Article
Anatomy & Morphology
Robert H. Anderson, Wouter H. Lamers, Jill P. J. M. Hikspoors, Timothy J. Mohun, Simon D. Bamforth, Bill Chaudhry, Lorraine Eley, Janet Kerwin, Moira Crosier, Deborah J. Henderson
Summary: The separation of the outflow tract of the developing heart into the systemic and pulmonary arterial channels is still controversial and not well understood. This study investigates the anatomical changes and developmental processes involved in the separation of the outflow channels, using histological and high-resolution imaging techniques. The findings provide insights into the development of the tripartite postnatal arrangement.
JOURNAL OF ANATOMY
(2023)
Article
Cardiac & Cardiovascular Systems
Ming-Tai Lin, Chun-An Chen, Shyh-Jye Chen, Jou-Hsuan Huang, Yu-Hsuan Chang, Shuenn-Nan Chiu, Chun-Wei Lu, Mei-Hwan Wu, Jou-Kou Wang
Summary: This study aimed to evaluate the efficacy of percutaneous pulmonary valve implantation (PPVI) on right ventricular (RV) function and graft remodeling in patients with native repaired right ventricular outflow tracts. The results showed that within 6 months after PPVI, all patients exhibited resolution of paradoxical septal motion and a significant reduction in RV volume, N-terminal pro-B-type natriuretic peptide levels, and valve eccentricity indices. However, only 9 patients (17.3%) achieved normalization of the RV ejection fraction (> 50%).
CANADIAN JOURNAL OF CARDIOLOGY
(2023)
Article
Medicine, General & Internal
Sargun Bajaj, Matthew T. Bennett, Simon W. Rabkin
Summary: This study applied data analytics to analyze the characteristics of premature ventricular complexes (PVC) and found that PVC with V1S plus V2S = 9.25 likely originated from the left ventricular outflow tract (LVOT), while PVC with V1R + V2R + V3R > 15.0 likely originated from the LVOT. PVC with V1S plus V2S > 12.75 likely originated from the right ventricular outflow tract (RVOT), and PVC with V1S plus V2S > 14.25 and all inferior leads positive likely originated from the RVOT. Importance rating: 8 out of 10.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Anatomy & Morphology
Ikram U. Haq, Samuel A. Shabtaie, Nicholas Y. Y. Tan, Nirusha Lachman, Samuel J. Asirvatham
Summary: This article focuses on outflow tract ventricular arrhythmias, the most common type of idiopathic ventricular arrhythmias. It highlights the three-dimensional spatial relationships between the ventricular outflow tracts using seven anatomical principles and discusses relevant clinical perspectives for electrophysiologists.
Article
Cardiac & Cardiovascular Systems
Raymond N. Haddad, Damien Bonnet, Ibrahim A. Abu Zahira, Mathilde Meot, Laurence Iserin, Sophie Malekzadeh-Milani
Summary: This study implanted Optimus-XXL stents in 15 patients with congenital heart disease, dysfunctional RVOTs, and target TPVR diameter >= 23 mm. The results showed that Optimus-XXL stents had good support stability and no fracture phenomenon, with good long-term effects.
CANADIAN JOURNAL OF CARDIOLOGY
(2022)
Article
Medicine, Research & Experimental
Andrew R. Kompa, Fay L. Khong, Yuan Zhang, Cindy Nguyen, Amanda J. Edgley, Owen L. Woodman, Grant McLachlan, Darren J. Kelly
Summary: This study evaluated the efficacy of NP202, a synthetic flavonol, on cardiac remodelling in a chronic model of myocardial infarction (MI). Results showed that NP202 improved left ventricular function and structure, especially at a higher dose. NP202 also reduced hypertrophy and interstitial fibrosis in the non-infarct region of the myocardium.
Article
Pharmacology & Pharmacy
Minyi Fu, Fangmei Luo, Eli Wang, Yueping Jiang, Shao Liu, Jun Peng, Bin Liu
Summary: The study demonstrates that magnolol can attenuate RV hypertrophy and fibrosis in hypoxia-induced PAH rats through inhibition of the JAK2/STAT3 signaling pathway, suggesting its potential clinical value for PAH therapy.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pediatrics
Jane Huang, Yogen Singh, Mohammad Adie, Shahab Noori, Mahmood Ebrahimi, Manuel Durand, Rowena Cayabyab, Rangasamy Ramanathan
Summary: This study evaluates the impact of assessing velocity time integral (VTI) at various locations across ventricular outflow tracts in neonates for calculating cardiac output (CO). Measurements were taken using transthoracic echocardiography at three different locations. The study found significant differences in VTI and CO measurements depending on the location of Doppler gate sampling.
