Review
Oncology
Noriyuki Umakoshi, Yusuke Matsui, Koji Tomita, Mayu Uka, Takahiro Kawabata, Toshihiro Iguchi, Takao Hiraki
Summary: This review summarizes the current evidence on image-guided thermal ablation therapies for extrahepatic metastases from hepatocellular carcinoma (HCC). Local ablative therapies, such as radiofrequency ablation, microwave ablation, and cryoablation, can be used in select patients for curative or palliative intent. The local control rate of thermal ablation therapy is relatively favorable, at approximately 70-90% in various organs.
Article
Oncology
Taiyang Zuo, Wenli Lin, Fengyong Liu, Jinshun Xu
Summary: The artificial pneumothorax technique is a feasible, safe, and efficient method for treating pulmonary metastases from HCC contiguous with the mediastinum.
Article
Radiology, Nuclear Medicine & Medical Imaging
Hang Zheng, Kaiwen Liu, Yao Yang, Bo Liu, Xinya Zhao, Yong Chen, Yuemin Feng, Min Meng, Xu Tan, Qiang Zhu
Summary: Compared to RFA, MWA showed better tumor control for subcapsular HCC within the Milan criteria. There was no difference in the incidence of major complications between the two groups.
EUROPEAN RADIOLOGY
(2022)
Review
Surgery
Moustafa Abdalla, Amelia T. T. Collings, Rebecca Dirks, Edwin Onkendi, Daniel Nelson, Ahmad Ozair, Emily Miraflor, Faique Rahman, Jake Whiteside, Mihir M. M. Shah, Subhashini Ayloo, Ahmed Abou-Setta, Iswanto Sucandy, Ali Kchaou, Samuel Douglas, Patricio Polanco, Timothy Vreeland, Joseph Buell, Mohammed T. T. Ansari, Aurora D. D. Pryor, Bethany J. J. Slater, Ziad Awad, William Richardson, Adnan Alseidi, D. Rohan Jeyarajah, Eugene Ceppa
Summary: This study compared laparoscopic versus percutaneous microwave ablation (MWA) and MWA versus radiofrequency ablation (RFA) in the treatment of hepatocellular carcinoma (HCC) and colorectal liver metastases (CRLM) lesions smaller than 5 cm. The meta-analyses showed that laparoscopic MW ablation had higher complication rates compared to a percutaneous approach, while MWA and RFA had similar outcomes for both HCC and CRLM lesions. However, more high-quality studies are needed to make definitive conclusions.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Oncology
Hidekatsu Kuroda, Tomoaki Nagasawa, Yudai Fujiwara, Hiroki Sato, Tamami Abe, Yohei Kooka, Kei Endo, Takayoshi Oikawa, Kei Sawara, Yasuhiro Takikawa
Summary: Microwave ablation using Thermosphere(TM) technology showed similar overall survival and recurrence-free survival outcomes compared to radiofrequency ablation for hepatocellular carcinoma. Despite no significant differences in survival outcomes between the two methods, microwave ablation required fewer insertions, making it a recommended treatment option for tumors larger than 2 cm.
Article
Surgery
Hong Jae Jeon, Hyuk Soo Eun, In Sun Kwon, Byung Seok Lee, Eaum Seok Lee, Woo Sun Rou, Jae Kyu Sung, Hee Seok Moon, Sun Hyung Kang, Hyun Seok Lee, Seok-Hwan Kim, Kwangsik Chun, Seok Hyun Kim
Summary: This study compared the therapeutic outcomes of laparoscopic radiofrequency ablation (LRFA) and percutaneous radiofrequency ablation (PRFA) in patients with hepatocellular carcinoma (HCC). The results revealed that LRFA was associated with longer recurrence-free survival and favorable overall survival compared to PRFA. Therefore, LRFA should be considered as the primary therapy for eligible HCC patients.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Review
Oncology
Yasunori Minami, Tomoko Aoki, Satoru Hagiwara, Masatoshi Kudo
Summary: Thermal ablation therapy, including RFA and MWA, is a widely used treatment for hepatocellular carcinomas. It achieves good outcomes with minimal invasiveness. Successful thermal ablation therapy requires understanding the principles and characteristics of the treatment, assessing the benefits and risks, precise needle control and visualization, utilizing imaging guidance techniques, and evaluating therapeutic response. This overview provides essential information for the clinical application of thermal ablation.
