized therapeutic strategy development in HCC.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Ying Zhao, Nan Wang, Jingjun Wu, Qinhe Zhang, Tao Lin, Yu Yao, Zhebin Chen, Man Wang, Liuji Sheng, Jinghong Liu, Qingwei Song, Feng Wang, Xiangbo An, Yan Guo, Xin Li, Tingfan Wu, Ai Lian Liu
Summary: The study investigated the role of CE-MRI radiomics analysis in predicting the response to TACE in HCC patients, showing that the combined three-phase radiomics model and clinical-radiological model provided better predictive ability, offering a promising tool for individualized follow-up and treatment guidance in HCC patients.
FRONTIERS IN ONCOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Charlotte Ebeling Barbier, Femke Heindryckx, Hans Lennernaes
Summary: Clinical data review highlights the limitations of transarterial chemoembolization (TACE) as a treatment for hepatocellular carcinoma (HCC) and the complex interactions between drug delivery, tumor targeting mechanisms, liver pathophysiology, patient and tumor heterogeneity, and resistance mechanisms. Understanding and addressing these factors are essential to improving the effectiveness of TACE and developing novel drug delivery systems for locoregional treatment of HCC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jae Seok Bae, Jeong Min Lee, Jeong Hee Yoon, Hyo-Jin Kang, Sun Kyung Jeon, Ijin Joo, Kyoung Bun Lee, Haeryoung Kim
Summary: The study compared the diagnostic performance of LI-RADS TRA using CT versus HBA-enhanced MRI in evaluating tumor viability in patients with hepatocellular carcinoma. The results showed that HBA-enhanced MRI was more sensitive than CT in detecting viable HCC, with similar specificity between the two imaging modalities.
Review
Oncology
Tushar Garg, Apurva Shrigiriwar, Peiman Habibollahi, Mircea Cristescu, Robert P. Liddell, Julius Chapiro, Peter Inglis, Juan C. Camacho, Nariman Nezami
Summary: Hepatocellular carcinoma is the most common liver cancer, and transarterial therapies play a crucial role in patient management. This article reviews the different types of transarterial therapies and discusses the pre-procedural, intra-procedural, and post-procedural patient management, along with a review of the literature.
Article
Immunology
Mengzhou Guo, Feng Qi, Qianwen Rao, Jialei Sun, Xiaojing Du, Zhuoran Qi, Biwei Yang, Jinglin Xia
Summary: This study demonstrated that serum levels of LAG-3 and PD-L1 were elevated in HCC patients, with high pre-TACE LAG-3 level associated with poorer prognosis, and patients with high levels of both LAG-3 and PD-L1 showing shorter overall survival.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Gastroenterology & Hepatology
Ling Li, Yicheng Zhang, Yang Zhou, Haijie Hu, Yizong Hu, Christos Georgiades, Hai-Quan Mao, Florin M. Selaru
Summary: Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related mortality worldwide. Current therapies for Barcelona Clinic Liver Cancer (BCLC)-B patients have shown minimal improvement in clinical outcomes. This study identified bortezomib (BTZ) as a highly cytotoxic small molecule for HCC and designed sustained release BTZ nanoparticles (BTZ-NP) that showed a release of BTZ over 30 days. In vivo tests demonstrated that BTZ-NP effectively controlled tumor size and improved survival in three animal models, making it a promising localized treatment for HCC.
Review
Oncology
Khalid I. Bzeizi, Mohammad Arabi, Negar Jamshidi, Ali Albenmousa, Faisal M. Sanai, Waleed Al-Hamoudi, Saad Alghamdi, Dieter Broering, Saleh A. Alqahtani
Summary: DEB-TACE treatment shows better objective response, disease control, and lower all-cause mortality with fewer severe complications compared to C-TACE, while not demonstrating clear superiority in complete or partial response, disease stability, or controlling disease progression.
Article
Engineering, Biomedical
Minjiang Chen, Gaofeng Shu, Xiuling Lv, Xiaoling Xu, Chenying Lu, Enqi Qiao, Shiji Fang, Lin Shen, Nannan Zhang, Jun Wang, Chunmiao Chen, Jingjing Song, Zhuang Liu, Yongzhong Du, Jiansong Ji
Summary: A PT/DOX-MS microsphere was developed in this study, which showed superior efficacy in treating HCC by co-delivering doxorubicin and PT-2385. The microsphere exhibited multiple mechanisms to inhibit tumor growth, including blocking tumor cell cycle, promoting cell apoptosis, and inhibiting tumor angiogenesis.