EUROPEAN JOURNAL OF PEDIATRICS
(2023)
Article
Cardiac & Cardiovascular Systems
M. Nies, R. Schleberger, L. Dinshaw, N. Klatt, P. Muenkler, C. Jungen, L. Rottner, M. D. Lemoine, B. Reissmann, A. Rillig, A. Metzner, P. Kirchhof, C. Meyer
Summary: This study analyzed the spatial displacement of mapping catheter during premature ventricular contractions (PVC) using hybrid activation mapping, and explored options for correction. The results showed that ectopic activation of the ventricular myocardium during PVCs resulted in spatial displacement of mapping points, which was significantly larger for PVCs with non-outflow-tract origin. Correction for spatial displacement may improve the accuracy of catheter ablation in PVC treatment.
BMC CARDIOVASCULAR DISORDERS
(2022)
Article
Multidisciplinary Sciences
Boris Barbarics, Katja Eildermann, Lars Kaderali, Lukas Cyganek, Uwe Plessmann, Julius Bodemeyer, Thomas Paul, Philipp Stroebel, Henning Urlaub, Theodorus Tirilomis, Christof Lenz, Hanibal Bohnenberger
Summary: Aortic valve stenosis (AVS) is a common valve disease, but biological understanding of myocardial changes at the proteome level is still lacking. This study used high-resolution mass spectrometry to analyze FFPE human myocardial tissue samples from AVS patients, revealing significant upregulation and downregulation of multiple proteins associated with AVS-related changes such as cardiac hypertrophy, fibrosis, impaired mitochondria, and reduced blood supply. The findings provide a workflow for quantitative proteomics of human FFPE heart tissue and a comprehensive proteomic resource for AVS induced changes in the human myocardium.
SCIENTIFIC REPORTS
(2021)
Review
Cell Biology
Matthew Amoni, Eef Dries, Sebastian Ingelaere, Dylan Vermoortele, H. Llewelyn Roderick, Piet Claus, Rik Willems, Karin R. Sipido
Summary: Ischemic heart disease is a common cause of lethal ventricular arrhythmias and sudden cardiac death, with implantable cardioverter defibrillators and ablation therapy being the most effective treatments. Advances in mechanistic insights and technological innovation have led to improved interventional approaches, while pharmacological management still needs improvement.
Article
Medical Laboratory Technology
Zhen-Wei Wang, Sheng-Jue Xiao, Nai-Feng Liu
Summary: This study investigated the association of lipoprotein(a) [Lp(a)] with echocardiography-estimated left ventricular hypertrophy (LVH) in patients with new-onset acute myocardial infarction (AMI). The results showed that the concentration of Lp(a) was higher in the LVH group compared with the non-LVH group. Logistic regression analysis revealed a strong independent association between higher Lp(a) levels and increased risk of LVH. Subgroup and sensitivity analyses further confirmed the association of Lp(a) with LVH.
CLINICA CHIMICA ACTA
(2023)
Article
Cardiac & Cardiovascular Systems
Tobias Reichlin, Samuel H. Baldinger, Etienne Pruvot, Laurence Bisch, Peter Ammann, David Altmann, Benjamin Berte, Richard Kobza, Laurent Haegeli, Christian Schlatzer, Andreas Mueller, Mehdi Namdar, Dipen Shah, Haran Burri, Giulio Conte, Angelo Auricchio, Sven Knecht, Stefan Osswald, Babken Asatryan, Jens Seiler, Laurent Roten, Michael Kuhne, Christian Sticherling
Summary: This retrospective multi-center study compared outcomes of idiopathic outflow tract PVC ablation using standard ablation catheters versus CF-sensing catheters. The study found that the use of CF-sensing technology did not result in increased success rates or decreased complication rates in the treatment of idiopathic outflow tract PVCs.
