Article
Hematology
Tiantian Chu, Shuhong Hu, Jiaqian Qi, Xueqian Li, Xiang Zhang, Yaqiong Tang, Meng Yang, Yang Xu, Chang-Geng Ruan, Yue Han, De-Pei Wu
Summary: This study investigated the effects of TNF alpha on megakaryocyte and platelet generation and found that TNF alpha had differential effects on their production at different concentrations.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2022)
Review
Medicine, General & Internal
Dominika Siwik, Magdalena Gajewska, Katarzyna Karon, Kinga Pluta, Mateusz Wondolkowski, Radoslaw Wilimski, Lukasz Szarpak, Krzysztof J. Filipiak, Aleksandra Gasecka
Summary: ASA has multiple beneficial effects after CABG, including anti-inflammatory, anticancerogenic, hypotensive, antiproliferative, anti-osteoporotic, and neuroprotective actions, which can reduce the risk of complications and promote postoperative recovery.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Xiaoying Kang, Tong Jiao, Haiyang Wang, John Pernow, Karin Wirdefeldt
Summary: This study evaluated the repurposing potential of TNF inhibitors for coronary artery disease (CAD) and ischemic stroke (IS) using drug-target Mendelian randomization design. The findings suggest that TNF/TNFR1 blockade does not have a protective effect on CAD or IS. Further research is needed to explore potential strategies to counteract the detrimental effects of circulating TNF on CAD and IS.
Article
Medicine, General & Internal
Ali Rafiei, Reza Ahmadi, Shakiba Kazemian, Tina Rahimzadeh-Fallah, Mina Mohammad-Rezaei, Fatemeh Azadegan-Dehkordi, Samira Sanami, Yousef Mirzaei, Farzad Aghaei, Nader Bagheri
Summary: Coronary artery disease (CAD) is a major cause of death worldwide. Recent evidence suggests that inflammation plays a crucial role in the progression of atherosclerosis. This study aimed to compare serum levels of interleukin-37 (IL-37) in CAD patients and controls, and investigate its correlation with oxidative stress, cholesterol homeostasis, and inflammation. The results showed that CAD patients had significantly lower levels of IL-37 compared to controls, and IL-37 was significantly increased in men with CAD compared to women with CAD. IL-37 was also inversely correlated with various inflammatory markers and oxidative stress, and positively correlated with antioxidant power.
JOURNAL OF INVESTIGATIVE MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Andy Ruiz, Yadira Palacios, Irene Garcia, Leslie Chavez-Galan
Summary: Tumor necrosis factor (TNF) is a key cytokine regulating inflammatory responses and plays a crucial role in granuloma formation during mycobacterial infections. The interactions between soluble and transmembrane TNF with their receptors influence effector mechanisms, providing insights into potential therapeutic strategies against mycobacterial infections. Understanding the structural and activation pathways of TNF and its receptors can offer valuable knowledge for developing more efficient therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
Afrouz Behboudi, Tilia Thelander, Duygu Yazici, Yeliz Celik, Tulay Yucel-Lindberg, Erik Thunstrom, Yuksel Peker
Summary: Obstructive sleep apnea is common in patients with coronary artery disease, and the TNF-alpha-308A allele appears to modulate circulatory TNF-alpha levels and mitigate excessive daytime sleepiness in this population.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Yeliz Celik, Yueksel Peker, Tuelay Yucel-Lindberg, Tilia Thelander, Afrouz Behboudi
Summary: This study examined the effect of TNF-alpha (-308G/A) gene polymorphism on circulating TNF-alpha levels after continuous positive airway pressure (CPAP) therapy in coronary artery disease (CAD) patients with obstructive sleep apnea (OSA). The results suggest that individuals with the TNF-alpha A allele have a smaller response to CPAP treatment regarding the decline in circulating TNF-alpha levels.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Immunology
Maha Sellami, Nicola Luigi Bragazzi, Baha Aboghaba, Mohamed A. Elrayess
Summary: This review summarizes the effects of acute and chronic exercise on immunoglobulins and cytokines in the elderly. Acute endurance exercise increases salivary SIgA, while acute muscle strengthening exercise raises levels of IL-6, IL-8, and TNF-alpha. Chronic exercise, both short-term and long-term, leads to improvements in immune function.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Holger Loerchner, Laia Canes Esteve, Maria Elisa Goes, Roxanne Harzenetter, Nathalie Brachmann, Praveen Gajawada, Stefan Guenther, Nicolas Doll, Jochen Poeling, Thomas Braun
Summary: This study reveals that TNF alpha recruits VEGFA-expressing neutrophils for muscle tissue revascularization through the CCL20-CCR6 axis. This finding provides a promising approach for revascularization, especially in diabetic conditions.