Article
Nanoscience & Nanotechnology
Lingwei Liu, Jialang Zhuang, Jizhou Tan, Ting Liu, Wenzhe Fan, Yuanqing Zhang, Jiaping Li
Summary: Transcatheter arterial chemoembolization (TACE) is the preferred treatment for intermediate hepatocellular carcinoma (HCC). However, there are still challenges in effectively targeting cancer cells without damage to normal liver cells. Researchers have developed multifunctional nanoparticles using a simple solvothermal method, which can achieve both photothermal effects and low pH-triggered drug release. The results demonstrate that these nanoparticles have high efficacy and biocompatibility for HCC treatment.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Engineering, Biomedical
Sera Hong, Won Seok Choi, Baskaran Purushothaman, Jaemoon Koh, Hyo-Cheol Kim, Jin Wook Chung, Joon Myong Song, Jin Woo Choi
Summary: Through the technique of transparent tissue imaging, this study provides the first elucidation of the role of anti-cancer drugs in transarterial chemoembolization (TACE). The results indicate that the drugs have limited penetration distance and induce extensive tumor necrosis. Drug loading does not significantly affect immune responses. These findings are significant for a better understanding of drug delivery mechanisms in TACE and reevaluation of drug use in this procedure.
ACTA BIOMATERIALIA
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Dongdong Xia, Qiuhe Wang, Wei Bai, Enxin Wang, Zhexuan Wang, Wei Mu, Junhui Sun, Ming Huang, Guowen Yin, Hailiang Li, Hui Zhao, Chunqing Zhang, Jing Li, Jianbing Wu, Xiaoli Zhu, Shufa Yang, Xingnan Pan, Jiaping Li, Zixiang Li, Guohui Xu, Haibin Shi, Hui Zhang, Yuelin Zhang, Rong Ding, Hui Yu, Lin Zheng, Xiaohu Yang, Guangchuan Wang, Nan You, Long Feng, Shuai Zhang, Wukui Huang, Tao Xu, Wenzhe Fan, Xueda Li, Xuegang Yang, Weizhong Zhou, Wenjun Wang, Xiaomei Li, Zhengyu Wang, Bohan Luo, Jing Niu, Jie Yuan, Yong Lv, Kai Li, Wengang Guo, Zhanxin Yin, Daiming Fan, Jielai Xia, Guohong Han
Summary: The relationship between initial/best objective response rate (ORR) and tumor burden was investigated in patients with unresectable hepatocellular carcinoma (HCC) undergoing transarterial chemoembolization (TACE). The results showed that both initial and best ORR were associated with tumor burden and could predict overall survival (OS) in patients with low/intermediate tumor burden. However, only best ORR exhibited qualified surrogacy in patients with high tumor burden.
EUROPEAN RADIOLOGY
(2022)
Review
Pharmacology & Pharmacy
Philippe Icard, Luca Simula, Zherui Wu, Diana Berzan, Philippe Sogni, Anthony Dohan, Raphael Dautry, Antoine Coquerel, Hubert Lincet, Mauro Loi, David Fuks
Summary: Hepatocellular carcinoma is the third leading cause of cancer death in men globally, with poor prognosis and limited sensitivity to conventional treatments. Targeting the Warburg effect to increase drug delivery into tumors may improve treatment effectiveness.
DRUG RESISTANCE UPDATES
(2021)
Article
Chemistry, Multidisciplinary
Chengrui Zhong, Yi Niu, Wenwu Liu, Yichuan Yuan, Kai Li, Yunxing Shi, Zhiyu Qiu, Keren Li, Zhu Lin, Zhenkun Huang, Dinglan Zuo, Zhiwen Yang, Yadi Liao, Yuanping Zhang, Chenwei Wang, Jiliang Qiu, Wei He, Yunfei Yuan, Binkui Li
Summary: This study identifies S100A9 as a key driver for post-TACE HCC progression by promoting mitochondrial fission and reactive oxygen species production. Higher S100A9 levels are associated with worse prognosis in HCC patients.