Article
Veterinary Sciences
Takahiro Saito, Ryohei Suzuki, Yunosuke Yuchi, Haru Fukuoka, Shuji Satomi, Takahiro Teshima, Hirotaka Matsumoto
Summary: In recent years, hypertrophic cardiomyopathy (HCM) in cats has become more common due to improvements in diagnostic techniques. This study compared myocardial function in HCM-affected cats with and without left ventricular outflow tract obstruction (DLVOTO) using speckle-tracking echocardiography. The results showed that LV myocardial function was more compromised in HCM-affected cats with DLVOTO, indicating the importance of DLVOTO in affecting LV function in HCM-affected cats.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Cardiac & Cardiovascular Systems
M. Alvarez-Fuente, M. Toledano, E. Garrido-Lestache, I. Sanchez, I. Molina, N. Rivero, I. Garcia-Ormazabal, M. J. del Cerro
Summary: This article describes a single center experience with percutaneous balloon expandable pulmonary valves in nRVOT, including the techniques used, observed complications, and short to mid-term follow-up.
PEDIATRIC CARDIOLOGY
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Emanuele Monda, Giuseppe Limongelli
Article
Medicine, General & Internal
Claudia Cattapan, Alvise Guariento, Olimpia Bifulco, Raphael Caraffa, Francesco Bertelli, Elena Reffo, Massimo Padalino, Giovanni Di Salvo, Vladimiro Vida
Summary: By conducting three-dimensional heart segmentations and reconstructions on 30 patients, a scoring system called PAPVR score was established to predict the type of surgical repair, improving the quality of surgical planning.
JOURNAL OF CLINICAL MEDICINE
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Emanuele Monda, Giuseppe Limongelli
EUROPEAN JOURNAL OF HEART FAILURE
(2023)
Article
Biochemistry & Molecular Biology
Emanuele Monda, Michele Lioncino, Martina Caiazza, Vincenzo Simonelli, Claudia Nesti, Marta Rubino, Alessia Perna, Alfredo Mauriello, Alberta Budillon, Vincenzo Pota, Giorgia Bruno, Antonio Varone, Vincenzo Nigro, Filippo Maria Santorelli, Giuseppe Pacileo, Maria Giovanna Russo, Giulia Frisso, Simone Sampaolo, Giuseppe Limongelli
Summary: This study describes a group of patients with cardiomyopathy caused by neuromuscular diseases or mitochondrial diseases. The clinical phenotype of these patients was described through comprehensive clinical, molecular, and histological characteristics. A multidisciplinary evaluation and genetic testing play a key role in diagnosing these rare diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Emanuele Monda, Giuseppe Limongelli
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2023)
Review
Medicine, General & Internal
Biagio Castaldi, Elena Cuppini, Jennifer Fumanelli, Angela Di Candia, Jolanda Sabatino, Domenico Sirico, Vladimiro Vida, Massimo Padalino, Giovanni Di Salvo
Summary: Pediatric heart failure is a clinically important condition with high morbidity and mortality. It differs from adult heart failure in terms of etiology, physiology, clinical course, and therapeutic approaches. New drugs and non-pharmacological therapies have been developed to identify personalized treatment regimens. This article reviews the potential new drugs and non-pharmacological therapies for pediatric heart failure.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Pediatrics
Marco Vecchiato, Andrea Ermolao, Emanuele Zanardo, Francesca Battista, Giacomo Ruvoletto, Stefano Palermi, Giulia Quinto, Gino Degano, Andrea Gasperetti, Massimo A. Padalino, Giovanni Di Salvo, Daniel Neunhaeuserer
Summary: This study investigates the overshoot of respiratory exchange ratio (RER) after exercise in young patients with congenital heart disease (CHD) and compares it with healthy controls. The results show that CHD patients have a lower magnitude of RER overshoot, indicating reduced cardiorespiratory fitness. Therefore, RER overshoot should be included as part of routine exercise testing in CHD patients to improve prognostic risk stratification accuracy.
Review
Pediatrics
Pier Paolo Bassareo, Massimo Chessa, Giovanni Di Salvo, Kevin Patrick Walsh, Colin Joseph Mcmahon
Summary: Patients with congenital heart disease (CHD) require lifelong surveillance, but loss of follow-up is a common problem, leading to worsening health and increased morbidity and mortality. A systematic review found a worldwide average loss of follow-up of 26.1%, with significant variation by continent and country. The highest discontinuity was seen in the USA and in patients with simple CHD. Strategies to minimize loss of follow-up include planning transition rules, involving general practitioners, and fostering good relationships between pediatric and adult CHD teams.