CIRCULATION RESEARCH
(2023)
Article
Medicine, General & Internal
Tiago Pereira-da-Silva, Patricia Napoleao, Marina C. Costa, Andre F. Gabriel, Mafalda Selas, Filipa Silva, Francisco J. Enguita, Rui Cruz Ferreira, Miguel Mota Carmo
Summary: The study revealed a negative correlation between miR-146a expression levels and TNF-alpha levels in patients with SCAD, irrespective of other metabolic or inflammatory markers, as well as with the severity of coronary artery disease. This highlights the potential therapeutic use of miR-146a in TNF-alpha-based inflammation in SCAD.
MEDICINA-LITHUANIA
(2021)
Article
Biochemistry & Molecular Biology
Elzbieta Lazar-Poloczek, Ewa Romuk, Wojciech Jachec, Wiktoria Stanek, Bartosz Stanek, Monika Szoltysik, Tomasz Techmanski, Maja Hasterok, Celina Wojciechowska
Summary: This study aimed to compare the levels of adipokines, TNF-alpha, and soluble receptors in heart failure patients with different BMI. The study found that obese patients had the lowest NT-proBNP concentrations and higher leptin levels. TNF-alpha concentrations were positively correlated with sTNFr1 in all groups. Higher levels of sTNFr1 were associated with higher sTNFr2 and CRP levels. Obese patients may respond better to anti-TNF therapy.
Review
Oncology
Wei-Cheng Tseng, Hou-Chuan Lai, Yi-Hsuan Huang, Shun-Ming Chan, Zhi-Fu Wu
Summary: Cancer is a leading cause of death worldwide, and surgical resection is the main treatment for solid tumors. However, surgery-induced stress responses can lead to immunosuppression and cancer regrowth and spread. The tumor microenvironment, particularly the presence of tumor necrosis factor alpha (TNF-alpha), plays a crucial role in cancer progression and immune surveillance. Anesthetic agents and perioperative management have varying effects on inflammation, immune responses, and cancer-promoting signaling pathways, which may affect long-term cancer outcomes.
Review
Medicine, Research & Experimental
Farid Ghorbaninezhad, Patrizia Leone, Hajar Alemohammad, Basira Najafzadeh, Niloufar Nourbakhsh, Marcella Prete, Eleonora Malerba, Hossein Saeedi, Neda Tabrizi, Vito Racanelli, Behzad Baradaran
Summary: This study reviews the dual role of tumor necrosis factor-alpha (TNF-alpha) in systemic lupus erythematosus (SLE), as well as the efficacy and safety of anti-TNF-alpha therapies in SLE.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Yi-Wen Duan, Shao-Xia Chen, Qiao-Yun Li, Ying Zang
Summary: This review focuses on the neuroimmune mechanism of neuropathic pain. TNF-alpha plays a crucial role in inducing and modulating neuropathic pain by facilitating peripheral and central sensitization. It controls cell survival and death through an inflammatory response and programmed cell death mechanisms. Overproduction of TNF-alpha in certain brain structures has an important role in pain-associated emotional disorders and memory deficits. The review also highlights the research prospects of the TNF-alpha-necroptosis pathway in pain modulation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Sayed Tanveer Abbas Gilani, Dilshad Ahmed Khan, Amer Rauf, Zujaja Hina Haroon, Kumail Abbas Khan, Faheem Ul Hassan
Summary: This study investigated the application of inflammatory biomarkers in the early diagnosis of coronary artery disease (CAD). The results showed that biomarkers such as NF-kappa B and TNF-alpha have high diagnostic accuracy in patients with angina and are correlated with disease severity. These biomarkers may serve as noninvasive tools for diagnosing CAD.
