Journal
CARDIOLOGY CLINICS
Volume 27, Issue 2, Pages 329-+Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.ccl.2008.12.008
Keywords
Molecular imaging; Angiogenesis; Inflammation; Ventricular remodeling; Apoptosis; Radionuclide imaging; SPECT/CT; PET/CT
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Funding
- NCRR NIH HHS [S10 RR018039, S10 RR018039-01A1] Funding Source: Medline
- NHLBI NIH HHS [R01 HL065662-01A1, R01 HL078650-02, R01 HL065662-07, R01 HL065662-06, L30 HL115713, R01 HL078650-03, F32 HL097422, R01 HL065662, R01 HL065662-05A1, R01 HL078650-01, R01 HL078650-04, R01 HL078650, R01 HL065662-03, R01 HL065662-04, R01 HL065662-02] Funding Source: Medline
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Molecular imaging represents a targeted approach to noninvasively assess biologic (both physiologic and pathologic) processes in vivo. Ideally the goal of molecular imaging is not just to provide diagnostic and prognostic information based on identification of the molecular events associated with a pathologic process but rather to guide individually tailored pharmacologic, cell-based, or genetic therapeutic regimens. This article reviews the recent advances in myocardial molecular imaging in the context of the cardiovascular processes of angiogenesis, apoptosis, inflammation, and ventricular remodeling. The focus is on radiotracer-based single photon emission computed tomography and positron emission tomography molecular imaging approaches.
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