Article
Genetics & Heredity
Martina Caiazza, Alberto Budillon, Emanuele Monda, Giustina Aruta, Augusto Esposito, Francesca Del Vecchio Blanco, Giulio Piluso, Vincenzo Nigro, Gioacchino Scarano, Giuseppe Limongelli
Summary: Ayme-Gripp Syndrome (AGS) is a rare syndrome characterized by peculiar facial traits combined with early bilateral cataracts, sensorineural hearing loss, and variable neurodevelopmental abnormalities. This paper reports the first case of a 6-year-old girl with AGS who displayed a milder phenotype with no cataracts and deafness. The study also includes a systematic review of previously published cases, focusing on clinical manifestation and genotype.
AMERICAN JOURNAL OF MEDICAL GENETICS PART A
(2023)
Letter
Cardiac & Cardiovascular Systems
Emanuele Monda, Giuseppe Limongelli
Article
Genetics & Heredity
Paolo Fontana, Alberto Budillon, Domenico Simeone, Francesca Del Vecchio Blanco, Martina Caiazza, Alessandra D'Amico, Fortunato Lonardo, Vincenzo Nigro, Giuseppe Limongelli, Gioacchino Scarano
Summary: Glycosylphosphatidylinositol biosynthesis defect 15 is a rare autosomal recessive disorder caused by biallelic loss of function of GPAA1. Less than twenty reported patients usually have compound heterozygous GPAA1 variants. The main clinical features include intellectual disability, hypotonia, seizures, and cerebellar atrophy. This case of a 4-year-old male with a novel homozygous variant expands the clinical spectrum of the GPAA1-related disorder and provides insights into phenotypic differences compared to defects of other subunits of the transamidase complex.
Article
Medicine, General & Internal
Jennifer Fumanelli, Silvia Garibaldi, Biagio Castaldi, Angela Di Candia, Alessandra Pizzuto, Domenico Sirico, Magdalena Cuman, Gianluca Mirizzi, Pietro Marchese, Massimiliano Cantinotti, Marcello Piacenti, Nadia Assanta, Cecilia Viacava, Giovanni Di Salvo, Giuseppe Santoro
Summary: This study evaluated the short- and medium-term electrocardiographic changes after percutaneous ASD closure with GCO in a pediatric population. The results showed that percutaneous ASD closure with the GCO device resulted in significant improvement in intra-atrial, atrio-ventricular, and intraventricular electrical homogeneity. These electrical changes persisted over a medium-term follow-up period. Additionally, the closure procedure led to a decrease in right heart volumes.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Domenico Sirico, Giulia Spigariol, Heba Talat Mahmoud, Alessia Basso, Elena Cuppini, Martina Avesani, Jolanda Sabatino, Biagio Castaldi, Giovanni Di Salvo
Summary: This study explores the immediate changes in right ventricle mechanics in pediatric patients after percutaneous balloon pulmonary valvuloplasty. The results show that there is a significant reduction in transpulmonary gradient, ratio between right ventricle and aortic systolic pressure, and transvalvar pressure gradient. The analysis of right ventricular mechanics demonstrates an increase in myocardial deformation in the apical segments.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Immunology
Jolanda Sabatino, Costanza Di Chiara, Daria Lauretta, Jennifer Fumanelli, Greta Luana D'Ascoli, Daniele Dona, Sandra Cozzani, Andrea Oletto, Carlo Giaquinto, Giovanni Di Salvo
Summary: This study conducted a comprehensive evaluation of cardiac function in vaccinated children and found no impairment in cardiac function after mRNA COVID-19 vaccination. However, there was a slight reduction in cardiac function in children who had previously been infected with COVID-19.
Review
Pediatrics
Sara Moscatelli, Valeria Pergola, Raffaella Motta, Federico Fortuni, Nunzia Borrelli, Jolanda Sabatino, Isabella Leo, Martina Avesani, Claudia Montanaro, Elena Surkova, Massimo Mapelli, Marco Alfonso Perrone, Giovanni di Salvo
Summary: Tetralogy of Fallot (TOF) is a common complex congenital heart disease that requires long-term monitoring for potential complications. Cardiovascular imaging plays a key role in the diagnosis and assessment of TOF patients, guiding patient management and providing prognostic information. Understanding the pathophysiology, expected sequelae, and advantages and limitations of different non-invasive imaging modalities is crucial for optimal management of TOF patients.