JOURNAL OF INTERFERON AND CYTOKINE RESEARCH
(2022)
Article
Cardiac & Cardiovascular Systems
Agata Tyminska, Krzysztof Ozieranski, Marek Wawrzacz, Pawel Balsam, Cezary Maciejewski, Magdalena Kleszczewska, Magdalena Zawadzka, Michal Marchel, Maria G. Crespo-Leiro, Aldo P. Maggioni, Jaroslaw Drozdz, Grzegorz Opolski, Marcin Grabowski, Agnieszka Kaplon-Cieslicka
Summary: Heart rate control in patients with heart failure after hospitalization is unsatisfactory, possibly due to inadequate doses of beta-blockers and neglect of other heart rate lowering drugs.
CARDIOLOGY JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Krzysztof Milewski, Pawel Balsam, Mateusz Kachel, Bronislaw Sitek, Aleksandra Kolarczyk-Haczyk, Szymon Skoczynski, Piotr Hirnle, Monika Gawalko, Lukasz Koltowski, Renata Glowczynska, Tomasz Zajac, Andrzej Malecki, Agata Nowak, Pawel Kazmierczak, Ewa Piotrowicz, Ryszard Piotrowicz, Milosz Jaguszewski, Grzegorz Opolski, Marcin Grabowski
Summary: Telerehabilitation (TR) was developed to overcome geographical barriers and staff deficiencies in delivering rehabilitation services, especially during crisis situations like the COVID-19 pandemic. It has been shown to have similar clinical outcomes and cost-effectiveness compared to traditional rehabilitation, but also has limitations such as lack of direct contact and patient competencies in handling mobile devices. This article discusses the current status of TR, with a focus on cardiac rehabilitation, covering technical/organizational and legal aspects, indications, cost-effectiveness, and future directions.
CARDIOLOGY JOURNAL
(2023)
Article
Multidisciplinary Sciences
Szczepan Wiecha, Przemyslaw Seweryn Kasiak, Igor Cieslinski, Tim Takken, Tomasz Palka, Beat Knechtle, Pantelis T. Nikolaidis, Lukasz A. Malek, Marek Postula, Artur Mamcarz, Daniel Sliz
Summary: This study compared predicted VO2max (pVO2max) with directly measured VO2max and found that the accuracy of available prediction models has not been validated in endurance athletes. The models underestimated pVO2max in younger and higher trained athletes, and overestimated pVO2max in older and lower trained athletes. These models should only be used as a supplemental method for physicians and new models need to be developed for clinical practice and sports diagnostics.
Article
Cardiac & Cardiovascular Systems
Aleksandra Gasecka, Oliwia Fidali, Aleksandra Klebukowska, Karolina Jasinska-Gniadzik, Piotr Szwed, Karolina Witkowska, Ceren Eyileten, Marek Postula, Marcin Grabowski, Krzysztof J. Filipiak, Marcin Ufnal
Summary: This study investigates the association between plasma concentrations of gut metabolites and major adverse cardiac and cerebrovascular events (MACCE) after acute myocardial infarction (AMI). The findings suggest that increased levels of trimethylamine-N-oxide (TMAO) may be an independent predictor of MACCE and contribute to post-AMI cardiac dysfunction.
POSTEPY W KARDIOLOGII INTERWENCYJNEJ
(2023)
Article
Physiology
Rafal Pawlowski, Pawel Zalewski, Julia Newton, Agnieszka Piatkowska, Edward Kozluk, Grzegorz Opolski, Katarzyna Buszko
Summary: Heart Rate Asymmetry (HRA) refers to the differences between accelerations and decelerations in human heart rate. The methods used for HRA assessment can also be applied to evaluate asymmetry in blood pressure variations (BPA). Through the analysis of heart rate and blood pressure signals from vasovagal patients and healthy individuals, it was found that HRA indicators changed only in the control group during tilt stage. Additionally, the vasovagal patients had significantly different pulse pressures compared to the healthy subjects.
FRONTIERS IN PHYSIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Chiara Siracusa, Jolanda Sabatino, Isabella Leo, Ceren Eyileten, Marek Postula, Salvatore De Rosa
Summary: Lack of timely intervention strategies for acute ischemic stroke due to limited understanding of underlying mechanisms. Circular RNAs involved in pathophysiological processes of ischemic stroke, providing potential therapeutic targets and clinical biomarkers.
Article
Cardiac & Cardiovascular Systems
Monika Budnik, Monika Gawalko, Piotr Lodzinski, Agata Tyminska, Krzysztof Ozieranski, Marcin Grabowski, Michal Peller, Anna Wancerz, Marek Kiliszek, Grzegorz Opolski, Radoslaw Lenarczyk, Zbigniew Kalarus, Gregory Y. H. Lip, Pawel Balsam
Summary: Heart failure has a significant impact on clinical outcomes in atrial fibrillation patients, leading to higher mortality rates and more frequent cardiovascular interventions and events. There is no statistically significant difference in long-term outcomes among different types of heart failure.