Article
Radiology, Nuclear Medicine & Medical Imaging
Yi Yang, Yi Chen, Feng Ye, Xiaojing Cao, Yujing Xin, Yanan Wang, Yong Lei, Xiao Li, Duiping Feng, Xiang Zhou, Qingsheng Fan
Summary: This study aimed to identify risk factors and develop a model to predict recurrence-free survival after radiofrequency ablation (RFA) for hepatocellular carcinoma (HCC) within the Milan criteria. Results showed male gender, multiple tumors, and cirrhosis as independent risk factors for late recurrence. Late recurrence is mainly attributed to de novo HCC in the context of cirrhosis.
EUROPEAN RADIOLOGY
(2021)
Article
Oncology
Qingsong Deng, Minglian He, Chunchuan Fu, Kai Feng, Kuansheng Ma, Leida Zhang
Summary: Radiofrequency ablation (RFA) is an effective treatment method for hepatocellular carcinoma (HCC), with characteristics of being minimally invasive, safe, and having good local tumor control ability. With technological advancements, RFA is playing an increasingly important role in the comprehensive treatment of HCC.
INTERNATIONAL JOURNAL OF HYPERTHERMIA
(2022)
Article
Gastroenterology & Hepatology
Hideyuki Tamai, Jumpei Okamura
Summary: The study showed that the new generation microwave thermosphere ablation (MTA) could provide safer and more curative treatment for small hepatocellular carcinoma (HCC) in a shorter ablation time compared to radiofrequency ablation (RFA). The MTA group had significantly lower 3-year local tumor progression rate and total complication rate than the RFA group.
CLINICAL AND MOLECULAR HEPATOLOGY
(2021)
Article
Oncology
Sooyeon Kim, Jungsue Lee, Chai Hong Rim
Summary: This meta-analysis investigates the benefits of local treatment for oligometastasis in hepatocellular carcinoma (HCC) and finds that it significantly improves survival rates and outcomes.
Article
Surgery
Tomoki Ryu, Yuko Takami, Yoshiyuki Wada, Shin Sasaki, Hajime Imamura, Hiroki Ureshino, Hideki Saitsu
Summary: This study retrospectively reviewed 81 patients with multifocal hepatocellular carcinoma who underwent combined hepatectomy and microwave ablation, finding an overall survival rate of 54% at 5 years. The major complication rate post-surgery was 10%, with certain factors like des-gamma-carboxy prothrombin level and tumor characteristics identified as independent risk factors for survival outcomes. The study concludes that the combined procedure is safe and feasible for selected patients with multifocal HCC.
ASIAN JOURNAL OF SURGERY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Chao An, Wang-Zhong Li, Zhi-Mei Huang, Xiao-Ling Yu, Yu-Zhi Han, Fang-Yi Liu, Song-Song Wu, Jie Yu, Ping Liang, Jinhua Huang
Summary: In patients with small single perivascular hepatocellular carcinoma, microwave ablation exhibited better tumor control than radiofrequency ablation, with a significantly higher local tumor progression rate observed in the radiofrequency ablation group. Additionally, there was a significant interaction effect of ablation modality and type of peritumoral vessel on local tumor progression, with differences observed in periportal HCC but not perivenous HCC.
EUROPEAN RADIOLOGY
(2021)
Article
Oncology
Melanie A. Kimm, Sophia Kaestle, Matthias M. R. Stechele, Elif Oecal, Lisa Richter, Muzaffer R. Uemuetlue, Regina Schinner, Osman Oecal, Lukas Salvermoser, Marianna Alunni-Fabbroni, Max Seidensticker, S. Nahum Goldberg, Jens Ricke, Moritz Wildgruber
Summary: This study found that local ablative therapies may have systemic effects on circulating immune cells in HCC patients. The levels of mMDSCs increased in almost all patients following local ablation, and there were varying alterations in monocyte subpopulations depending on the type of ablation. Liquid biopsy of circulating monocytes may provide information on the inflammatory response and immune reaction following local ablation.
FRONTIERS IN ONCOLOGY
(2022)
Review
Oncology
Peiman Habibollahi, Rahul A. Sheth, Erik N. K. Cressman
Summary: Liver cancer is a growing global concern with limited treatment options. The most common treatment methods are ablation techniques such as radiofrequency ablation and microwave ablation. However, difficulties in completely identifying residual cancer cells remain in these procedures, highlighting the need for further advancements in treatment strategies.