Review
Cardiac & Cardiovascular Systems
Karolina Gumiezna, Piotr Barus, Grazyna Sygitowicz, Agnieszka Wisniewska, Dorota Ochijewicz, Karolina Pasierb, Dominika Klimczak-Tomaniak, Ewa Kuca-Warnawin, Janusz Kochman, Marcin Grabowski, Grzegorz Opolski, Mariusz Tomaniak, Krzysztof J. Filipiak
Summary: Immature platelet fraction (IPF) has been found to play important roles in diagnosis, prognosis, and potential therapy in cardiovascular medicine. It serves as an independent predictor of cardiovascular death in patients with acute coronary syndromes, particularly ST-segment elevation myocardial infarction. Additionally, IPF can be used for monitoring antiplatelet therapy.
CARDIOLOGY JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Gloria M. M. Gager, Ceren Eyileten, Marek Postula, Anna Nowak, Aleksandra Gasecka, Bernd Jilma, Jolanta M. M. Siller-Matula
Summary: This study investigated the relationship between blood-derived microRNAs (miRNAs) and long-term all-cause mortality in patients with non-ST-segment elevation acute coronary syndrome (NSTE-ACS). The expression of miR-223 was found to be associated with improved long-term survival in NSTE-ACS patients. This hypothesis-generating study suggests that miR-223 may be a suitable predictor for long-term all-cause mortality.
Review
Health Care Sciences & Services
Chiara Siracusa, Niccolo Vono, Maria Benedetta Morano, Jolanda Sabatino, Isabella Leo, Ceren Eyileten, Eleonora Cianflone, Marek Postula, Daniele Torella, Salvatore De Rosa
Summary: Despite improvements in diagnosis and treatment, ischemic stroke remains a challenge with significant morbidity and mortality. The identification of high-risk individuals, timely diagnosis, recognition of different clinical forms, treatment response assessment, and prognostic evaluation are unmet clinical needs. This article provides an overview of circular RNAs as potential biomarkers in stroke, aiming to gather comprehensive information on this promising class of molecules.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Bela Merkely, Robert Hatala, Jerzy K. Wranicz, Gabor Duray, Csaba Foldesi, Zoltan Som, Marianna Nemeth, Kinga Goscinska-Bis, Laszlo Geller, Endre Zima, Istvan Osztheimer, Levente Molnar, Julia Karady, Gerhard Hindricks, Ilan Goldenberg, Helmut Klein, Matyas Szigeti, Scott D. Solomon, Valentina Kutyifa, Attila Kovacs, Annamaria Kosztin, BUDAPEST CRT Upgrade Invest
Summary: De novo implanted cardiac resynchronization therapy with defibrillator (CRT-D) reduces the risk of morbidity and mortality in patients with left bundle branch block, heart failure and reduced ejection fraction (HFrEF). However, among HFrEF patients with right ventricular pacing (RVP), the efficacy of CRT-D upgrade is uncertain.
EUROPEAN HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Ovidio De Filippo, Victoria L. Cammann, Corrado Pancotti, Davide Di Vece, Angelo Silverio, Victor Schweiger, David Niederseer, Konrad A. Szawan, Michael Wuerdinger, Iva Koleva, Veronica Dusi, Michele Bellino, Carmine Vecchione, Guido Parodi, Eduardo Bossone, Sebastiano Gili, Michael Neuhaus, Jennifer Franke, Benjamin Meder, Milosz Jaguszewski, Michel Noutsias, Maike Knorr, Thomas Jansen, Wolfgang Dichtl, Dirk von Lewinski, Christof Burgdorf, Behrouz Kherad, Carsten Tschoepe, Annahita Sarcon, Jerold Shinbane, Lawrence Rajan, Guido Michels, Roman Pfister, Alessandro Cuneo, Claudius Jacobshagen, Mahir Karakas, Wolfgang Koenig, Alexander Pott, Philippe Meyer, Marco Roffi, Adrian Banning, Mathias Wolfrum, Florim Cuculi, Richard Kobza, Thomas A. Fischer, Tuija Vasankari, K. E. Juhani Airaksinen, L. Christian Napp, Rafal Dworakowski, Philip Maccarthy, Christoph Kaiser, Stefan Osswald, Leonarda Galiuto, Christina Chan, Paul Bridgman, Daniel Beug, Clement Delmas, Olivier Lairez, Ekaterina Gilyarova, Alexandra Shilova, Mikhail Gilyarov, Ibrahim El-Battrawy, Ibrahim Akin, Karolina Polednikova, Petr Tousek, David E. Winchester, Michael Massoomi, Jan Galuszka, Christian Ukena, Gregor Poglajen, Pedro Carrilho-Ferreira, Christian Hauck, Carla Paolini, Claudio Bilato, Yoshio Kobayashi, Ken Kato, Iwao Ishibashi, Toshiharu Himi, Jehangir Din, Ali Al-Shammari, Abhiram Prasad, Charanjit S. Rihal, Kan Liu, P. Christian Schulze, Matteo Bianco, Lucas Joerg, Hans Rickli, Goncalo Pestana, Thanh H. Nguyen, Michael Boehm, Lars S. Maier, Fausto J. Pinto, Petr Widimsky, Stephan B. Felix, Ruediger C. Braun-Dullaeus, Wolfgang Rottbauer, Gerd Hasenfuss, Burkert M. Pieske, Heribert Schunkert, Monika Budnik, Grzegorz Opolski, Holger Thiele, Johann Bauersachs, John D. Horowitz, Carlo Di Mario, Francesco Bruno, William Kong, Mayank Dalakoti, Yoichi Imori, Thomas Muenzel, Filippo Crea, Thomas F. Luescher, Jeroen J. Bax, Frank Ruschitzka, Gaetano Maria De Ferrari, Piero Fariselli, Jelena R. Ghadri, Rodolfo Citro, Fabrizio D'Ascenzo, Christian Templin
Summary: A machine learning model was developed to predict the risk of in-hospital death for Takotsubo syndrome (TTS) patients and perform clustering to identify different risk profiles. The model demonstrated high discriminative capability and the clustering revealed six groups associated with different risks of in-hospital death.
EUROPEAN JOURNAL OF HEART FAILURE
(2023)
Article
Cardiac & Cardiovascular Systems
Ewa Piotrowicz, Michael Pencina, Ilona Kowalik, Piotr Orzechowski, Maciej Banach, Renata Glowczynska, Wojciech Zareba, Grzegorz Opolski, Dominika Szalewska, Slawomir Pluta, Zbigniew Kalarus, Robert Irzmanski, Ryszard Piotrowicz
Summary: This study aimed to identify predictors influencing long-term cardiovascular mortality or HF hospitalization based on clinical status and measurements obtained after a 9-week comprehensive telerehabilitation program. The risk factors collected at the end of the 9-week telerehabilitation period performed well in stratifying patients based on their 2-year risk of the composite outcome.
KARDIOLOGIA POLSKA
(2023)
Article
Biochemistry & Molecular Biology
Sonia Borodzicz-Jazdzyk, Agnieszka Kolodzinska, Katarzyna Czarzasta, Malgorzata Wojciechowska, Renata Glowczynska, Benedykt Szczepankiewicz, Liana Puchalska, Grzegorz Opolski, Agnieszka Cudnoch-Jedrzejewska
Summary: The aim of this study was to evaluate the presence and dynamics of necroptosis and pyroptosis in the rat model of TTS. The results showed higher plasma concentrations of interleukin-1β in TTS patients compared to controls. Protein expression associated with necroptosis and pyroptosis was observed in the myocardium after the injection of isoprenaline. These findings suggest that TTS is associated with inflammatory-associated programmed cell death and inflammation may occur simultaneously with cardiomyocyte death.
Article
Cardiac & Cardiovascular Systems
Jakub Maksym, Agnieszka Kaplon-Cieslicka, Piotr Scislo, Zenon Huczek, Michal Marchel, Radoslaw Piatkowski, Janusz Kochman, Grzegorz Opolski, Marcin Grabowski, Tomasz Mazurek
Summary: This study investigated the safety and efficacy of LAAC procedure followed by antiplatelet therapy in a high-risk population. The results showed that this treatment strategy was safe and effective in high-risk patients. Peri-procedural complications and treatment endpoints were evaluated.
POSTEPY W KARDIOLOGII INTERWENCYJNEJ
(2023)